March 2008 Volume 14 Number 3, pp 255 - 253
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Focus on Asthma and Allergy
Respiratory diseases, including allergies, asthma and chronic obstructive pulmonary disorder, are a major public health burden worldwide. The prevalence of these diseases is increasing, and there is a continued need for new and improved therapies.
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EDITORIAL
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Getting with the program p223
An Institute of Medicine report recommends that the United States government create a program to provide consistent guidelines for clinical interventions. The reliability of the guidelines will depend on the availability of the clinical data to be assessed.
doi:10.1038/nm0308-223
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpT50Ec
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NEWS
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As demand for organs expands, so does transplant technology p225
Alisa Opar
doi:10.1038/nm0308-225
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpT60Ed
New plan proposed to help resolve conflicting medical advice p226
Meredith Wadman
doi:10.1038/nm0308-226a
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpT70Ee
Despite potential side effects, two drugs make a comeback p226
Genevive Bjorn
doi:10.1038/nm0308-226b
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpT80Ef
India continues crackdown, dismissing hundreds of AIDS groups p227
T.V. Padma
doi:10.1038/nm0308-227a
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUA0Ep
Swiss stance on HIV transmission sparks concern p227
Genevive Bjorn
doi:10.1038/nm0308-227b
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUB0Eq
News in brief pp228 - 229
Timeline of events...a brief look at the headlines from the past month
doi:10.1038/nm0308-228
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUC0Er
The fight of your life p230
Roxanne Khamsi
doi:10.1038/nm0308-230
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUD0Es
A matter of the heart pp231 - 233
Depression and negative emotions seem to worsen cardiac health, whereas a good laugh might improve blood vessel function. Clues from new experiments could help explain why and suggest better treatments for heart disease. Amy Coombs reports.
Amy Coombs
doi:10.1038/nm0308-231
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUE0Et
Q & A: Anna Veiga p234
Despite the restrictions and controversy confronting stem cell research, labs around the world continue to derive new human embryonic stem cell lines and make them available to the global research community. The EU-funded Human Embryonic Stem Cell Registry (hESCreg) seeks to bring order to the growing number of available stem cell lines and the flood of related data, beginning with the cell lines created in European labs. The web-based registry, launched in January 2008 and accessible at http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUF0Eu aims to serve as a one-stop source of information about the origins and traits of these cell lines. Anna Veiga, the hESCreg scientific coordinator and director of the stem cell bank at the Centre of Regenerative Medicine in Barcelona, talks with Doug Sipp about how the project was conceived and where it might lead.
Doug Sipp
doi:10.1038/nm0308-234
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUG0Ev
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CORRESPONDENCE
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No effect of endogenous TRIM5[alpha] on HIV-1 production pp235 - 236
Fengwen Zhang, David Perez-Caballero, Theodora Hatziioannou and Paul D Bieniasz
doi:10.1038/nm0308-235
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUH0Ew
Reply to: No effect of endogenous TRIM5[alpha] on HIV-1 production pp236 - 238
Ryuta Sakuma et al.
doi:10.1038/nm0308-236
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUI0Ex
The validity of alternative medicine p238
David Jay Brown
doi:10.1038/nm0308-238a
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUJ0Ey
Reply to: The validity of alternative medicine pp238 - 239
Bruno J Strasser
doi:10.1038/nm0308-238b
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUK0Ez
Laboratory animals deserve better legal protection p239
Jonathan Balcombe
doi:10.1038/nm0308-239a
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUL0E1
Animal experiments "represent outdated science" p239
Kathy Guillermo
doi:10.1038/nm0308-239b
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUM0E2
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BOOK REVIEW
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Autism without borders p241
Morton Ann Gernsbacher reviews Unstrange Minds: Remapping the World of AutismRoy R Grinker
doi:10.1038/nm0308-241
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUN0E3
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NEWS AND VIEWS
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Taking two cuts at pain pp243 - 244
Matrix metalloproteases (MMPs) are shedding their traditional roles in tissue remodeling and appearing as players in diseases of the nervous system. MMP2 and MMP9 provide the latest example, with converging roles in chronic pain after peripheral nerve injury (pages 331-336).
