Signaling Gateway - 4 January 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0M40ED
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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BONE MORPHOGENETIC PROTEIN ANTAGONISTS: MIGHTY MORPHIN SMALL MOLECULES
A screen for chemical antagonists of the bone morphogenetic protein
(BMP) pathway has identified dorsomorphin as a selective inhibitor
of BMP receptor-mediated SMAD1/5/8 phosphorylation.
Original research paper: Nature Chemical Biology 4, 33-41 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0vP0EM
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0HIE0Ec
Rock2
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0BkiZ0EC
Rock2 is a serine/threonine kinase that is activated by association
with RhoGTP. Activation of Rock2 leads to the stabilization of
filamentous actin and increased myosin ATPase activity. These events
promote the formation of contractile actin-myosin bundles (often
called stress fibers) and integrin-containing focal adhesions.
Through modulating actin-myosin contractility, Rock2 has a
significant role in the regulation of cell morphology, motility and
adhesion.
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0BUuz0EY
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Selected Updates
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THERAPEUTICS: SMAC IT TO THEM!
Compounds that activate or mimic the pro-apoptotic protein SMAC
(second mitochondrial-derived activator of caspase) cause regression
of human lung cancer xenografts by increasing apoptotic signaling
through tumor necrosis factor receptor 1 (TNFR1).
Original research paper: Cell 131, 682-693 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Bkia0EJ
DEVELOPMENTAL BIOLOGY: RETINOIC ACID PASSES THE MORPHOGEN TEST
The anterior-to-posterior retinoic acid (RA) concentration gradient
is established by the opposing effects of a locally acting,
RA-induced degradation enzyme and fibroblast growth factor (Fgf),
which represses RA degradation.
Original research paper: PLoS Biol. 5, e304 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Bkib0EK
G-PROTEIN-COUPLED RECEPTORS: CRYSTAL CLEAR
A collection of papers describing the crystal structure of the
G-protein-coupled beta2-adrenergic receptor (beta2AR) may facilitate
the development of drugs that specifically interfere with
ligand-receptor binding of related GPCRs.
Original research paper: Science 318, 1258-1265 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0BkkX0EC
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0BkkZ0EE
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Research Library
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NUMB CONTROLS P53 TUMOUR SUPPRESSOR ACTIVITY
Nature 451, 76-80 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Bkid0EM
DEFECTIVE MAST CELL EFFECTOR FUNCTIONS IN MICE LACKING THE CRACM1
PORE SUBUNIT OF STORE-OPERATED CALCIUM RELEASE-ACTIVATED CALCIUM
CHANNELS
Nature Immunology 9, 89-96 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Bkie0EN
CILIARY PROTEINS LINK BASAL BODY POLARIZATION TO PLANAR CELL
POLARITY REGULATION
Nature Genetics 40, 69-77 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Bkif0EO
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Signaling News
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DRUNKEN FLIES GET HYPERSEXUAL
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Bkka0EL
From the annals of insect biology comes a cautionary tale for those
recovering from their post-New Year's celebration: heavy boozing has
been shown to send male fruitflies into a lusty fog. The findings
could be used to further establish a fly model system for the study
of alcoholism.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Crw0E3
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Gateway Updates
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NATURE PROTOCOLS: RECIPES FOR RESEARCHERS
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Bkig0EP
Nature Protocols is an online resource for authoritative,
peer-reviewed 'Nature Protocols' and an interactive 'Protocols
Network'. The two create a dynamic forum for scientists to upload
and comment on protocols.
Featured peer-reviewed protocols for January include:
Preparation of intact yeast artificial chromosome DNA for transgenesis of mice
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0BhHV0EW
Measurement of cell proliferation by heavy water labeling
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Bjh40EW
Sign up to receive the table of contents e-alert for Nature Protocols.
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W02Bg0Eh
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Signaling Job of the Week
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Senior Research Technician
Employer: Emory University School of Medicine
Location: Atlanta, Georgia, USA
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Bkih0EQ
A Senior Research Technician position is available at the Emory
University School of Medicine to study the molecular signaling events
that permit cancer progression. Applicants should be able to perform
a wide range of highly technical and complex research, including cell
culture and molecular biology techniques. Previous animal handling
experience is required.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0Ba6W0E7
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http://ealerts.nature.com/cgi-bin24/DM/y/eiUj0Xztnp0H2W0dIO0EG
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