20 March 2008 Volume 452 Number 7185, pp253-386
Visit Nature online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0d4W0E4
Please note that you need to be a subscriber to enjoy full text
access to Nature online. To purchase a subscription, please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Z4L0Ei
Alternatively, to recommend a subscription to your library,
please visit
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BRQi0Ee
======================================================================
You think Taq is hot? This is pure Phire
Finnzymes new Phire Hot Start DNA Polymerase outperforms every
Taq-based polymerase on the market. If you want significantly shorter PCR
runs yet high yields and specificity then this was developed for you.
Have a look:
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqg10Eb
======================================================================
www.AltTox.org is a website that offers three ways for
interested stakeholders to accelerate progress on
non-animal methods of toxicity testing: participating
in discussion forums on key technical and policy
issues, contributing invited commentaries on the way
forward, and accessing succinct background
information on key topics.
======================================================================
Nature Protocols - Qualitative, Authoritative Protocols in Print and Online
Did you know that you can now purchase a personal print subscription
to Nature Protocols?
Receive your own personal print copy delivered directly to your door
each month, plus access to the journal online.
Subscribe today to ensure you have the latest protocols at your finger
tips. http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB04Yq0EK
Visit www.natureprotocols.com
======================================================================
----------------------
EDITORIALS
----------------------
A fresh approach to water p253
The water shortage that threatens humanity will have wide-ranging
consequences for agriculture and energy production, requiring
significant shifts in the way this precious resource is managed.
doi:10.1038/452253a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqg20Ec
Warning signs p254
Giving drug firms immunity from prosecution over inaccurate labelling
would not serve the public.
doi:10.1038/452254a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqg30Ed
The EIT farce p254
Universities should target the challenges that a virtual technology
powerhouse probably won't meet.
doi:10.1038/452254b
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqg40Ee
----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights pp256-257
doi:10.1038/452256a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqg50Ef
----------------------
JOURNAL CLUB
----------------------
Journal club p257
Masayuki Inoue
doi:10.1038/452257a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqg60Eg
----------------------
NEWS
----------------------
222 NIH grants: 22 researchers pp258-259
Grandee grantees are sitting pretty through agency cash crisis.
Eric Hand
doi:10.1038/452258a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqg70Eh
The Solar System's first breath pp259-260
NASA's Genesis probe offers clues to the Sun's oxygen.
Eric Hand
doi:10.1038/452259a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqg80Ei
Purification with a pinch of salt pp260-261
Climate change, growing populations and political concerns are
prompting governments and investors from California to China to take a
fresh look at desalination.
Quirin Schiermeier wades in.
doi:10.1038/452260a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhA0Es
Q&A
Banking on the future of stem cells p263
Representatives of 21 stem-cell funding agencies from 19 countries —
members of the International Stem Cell Forum — met in San Francisco at
the end of February to discuss collaborations and how to coordinate
cell banks and registries. Among them was Leszek Borysiewicz, head of
the UK Medical Research Council (MRC), who spoke to Nature about the
effort.
Monya Baker
doi:10.1038/452263a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhB0Et
Sidelines p264
Scribbles on the margins of science.
doi:10.1038/452264a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhC0Eu
Fly's eye detector spies cosmic-ray cut-off pp264-265
Philip Ball
doi:10.1038/452264b
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhD0Ev
Snapshot: Zooloddities p265
Anna Petherick
doi:10.1038/452265a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhE0Ew
Stem-cell patents confirmed pp265-266
Victory for Wisconsin foundation in landmark ruling.
Erika Check Hayden
doi:10.1038/452265b
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhF0Ex
Revised ozone standard angers environmentalists pp266
doi:10.1038/452266a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhG0Ey
Wellcome awards reveal microscopic masterpieces pp266
doi:10.1038/452266b
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhH0Ez
Fresh safety concerns for popular anaemia drugs pp266
doi:10.1038/452266c
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhI0E1
Saturn flyby is a success despite computer glitch pp267
doi:10.1038/452267a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhJ0E2
Bonn to play host to dementia research centre p267
doi:10.1038/452267b
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhK0E3
Korean institute inquiry prompts two retractions pp267
doi:10.1038/452267c
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhL0E4
----------------------
NEWS FEATURES
----------------------
Water under pressure pp269
doi:10.1038/452269a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhM0E5
Water: A long dry summer pp270-273
In parts of the world already facing unreliable food supplies, an
uncertain climate adds to the future stress for soils, plants and
people.
