January 2008 Volume 15 Number 1, pp 1 - 114
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Nature Methods' Method of the Year 2007.
Technological developments often drive scientific progress, so let's celebrate methods development for its own sake! Nature Methods' editors have selected the methodological development that most impressed them in 2007 because it came into its own and started impacting a wide variety of research areas. Visit the Nature Methods website at http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0K7N0Et to discover the champion, read the story of its development and hear from expert users about its applications. And since the decision was tough, there is also a selection of 'Methods to Watch' for the years to come!
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EDITORIAL
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A tribute to a very special scientist p1
doi:10.1038/nsmb0108-1
http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjG0EH
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TRIBUTE
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A Tribute to Arthur Kornberg 1918-2007 pp2 - 17
doi:10.1038/nsmb0108-2
http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjH0EI
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NEWS AND VIEWS
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Stuttering against marginotomy pp18 - 19
Stuttering by telomerase contributes to the natural heterogeneity
of fission yeast telomeric repeat sequences.
Manuel Ares, Jr. and Kausik Chakrabarti
doi:10.1038/nsmb0108-18
http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjI0EJ
DNA damage: ubiquitin marks the spot pp20 - 22
DNA damage activates signaling cascades driven by the ATM-ATR protein
kinases, culminating in the recruitment of repair proteins to
the damage site through poorly understood mechanisms. Now a flurry
of papers reveals how ATM-dependent phosphorylation of mediator and
chromatin-associated proteins at sites of double-strand breaks
promotes ubiquitylation of local nucleosomes, thereby eliciting a
powerful signal for recruitment of repair complexes to the damage
site.
Eric J Bennett and J Wade Harper
doi:10.1038/nsmb0108-20
http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjJ0EK
The intelligent clock and the Rube Goldberg clock pp23 - 24
Circadian rhythms are generated by cell-autonomous molecular clocks
in organisms ranging from cyanobacteria to humans. Recent research
on the mechanisms of molecular clocks call for a reflection on the
cause and necessity of complexity in biological systems.
Aziz Sancar
doi:10.1038/nsmb0108-23
http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjK0EL
Research Highlights p25
doi:10.1038/nsmb0108-25
http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjL0EM
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ARTICLES
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TER1, the RNA subunit of fission yeast telomerase pp26 - 33
Jessica Leonardi, Jessica A Box, Jeremy T Bunch and Peter Baumann
doi:10.1038/nsmb1343
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjM0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjN0EO
Identification and characterization of the Schizosaccharomyces pombe
TER1 telomerase RNA pp34 - 42
Christopher J Webb and Virginia A Zakian
doi:10.1038/nsmb1354
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjO0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjP0EQ
Structural and functional studies of ALIX interactions with YPXnL
late domains of HIV-1 and EIAV pp43 - 49
Qianting Zhai et al.
doi:10.1038/nsmb1319
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjQ0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjR0ES
Structural basis for synaptic adhesion mediated by neuroligin-neurexin
interactions pp50 - 56
Xiaoyan Chen et al.
doi:10.1038/nsmb1350
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjS0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjT0EU
tRNA-mRNA mimicry drives translation initiation from a viral IRES
pp57 - 64
David A Costantino, Jennifer S Pfingsten, Robert P Rambo and
Jeffrey S Kieft
doi:10.1038/nsmb1351
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjU0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjV0EW
Crystal structure of SopA, a Salmonella effector protein mimicking a
eukaryotic ubiquitin ligase pp65 - 70
Jianbo Diao et al.
doi:10.1038/nsmb1346
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjW0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjX0EY
RNA polymerase II pauses and associates with pre-mRNA processing
factors at both ends of genes pp71 - 78
Kira Glover-Cutter, Soojin Kim, Joaquin Espinosa and David L Bentley
doi:10.1038/nsmb1352
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjY0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BkjZ0Ea
Pot1 and cell cycle progression cooperate in telomere length
regulation pp79 - 84
Dmitri Churikov and Carolyn M Price
doi:10.1038/nsmb1331
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkja0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjb0Ei
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex
and stimulate its RNA helicase activity pp85 - 93
Hala Chamieh, Lionel Ballut, Fabien Bonneau and Herve Le Hir
doi:10.1038/nsmb1330
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjc0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjd0Ek
The structure of a DnaB-family replicative helicase and its
interactions with primase pp94 - 100
Ganggang Wang et al.
doi:10.1038/nsmb1356
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkje0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjf0Em
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BRIEF COMMUNICATIONS
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Structural basis for the catalytic mechanism of phosphothreonine
lyase pp101 - 102
Linjie Chen et al.
doi:10.1038/nsmb1329
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjg0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjh0Eo
Structural basis for the coevolution of a viral RNA-protein complex
pp103 - 105
Jeffrey A Chao, Yury Patskovsky, Steven C Almo and Robert H Singer
doi:10.1038/nsmb1327
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkji0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjj0Eq
Subunit organization and functional transitions in Ci-VSP
pp106 - 108
Susy C Kohout, Maximilian H Ulbrich, Sarah C Bell and Ehud Y Isacoff
doi:10.1038/nsmb1320
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjk0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjl0Es
Distinct binding modes specify the recognition of methylated histones
H3K4 and H4K20 by JMJD2A-tudor pp109 - 111
Joseph Lee, James R Thompson, Maria Victoria Botuyan and Georges Mer
doi:10.1038/nsmb1326
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjm0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjn0Eu
Structural basis for activation of the autoinhibitory C-terminal
kinase domain of p90 RSK2 pp112 - 113
Margarita Malakhova et al.
doi:10.1038/nsmb1347
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjo0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjp0Ew
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ERRATUM
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Erratum: L3MBTL1 recognition of mono- and dimethylated histones p114
Jinrong Min et al.
doi:10.1038/nsmb0108-114
http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0Bkjq0Ex
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Obesity
New Publisher, New Look, New Editors in 2008
Beginning January 2008, Nature Publishing Group will publish Obesity on behalf of The Obesity Society. At that time, the journal will re-launch with a new look, editor, and editorial team. Obesity is intended to increase knowledge, foster research and promote better treatment for people with obesity and their loved ones. The journal publishes important, peer-reviewed, original, scientific articles, as well as relevant review articles, commentaries, and public health and medical developments.
http://ealerts.nature.com/cgi-bin24/DM/y/eiUt0Xztnp0Hjh0BeQt0EV
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