Signaling Gateway - 18 January 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0M40EP
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
CELL CYCLE: GABA KEEPS EMBRYONIC STEM CELLS IN CHECK
gamma-aminobutyric acid (GABA) receptor-mediated signaling causes
S-phase cell cycle arrest in embryonic stem (ES) cells and neural
crest stem (NCS) cells by promoting phosphorylation of histone H2AX.
Original research paper: Nature advance online publication,
9 January 2008 (doi:10.1038/nature06488).
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0vP0EY
------------------------
Molecule Pages
------------------------
The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0HIE0Eo
PSTPIP2
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0Blkn0El
The murine cytoskeletal-associated protein PSTPIP2 is part of the
'Pombe Cdc15 Homology' (PCH) family. PSTPIP2 regulates the
organization of the actin cytoskeleton as well as macrophage
morphology and motility in response to Colony Stimulating Factor-1
(CSF-1). In COS-7 cells, it has been reported that PSTPIP2 could
bind phospholipids and deform the plasma membrane into narrow tubes.
Also published this week:
Trpm1
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0Blko0Em
Trpm3
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0Blkp0En
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BUuz0Ek
-------------------
Selected Updates
-------------------
STEM CELLS: RINGING THE CHANGES
In embryonic stem cells, RING1-mediated ubiquitination of histone H2A
restricts RNA polymerase II from transcribing genes that would
otherwise promote development and differentiation.
Original research paper: Nature Cell Biol. 9, 1428-1435 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BlhE0E2
TUMORIGENESIS: KEEPING A GOOD THING DOWN
Myc-induced tumorigenesis causes widespread repression of microRNAs,
suggesting that re-expression of microRNAs could block the growth of
Myc-positive tumors.
Original research paper: Nature Genet. 40, 43-50 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BlhF0E3
METABOLIC DISEASE: NEW OPPORTUNITY FOR SEROTONIN RECEPTOR AGONISTS
Serotonin 2C receptor agonists have been shown to improve glucose
tolerance and reduce plasma insulin levels, indicating that
pharmacological modulation of serotonin receptor activity may be an
effective new approach to treat type 2 diabetes.
Original research paper: Cell Metab. 6, 398-405 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BlhG0E4
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BkkZ0EQ
------------------------
Research Library
------------------------
CYCLIC DERMAL BMP SIGNALLING REGULATES STEM CELL ACTIVATION DURING
HAIR REGENERATION
Nature 451, 340-344 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BlhH0E5
THE CONTRIBUTION OF TRANSCRIPTION FACTOR IRF1 TO THE
INTERFERON-gamma–INTERLEUKIN 12 SIGNALING AXIS AND TH1 VERSUS TH-17
DIFFERENTIATION OF CD4+ T CELLS
Nature Immunology 9, 34-41 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BlhI0E6
GENERATION OF INDUCED PLURIPOTENT STEM CELLS WITHOUT MYC FROM MOUSE
AND HUMAN FIBROBLASTS
Nature Biotechnology 26, 101-106 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BlhJ0E7
------------------------
Signaling News
------------------------
CHRONIC-PAIN TREATMENT WITHOUT SIDE EFFECTS
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BlhK0E8
A report in Nature describes the identification of a promising
benzodiazepine-related painkiller that dulls pain in rats without
causing sedation. The drug may work by selectively targeting the
alpha2 and alpha3 subunits of the pentameric GABAA receptor and
sparing the alpha1 subunit; activation of the alpha1 subunit has been
linked to drowsiness.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0Crw0EG
-------------------------
Gateway Updates
-------------------------
NCI-NATURE PATHWAY INTERACTION DATABASE - JANUARY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BGyx0EY
The Pathway Interaction Database is a free, high quality resource of
signaling pathways in human cells for biologists and bioinformaticians
to explore, visualize and mine signaling events.
This month's update features:
Proteoglycan syndecan-mediated signaling events
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BkuP0EQ
IL6-mediated signaling events
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BkuO0EP
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BJYy0E5
-----------------------------
Signaling Job of the Week
-----------------------------
Staff Scientist
Employer: Institute on Aging, National Institutes of Health
Location: Baltimore, Maryland
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BlhL0EA
A Staff Scientist position is available in the DNA Repair Unit of
the Laboratory of Cellular and Molecular Biology at the National
Institute on Aging. This is a renewable position with an initial
five-year appointment for highly motivated individuals with expertise
in the biochemistry and signaling pathways of DNA damage and repair.
Previous experience with DNA repair techniques is desirable.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0Ba6W0EK
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0dIO0ES
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BCGZ0EA
For further technical assistance or any other enquiries, please click here:
http://ealerts.nature.com/cgi-bin24/DM/y/eiib0Xztnp0H2W0BByD0Eb
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2008 Nature Publishing Group
---------------------------------------------------------------------