Quirin Schiermeier reports on water strategies for a drier world.
doi:10.1038/452270a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhN0E6
Water: More crop per drop pp273-277
Farmers' yields in the developing world are often limited by
unreliable rains. Improving their harvests will require plant
breeders, agronomists and geneticists to pull together — but can these
experts work out their differences?
Emma Marris reports.
doi:10.1038/452273a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhO0E7
Water: Muddy waters pp278-281
India's population is growing, and its water supplies are not keeping
pace. Can an ambitious scheme to connect up the country's rivers slake
the nation's deepening thirst?
Daemon Fairless investigates.
doi:10.1038/452278a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhP0E8
----------------------
CORRESPONDENCE
----------------------
Wildlife disease can put conservation at risk p282
Darrick T. Evensen
doi:10.1038/452282a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhQ0EA
Hall and Keynes join Arbor in the citation indexes p282
Daniel C. Postellon
doi:10.1038/452282b
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhR0EB
Growth of activism calls for more thoughtful solutions p282
doi:10.1038/452282c
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhS0EC
How genetic censorship would harm everyone p282
Marcelino Fuentes
doi:10.1038/452282d
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhT0ED
Qualities of a lone author are beneficial to science p282
Kevin Hallock
doi:10.1038/452282e
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhU0EE
----------------------
COMMENTARIES
----------------------
Improving on haves and have-nots pp283-284
All-or-nothing targets for global access to basic amenities such as
drinking water and sanitation are outdated. The time has come, says
Jamie Bartram, for a more fluid approach.
doi:10.1038/452283a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhV0EF
The energy challenge pp285-286
Global energy consumption is expected to grow by 50% by 2030,
squeezing already scarce water resources.
Mike Hightower and Suzanne A. Pierce recommend ways to integrate water
and energy planning.
doi:10.1038/452285a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhW0EG
----------------------
BOOKS AND ARTS
----------------------
Internet as utility? pp287-288
A sceptic argues that the electricity industry's tale predicts a
digital future of diminished privacy.
John Browning reviews The Big Switch: Our New Digital Destiny
by Nicholas Carr
doi:10.1038/452287a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhX0EH
Film: Water policy in the can p288
Emma Marris
doi:10.1038/452288a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhY0EI
Exhibition: Water works p289
Nick Thomas
doi:10.1038/452289a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqhZ0EJ
Galileo the artist p289
Thomas de Padova reviews Galilei der Kunstler. Die Zeichnung, der
Mond, die Sonne by Horst Bredekamp
doi:10.1038/452289b
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqha0EQ
Echoes of time in images of the Antarctic p290
British landscape artist Chris Drury imaginatively interprets radar
pictures taken of ancient ice layers underneath the south pole.
Martin Kemp reviews
doi:10.1038/452290a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhb0ER
----------------------
ESSAY
----------------------
Water: Water -- an enduring mystery pp291-292
Yet another theory of liquid water structure raises questions about
interdisciplinarity, drug design, astrobiology, molecular biology,
geochemistry and more.
Philip Ball
doi:10.1038/452291a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhc0ES
----------------------
NEWS AND VIEWS
----------------------
Particle physics: Song of the electroweak penguin pp293-294
An unexpected imbalance in how particles containing the heaviest
quarks decay might reveal exotic influences -- and perhaps help to
explain why matter, rather than antimatter, dominates the Universe.
Michael E. Peskin
doi:10.1038/452293a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhd0ET
Physiology: Brain comes to light pp294-295
To perceive seasons, animals compare changes in day length with the
constant cycle of their inner circadian clock. At a molecular level,
light signals trigger coordinated gene-expression events in the brain.
Hitoshi Okamura
doi:10.1038/452294a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhe0EU
50 & 100 Years Ago p295
doi:10.1038/452295a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhf0EV
Extrasolar planets: A whiff of methane pp296-297
Investigations of planets outside our Solar System are becoming ever
more sophisticated. The latest development is the discovery of a
carbon-containing molecule in the atmosphere of one such extrasolar
body.
