Signaling Gateway - 8 February 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0M40Ei
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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TUMOR CELL INVASION: IT'S NOT JUST ROCK 'N' RHO
The kinase PDK1 promotes cancer cell migration and invasion by
blocking the interaction between RhoE and ROCK1.
Original research paper: Nature Cell Biology 10, 127-137 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0vP0Er
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0HIE0E8
Ptp1b
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BnEc0EJ
Ptp1b (protein tyrosine phosphatase 1B) plays a major role in
inhibiting signaling downstream of the insulin and leptin receptors.
However, Ptp1b also dephosphorylates the inhibitory Tyr 527 site in
Src, thereby activating this kinase. Ptp1b also has a positive role
in a mouse model of Neu-induced breast cancer. Therefore, Ptp1b has
attracted particular attention as a potential therapeutic target in
obesity, diabetes and now, cancer.
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BUuz0E4
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Selected Updates
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CELL SIGNALLING: BALANCING ACT
The transcription factor E2F1 transactivates different subsets of
target genes to orchestrate either proliferation or apoptosis through
differential activation of the PI3K-Akt pathway.
Original research paper: Cancer Cell 13, 11–22 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BnEd0EK
CELL DEATH: ...AND A NICE CHIANTI
Entosis, a form of non-apoptotic cell death in which one cell is
completely internalized within another cell, requires activation of
the Rho-ROCK pathway and upregulation of myosin II activity in the
internalizing cell.
Original research paper: Cell 131, 966–979 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BnEe0EL
ANTICANCER DRUGS: REDESIGNING KINASE INHIBITORS
A re-engineered version of the kinase inhibitor imatinib retains its
potent activity against gastrointestinal stromal tumors but exhibits
reduced cardiac toxicity, suggesting that modifying other kinase
inhibitors could increase their safety and efficacy.
Original research paper: J. Clin. Invest. 117, 4044–4054 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BnEf0EM
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BmlI0EV
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Research Library
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ACUTE UPREGULATION OF AN NKG2D LIGAND PROMOTES RAPID REORGANIZATION
OF A LOCAL IMMUNE COMPARTMENT WITH PLEIOTROPIC EFFECTS ON
CARCINOGENESIS
Nature Immunology 9, 146-154 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BnEg0EN
DOK1 MEDIATES HIGH-FAT DIET–INDUCED ADIPOCYTE HYPERTROPHY AND OBESITY
THROUGH MODULATION OF PPAR-gamma PHOSPHORYLATION
Nature Medicine 14, 188-193 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BnEh0EO
MUTATIONS IN PERICENTRIN CAUSE SECKEL SYNDROME WITH DEFECTIVE
ATR-DEPENDENT DNA DAMAGE SIGNALING
Nature Genetics 40, 232-236 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BnEi0EP
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Signaling News
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RESEARCH HORIZONS FROM NATURE
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0Bm6v0EM
'Horizons' is a new weekly series in Nature that features experts
speculating on what will happen in their fields over the next few
years. The Horizons articles this week discuss the potential of
systems biology to uncouple disease and old age, a new 'open'
approach to chemistry and the marriage of fossil evidence and systems
biology in the study of evolutionary developmental biology, among
other topics.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0Crw0EZ
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Gateway Updates
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THE CELL MIGRATION GATEWAY - FEBRUARY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0ll80E6
The Cell Migration Update is a comprehensive FREE online resource to
keep you abreast of the latest findings in the field.
This month's update features:
Cancer metastasis: Protection from small RNAs
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0Bm3P0Ef
Nanotechnology: Drawing tumour cells from blood
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0Bm3V0El
Sign up to receive the monthly table of contents e-alert for the
Cell Migration Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BJrg0EW
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Signaling Job of the Week
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Independent Junior Research Group Leader
Employer: University of Frankfurt
Location: Frankfurt, Germany
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0BnEj0EQ
The Center for Drug Research, Development and Safety at the University
of Frankfurt, Germany invites applications for an Independent Junior
Research Group Leader in the field of Lipid Signaling. Candidates
with a strong track record of research on the arachidonic acid,
endocannabinoid or sphingolipid signaling cascades are encouraged to
apply.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0Ba6W0Ed
To advertize a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ei3o0Xztnp0H2W0vqs0EL
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