April 2008 Volume 128 Number 4, pp 765 - 1053
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The Journal of Investigative Dermatology features timely, peer-reviewed contributions highlighting experimental, theoretical, and clinical
aspects in cutaneous biology and skin disease. If you can't access the articles below, recommend a site licence to your librarian by visiting http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BSup0El
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EDITORIALS
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Clinical Snippets
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Research Snippets
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Editors' Picks
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprD0ET
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprE0EU
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JOURNAL CLUB
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Chronic Diseases and Non-Melanoma Skin Cancer: Is There an Association?
Yvonne Romagosa, Shasa Hu and Robert S Kirsner
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprF0EV
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprG0EW
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Charles M. Lapiere (1931-2007)
Thomas Krieg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprH0EX
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprI0EY
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COMMENTARIES
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T-Cell Clonality Assays: How Do They Compare?
Antonio Cozzio and Lars E French
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprJ0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprK0Ea
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprL0Eb
Vitamin D Regulation of Cathelicidin in the Skin: Toward a Renaissance of Vitamin D in Dermatology?
Siegfried Segaert
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprM0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprN0Ed
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprO0Ee
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PERSPECTIVES
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A Systems Biology Approach to Anatomic Diversity of Skin
John L Rinn, Jordon K Wang, Helen Liu, Kelli Montgomery, Matt van de Rijn and Howard Y Chang
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprP0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprQ0Eg
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprR0Eh
The Role of Smads in Skin Development
Philip Owens, Gangwen Han, Allen G Li and Xiao-Jing Wang
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprS0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprT0Ej
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprU0Ek
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ORIGINAL ARTICLES
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APPENDAGES
RSPO4 Is the Major Gene in Autosomal-Recessive Anonychia and Mutations Cluster in the Furin-Like Cysteine-Rich Domains of the Wnt Signaling Ligand R-spondin 4
Nadina Ortiz Bruchle, Jorge Frank, Valeska Frank, Jan Senderek, Ahmet Akar, Erol Koc, Dimitris Rigopoulos, Maurice van Steensel, Klaus Zerres and Carsten Bergmann
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprV0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprW0Em
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprX0En
CELL BIOLOGY
All-trans Retinoic Acid-Induced Hyaluronan Production and Hyperplasia Are Partly Mediated by EGFR Signaling in Epidermal Keratinocytes
Sanna M Pasonen-Seppanen, Edward V Maytin, Kari J Torronen, Juha M T Hyttinen, Vincent C Hascall, Donald K MacCallum, Anne H Kultti, Tiina A Jokela, Markku I Tammi and Raija H Tammi
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprY0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BprZ0Ep
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpra0Ew
Methionine Sulfoxide Reductases A and B Are Deactivated by Hydrogen Peroxide (H2O2) in the Epidermis of Patients with Vitiligo
Karin U Schallreuter, Katharina Rubsam, Nicholas C J Gibbons, Derek J Maitland, Bhaven Chavan, Carsten Zothner, Hartmut Rokos and John M Wood
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprb0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprc0Ey
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprd0Ez
Histone Acetylation in Keratinocytes Enables Control of the Expression of Cathelicidin and CD14 by 1,25-Dihydroxyvitamin D3
Jurgen Schauber, Yuko Oda, Amanda S Buchau, Qian-Chun Yun, Andreas Steinmeyer, Ulrich Zugel, Daniel D Bikle and Richard L Gallo
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpre0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprf0E2
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprg0E3
Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis
Soline Estrach, Ralf Cordes, Katsuto Hozumi, Achim Gossler and Fiona M Watt
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprh0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpri0E5
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprj0E6
Multiple PKC[delta] Tyrosine Residues Are Required for PKC[delta]-Dependent Activation of Involucrin Expression[mdash]a Key Role of PKC[delta]-Y311
Ling Zhu, Chaya Brodie, Sivaprakasam Balasubramanian and Richard L Eckert
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprk0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprl0E8
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprm0EA
CONNECTIVE TISSUE
