February 2008 Volume 15 Number 2, pp 115 - 215
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Nature Methods' special issue on Structural Genomics
Having trouble expressing your favorite protein? Struggling to get cry
stals? Wondering how large structural genomics centers do it? Check out the February 2008 issue of Nature Methods for special content in structural biology and structural genomics. A Commentary, Review, Perspective and Technology Feature address methodological issues related to protein expression, purification and crystallization in the context of large scale structural genomics initiatives, as well as small scale lab production. Visit Nature Methods for a useful and practical reference.
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Hwa0Eq
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EDITORIAL
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Sequencing the microbial soup p115
Metagenomics has the potential to shed light on one of the least
understood group of organisms on Earth, while also providing useful
tools for many fields in biology.
doi:10.1038/nsmb0208-115
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmoy0Ep
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CORRESPONDENCE
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Bermuda Principles meet structural biology p116
Aled Edwards
doi:10.1038/nsmb0208-116
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmoz0Eq
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MEETING REPORT
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Structures and diseases pp117 - 120
Structural biology is making significant contributions toward an
understanding of molecular constituents and mechanisms underlying
human diseases at an atomic resolution, as discussed at the
international Murnau Conference on Structural Biology of Disease
Mechanisms held in September 2007 in Murnau, Germany.
K Ulrich Wendt, Manfred S Weiss, Patrick Cramer and Dirk W Heinz
doi:10.1038/nsmb0208-117
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmo10Ed
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NEWS AND VIEWS
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Stop and go: regulation of chain length in the biosynthesis of
bacterial polysaccharides pp121 - 123
An immense range of polysaccharide structures is expressed on the
bacterial surface. The length of the polymer can be a crucial
attribute for virulence. Members of a family of 'polysaccharide
copolymerase' proteins are essential for the regulation of polymer
chain length, participating in one widespread biosynthesis scheme.
Chris Whitfield and Kane Larue
doi:10.1038/nsmb0208-121
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmo20Ee
DNA torsional stress propagates through chromatin fiber and
participates in transcriptional regulation pp123 - 125
Transient mechanical stresses induced by molecular motors that
move DNA can propagate through the chromatin fiber and trigger
local DNA alterations that in turn allow for specific DNA-protein
interactions. Hence, DNA supercoiling modulations and chromatin
conformational dynamics concur in gene regulation.
Christophe Lavelle
doi:10.1038/nsmb0208-123
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmo30Ef
Understanding how the replisome works pp125 - 127
Recent papers shed insight into the architecture and dynamics of
the components of the bacterial replisome.
Kenneth J Marians
doi:10.1038/nsmb0208-125
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmo40Eg
Energizing type III secretion machines: what is the fuel?
pp127 - 128
Bacterial type III secretion machines have adapted to carry out
numerous functions, ranging from locomotion to protein delivery
into nucleated cells. One of the most intriguing issues is the
source of energy that fuels their activities. Despite recent
advances, there are still many questions to be resolved.
Jorge E. Galan
doi:10.1038/nsmb0208-127
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmo50Eh
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RESEARCH HIGHLIGHTS
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Research Highlights p129
doi:10.1038/nsmb0208-129
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmo60Ei
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ARTICLES
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Bacterial polysaccharide co-polymerases share a common framework for
control of polymer length pp130 - 138
Ante Tocilj et al.
doi:10.1038/nsmb.1374
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmo70Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0Bmo80Ek
Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis
rates and substrate energy landscapes pp139 - 145
Andreas Martin, Tania A Baker and Robert T Sauer
doi:10.1038/nsmb.1380
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpA0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpB0Ev
The functional response of upstream DNA to dynamic supercoiling in vivo
pp146 - 154
Fedor Kouzine, Suzanne Sanford, Zichrini Elisha-Feil and David Levens
doi:10.1038/nsmb.1372
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpC0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpD0Ex
Crystal structure of the multifunctional Gbeta5-RGS9 complex
pp155 - 162
Matthew L Cheever et al.
doi:10.1038/nsmb.1377
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpE0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpF0Ez
Identification of a DNA primase template tracking site redefines the
geometry of primer synthesis pp163 - 169
Jacob E Corn, Jeffrey G Pelton and James M Berger
doi:10.1038/nsmb.1373
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpG0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpH0E2
Single-molecule studies of fork dynamics in Escherichia coli DNA
replication pp170 - 176
Nathan A Tanner et al.
doi:10.1038/nsmb.1381
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpI0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpJ0E4
Structure of the SAM-II riboswitch bound to S-adenosylmethionine
pp177 - 182
Sunny D Gilbert, Robert P Rambo, Daria Van Tyne and Robert T Batey
doi:10.1038/nsmb.1371
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpK0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpL0E6
Polypyrimidine tract binding protein controls the transition from exon
definition to an intron defined spliceosome pp183 - 191
Shalini Sharma et al.
doi:10.1038/nsmb.1375
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpM0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpN0E8
Superwobbling facilitates translation with reduced tRNA sets
pp192 - 198
Marcelo Rogalski, Daniel Karcher and Ralph Bock
doi:10.1038/nsmb.1370
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpO0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpP0EB
Engineered disulfide bonds support the functional rotation mechanism
of multidrug efflux pump AcrB pp199 - 205
Markus A Seeger et al.
doi:10.1038/nsmb.1379
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpQ0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpR0ED
Structural insights into the dual activity of RNase J pp206 - 212
Ines Li de la Sierra-Gallay, Lena Zig, Ailar Jamalli and Harald Putzer
doi:10.1038/nsmb.1376
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpS0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpT0EF
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TECHNICAL REPORT
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A protein-based EM label for RNA identifies the location of exons in
spliceosomes pp213 - 215
Eric A Alcid and Melissa S Jurica
doi:10.1038/nsmb.1378
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpU0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BmpV0EH
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Obesity
New Publisher, New Look, New Editors in 2008
Nature Publishing Group is proud to publish Obesity on behalf of The Obesity Society. The journal has re-launched with a new look, editor, and editorial team, and aims to increase knowledge, foster research and promote better treatment for people with obesity and their loved ones. Obesity publishes important, peer-reviewed, original, scientific articles, as well as relevant review articles, commentaries, and public health and medical developments.
http://ealerts.nature.com/cgi-bin24/DM/y/eiyu0Xztnp0Hjh0BeQt0E7
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