Adult Stem Cells Beneficial In Heart Failure Recovery
Main Category: Cardiovascular / Cardiology
Also Included In: Stem Cell Research
Article Date: 28 Jan 2008 - 1:00 PST
A study in the Clinical and Experimental Pharmacology and Physiology
published by Wiley-Blackwell shows that administration of adult bone
marrow stem cells (BMC) and mesenchymal stems cells (MSC) can aid in
the recovery of myocardial infarction (MI) - commonly known as heart
attack - and consequently increase survival rates.
The study - "Systemic Delivery of Adult Stem cells Improves Cardiac
Function in Spontaneously Hypertensive Rats" - is designed to
evaluate the impact of systemic delivery of BMC and MSC on
spontaneously hypertensive rats induced with MI.
Lead author, Dr. Nardi says "Our research is the first to show this
type of stem cell activity in a physiological model of MI, as we used
spontaneously hypertensive rats which closely represent the disease
in humans."
The treatment with stem cells resulted in statistically different
mortality rates- 0% for rats treated with BSC, 17% for rats treated
with MSC and 45% for non-treated rats. Rats that were treated also
showed significant recovery of heart function and capacity.
"Results suggest that injected BMC can bring about therapeutic
effects, especially in tissue regeneration. It speeds up the adaptive
remodeling of the heart and consequently increases survival rates",
says Dr. Nardi.
Although many studies have shown the potential beneficial effects of
stem cell therapies in treatment for heart failure, delivery methods
are still under investigation.
Author of the editorial commentary in this issue, John Haynes
says "In this issue, Nardi and co-workers have demonstrated
significant improvement in cardiac function and reduction in
mortality of the rats following the administration of BSC bringing us
closer to unraveling the mystery of the stem cell."
About Clinical and Experimental Pharmacology and Physiology
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(hypotheses) on the results of clinical and experimental work in
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occasionally.
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The CNS Healing Group
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