February 2008 Volume 22 Number 2, pp 231 - 462
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LEADING ARTICLE
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Clinically relevant end points and new drug approvals for myeloma
K C Anderson, R A Kyle, S V Rajkumar, A K Stewart, D Weber and P
Richardson
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXn0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXo0Ey
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REVIEWS
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Genetics of therapy-related myelodysplasia and acute myeloid leukemia
J Pedersen-Bjergaard, M K Andersen, M T Andersen and D H Christiansen
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXp0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXq0E1
NK cell receptors and their ligands in leukemia
S Verheyden and C Demanet
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXr0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXs0E3
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ORIGINAL ARTICLES
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Phase I//II study of gemtuzumab ozogamicin added to fludarabine,
melphalan and allogeneic hematopoietic stem cell transplantation for
high-risk CD33 positive myeloid leukemias and myelodysplastic syndrome
M de Lima, R E Champlin, P F Thall, X Wang, T G Martin, J D Cook, G
McCormick, M Qazilbash, P Kebriaei, D Couriel, E J Shpall, I Khouri, P
Anderlini, C Hosing, K W Chan, B S Andersson, P A Patah, Z Caldera, E
Jabbour and S Giralt
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXt0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXu0E5
DNA repair polymorphisms and outcome of chemotherapy for acute
myelogenous leukemia: a report from the Children's Oncology Group
D Bhatla, R B Gerbing, T A Alonzo, P A Mehta, K Deal, J Elliott, S
Meshinchi, H Geiger, J P Perentesis, B J Lange and S M Davies
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXv0E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXw0E7
Phosphorylation of PML is essential for activation of C//EBP[epsiv]
and PU.1 to accelerate granulocytic differentiation
Y Tagata, H Yoshida, L A Nguyen, H Kato, H Ichikawa, F Tashiro and I
Kitabayashi
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXx0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXy0EA
Outcomes after HLA-matched sibling transplantation or chemotherapy in
children with acute lymphoblastic leukemia in a second remission after
an isolated central nervous system relapse: a collaborative study of
the Children's Oncology Group and the Center for International Blood
and Marrow Transplant Research
M Eapen, M-J Zhang, M Devidas, E Raetz, J C Barredo, A K Ritchey, K
Godder, S Grupp, V A Lewis, K Malloy, W L Carroll, S M Davies and B M
Camitta
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnXz0EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnX10Ew
Release of angiopoietin-1 by primary human acute myelogenous leukemia
cells is associated with mutations of nucleophosmin, increased by bone
marrow stromal cells and possibly antagonized by high systemic
angiopoietin-2 levels
K J Hatfield, R Hovland, A M Oyan, K H Kalland, A Ryningen, B T
Gjertsen and O Bruserud
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnX20Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnX30Ey
Efficient detection of leukemia-related fusion transcripts by
multiplex PCR applied on a microelectronic platform
B Corradi, G Fazio, C Palmi, V Rossi, A Biondi and G Cazzaniga
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnX40Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnX50E1
Cooperating mutations of receptor tyrosine kinases and Ras genes in
childhood core-binding factor acute myeloid leukemia and a comparative
analysis on paired diagnosis and relapse samples
L-Y Shih, D-C Liang, C-F Huang, Y-T Chang, C-L Lai, T-H Lin, C-P Yang,
I-J Hung, H-C Liu, T-H Jaing, L-Y Wang and T-C Yeh
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnX60E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnX70E3
High incidence of avascular necrosis in adolescents with acute
lymphoblastic leukaemia: a UKALL XII analysis
B Patel, S M Richards, J M Rowe, A H Goldstone and A K Fielding
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnX80E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYA0EF
Marrow fibrosis predicts early fatal marrow failure in patients with
myelodysplastic syndromes
G Buesche, H Teoman, W Wilczak, A Ganser, H Hecker, L Wilkens, G
Gohring, B Schlegelberger, O Bock, A Georgii and H Kreipe
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYB0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYC0EH
Efficient gene transfer in CLL by mRNA electroporation
F Van Bockstaele, V Pede, E Naessens, S Van Coppernolle, V Van
Tendeloo, B Verhasselt and J Philippe
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYD0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYE0EJ
Small RNAs analysis in CLL reveals a deregulation of miRNA expression
