Signaling Gateway - 29 February 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0M40EY
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
GPCRS: ADRENERGIC RECEPTOR GETS BENT OUT OF SHAPE BY MORPHINE
Morphine inhibits adrenergic receptor signaling by inducing a
trans-conformational switch in the alpha2A-adrenergic receptor
(alpha2A-AR) when in a complex with the morphine receptor, MOR.
Original research paper:Nature Chemical Biology 4, 126-131 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0vP0Eh
------------------------
Molecule Pages
------------------------
The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0HIE0Ex
PDE6B
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1A0EG
Phosphodiesterase 6B (PDE6B) is a catalytic subunit of the
rod-specific cyclic nucleotide phosphodiesterase 6 (PDE6) enzyme.
PDE6 is highly selective for cyclic GMP over cyclic AMP. PDE6 serves
as an effector enzyme in the rod phototransduction cascade. Mutations
in PDE6B can lead to autosomal recessive retinitis pigmentosa, a
common hereditary retinal degeneration leading to vision loss caused
by the death of the rod and cone photoreceptors.
Also published this week:
DHHC3
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1B0EH
DHHC7
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1C0EI
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0BUuz0Et
-------------------
Selected Updates
-------------------
TUMOUR IMMUNOTHERAPY: LITTLE PIG, LITTLE PIG, LET ME COME IN
When the endothelin B receptor (ETBR) is highly expressed in the
tumor endothelium it blocks T-cell homing, suggesting that
pharmacologic inhibition of ETBR might cause immunotherapy-induced
T cells to gain access to the tumor.
Original research paper: Nature Med. 14, 28-36 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1D0EJ
STEM CELLS: SAFEGUARDING PLURIPOTENCY
The transcription factor Nanog safeguards pluripotent cells against
premature differentiation and plays a central role in the production
of germ cells.
Original research paper: Nature 450, 1230-1234 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1E0EK
GENE REGULATION: GATHERING A BOUQUET OF miRNA TARGETS
An efficient and robust biochemical screen for microRNAs and their
targeted mRNAs allows unprecedented in vivo characterization of
microRNA-regulated genes.
Original research paper: Mol. Cell 28, 598-613 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1F0EL
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0BmlI0EL
------------------------
Research Library
------------------------
RESISTANCE TO THERAPY CAUSED BY INTRAGENIC DELETION IN BRCA2
Nature 451, 1111-1115 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1G0EM
SMAD3 AND NFAT COOPERATE TO INDUCE FOXP3 EXPRESSION THROUGH ITS
ENHANCER
Nature Immunology 9, 194-202 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1H0EN
DUAL ROLE OF PROAPOPTOTIC BAD IN INSULIN SECRETION AND BETA CELL
SURVIVAL
Nature Medicine 14, 144-153 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1I0EO
------------------------
Signaling News
------------------------
NATURE NEWS: REVAMP FOR US AND UK GRANTS
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Yg40ET
United States and United Kingdom funding agencies are transforming
the way grants are awarded to institutions and researchers. Two news
stories chronicle the changes in store for the US National Institutes
of Health and the UK Higher Education Funding Council for England,
and examine the potential consequences for scientists.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Crw0EP
-------------------------
Gateway Updates
-------------------------
NEUROSCIENCE GATEWAY - FEBRUARY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0BmlM0EP
The Neuroscience Gateway is a comprehensive FREE online resource for
news, highlights and research on neuroscience.
This month's update features:
Neurogenesis: New kids on the block
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0BoMw0Ec
Neural pathways: Short circuit
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0BnBO0Ek
Sign up to receive the table of contents e-alert for the
Neuroscience Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0BmlN0EQ
-----------------------------
Signaling Job of the Week
-----------------------------
Postdoctoral Position
Employer: King's College London
Location: London, UK
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0Bo1J0EP
A postdoctoral position is available at the Medical Research Council
Centre for Developmental Neurobiology. The project will focus on the
temporal and spatial regulation of PI3K/PTEN signaling in neuronal
growth cones and primary neurons. Applicants should have a strong
background in live-cell imaging, biochemistry and molecular biology.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0BnjC0EE
To advertize a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0vqs0EB
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0dIO0Eb
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0BCGZ0EJ
For further technical assistance or any other enquiries, please click here:
http://ealerts.nature.com/cgi-bin24/DM/y/ejTC0Xztnp0H2W0BByD0Ek
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2008 Nature Publishing Group
---------------------------------------------------------------------
