February 2008 Volume 6 Number 2
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This month's FEATURED article:
Exit strategies of intracellular pathogens
Kevin Hybiske & Richard S. Stephens
p99 | doi:10.1038/nrmicro1821
http://www.nature.com/nrmicro/journal/v6/n2/full/nrmicro1821.html
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In this issue
p89 | doi:10.1038/nrmicro1851
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVi0Eg
Editorial: Surviving and thriving in a big pond
p90 | doi:10.1038/nrmicro1850
In an increasingly globalized world, appropriate investment in the generation and exploitation of knowledge is important for maintaining economic competitiveness. For small economies to grow and prosper, excelling in research and development will be essential.
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVj0Eh
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RESEARCH HIGHLIGHTS
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Bacterial pathogenesis: The enemy within...
p91 | doi:10.1038/nrmicro1846
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVk0Ei
IN BRIEF
Biofilms | Computational biology | Structural biology
p92 | doi:10.1038/nrmicro1837
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVl0Ej
Bacterial toxins: A new way to hijack the cell
p92 | doi:10.1038/nrmicro1841
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVm0Ek
Environmental microbiology: Caulobacter cleans up
p93 | doi:10.1038/nrmicro1843
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVn0El
Bacterial pathogenesis: Chain of transmission
p93 | doi:10.1038/nrmicro1844
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVo0Em
Malaria: Malaria eats out
p94 | doi:10.1038/nrmicro1842
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVp0En
Microbial physiology: Five ways to cycle carbon
p94 | doi:10.1038/nrmicro1847
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVq0Eo
Malaria: Picking Plasmodium falciparum apart
p95 | doi:10.1038/nrmicro1848
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVr0Ep
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NEWS AND ANALYSIS
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DISEASE WATCH
In the News
p96 | doi:10.1038/nrmicro1849
http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVs0Eq
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REVIEWS
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Exit strategies of intracellular pathogens
Kevin Hybiske and Richard S. Stephens
p99 | doi:10.1038/nrmicro1821
The exit of intracellular bacteria from host cells is a crucial stage in microbial pathogenesis that is driven by an evolutionary requirement for efficient dissemination to neighbouring cells and transmission to new hosts. In this comprehensive Review, the authors discuss the diverse repertoire of strategies that is used by intracellular pathogens to escape their host cells.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVt0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVu0Es
Inter-kingdom signalling: communication between bacteria and their hosts
David T. Hughes and Vanessa Sperandio
p111 | doi:10.1038/nrmicro1836
Mutually beneficial relationships between prokaryotes and eukaryotes are possible because of the ability of microorganisms and their hosts to communicate with each other. In this Review, David Hughes and Vanessa Sperandio discuss how inter-kingdom communication can be 'hijacked' by bacterial pathogens, and how hosts can fight back.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVv0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVw0Eu
Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis
Harry J. Flint, Edward A. Bayer, Marco T. Rincon, Raphael Lamed and Bryan A. White
p121 | doi:10.1038/nrmicro1817
Dietary plant polysaccharides are a major energy source for the anaerobic microbiota that inhabit the mammalian large intestine and rumen. Flint and colleagues discuss polysaccharide utilization by gut anaerobes, focusing on two examples, the use of insoluble structural polysaccharides by Ruminococcus flavefaciens and the use of starch by Bacteroides thetaiotaomicron.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVx0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVy0Ew
Complement evasion by human pathogens
John D. Lambris, Daniel Ricklin and Brian V. Geisbrecht
p132 | doi:10.1038/nrmicro1824
The complement system is an essential and efficient component of the immune system's antimicrobial machinery, but many pathogens have developed parallel routes of escape. Understanding complement processes and interactions on a molecular level is essential for the development of novel therapies, and this Review provides a comprehensive overview and update of recent developments in this field.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlVz0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlV10Ek
The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
Gunilla B. Karlsson Hedestam, Ron A.M. Fouchier, Sanjay Phogat, Dennis R. Burton, Joseph Sodroski and Richard T. Wyatt
p143 | doi:10.1038/nrmicro1819
Most viral vaccines protect against disease by generating neutralizing antibodies. This Review examines the problem of eliciting broad HIV-1 neutralization through vaccination by drawing parallels with the successful subunit influenza virus vaccine and with efforts to develop a pandemic influenza vaccine.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlV20El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlV30Em
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PERSPECTIVES
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INNOVATION
New surveyor tools for charting microbial metabolic maps
Rainer Breitling, Dennis Vitkup and Michael P. Barrett
p156 | doi:10.1038/nrmicro1797
For the full potential of microbial genomics to be realized, a complete understanding of the metabolic capacities of microbial life is required. In this Innovation, the authors discuss new system-biology technologies that enable the identification of novel metabolites and their biochemical connections within metabolic networks.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlV40En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0Bk830EH
OPINION
Morphological plasticity as a bacterial survival strategy
Sheryl S. Justice, David A. Hunstad, Lynette Cegelski and Scott J. Hultgren
p162 | doi:10.1038/nrmicro1820
Filamentation has been implicated in bacterial survival of exposure to environmental stresses, but in this Opinion, Sheryl S. Justice and colleagues propose that the morphological plasticity of pathogenic bacteria is a direct and adaptive response to the sensing of environmental changes.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlV50Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eig30Xztnp0Hje0BlV60Ep
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