and novel miRNA candidates of putative relevance in CLL pathogenesis
S Marton, M R Garcia, C Robello, H Persson, F Trajtenberg, O Pritsch,
C Rovira, H Naya, G Dighiero and A Cayota
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYF0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYG0EL
The BCL-2 promoter (-938C>A) polymorphism does not predict clinical
outcome in chronic lymphocytic leukemia
M A Kaderi, M Norberg, F Murray, M Merup, C Sundstrom, G Roos, A
Aleskog, K Karlsson, T Axelsson, G Tobin and R Rosenquist
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYH0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYI0EN
Involvement of mature donor T cells in the NK cell reconstitution
after haploidentical hematopoietic stem-cell transplantation
S Nguyen, M Kuentz, J-P Vernant, N Dhedin, D Bories, P Debre and V
Vieillard
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYJ0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYK0EP
Combination therapy of an anticancer drug with the FNIII14 peptide of
fibronectin effectively overcomes cell adhesion-mediated drug
resistance of acute myelogenous leukemia
T Matsunaga, F Fukai, S Miura, Y Nakane, T Owaki, H Kodama, M Tanaka,
T Nagaya, R Takimoto, T Takayama and Y Niitsu
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYL0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYM0ER
Enhanced antitumor activity by a selective conditionally replicating
adenovirus combining with MDA-7//interleukin-24 for B-lymphoblastic
leukemia via induction of apoptosis
W Qian, J Liu, Y Tong, S Yan, C Yang, M Yang and X Liu
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYN0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYO0ET
The BCL2 rheostat in glucocorticoid-induced apoptosis of acute
lymphoblastic leukemia
C Ploner, J Rainer, H Niederegger, M Eduardoff, A Villunger, S Geley
and R Kofler
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYP0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYQ0EV
Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by
caspase-3 and its contribution to increased apoptotic sensitivity
Y Lu, Z-G Peng, T-T Yuan, Q-Q Yin, L Xia and G-Q Chen
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYR0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYS0EX
Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell
lymphoma
S Nagel, E Leich, H Quentmeier, C Meyer, M Kaufmann, H G Drexler, A
Zettl, A Rosenwald and R A F MacLeod
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYT0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYU0EZ
Sezary syndrome is a unique cutaneous T-cell lymphoma as identified by
an expanded gene signature including diagnostic marker molecules CDO1
and DNM3
N Booken, A Gratchev, J Utikal, C Weisz, X Yu, M Qadoumi, M Schmuth, N
Sepp, D Nashan, K Rass, T Tuting, C Assaf, E Dippel, R Stadler, C-D
Klemke and S Goerdt
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYV0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYW0Eb
Gene expression profiling suggests primary central nervous system
lymphomas to be derived from a late germinal center B cell
M Montesinos-Rongen, A Brunn, S Bentink, K Basso, W K Lim, W Klapper,
C Schaller, G Reifenberger, J Rubenstein, O D Wiestler, R Spang, R
Dalla-Favera, R Siebert and M Deckert
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYX0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYY0Ed
Atacicept (TACI-Ig) inhibits growth of TACIhigh primary myeloma cells
in SCID-hu mice and in coculture with osteoclasts
S Yaccoby, A Pennisi, X Li, S R Dillon, F Zhan, B Barlogie and J D
Shaughnessy
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYZ0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYa0El
Prevention of thalidomide- and lenalidomide-associated thrombosis in
myeloma
A Palumbo, S V Rajkumar, M A Dimopoulos, P G Richardson, J San Miguel,
B Barlogie, J Harousseau, J A Zonder, M Cavo, M Zangari, M Attal, A
Belch, S Knop, D Joshua, O Sezer, H Ludwig, D Vesole, J Blade, R Kyle,
J Westin, D Weber, S Bringhen, R Niesvizky, A Waage, M von
Lilienfeld-Toal, S Lonial, G J Morgan, R Z Orlowski, K Shimizu, K C
Anderson, M Boccadoro, B G Durie, P Sonneveld and M A Hussein
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYb0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYc0En
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LETTERS TO THE EDITOR
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Nucleophosmin leukaemic mutants contain C-terminus peptides that bind
HLA class I molecules
A Liso, D Colau, R Benmaamar, A De Groot, W Martin, R Benedetti, G
Specchia, M P Martelli, P Coulie and B Falini
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYd0Eo
CD34+//Ph+ cells are still detectable in chronic myeloid leukemia
patients with sustained and prolonged complete cytogenetic remission
during treatment with imatinib mesylate
M Bocchia, M Ippoliti, A Gozzetti, E Abruzzese, S Calabrese, M
Amabile, M T Pirrotta, R Crupi, D Tozzuoli, M M Trawinska, M Defina, G
Martinelli and F Lauria
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYe0Ep