Adam P. Showman
doi:10.1038/452296a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhg0EW
Drug discovery: Schistosome treatment p296
Sadaf Shadan
doi:10.1038/452296b
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhh0EX
Human behaviour: Punisher pays pp297-298
The tendency of humans to punish perceived free-loaders, even at a
cost to themselves, is an evolutionary puzzle: punishers perish, and
those who benefit the most are those who have never punished at all.
Manfred Milinski and Bettina Rockenbach
doi:10.1038/452297a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhi0EY
Quantum physics: Disturbance without the force pp298-299
Charged particles influenced by electromagnetic fields, even when the
two never touch? Surely, it can only be quantum physics. But
surprisingly, the quantum nature of this particular effect has been
disputed.
Akira Tonomura and Franco Nori
doi:10.1038/452298a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhj0EZ
----------------------
BRIEF COMMUNICATIONS ARISING
----------------------
Do abnormal responses show utilitarian bias? pE5
Guy Kahane and Nicholas Shackel
doi:10.1038/nature06785
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhk0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhl0Eb
Koenigs et al. reply ppE5-E6
M. Koenigs et al.
doi:10.1038/nature06804
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhm0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhn0Ed
----------------------
REVIEW
----------------------
Science and technology for water purification in the coming decades pp301-310
This article highlights some of the science and technology being
developed to improve the disinfection and decontamination of water, as
well as efforts to increase water supplies through the safe reuse of
wastewater and efficient desalination of sea and brackish water.
Mark A. Shannon et al.
doi:10.1038/nature06599
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqho0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhp0Ef
----------------------
ARTICLES
----------------------
Ancient, highly heterogeneous mantle beneath Gakkel ridge, Arctic Ocean pp311-316
Some refractory rocks from the ultra slow spreading Gakkel ridge
(Arctic Ocean) have model ages up to 2 billion years, implying the
long term preservation of refractory domains in the asthenospheric
mantle rather than their erasure by mantle convection. It is suggested
that the upwelling mantle beneath mid ocean ridges is highly
heterogeneous, which make its composition difficult to be constrained
by mid ocean ridge basalts alone.
Chuan-Zhou Liu et al.
doi:10.1038/nature06688
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhq0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhr0Eh
Thyrotrophin in the pars tuberalis triggers photoperiodic response pp317-322
This paper examines the changes in gene expression during the first
exposure to a long day (such as those found in spring) in Japanese
quails and find that two waves of genes are induced as part of the
photoperiodic response. This paper also identifies thyrotrophin
expression in the pars tuberalis as a critical event in triggering
this photoperiodic response.
Nobuhiro Nakao et al.
doi:10.1038/nature06738
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhs0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqht0Ej
Translational control of the innate immune response through IRF-7 p323-328
Production of type-I interferon is regulated by the transcription
factor IRF-7. This paper shows that IRF 7 is negatively regulated by
translational repressor proteins 4E BP1 and 4E BP2. Viral infection
promotes mTOR-mediated phosphorylation of the repressor proteins and
allows type I interferon production to proceed.
Rodney Colina et al.
doi:10.1038/nature06730
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhu0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhv0El
----------------------
LETTERS
----------------------
The presence of methane in the atmosphere of an extrasolar planet pp329-331
Water, carbon monoxide and methane are anticipated to be the main
molecules (other than hydrogen) in the atmosphere of extrasolar
planets. This paper reports a near infrared transmission spectrum of
the planet HD 189733b that shows the presence of methane and water,
however, carbon monoxide is not seen.
Mark R. Swain, Gautam Vasisht and Giovanna Tinetti
doi:10.1038/nature06823
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhw0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhx0En
Difference in direct charge-parity violation between charged and
neutral B meson decays pp332-335
This study measures direct CP violation in B meson decays. Previous
work suggested a difference in the decay of charged and neutral
particles, but the large uncertainties on these measurements made it
difficult to say whether the difference was real. This study reduces
the uncertainty on the charged particle decay rate asymmetry by a
factor of 1.7. Although firm conclusions cannot be drawn from this
result, the measurement provides stronger evidence for a large
deviation in direct CP violation between charged and neutral B meson
decays and possible new sources of CP violation beyond the standard
model.
doi:10.1038/nature06827
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhy0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqhz0Ep
Super-chondritic Sm/Nd ratios in Mars, the Earth and the Moon pp336-339
High precision neodymium isotope data for 16 martian meteorites is
presented, and shows that Mars has a non chondritic composition. The
Earth, Moon and Mars therefore seem to have all accreted in a portion
of the inner solar system with ~5 percent higher Sm/Nd ratio compared
with material accreted in the asteroid belt.
