Parkinson's disease stem cell research welcomed
A leading Irish researcher has welcomed as a step forward new Swedish
stem cell research, which may help patients with Parkinson's disease.
Researchers have developed new ways to grow brain cells in the
laboratory using neural stem cells in a bid to treat patients with
Parkinson's disease, according to latest research from Sweden.
Prof Ernest Arenas of the Karolinska Institute in Stockholm presented
his research to the EuroSTELLS "Stem Cell Niches" conference in
Barcelona last month.
Prof Arenas's team studied the development of neurons in animals to
determine the important biological molecules in the brain that were
necessary for the cells to grow and function efficiently. It was
shown that when the protein Wnt5A, together with a second protein
noggin, was included in cultures of stem cells, far more dopaminergic
neurons were produced than when these ingredients were not present.
The researchers almost completely reversed the behavioural
abnormalities in the brains of the animals whose sustantia nigra had
been damaged.
According to the researchers, verification of this approach with
human cells is ongoing and if the study is successful, it may lead to
a clinical trial.
Prof Frank Barry of the Regenerative Medicine Institute at NUI Galway
told IMN that there has been strong interest in developing new
treatments for Parkinson's disease using stem cells.
"Progress in the past has been up and down but this latest
development looks quite interesting,
application of stem cells is being refined in terms of Parkinson's
disease and appears to be quite sharply defined in this research, he
added.
"The use of neural stem cells as opposed to embryonic stem cells
means that there would not be worries about neurons differentiating
abnormally or uncontrollably,
Danielle Barron
danielleb@imn.
http://www.irishmed
Category=news&
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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