April 2008 Volume 9 Number 4, pp 331 - 443
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Study difficult targets like lipid kinases with higher sensitivity and reduced interference using the AdaptaTM Universal Kinase Assay Kit.
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Natureevents Directory 2008
The FREE digital edition of the Natureevents Directory 2008 is now
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Nature Reviews Immunology Poster on innate immunity: sensing and signalling
The innate immune system is the first line of defence against invading
pathogens. Detection of such pathogens is a complex business, involving
several families of pattern-recognition receptors and an array of
signalling molecules.
This poster provides an overview of the components and networks involved
in pathogen sensing and signalling in the innate immune system.
Access the Poster FREE online!
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EDITORIALS
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Through the Signaling Gateway p331
New accession codes and links pack even more information into Nature
Immunology research articles
doi:10.1038/ni0408-331a
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFc0Ek
Immunology around the world p331
Hearing about past and present issues in the world community of
immunology can enrich all of us.
doi:10.1038/ni0408-331b
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFd0El
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OBITUARY
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Frank J. Dixon 1920-2008 p333
Michael B A Oldstone
doi:10.1038/ni0408-333
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFe0Em
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ESSAY
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A memoir of AID, which engraves antibody memory on DNA pp335 - 337
Tasuku Honjo recounts his work aimed at unraveling the molecular
mystery of how antibodies undergo antigen-induced maturation.
Tasuku Honjo
doi:10.1038/ni0408-335
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFf0En
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COMMENTARY
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Immunology in China: the past, present and future pp339 - 342
Over the past decade immunological research in China has developed
rapidly. This commentary describes the history, summarizes the
present research funding system, institutions and representative
work, and discusses the future of immunological research in China.
Xuetao Cao
doi:10.1038/ni0408-339
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFg0Eo
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NEWS AND VIEWS
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Location, location, location: identifying the neighborhoods of LPS
signaling pp343 - 345
TLR4 somehow manages to activate both MyD88- and TRIF-dependent
signaling. According to Medzhitov and colleagues, TLR4 engages MyD88
and TRIF sequentially at the cell surface and in endosomes,
respectively, thereby providing access to distinct pools of
signaling proteins.
Colin Watts
doi:10.1038/ni0408-343
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFh0Ep
New niches for B cells pp345 - 346
The bone marrow contains specialized microenvironments that maintain
blood cells and supply the requisite factors for their development.
Newly identified bone marrow-resident dendritic cells create unique
niches for mature B cells.
Takashi Nagasawa
doi:10.1038/ni0408-345
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFi0Eq
A new player in lymphocyte homing pp347 - 348
The homing of lymphocytes to secondary lymphoid organs occurs at
specialized blood vessels, the high endothelial venules. Autotaxin,
a phospholipid-producing enzyme secreted by high endothelial venule
endothelium, is a new participant found to facilitate the entry of l
ymphocytes into secondary lymphoid organs.
Dietmar Vestweber and Martin K Wild
doi:10.1038/ni0408-347
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFj0Er
TRIM-ing down Tolls pp348 - 350
Activation of the transcription factor NF-kappaB by Toll-like
receptors must be controlled to avoid excessive inflammation. The
tripartite-motif protein family member TRIM30alpha has now been
shown to mediate a negative regulatory feedback mechanism curtailing
such responses.
Andrew G Bowie
doi:10.1038/ni0408-348
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFk0Es
Research Highlights p351
doi:10.1038/ni0408-351
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFl0Et
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REVIEW
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Post-transcriptional control of cytokine production
pp353 - 359
Paul Anderson
doi:10.1038/ni1584
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFm0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFn0Ev
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Junior Faculty Position,
Depart. of Immunobiology Yale University
Qualified applicants in all areas of immunobiology are invited to apply.
Deadline: June 1st.
Applications to Peter Cresswell, Ph.D.,
Dept. of Immunobiology,
Yale University School of Medicine,
P.O. Box 208011, New Haven, CT 06520-8011
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ARTICLES
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TRAM couples endocytosis of Toll-like receptor 4 to the induction
of interferon-beta pp361 - 368
Jonathan C Kagan et al.
doi:10.1038/ni1569
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFo0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFp0Ex
TRIM30alpha negatively regulates TLR-mediated NF-kappaB
activation by targeting TAB2 and TAB3 for degradation pp369 - 377
Mude Shi et al.
doi:10.1038/ni1577
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFq0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFr0Ez
TNF activates an IRF1-dependent autocrine loop leading to sustained
expression of chemokines and STAT1-dependent type I
interferon-response genes pp378 - 387
Anna Yarilina et al.
doi:10.1038/ni1576
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFs0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFt0E2
Perivascular clusters of dendritic cells provide critical survival
signals to B cells in bone marrow niches pp388 - 395
Anita Sapoznikov et al.
doi:10.1038/ni1571
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFu0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFv0E4
Association between the Igk and Igh immunoglobulin loci mediated by t
he 3[prime] Igk enhancer induces 'decontraction' of the Igh locus in
pre-B cells pp396 - 404
Susannah L Hewitt et al.
doi:10.1038/ni1567
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFw0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFx0E6
Lymphoproliferative disease and autoimmunity in mice with increased
miR-17-92 expression in lymphocytes pp405 - 414
Changchun Xiao et al.
doi:10.1038/ni1575
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFy0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqFz0E8
Autotaxin, an ectoenzyme that produces lysophosphatidic acid,
promotes the entry of lymphocytes into secondary lymphoid organs
pp415 - 423
Hidenobu Kanda et al.
doi:10.1038/ni1573
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqF10Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqF20Ev
Regulation of T cell survival through coronin-1-mediated
generation of inositol-1,4,5-trisphosphate and calcium mobilization
after T cell receptor triggering pp424 - 431
Philipp Mueller et al.
doi:10.1038/ni1570
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqF30Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqF40Ex
Dual functions for the endoplasmic reticulum calcium sensors
STIM1 and STIM2 in T cell activation and tolerance
pp432 - 443
Masatsugu Oh-hora et al.
doi:10.1038/ni1574
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqF50Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BqF60Ez
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Focus on Asthma and Allergy
Respiratory diseases, including allergies, asthma and chronic obstructive
pulmonary disorder, are a major public health burden worldwide. The prevalence
of these diseases is increasing, and there is a continued need for new and improved therapies.
This Focus issue of Nature Reviews Immunology highlights the latest advances
in our understanding of the immune bases of these respiratory diseases
and how this knowledge can be translated into effective treatment strategies.
Access the Focus articles FREE online for the month of March at
http://ealerts.nature.com/cgi-bin24/DM/y/ejiX0Xztnp0HjR0BodK0Eo
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