Clinical characteristics and outcomes in patients with t(8;21) acute
myeloid leukemia in Japan
H Narimatsu, T Yokozawa, H Iida, M Tsuzuki, M Hayakawa, T Takeo, M
Iino, T Ichihashi, C Kato, A Sawamoto, H Sao, M Yanada, N Emi, H
kiyoi, T Yamaguchi, T Naoe, R Suzuki and I Sugiura
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYf0Eq
Congenital transfusion-dependent anemia and thrombocytopenia with
myelodysplasia due to a recurrent GATA1G208R germline mutation
C P Kratz, C M Niemeyer, A Karow, M Volz-Fleckenstein, A Schmitt-Graff
and B Strahm
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYg0Er
A simple FISH assay for the detection of 3q26 rearrangements in
myeloid malignancy
V De Melo, M Vetter, H Mazzullo, J D Howard, D R Betts, E P Nacheva, J
F Apperley and A G Reid
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYh0Es
Proposed criteria for the diagnosis of post-polycythemia vera and
post-essential thrombocythemia myelofibrosis: a consensus statement
from the international working group for myelofibrosis research and
treatment
G Barosi, R A Mesa, J Thiele, F Cervantes, P J Campbell, S Verstovsek,
B Dupriez, R L Levine, F Passamonti, J Gotlib, J T Reilly, A M
Vannucchi, C A Hanson, L A Solberg, A Orazi and A Tefferi
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYi0Et
Lack of a relationship between the common 8q24 variant rs6983267 and
risk of chronic lymphocytic leukemia
G S Sellick, P Broderick, S Fielding, D Catovsky and R S Houlston
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYj0Eu
High incidence of acute promyelocytic leukemia in children in
northwest Italy, 1980-2003: a report from the Childhood Cancer
Registry of Piedmont
M M Maule, E Dama, M L Mosso, C Magnani, G Pastore and F Merletti
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYk0Ev
Expression of MUM1//IRF4 mRNA as a prognostic marker in patients with
multiple myeloma
D Heintel, N Zojer, M Schreder, K Strasser-Weippl, B Kainz, M Vesely,
H Gisslinger, J Drach, A Gaiger, U Jager and H Ludwig
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYl0Ew
Evidence for the interaction of imatinib at the transport-substrate
site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1
(P-glycoprotein) and ABCG2
S Shukla, Z E Sauna and S V Ambudkar
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYm0Ex
A novel silver (I) chelate: cytotoxicity and apoptotic mechanism of
action on human hematopoietic malignancies
K I Batarseh
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYn0Ey
The JAK2V617F mutation may be present several years before the
occurrence of overt myeloproliferative disorders
C Bellanne-Chantelot, P Jego, P Lionne-Huyghe, M Tulliez and A Najman
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYo0Ez
Classification of myeloproliferative disorders in the JAK2 era: is
there a role for red cell mass?
B Cassinat, C Laguillier, C Gardin, V de Beco, S Burcheri, P Fenaux, C
Chomienne and J-J Kiladjian
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYp0E1
Detection of an MPLW515 mutation in a case with features of both
essential thrombocythemia and refractory anemia with ringed
sideroblasts and thrombocytosis
S Schnittger, U Bacher, C Haferlach, R Dengler, A Krober, W Kern and T
Haferlach
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYq0E2
The DC-derived protein DC-STAMP influences differentiation of myeloid
cells
D Eleveld-Trancikova, R A J Janssen, I A M Hendriks, M W G Looman, V
Moulin, B J H Jansen, J H Jansen, C G Figdor and G J Adema
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYr0E3
Translocation t(4;14) retains prognostic significance even in the
setting of high-risk molecular signature
W J Chng, W M Kuehl, P L Bergsagel and R Fonseca
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYs0E4
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CORRIGENDA
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Translocation t(4;14) retains prognostic significance even in the
setting of high-risk molecular signature
W J Chng, W M Kuehl, P L Bergsagel and R Fonseca
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYt0E5
Addition of intravenous iron to epoetin beta increases hemoglobin
response and decreases epoetin dose requirement in anemic patients
with lymphoproliferative malignancies: a randomized multicenter study
M Hedenus, G Birgegard, P Nasman, L Ahlberg, T Karlsson, B Lauri, J
Lundin, G Larfars and A Osterborg
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20BnYu0E6
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Cell Death & Differentiation Special Issue on Immunity
In this issue of CDD, several reviews focus on the role of death, at
the cellular level, in immunity.
Select reviews on:
- NK cells at the interface between innate and adaptive immunity
- Apoptosis and the immune system
- Clearance of apoptotic cells by phagocytes
- Mechanisms of granule-dependent killing
Visit CDD online to view these articles.
http://ealerts.nature.com/cgi-bin24/DM/y/ejBW0Xztnp0Hi20Bm580ET
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