Propionibacterium acnes Stimulates Pro-Matrix Metalloproteinase-2 Expression through Tumor Necrosis Factor-[alpha] in Human Dermal Fibroblasts
Jee-Young Choi, Mei Shan Piao, Jee-Bum Lee, Jong Seok Oh, In-Gyu Kim and Seung-Chul Lee
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprn0EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpro0EC
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprp0ED
Inhibitors of Dipeptidyl Peptidase IV-Like Activity Mediate Antifibrotic Effects in Normal and Keloid-Derived Skin Fibroblasts
Anja Thielitz, Robert W Vetter, Bianca Schultze, Sabine Wrenger, Luca Simeoni, Siegfried Ansorge, Klaus Neubert, Jurgen Faust, Petra Lindenlaub, Harald P M Gollnick and Dirk Reinhold
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprq0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprr0EF
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprs0EG
GENETICS
Mutations in R-Spondin 4 (RSPO4) Underlie Inherited Anonychia
Yoshiyuki Ishii, Muhammad Wajid, Hisham Bazzi, Katherine A Fantauzzo, Alison G Barber, Diana C Blaydon, Ju-Suk Nam, Jeong K Yoon, David Peter Kelsell and Angela M Christiano
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprt0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpru0EI
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprv0EJ
IMMUNOLOGY/INFECTION
Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic Sclerosis
Julie Bayle, Jennifer Fitch, Kimberly Jacobsen, Rajiv Kumar, Robert Lafyatis and Raphael Lemaire
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprw0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprx0EL
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpry0EM
Age-Related Differences in Sensitivity of Peripheral Blood Monocytes to Lipopolysaccharide and Staphylococcus Aureus Toxin B in Atopic Dermatitis
Marie Mandron, Marie-Francoise Aries, Franck Boralevi, Helene Martin, Marie Charveron, Alain Taieb and Christian Davrinche
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bprz0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpr10EA
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpr20EB
Glove-Derived Foreign Proteins Induce Allergen-Specific IgE in a Mouse Model
Marion Busch, Claudia Schroder, Jens-Malte Baron, Hagen Ott, Thomas Bruckner, Thomas L Diepgen and Vera Mahler
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpr30EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpr40ED
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpr50EE
Activation of T-Cells from Allergic Patients and Volunteers by p-Phenylenediamine and Bandrowski's Base
Eve Marie Coulter, Claire Jenkinson, Ying Wu, John Farrell, Brian Foster, Andrew Smith, Carolann McGuire, Camilla Pease, David Basketter, Clodagh King, Peter Simon Friedmann, Munir Pirmohamed, Brian Kevin Park and Dean J Naisbitt
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpr60EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpr70EG
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpr80EH
KERATINOCYTES/EPIDERMIS
Regulation of Epidermal Tight-Junctions (TJ) during Infection with Exfoliative Toxin-Negative Staphylococcus Strains
Ulrich Ohnemus, Klaas Kohrmeyer, Pia Houdek, Holger Rohde, Ewa Wladykowski, Sabine Vidal, Matthias A Horstkotte, Martin Aepfelbacher, Nina Kirschner, Martin J Behne, Ingrid Moll and Johanna M Brandner
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsA0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsB0ES
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsC0ET
Co-Regulation and Interdependence of the Mammalian Epidermal Permeability and Antimicrobial Barriers
Karin M Aberg, Mao-Qiang Man, Richard L Gallo, Tomas Ganz, Debra Crumrine, Barbara E Brown, Eung-Ho Choi, Dong-Kun Kim, Jens M Schroder, Kenneth R Feingold and Peter M Elias
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsD0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsE0EV
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsF0EW
Chronic Diseases Requiring Hospitalization and Risk of Non-Melanoma Skin Cancers[mdash]A Population Based Study from Denmark
Annette O Jensen, Anne B Olesen, Claus Dethlefsen, Henrik T Sorensen and Margaret R Karagas
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsG0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsH0EY
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsI0EZ
IFN-[alpha] Enhances Poly-IC Responses in Human Keratinocytes by Inducing Expression of Cytosolic Innate RNA Receptors: Relevance for Psoriasis
Errol P Prens, Marius Kant, Grietje van Dijk, Leontine I van der Wel, Sabine Mourits and Leslie van der Fits
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsJ0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsK0Eb
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsL0Ec
Isolation of Pathogenic Monoclonal Anti-Desmoglein 1 Human Antibodies by Phage Display of Pemphigus Foliaceus Autoantibodies
Ken Ishii, Chenyan Lin, Don L Siegel and John R Stanley
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsM0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsN0Ee
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsO0Ef
MELANOCYTES/MELANOMA
Hyperthermia Induces Endoplasmic Reticulum-Mediated Apoptosis in Melanoma and Non-Melanoma Skin Cancer Cells
Yiqun G Shellman, William R Howe, Leslie A Miller, Nathaniel B Goldstein, Theresa R Pacheco, Roop L Mahajan, Susan M LaRue and David A Norris
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsP0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsQ0Eh
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsR0Ei
The Multidrug Transporter P-Glycoprotein: A Mediator of Melanoma Invasion?
