March 2008 Volume 8 Number 3
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Focus on Asthma and Allergy
Respiratory diseases, including allergies, asthma and chronic
obstructive
pulmonary disorder, are a major public health burden worldwide.
The prevalence of these diseases is increasing, and there is a
continued
need for new and improved therapies.
This Focus issue of Nature Reviews Immunology highlights the latest
advances in our understanding of the immune bases of these respiratory
diseases and how this knowledge can be translated into effective
treatment
strategies.
Access the Focus articles FREE online for the month of March at
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0BodK0E4 .
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This month's FEATURED article:
Discovering susceptibility genes for asthma and allergy
Donata Vercelli
p169 | doi:10.1038/nri2257
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0BocY0EI
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From the editors
p161 | doi:10.1038/nri2288
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0BocZ0EJ
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RESEARCH HIGHLIGHTS
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Allergy and Asthma: Calling all TH2 cells
p162 | doi:10.1038/nri2285
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Boca0EQ
Mucosal immunology: Antimicrobial function for IL-22
p163 | doi:10.1038/nri2290
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocb0ER
IN BRIEF
HIV | Immune responses | Regulatory T cells
p163 | doi:10.1038/nri2292
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocc0ES
Allergy and Asthma: Regulation of TGF[beta]1 PINned down
p164 | doi:10.1038/nri2286
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocd0ET
Vaccines: TBK1 mediates DNA vaccine immunogenicity
p164 | doi:10.1038/nri2287
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Boce0EU
IN THE NEWS
Drug-free after transplantation
p164 | doi:10.1038/nri2289
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocf0EV
Stem cells: Immunosuppression by mesenchymal stem cells
p165 | doi:10.1038/nri2284
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocg0EW
Innate immunity: New role for cathepsin K
p166 | doi:10.1038/nri2282
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Boch0EX
Allergy and Asthma: What 'drives' IL-4 versus IL-13 signalling?
p166 | doi:10.1038/nri2283
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Boci0EY
IN BRIEF
Allergy and asthma | T-cell development
p167 | doi:10.1038/nri2293
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocj0EZ
Allergy and Asthma: Mother knows best
p168 | doi:10.1038/nri2277
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bock0Ea
B-cell signalling: Synapse formation wRAPped up with help from RAC2
p168 | doi:10.1038/nri2291
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocl0Eb
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Focus on: Allergy and Asthma
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocm0Ec
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REVIEWS
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Discovering susceptibility genes for asthma and allergy
Donata Vercelli
p169 | doi:10.1038/nri2257
A number of susceptibility genes for asthma and allergy have been
identified in recent years. Here, Donata Vercelli discusses these
genes and reviews the techniques used by geneticists to identify them.
She also highlights the outstanding challenges in the field.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0BocY0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocn0Ed
Immunology of asthma and chronic obstructive pulmonary disease
Peter J. Barnes
p183 | doi:10.1038/nri2254
Asthma and chronic obstructive pulmonary disease both involve chronic
inflammation of the lungs. But Peter Barnes explains how the
inflammatory mediators and cells involved differ between the two
diseases and how this affects their responsiveness to corticosteroids
and other anti-inflammatory therapies.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Boco0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocp0Ef
Dendritic cells and epithelial cells: linking innate and adaptive
immunity in asthma
Hamida Hammad and Bart N. Lambrecht
p193 | doi:10.1038/nri2275
In addition to providing a physical barrier, epithelial cells have a
role in initiating and maintaining allergic responses to inhaled
allergens. As discussed in this Review, epithelial cells can influence
the polarization of lung dendritic cells and are themselves influenced
by innate and adaptive immune responses during allergic inflammation.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocq0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocr0Eh
IgE in allergy and asthma today
Hannah J. Gould and Brian J. Sutton
p205 | doi:10.1038/nri2273
Recent advances in the structural determination of IgE and its
receptors and associated molecules have provided insight into the
functions and regulation of IgE. This is now helping to direct the
design of new IgE-targeted therapies for asthma and allergy.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocs0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Boct0Ej
Treatment strategies for allergy and asthma
Stephen T. Holgate and Riccardo Polosa
p218 | doi:10.1038/nri2262
Understanding the mechanisms of allergic inflammation is important for
the improvement of current therapies and the development of novel
therapies. This Review describes the current therapeutic strategies
for allergy and asthma and highlights several innovative future
strategies.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocu0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocv0El
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PERSPECTIVE
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OPINION
The molecular basis for public T-cell responses?
Vanessa Venturi, David A. Price, Daniel C. Douek and Miles P.
Davenport
p231 | doi:10.1038/nri2260
Given that T-cell receptor (TCR) repertoires are randomly generated,
how come T cells bearing identical TCRs often dominate the response to
an antigen in many individuals? Here, the authors provide a molecular
explanation to the conundrum of public T-cell responses.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocx0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocy0Eo
Corrigendum: Micromanagement of the immune system by microRNAs
Harvey F. Lodish, Beiyan Zhou, Gwen Liu and Chang-Zheng Chen
p238 | doi:10.1038/nri2280
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocz0Ep
Erratum: Innate immunity: TAMing inflammation
Jennifer Middleton
doi:10.1038/nri2271
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bocw0Em
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Cell Death & Differentiation Special Issue on Immunity
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bm580Ev
In this issue of CDD, several reviews focus on the role of death, at
the cellular level, in immunity.
Select reviews on:
- NK cells at the interface between innate and adaptive immunity
- Apoptosis and the immune system
- Clearance of apoptotic cells by phagocytes
- Mechanisms of granule-dependent killing
Visit CDD online to view these articles
http://ealerts.nature.com/cgi-bin24/DM/y/ejO30Xztnp0Hjd0Bm580Ev
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