March 2008 Volume 26 Number 3, pp 247 - 356
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EDITORIAL
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Off the rails p247
To restore its scientific credibility, the International Assessment of Agricultural Science and Technology for Development (IAASTD) should rethink its vision for biotech.
doi:10.1038/nbt0308-247
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplo0Ek
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NEWS
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Cloned animals deemed safe to eat, but labeling issues loom pp249 - 250
Jeffrey L Fox
doi:10.1038/nbt0308-249
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplp0El
Recombinant thrombin approved p250
Mark Ratner
doi:10.1038/nbt0308-250
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplq0Em
Genzyme and Isis strike megadeal pp251 - 253
George S. Mack
doi:10.1038/nbt0308-251
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplr0En
Human embryos cloned p252
Lisa Melton
doi:10.1038/nbt0308-252a
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpls0Eo
BiDil flops p252
Brady Huggett
doi:10.1038/nbt0308-252b
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplt0Ep
Start-ups weigh benefits of corporate incubators pp254 - 255
Emily Waltz
doi:10.1038/nbt0308-254
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplu0Eq
Another inhaled insulin casualty p255
Susan Aldridge
doi:10.1038/nbt0308-255a
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplv0Er
Plant biotechs defect p255
Susan Aldridge
doi:10.1038/nbt0308-255b
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplw0Es
HIV vaccine controversy p256
KS Jayaraman
doi:10.1038/nbt0308-256a
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplx0Et
1000 Genomes project p256
Susan Aldridge et al.
doi:10.1038/nbt0308-256b
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bply0Eu
Investor malaise stalks UK, European biotech pp256 - 257
Peter Mitchell
doi:10.1038/nbt0308-256c
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bplz0Ev
PROFILE
Tony Conner p259
Public distaste for genetically modified crops shows little sign of abating. Tony Conner thinks he's found a solution: tailor crops to be more palatable to the public.
Jim Kling
doi:10.1038/nbt0308-259
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpl10Ei
DATA PAGE
Brazil surpasses US in new transgenic crop plantings p260
Stacy Lawrence
doi:10.1038/nbt0308-260
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpl20Ej
NEWS FEATURE
Vintage genetic engineering pp261 - 263
With the genome of the grapevine in hand, how likely are enologists and wine growers to resort to genetic engineering to tackle the problems facing viticulture? Laura DeFrancesco reports.
Laura DeFrancesco
doi:10.1038/nbt0308-261
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpl30Ek
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BIOENTREPRENEUR
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BUILDING A BUSINESS
Entrepreneurial outreach pp265 - 267
Starting and sustaining a business in the life sciences is not for the faint of heart. And in an increasingly complex business environment, biotech entrepreneurs should look for complementary partners and new business opportunities to effectively build their companies.
Rohit Shukla
doi:10.1038/bioe.2008.2
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpl40El
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OPINION AND COMMENT
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CORRESPONDENCE
Do amniotic fluid-derived stem cells differentiate into neurons in vitro? pp269 - 270
Mauro Toselli, Elisabetta Cerbai, Ferdinando Rossi and Elena Cattaneo
doi:10.1038/nbt0308-269
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpl50Em
Response to Do amniotic fluid-derived stem cells differentiate into neurons in vitro? pp270 - 271
doi:10.1038/nbt0308-270
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpl60En
iPS cells and the politics of promise pp271 - 272
Herbert Gottweis and Stephen Minger
doi:10.1038/nbt0308-271
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpl70Eo
The 20-year African biotech plan pp272 - 274
Jerome Amir Singh and Abdallah S Daar
doi:10.1038/nbt0308-272
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpl80Ep
BLOSUM62 miscalculations improve search performance pp274 - 275
Mark P Styczynski, Kyle L Jensen, Isidore Rigoutsos and Gregory Stephanopoulos
doi:10.1038/nbt0308-274
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmA0Ez
COMMENTARY
When biotech crosses borders pp277 - 282
Elena Angulo and Ben Gilna
doi:10.1038/nbt0308-277
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmB0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmC0E2
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FEATURE
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Chasing biotech across Europe pp283 - 288
European governments recognize that the biotech industry is important to their economic development, but can the sector overcome the obstacles hindering its growth?