Marisa Colone, Annarica Calcabrini, Laura Toccacieli, Giuseppina Bozzuto, Annarita Stringaro, Massimo Gentile, Maurizio Cianfriglia, Alessandra Ciervo, Michele Caraglia, Alfredo Budillon, Giuseppina Meo, Giuseppe Arancia and Agnese Molinari
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsS0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsT0Ek
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsU0El
Expression of Ligands to NKp46 in Benign and Malignant Melanocytes
Emanuela Cagnano, Oren Hershkovitz, Alon Zilka, Ahuva Bar-Ilan, Alexandra Golder, Netta Sion-Vardy, Alexander Bogdanov-Berezovsky, Ofer Mandelboim, Daniel Benharroch and Angel Porgador
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsV0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsW0En
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsX0Eo
mTOR Is Activated in the Majority of Malignant Melanomas
Magdalena Karbowniczek, Cynthia S Spittle, Tasha Morrison, Hong Wu and Elizabeth P Henske
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsY0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0BpsZ0Eq
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsa0Ex
Evaluation of Twenty-One Human Adenovirus Types and One Infectivity-Enhanced Adenovirus for the Treatment of Malignant Melanoma
Dennis Hoffmann, Wibke Bayer, Albert Heim, Anja Potthoff, Dirk M Nettelbeck and Oliver Wildner
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsb0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsc0Ez
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsd0E1
NEUROBIOLOGY
Metabolism and Biological Activities of Topical 4-Oxoretinoids in Mouse Skin
Olivier Sorg, Christian Tran, Pierre Carraux, Denise Grand, Christelle Barraclough, Jean-Francois Arrighi, Patrick Descombes, Vincent Piguet and Jean-Hilaire Saurat
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpse0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsf0E3
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsg0E4
Dynamic Expression of Erbb Pathway Members during Early Mammary Gland Morphogenesis
Olivia Wansbury, Heena Panchal, Michelle James, Suzanne Parry, Alan Ashworth and Beatrice Howard
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsh0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsi0E6
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsj0E7
PHOTOBIOLOGY
UVB-Induced Activation of NF-[kappa]B is Regulated by the IGF-1R and Dependent on p38 MAPK
Davina A Lewis and Dan F Spandau
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsk0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsl0EA
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsm0EB
TUMOR BIOLOGY
TCR[gamma]-Chain Gene Rearrangement by PCR-Based GeneScan: Diagnostic Accuracy Improvement and Clonal Heterogeneity Analysis in Multiple Cutaneous T-Cell Lymphoma Samples
Renata Ponti, Maria T Fierro, Pietro Quaglino, Bonello Lisa, Francia di Celle Paola, Ortoncelli Michela, Fava Paolo, Alessandra Comessatti, Mauro Novelli and Maria G Bernengo
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsn0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpso0ED
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsp0EE
WOUND HEALING
A Murine Living Skin Equivalent Amenable to Live-Cell Imaging: Analysis of the Roles of Connexins in the Epidermis
Eve E Kandyba, Malcolm B Hodgins and Patricia E Martin
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsq0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsr0EG
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpss0EH
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LETTER TO THE EDITOR
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Somatic Mutation Analysis in NF1 Cafe au lait Spots Reveals Two NF1 Hits in the Melanocytes
Sofie De Schepper, Ophelia Maertens, Tom Callens, Jean-Marie Naeyaert, Jo Lambert and Ludwine Messiaen
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpst0EI
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/ejeW0Xztnp0Hiw0Bpsu0EJ
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