Signaling Gateway - 22 February 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0M40EB
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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ANGIOGENESIS: PGC-1alpha PROVIDES A BREATH OF FRESH AIR
The transcriptional coactivator PGC-1alpha and transcription factor
ERR-alpha stimulate angiogenesis in hypoxic conditions by directly
upregulating VEGF expression.
Original research paper: Nature 451, 1008-1012 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0vP0EK
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0HIE0Ea
PDE6A
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoM80EC
Phosphodiesterase 6A (PDE6A) is a catalytic subunit of the
rod-specific cyclic nucleotide phosphodiesterase 6 (PDE6) enzyme.
PDE6 is highly selective for cyclic GMP over cyclic AMP. PDE6 serves
as an effector enzyme in the rod phototransduction cascade. Mutations
in PDE6A can lead to the development of autosomal recessive retinitis
pigmentosa, a common hereditary disease of retinal degeneration that
can result in vision loss caused by the death of the rod and cone
photoreceptors.
Also published this week:
ZnT3
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoNA0EM
Laminin beta 2
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoPF0ET
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BUuz0EW
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Selected Updates
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TUMOUR IMMUNOLOGY: TGFbeta BETRAYS IMMUNITY FOR TUMORIGENESIS
Mammary tumors deficient in the type II TGF-beta receptor recruit
myeloid cells that produce TGF-beta1 and matrix metalloproteinases,
which facilitate tumor invasion and metastasis.
Original research paper: Cancer Cell 13, 23-35 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoNB0EN
SIGNALLING: STRUCTURAL SURVEY
The crystal structure of the p110alpha catalytic subunit of PI3K in
complex with the p85alpha regulatory subunit illuminates the
mechanisms by which p110alpha oncogenic mutations activate the protein.
Original research paper: Science 318, 1744-1748 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoNC0EO
ANTICANCER DRUGS: REVERSING RESISTANCE
The small molecule obatoclax inhibits pro-survival BCL2 family
members, thus restoring the sensitivity of drug-resistant tumors to
several new anticancer drugs.
Original research paper: Proc. Natl Acad. Sci. USA 104, 19512-19517 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoND0EP
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BmlI0Ew
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Research Library
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PHOSPHOINOSITIDE SIGNALLING LINKS O-GlcNAc TRANSFERASE TO INSULIN
RESISTANCE
Nature 451, 964-969 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoNE0EQ
NANOG MAINTAINS PLURIPOTENCY OF MOUSE EMBRYONIC STEM CELLS BY
INHIBITING NFkappaB AND COOPERATING WITH STAT3
Nature Cell Biology 10, 194-201 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoNF0ER
INTERLEUKIN 17-PRODUCING T HELPER CELLS AND INTERLEUKIN 17 ORCHESTRATE
AUTOREACTIVE GERMINAL CENTER DEVELOPMENT IN AUTOIMMUNE BXD2 MICE
Nature Immunology 9, 166-175 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoNG0ES
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Signaling News
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NATURE INSIGHT: CARDIOVASCULAR DISEASE
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoPD0ER
Cardiovascular disease is the most common cause of death worldwide.
This FREE Nature Insight explores recent progress in understanding
the mechanisms that lead to cardiovascular disease and discusses the
implications of these advances for identifying new therapeutic targets.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0Crw0E1
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - FEBRUARY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BKHW0E1
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Neurotoxins and cancer cells: Gangliosides gangs up
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0Bnky0Ek
Protein-glycan interaction: An umbrella embraces the virus cone
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0Bnkz0El
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BJYw0Eo
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Signaling Job of the Week
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Postdoctoral Research Fellow
Employer: National University of Singapore
Location: Singapore
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BoNI0EU
Two postdoctoral research fellow positions are available at the
Inflammation and Cancer Laboratory at the National University of
Singapore. Potential research projects will focus on tumor immunology
and immunotherapy, as well as the signaling pathways associated with
T and B cell development, activation and survival.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0BnjC0Ep
To advertize a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0vqs0Em
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http://ealerts.nature.com/cgi-bin24/DM/y/ejK50Xztnp0H2W0dIO0EE
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