Guillaume Caro, Bernard Bourdon, Alex N. Halliday and Ghylaine Quitte
doi:10.1038/nature06760
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqh10Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqh20Ed
Biodiversity and biogeography of phages in modern stromatolites and
thrombolites p340-343
Use of a comparative metagenomic approach suggests that phage communities
in microbialites are endemic, and that marine and freshwater systems
may share a common ancestral viral community.
Christelle Desnues et al.
doi:10.1038/nature06735
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqh30Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqh40Ef
Survival variability and population density in fish populations pp344-347
The relationship between the variability of survival and population
abundance of wild fish based on a global compilation of fisheries data
is examined, and it is concluded that density dependent survival
variability increases at low population sizes, with important
consequences for fisheries management.
Coilin Minto, Ransom A. Myers and Wade Blanchard
doi:10.1038/nature06605
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqh50Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqh60Eh
Winners don't punish pp348-351
An experimental economics approach finds that punishment increases the
frequency of cooperation, but not the average payoff. Thus, the option
of costly punishment does not confer an advantage to the group.
Moreover, players who end up with the highest total payoff ('winners')
do not use punishment, whereas players who end up with the lowest
payoff ('losers') use punishment most frequently.
Anna Dreber, David G. Rand, Drew Fudenberg and Martin A. Nowak
doi:10.1038/nature06723
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqh70Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqh80Ej
Identifying natural images from human brain activity p352-355
Recent functional magnetic resonance imaging (fMRI) studies have shown
that it is possible to deduce simple features in the visual scene or
to which category it belongs. A decoding method based on quantitative
receptive field models that characterize the relationship between
visual stimuli and fMRI activity in early visual areas has now been
developed. These models make it possible to identify, out of a large
set of completely novel complex images, which specific image was seen
by an observer.
Kendrick N. Kay, Thomas Naselaris, Ryan J. Prenger & Jack L. Gallant
doi:10.1038/nature06713
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiA0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiB0Eu
Memory CD4 T cells emerge from effector T-cell progenitors p356-360
Naive CD4 and CD8 T cells give rise to effector and long lived memory
T cells after activation by antigen. This paper provides evidence that
memory CD4 T cells, similar to their CD8 counterparts, differentiatein
a linear fashion from effector cells rather than by an alternative
differentiation pathway.
Laurie E. Harrington, Karen M. Janowski, James R. Oliver, Allan J. Zajac
& Casey T. Weaver
doi:10.1038/nature06672
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiC0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiD0Ew
Preserving cell shape under environmental stress p361-364
An investigation into how poikilothermic organisms are able to maintain
highly effective mechanical responses finds that a protein called Spam
forms an extracellular shield that guards mechanosensory neurons from
environmental insult. Spam also enables cells to resist physically and
chemically induced deformation.
Boaz Cook, Robert W. Hardy, William B. McConnaughey & Charles S. Zuker
doi:10.1038/nature06603
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiE0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiF0Ey
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis pp365-369
The transcription factor REST has been implicated in tumourigenesis,
and beta-TrCP regulates REST degradation. REST, in turn, controls the
chromosome stability by regulating the expression of spindle
checkpoint protein Mad2, suggesting that this mechanism contributes
to the roles of beta-TrCP and REST in transformation.
Daniele Guardavaccaro et al.
doi:10.1038/nature06641
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiG0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiH0E1
SCFbeta-TRCP controls oncogenic transformation and neural
differentiation through REST degradation pp370-374
The transcription factor REST plays important roles in opposing
neuronal differentiation and in some human tumours. beta-TrCP is
identified as an important regulator of REST degradation.
Thomas F. Westbrook et al.
doi:10.1038/nature06780
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiI0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiJ0E3
X-ray structure of a prokaryotic pentameric ligand-gated ion channel p375-379
The X-ray structure of a prokaryotic pentameric ligand-gated ion
channels (pLGIC) from the bacterium Erwinia chrysanthemi (ELIC) at
3.3 Å resolution is presented. This study reveals the first structure
of a pLGIC at high resolution and provides an important model system
for the investigation of the general mechanisms of ion permeation and
gating within the family.
