February 2008 Volume 8 Number 2
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This month's FEATURED article:
Shaping and reshaping CD8+ T–cell memory
John T. Harty & Vladimir P. Badovinac
p107 | doi:10.1038/nri2251
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4V0EK
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From the editors
p87 | doi:10.1038/nri2267
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4W0EL
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RESEARCH HIGHLIGHTS
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T-cell activation: Where the action's at
p88 | doi:10.1038/nri2268
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4X0EM
Tumour immunology: TGF[beta] betrays immunity for tumorigenesis
p89 | doi:10.1038/nri2263
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4Y0EN
IN THE NEWS
HIV: The ultimate hijacker
p89 | doi:10.1038/nri2266
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0BmLZ0En
Innate immunity: NF-[kappa]B is not alone
p90 | doi:10.1038/nri2259
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4Z0EO
Tumour immunotherapy: Little pig, little pig, let me come in
p90 | doi:10.1038/nri2265
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4a0EV
IN BRIEF
B-cell responses | Inflammation | T-cell activation
p90 | doi:10.1038/nri2269
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4b0EW
IN BRIEF
Inflammation | Mucosal immunology | Cytokines
p91 | doi:10.1038/nri2270
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4c0EX
Phagocytosis: Autophagy lends a hand
p92 | doi:10.1038/nri2258
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4d0EY
Thymocyte development: E proteins: manning the checkpoints
p92 | doi:10.1038/nri2261
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4e0EZ
Innate immunity: TAMing inflammation
p93 | doi:10.1038/nri2255
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4f0Ea
Dendritic cells: New DCs found deep in the skin
p94 | doi:10.1038/nri2256
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4g0Eb
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REVIEWS
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Evolving views on the genealogy of B cells
Robert S. Welner, Rosana Pelayo and Paul W. Kincade
p95 | doi:10.1038/nri2234
Views about the differentiation pathways of haematopoietic-cell lineages are evolving. No longer viewed as a series of binary fate decisions, evidence is emerging for the divergence, convergence and reversibility of haematopoiesis, as described here for B-cell development.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4h0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4i0Ed
Shaping and reshaping CD8+ T-cell memory
John T. Harty and Vladimir P. Badovinac
p107 | doi:10.1038/nri2251
Here, John Harty and Vladimir Badovinac describe the factors that control the generation of memory CD8+ T cells, discuss how these factors can characterize this response and highlight how the manipulation of these factors could reshape CD8+ T-cell memory.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4V0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4j0Ee
Micromanagement of the immune system by microRNAs
Harvey F. Lodish, Beiyan Zhou, Gwen Liu and Chang-Zheng Chen
p120 | doi:10.1038/nri2252
In this article, the authors provide a description of microRNA production and function, and discuss what is currently known about the role of microRNAs in the development and function of immune cells and in host-virus interactions.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4k0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4l0Eg
Phagocytosis and comparative innate immunity: learning on the fly
Lynda M. Stuart and R. Alan Ezekowitz
p131 | doi:10.1038/nri2240
Studies in Drosophila melanogaster are proving fruitful for our understanding of phagocytosis in development, tissue homeostasis and host defence. In this Review, parallels are drawn between phagocytosis in flies and mammals, providing insight into its complexity and the evolutionary origins of immunity.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4m0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4n0Ei
Regulation of immunological homeostasis in the respiratory tract
Patrick G. Holt, Deborah H. Strickland, Matthew E. Wikstrom and Frode L. Jahnsen
p142 | doi:10.1038/nri2236
The immune system has evolved specific mechanisms to deal with the unique problems encountered in the specialized microenvironment of the lung. This Review discusses the key mechanisms through which the local immune system maintains immunological homeostasis in the lung while preserving the integrity of the gas-exchange surfaces.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4o0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4p0Ek
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PERSPECTIVE
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OPINION
The reverse stop-signal model for CTLA4 function
Christopher E. Rudd
p153 | doi:10.1038/nri2253
Several models have been proposed to explain how cytotoxic T-lymphocyte antigen 4 (CLTA4) regulates T-cell activation but no model fully accounts for its overall function. Here, Christopher Rudd presents a new reverse stop-signal model, which can potentially explain multiple aspects of CTLA4 function.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4q0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4r0Em
Erratum: Creating immune privilege: active local suppression that benefits friends, but protects foes
Andrew L. Mellor and David H. Munn
p160 | doi:10.1038/nri2264
http://ealerts.nature.com/cgi-bin24/DM/y/eipJ0Xztnp0Hjd0Bl4s0En
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