(To me, the most important stem cell breakthrough - ever. Best case
senario keeps comprimised patients out of surgery using non-foreign
stem cells. Better to repair than cut/replace it.)
Stem Cells Modified to Home in Where They're Needed
Monday, January 14, 2008; 12:00 AM
Copyright © 2008 ScoutNews LLC. All rights reserved.
MONDAY, Jan. 14 (HealthDay News) -- U.S. researchers have found a way
to modify the surface of stem cells to direct them to where they're
needed, an advance that may prove useful in many areas of stem cell
therapy.
Researchers at the Biomedical Research Institute at Brigham and
Women's Hospital in Boston modified the surface of human mesenchymal
stem cells -- a type of adult stem cell that's a precursor of bone-
forming osteoblast cells. This modification directed the stem cells
through the bloodstream into bone, where they matured into new bone
cells.
"Without genetically reprogramming a stem cell, which could cause
adverse effects, we were able to navigate the cell to a predetermined
location -- a necessary first step toward achieving tissue
regeneration,
transplant physician, said in a prepared statement.
"Stem cells must have a routing cue to traffic to where they're
needed, just like you need a Zip code to deliver mail," Sackstein
added.
In this study, he and his colleagues modified the surface of the stem
cells to express the molecule HCELL, which is a homing receptor that
seeks out the adhesion molecule E-selectin found on the lining of
certain blood vessels, including those found in bone, the researchers
said.
The modified stem cells were injected into mice, where they migrated
to bone and made patches of human bone within the mouse bone.
The study was published online Jan. 13 and was expected to be in the
February print issue of the journal Nature Medicine.
http://www.healthce
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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