February 2008 Volume 10 Number 2, pp 111 - 245
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EDITORIAL
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Registries and banks p111
The European Registry for Human Embryonic Stem Cells (hESCreg)
adds an important global resource to the fragmented landscape
of stem cell research.
doi:10.1038/ncb0208-111
http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjo0Ex
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NEWS AND VIEWS
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Telomeric RNA enters the game pp113 - 115
Two studies report expression of telomeric-repeat-containing
RNAs in vertebrates. This discovery challenges the long-standing
notion that telomeres are transcriptionally inert.
Beatrice Horard and Eric Gilson
doi:10.1038/ncb0208-113
http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjp0Ey
Outsourcing CREB translation to axons to survive pp115 - 118
Nerve growth factor induces sensory neuron survival via
retrograde signalling from the axon to the cell body.
Local translation of the transcription factor CREB in the
axon, followed by its transport to the nucleus,
is involved in this process.
Andrew C. Lin and Christine E. Holt
doi:10.1038/ncb0208-115
http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjq0Ez
Facing up to Mena: Tes(ting) times for EVH1 domains pp118 - 120
Ena/VASP family members have a common binding interface
on their EVH1 domains for FPPPP motifs in partner proteins.
The finding that Tes, a protein lacking FPPPP motifs, competes
specifically for the FPPPP ligand site on Mena, provides new
insights into the differential regulation of Ena/VASP proteins.
J. Victor Small
doi:10.1038/ncb0208-118
http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjr0E1
Green light for chloroplast outer-membrane proteins pp120 - 122
Most chloroplast proteins are encoded in the cell nucleus,
translated in the cytosol, and targeted to the organelle in a
post-translational manner. Our understanding of how proteins
are targeted to the outer envelope membrane of chloroplasts
has been improved with the identification of a specific
soluble sorting factor.
Jocelyn Bedard and Paul Jarvis
doi:10.1038/ncb0208-120
http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjs0E2
Heads or tails: can Wnt tell which one is up? pp122 - 124
Planarian flatworms regenerate their heads and tails after
amputation. It turns out that they use Wnt-beta-catenin
signalling to determine where the head and the tail should form.
Elly M. Tanaka and Gilbert Weidinger
doi:10.1038/ncb0208-122
http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjt0E3
ERK and MDM2 prey on FOXO3a pp125 - 126
Constitutively active ERK signalling stimulates cell
proliferation, thereby contributing to tumorigenesis. We
now learn that ERK activity induces phosphorylation and
MDM2-mediated degradation of the tumour-suppressing transcription
factor FOXO3a, thus gaining new information on valuable targets
for human cancer therapeutic intervention.
Wensheng Yang, Nathan G. Dolloff and Wafik S. El-Deiry
doi:10.1038/ncb0208-125
http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmju0E4
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ARTICLES
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PDK1 regulates cancer cell motility by antagonising
inhibition of ROCK1 by RhoE pp127 - 137
Sophie Pinner and Erik Sahai
doi:10.1038/ncb1675
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjv0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjw0E6
ERK promotes tumorigenesis by inhibiting FOXO3a
via MDM2-mediated degradation pp138 - 148
Jer-Yen Yang et al.
doi:10.1038/ncb1676
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjx0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjy0E8
Intra-axonal translation and retrograde trafficking of
CREB promotes neuronal survival pp149 - 159
Llewellyn J. Cox et al.
doi:10.1038/ncb1677
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmjz0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmj10Ev
TBL1-TBLR1 and beta-catenin recruit each other to
Wnt target-gene promoter for transcription activation
and oncogenesis pp160 - 169
Jiong Li and Cun-Yu Wang
doi:10.1038/ncb1684
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmj20Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmj30Ex
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LETTERS
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Wingless secretion requires endosome-to-Golgi retrieval
of Wntless/Evi/Sprinter by the retromer complex pp170 - 177
Xavier Franch-Marro et al.
doi:10.1038/ncb1678
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmj40Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmj50Ez
Wingless secretion promotes and requires
retromer-dependent cycling of Wntless pp178 - 185
Fillip Port et al.
doi:10.1038/ncb1687
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmj60E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmj70E2
A beta-catenin gradient links the clock and
wavefront systems in mouse embryo segmentation pp186 - 193
Alexander Aulehla et al.
doi:10.1038/ncb1679
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0Bmj80E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkA0EE
Nanog maintains pluripotency of mouse embryonic stem
cells by inhibiting NFkappaB and cooperating with Stat3 pp194 - 201
Josema Torres and Fiona M. Watt
doi:10.1038/ncb1680
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkB0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkC0EG
The microRNAs miR-373 and miR-520c promote tumour
invasion and metastasis pp202 - 210
Qihong Huang et al.
doi:10.1038/ncb1681
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkD0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkE0EI
Membrane nanotubes physically connect T cells over
long distances presenting a novel route for
HIV-1 transmission pp211 - 219
Stefanie Sowinski et al.
doi:10.1038/ncb1682
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkF0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkG0EK
AKR2A-mediated import of chloroplast outer membrane
proteins is essential for chloroplast biogenesis pp220 - 227
Wonsil Bae et al.
doi:10.1038/ncb1683
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkH0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkI0EM
Developmentally regulated transcription of mammalian
telomeres by DNA-dependent RNA polymerase II pp228 - 236
Stefan Schoeftner and Maria A. Blasco
doi:10.1038/ncb1685
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkJ0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkK0EO
Sterol-dependent endocytosis mediates post-cytokinetic
acquisition of PIN2 auxin efflux carrier polarity pp237 - 244
Shuzhen Men et al.
doi:10.1038/ncb1686
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkL0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkM0EQ
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ERRATUM
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Erratum p245
doi:10.1038/ncb0208-245
http://ealerts.nature.com/cgi-bin24/DM/y/eiwv0Xztnp0HjD0BmkN0ER
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