Simon Beggs and Michael W Salter
doi:10.1038/nm0308-243
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUO0E4
The weakness of a big heart pp244 - 245
A well-known cell cycle regulator, p27KIP1, and protein kinase CK2-[alpha][acute] mediate pathologic growth of cardiomyocytes. The findings have potential implications for the development of new treatment approaches to cardiac hypertrophy (pages 315-324).
Thomas Force
doi:10.1038/nm0308-244
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUP0E5
Notch inhibition reverses kidney failure pp246 - 247
Inhibition of the Notch pathway reverses damage in a mouse model of kidney disease (pages 290-298). The findings suggest that blockade of the Notch pathway through inhibition of [gamma]-secretase activity may be an approach to combating glomerular failure.
Matthias Kretzler and Lisa Allred
doi:10.1038/nm0308-246
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUQ0E6
Interleukin-22: a sheep in wolf's clothing pp247 - 249
Interleukin-22, a component of the immune system most studied for its role in autoimmunity, has a more beneficial side. Two studies show how this cytokine fights off microbes in the mucosa of the lung and gut (pages 275-281 and 282-289).
Arian Laurence, John J O'Shea and Wendy T Watford
doi:10.1038/nm0308-247
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUR0E7
Reducing glutamate signaling pays off in fragile X pp249 - 250
A recent theory about the basis for fragile X syndrome is now validated in a mouse model. The findings point the way to treatment options targeting group 1 metabotropic glutamate receptors.
Gary J Bassell and Christina Gross
doi:10.1038/nm0308-249
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUS0E8
Research Highlights pp252 - 253
doi:10.1038/nm0308-252
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUT0EA
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BRIEF COMMUNICATION
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Perivascular nitric oxide gradients normalize tumor vasculature pp255 - 257
Satoshi Kashiwagi et al.
doi:10.1038/nm1730
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUU0EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUV0EC
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ARTICLES
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A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression pp258 - 265
Xiao-Tong Song et al.
doi:10.1038/nm1721
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUW0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUX0EE
Transcription factor FOXO3a controls the persistence of memory CD4+ T cells during HIV infection pp266 - 274
Julien van Grevenynghe et al.
doi:10.1038/nm1728
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUY0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUZ0EG
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia pp275 - 281
Shean J Aujla et al.
doi:10.1038/nm1710
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUa0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUb0EO
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens pp282 - 289
Yan Zheng et al.
doi:10.1038/nm1720
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUc0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUd0EQ
The Notch pathway in podocytes plays a role in the development of glomerular disease pp290 - 298
Thiruvur Niranjan et al.
doi:10.1038/nm1731
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUe0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUf0ES
Dimorphic effects of Notch signaling in bone homeostasis pp299 - 305
Feyza Engin et al.
doi:10.1038/nm1712
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUg0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUh0EU
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation pp306 - 314
Matthew J Hilton et al.
doi:10.1038/nm1716
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUi0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUj0EW
Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart pp315 - 324
Ludger Hauck et al.
doi:10.1038/nm1729
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUk0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUl0EY
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LETTERS
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Kindlin-3 is essential for integrin activation and platelet aggregation pp325 - 330
Markus Moser et al.
doi:10.1038/nm1722
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUm0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUn0Ea
Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain pp331 - 336
Yasuhiko Kawasaki et al.
doi:10.1038/nm1723
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUo0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUp0Ec
Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells pp337 - 342
Ingunn M Stromnes et al.
doi:10.1038/nm1715
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUq0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUr0Ee
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TECHNICAL REPORT
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Noninvasive assessment of cancer response to therapy pp343 - 349
Zhaozhong Han et al.
doi:10.1038/nm1691
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUs0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUt0Eg
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CORRIGENDUM
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Corrigendum: Pim-1 regulates cardiomyocyte survival downstream of Akt p350
John A Muraski et al.
doi:10.1038/nm0308-350
http://ealerts.nature.com/cgi-bin24/DM/y/ejZB0Xztnp0HjT0BpUu0Eh
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June 6, 2008
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