Ricarda J. C. Hilf & Raimund Dutzler
doi:10.1038/nature06717
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiK0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiL0E5
----------------------
CORRIGENDUM
----------------------
Structural basis for the function and inhibition of an influenza virus
proton channel p380
Amanda L. Stouffer et al.
doi:10.1038/nature06845
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiM0E6
----------------------
NATURE JOBS
----------------------
Prospect
Prospects p381
Should the NIH spread its wealth?
Gene Russo
doi:10.1038/nj7185-381a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiN0E7
Special Report
Closing the gaps p382
US researchers are keen to find ways to address health disparities
among minorities.
Paul Smaglik reports.
doi:10.1038/nj7185-382a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiO0E8
Career View
Mike Tyers, director of the Scottish Universities Life Sciences
Alliance, Edinburgh, Scotland p384
Cell-division researcher makes move from Canada to Scotland.
Jill U. Adams
doi:10.1038/nj7185-384a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiP0EA
Sea change in business studies p384
New degree for oceanographers with a business bent.
Virginia Gewin
doi:10.1038/nj7185-384b
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiQ0EB
Thinner air p384
I'm on a field-research high.
Aliza le Roux
doi:10.1038/nj7185-384c
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiR0EC
----------------------
FUTURES
----------------------
Shambles p386
A new career for the home help.
Alexander Hay
doi:10.1038/452386a
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiS0ED
------------------------------
ADVANCE ONLINE PUBLICATION
------------------------------
19 March 2008
Article
Kemp elimination catalysts by computational enzyme design
Daniela Röthlisberger et al.
doi:10.1038/nature06879
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiT0EE
Letters
Hydatellaceae are water lilies with gymnospermous tendencies
William E. Friedman
doi:10.1038/nature06733
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiU0EF
Chromatin dynamics during epigenetic reprogramming in the mouse germ line
Petra Hajkova et al.
doi:10.1038/nature06714
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiV0EG
Integration of growth and specification in chick wing digit-patterning
Matthew Towers, Ruth Mahood, Yili Yin & Cheryll Tickle
doi:10.1038/nature06718
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiW0EH
16 March 2008
Variations in DNA elucidate molecular networks that cause disease
Yanqing Chen et al.
doi:10.1038/nature06757
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiX0EI
Genetics of gene expression and its effect on disease
Valur Emilsson et al.
doi:10.1038/nature06758
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiY0EJ
Lateral presynaptic inhibition mediates gain control in an olfactory circuit
Shawn R. Olsen & Rachel I. Wilson
doi:10.1038/nature06864
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0BqiZ0EK
Tumour maintenance is mediated by eNOS
Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus & Christopher M. Counter
doi:10.1038/nature06778
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqia0ER
A neural representation of depth from motion parallax in macaque visual
cortex
Jacob W. Nadler, Dora E. Angelaki & Gregory C. DeAngelis
doi:10.1038/nature06814
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqib0ES
NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration
R. Grace Zhai, Fan Zhang, P. Robin Hiesinger, Yu Cao, Claire M. Haueter &
Hugo J. Bellen
doi:10.1038/nature06721
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Bqic0ET
======================================================================
Cell Migration Gateway - Leading the way in cell migration
New expandable KNOWLEDGEBASE * More Proteins * More Information
Research highlights, library of must-read articles, research data &
resources, reagents & protocols, news & events, and email alerts.
Visit the gateway to get FREE access to this comprehensive and regularly
updated resource for anyone interested in cell migration.
A collaboration between the Cell Migration Consortium and Nature
Publishing Group
======================================================================
You have been sent this Table of Contents Alert because you have opted
in to receive it. You can change or discontinue your e-mail alerts at
any time, by modifying your preferences on your nature.com account at:
http://ealerts.nature.com/cgi-bin24/DM/y/ejml0Xztnp0HjB0Zzu0EZ
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration
department: registration@nature.com
For print subscription enquiries, please contact our subscription
department: subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London-Paris-Munich-New Delhi-Tokyo-Melbourne-
San Diego-San Francisco-Washington-New York-Boston
(c) Copyright 2007 Nature Publishing Group
=====================================================================
