Signaling Gateway - 25 January 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0M40El
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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PATHOGEN RESPONSE: NLRX1 IS A PROSPECTIVE, SELECTIVE ANTI-INFECTIVE
The NLRX1 receptor inhibits the production of antiviral type I
interferon-beta (IFN-beta) by blocking the interaction between the
RNA helicase RIG-I and the mitochondrial antiviral signaling protein
MAVS.
Original research paper: Nature advance online publication,
16 January 2008 (doi:10.1038/nature06501).
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0vP0Eu
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0HIE0EC
Nup153
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Bl6O0Ej
Nup153 is one of about 30 proteins that comprise the nuclear pore
complex (NPC). The NPC provides a selective channel for transport of
protein and ribonucleoprotein between the cytoplasm and nucleus.
Nup153 is located on the nuclear face of the NPC and has roles in
trafficking as well as in creating certain architectural features of
the nuclear pore.
Also published this week:
Net1
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Bl6P0Ek
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0BUuz0E7
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Selected Updates
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LUNG INFLAMMATION: DISARMING NEUTROPHILS IN CYSTIC FIBROSIS
The antibacterial function of neutrophils is disabled in the lungs
by the cleavage of CXC-chemokine receptor 1 (CXCR1) in patients with
cystic fibrosis.
Original research paper: Nature Med. 13, 1423-1430 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Bl6Q0El
TUMOUR SUPPRESSORS: CRYSTAL CLEAR
Elucidating the crystal structure of the retinoblastoma
amino-terminal domain (RBN) has provided insight into the way it
contributes to RB function and tumor suppression.
Original research paper: Mol. Cell 28, 371-385 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Bl6R0Em
DIABETES: CONCENTRATING THE BENEFITS OF RED WINE?
Researchers have identified a series of small-molecule activators for
the protein deacetylase SIRT1 that show promising beneficial effects
in animal models of type 2 diabetes.
Original research paper: Nature 450, 712-716 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Bl6S0En
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0BkkZ0Em
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Research Library
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Kif3a CONSTRAINS beta-CATENIN-DEPENDENT Wnt SIGNALLING THROUGH DUAL
CILIARY AND NON-CILIARY MECHANISMS
Nat. Cell Biol. 10, 70-76 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Bl6T0Eo
WIDESPREAD microRNA REPRESSION BY Myc CONTRIBUTES TO TUMORIGENESIS
Nat. Genet. 40, 43-50 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Bl6U0Ep
A QUANTITATIVE ANALYSIS OF KINASE INHIBITOR SELECTIVITY
Nat. Biotech. 26, 127-132 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Bl6V0Eq
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Signaling News
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INTERNATIONAL GENOME PROJECT LAUNCHED
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Blux0ET
A much-anticipated international project to sequence the entire
genomes of 1,000 people was launched on Tuesday. The new three-year
project aims both to guide scientists towards more disease-associated
regions, and to hasten much of the costly follow-up research. Yet
some scientists question how accurate the finished genomes will be,
given the project's short timeline and low budget.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Crw0Ec
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - JANUARY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0BKHW0Ec
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Pathogens and tumors: C-Lectin the dock
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0BlBp0EU
Postnatal brain development: Eye candy enzymatics
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0BlBq0EV
Sign up monthly table of contents e-alert for the
Functional Glycomics Update
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0BJYw0EQ
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Signaling Job of the Week
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Post-doctoral position in GPCR signaling
Employer: University of Pittsburgh
Location: Pittsburgh, PA
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Bl6W0Er
The Department of Pharmacology at the University of Pittsburgh is
seeking a candidate for a post-doctoral fellowship position in an
interdisciplinary research program aimed at elucidating molecular
mechanisms of signal transduction mediated by G-protein-coupled
receptors in renal, skeletal and other cell systems. The candidate
should have a PhD or MD/PhD and have authored at least 2 articles
published in international journals.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0Ba6W0Eg
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http://ealerts.nature.com/cgi-bin24/DM/y/eipq0Xztnp0H2W0dIO0Eo
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