Barbara Nasto
doi:10.1038/nbt0308-283
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmD0E3
PATENTS
Monsanto Technology LLC v. Cargill: a matter of construction pp289 - 291
For the first time, a genetically modified plant patent is litigated in the United Kingdom's High Court.
Simon Cohen and Gareth Morgan
doi:10.1038/nbt0308-289
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmE0E4
Recent patent applications in microRNAs p292
doi:10.1038/nbt0308-292
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmF0E5
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NEWS AND VIEWS
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Digital mRNA profiling pp293 - 294
Color-coded probe pairs enable multiplexed gene expression analysis with a sensitivity that rivals PCR-based methods.
Paolo Fortina and Saul Surrey
doi:10.1038/nbt0308-293
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmG0E6
A toolkit for the cell's powerhouse pp294 - 296
Research on mitochondria will benefit from a new compendium of genetic and physiological data.
Eric A Schon
doi:10.1038/nbt0308-294
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmH0E7
Synthetic genomes brought closer to life pp296 - 297
An entire bacterial genome has been reconstructed by stitching together chemically synthesized DNA fragments, bringing the prospect of an artificial living organism one step closer.
Robert A Holt
doi:10.1038/nbt0308-296
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmI0E8
Metabolic engineering delivers next-generation biofuels pp298 - 299
The ability to produce 'higher-chain' alcohols in Escherichia coli could pave the way for advanced biofuels.
Jay D Keasling and Howard Chou
doi:10.1038/nbt0308-298
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmJ0EA
Tiny tiles, tiny targets pp299 - 300
A new label-free method for RNA detection uses programmable DNA tiles and atomic force microscopy.
David A Giljohann and Chad A Mirkin
doi:10.1038/nbt0308-299
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmK0EB
Research highlights p301
doi:10.1038/nbt0308-301
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmL0EC
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COMPUTATIONAL BIOLOGY
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PRIMER
What is principal component analysis? pp303 - 304
Principal component analysis is often incorporated into genome-wide expression studies, but what is it and how can it be used to explore high-dimensional data?
Markus Ringnér
doi:10.1038/nbt0308-303
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmM0ED
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RESEARCH
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PERSPECTIVE
Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE) pp305 - 312
Eric W Deutsch et al.
doi:10.1038/nbt1391
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmN0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmO0EF
BRIEF COMMUNICATION
Marked differences in differentiation propensity among human embryonic stem cell lines pp313 - 315
Kenji Osafune et al.
doi:10.1038/nbt1383
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmP0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmQ0EH
ARTICLES
Direct multiplexed measurement of gene expression with color-coded probe pairs pp317 - 325
Gary K Geiss et al.
doi:10.1038/nbt1385
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmR0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmS0EJ
Engineered lentivector targeting of dendritic cells for in vivo immunization pp326 - 334
Lili Yang et al.
doi:10.1038/nbt1390
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmT0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmU0EL
LETTER
Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein pp335 - 341
Joerg Petersen et al.
doi:10.1038/nbt1389
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmV0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmW0EN
RESOURCE
Large-scale chemical dissection of mitochondrial function pp343 - 351
Bridget K Wagner et al.
doi:10.1038/nbt1387
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmX0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmY0EP
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ERRATUM
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Erratum: Biotech patents still strong p352
Stacey Lawrence
doi:10.1038/nbt0308-352a
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0BpmZ0EQ
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CORRIGENDUM
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Corrigendum: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells p352
Fumitaka Osakada et al.
doi:10.1038/nbt0308-352b
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpma0EX
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NATUREJOBS
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CAREERS AND RECRUITMENT
Developing China's homegrown biotechnology workforce pp353 - 354
All the elements are in place for China's leap into the global biotech sector.
Grace Wong
doi:10.1038/nbt0308-353
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpmb0EY
PEOPLE
People p356
doi:10.1038/nbt0308-356
http://ealerts.nature.com/cgi-bin24/DM/y/ejcx0Xztnp0HjC0Bpmc0EZ
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