January 2008 Volume 14 Number 1
Visit Nature Medicine online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0MW50ET
Please note that you need to be a subscriber to enjoy full text access to Nature Medicine online. To purchase a subscription, please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0bKs0Ee
Alternatively, to recommend a subscription to your library, please visit
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BRQi0EQ
=====================================================================
Clinical Pharmacology & Therapeutics: Women's Health issue
Featuring:
Point-Counterpoint: insight on emergency contraception
State of the Art: advances in the treatment of breast cancer
Practice: emergency contraception update: a Canadian perspective
Visit http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BBTU0Er to view these articles from CPT's Women's Health issue.
=====================================================================
----------------------
EDITORIAL
----------------------
Turning a blind eye p1
A new proposal might allow drug makers to promote off-label uses of their products by distributing medical publications to US doctors. Stronger rules could assure that information--not propaganda--drives doctors' prescription practices.
doi:10.1038/nm0108-1
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkph0EL
----------------------
NEWS
----------------------
Climate change concerns prompt improved disease forecasting p3
Amy Coombs
doi:10.1038/nm0108-3
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpi0EM
Amidst challenges, UK research hub moves closer to relocation p4
Alisa Opar
doi:10.1038/nm0108-4
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpj0EN
Survey hints at uneven adoption of cancer vaccine p5
Barbara Boughton
doi:10.1038/nm0108-5
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpk0EO
News in brief pp6 - 7
Timeline of events...a brief history of the important news stories this month
doi:10.1038/nm0108-6
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpl0EP
Q & A: Marc Hodosh p8
These days, if you want to have your entire genome sequenced, you need to spend about a million dollars and wait for months. But the Archon X Prize for Genomics--an international competition for speedy gene mapping--might change this by giving companies a huge incentive to develop better DNA sequencing technologies. The $10 million prize, first announced in late 2006, was donated by Stewart Blusson, a philanthropist and mining multimillionaire. Marc Hodosh, senior director of the Archon X Prize, explains why genomics was chosen for an X Prize and predicts what lies ahead for the field.
Genevive Bjorn
doi:10.1038/nm0108-8
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpm0EQ
----------------------
CORRESPONDENCE
----------------------
Problems with the oral polio vaccine p9
Virendra K Bhasin
doi:10.1038/nm0108-9
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpn0ER
----------------------
BOOK REVIEW
----------------------
Cigarettes: down but not out p11
Henry A. Lester reviews The Cigarette Century: The Rise, Fall, and Deadly Persistence of the Product That Defined AmericaAllan M Brandt
doi:10.1038/nm0108-11
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpo0ES
----------------------
NEWS AND VIEWS
----------------------
Opening the gateway to tumors pp13 - 14
T cells can turn back cancer, but they don't always reach tumor cells in sufficient numbers to do so. A close look at the cells of tumor blood vessels suggests a way to boost T cell migration in individuals with cancer (pages 28-36).
Michael H Kershaw
doi:10.1038/nm0108-13
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpp0ET
Vasopressin: friend or foe? pp14 - 16
Vasopressin plays a vital part in homeostasis by regulating water excretion in the kidney. But it seems that vasopressin also dampens the inflammatory response to uropathogenic Escherichia coli--a finding that adds to a growing list of adverse actions of the 'antidiuretic hormone'.
Mark A Knepper and Robert A Star
doi:10.1038/nm0108-14
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpq0EU
Salt abuse: the path to hypertension pp16 - 17
Excess salt intake over many years can lead to high blood pressure. An essential signaling mechanism behind this effect is now uncovered (pages 64-68).
Wilhelm Schoner
doi:10.1038/nm0108-16
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpr0EV
The movers and shakers of deep brain stimulation pp17 - 19
Deep brain stimulation is increasingly used in the treatment of Parkinson's disease, essential tremor and other disorders, yet its mechanism of action remains unknown. New findings suggest that at least some of its action involves the release of adenosine, dampening tremors (pages 75-80).
Wael Asaad and Emad Eskandar
doi:10.1038/nm0108-17
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkps0EW
Short-circuit recovery from spinal injury pp19 - 20
Propriospinal neurons, whose axons never leave the spinal cord, aid in recovery after spinal cord injury--even when all axons from the brain have been damaged (pages 69-74).
Dennis J Stelzner
doi:10.1038/nm0108-19
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpt0EX
From lung injury to fibrosis pp20 - 21
Two hallmarks of lung fibrosis are vascular leakage and recruitment of fibroblasts into the alveoli. Lysophosphatidic acid is now implicated as a major regulator of both parameters (pages 45-54).
Klaus Ley and Alexander Zarbock
doi:10.1038/nm0108-20
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpu0EY
Research Highlights p23
doi:10.1038/nm0108-23
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpv0EZ
----------------------
BRIEF COMMUNICATION
----------------------
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge pp25 - 27
Mansun Law et al.
doi:10.1038/nm1698
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpw0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpx0Eb
----------------------
ARTICLES
----------------------
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy pp28 - 36
Ronald J Buckanovich et al.
doi:10.1038/nm1699
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpy0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkpz0Ed
Purging metastases in lymphoid organs using a combination of antigen-nonspecific adoptive T cell therapy, oncolytic virotherapy and immunotherapy pp37 - 44
Jian Qiao et al.
doi:10.1038/nm1681
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkp10EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkp20ER
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak pp45 - 54
Andrew M Tager et al.
doi:10.1038/nm1685
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkp30ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkp40ET
Modification of kidney barrier function by the urokinase receptor pp55 - 63
Changli Wei et al.
doi:10.1038/nm1696
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkp50EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkp60EV
----------------------
LETTERS
----------------------
G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension pp64 - 68
Angela Wirth et al.
doi:10.1038/nm1666
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkp70EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bkp80EX
Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury pp69 - 74
Gregoire Courtine et al.
doi:10.1038/nm1682
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqA0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqB0Ei
Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor pp75 - 80
Lane Bekar et al.
doi:10.1038/nm1693
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqC0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqD0Ek
Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion pp81 - 87
Fabienne Coury et al.
doi:10.1038/nm1694
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqE0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqF0Em
Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes pp88 - 92
Olivier Joffre et al.
doi:10.1038/nm1688
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqG0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqH0Eo
Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors pp93 - 97
Thomas R Bauer, Jr et al.
doi:10.1038/nm1695
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqI0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqJ0Eq
----------------------
TECHNICAL REPORT
----------------------
Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin pp98 - 103
Weiguo Hu et al.
doi:10.1038/nm1674
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqK0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0BkqL0Es
=====================================================================
A Bone Marrow Transplantation special issue on Myeloma
Guest edited by Ray Powles, Kenneth Anderson, Jean Luc Harrousseau and Bhawna Sirohi, this special issue comes at a crucial time, following three new targeted therapies which have recently been approved for myeloma. It gives guidance on how the sequence of treatments and supportive therapy can be put together to optimize the patient's treatment pathway, to produce prolonged normal symptom-free survival. It is a model for other Cancers.
The journal received an unrestricted educational grant from the Parkside Oncology Clinic in London which contributed to the costs of producing this issue of Bone Marrow Transplantation.
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Bjws0Ec
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:
http://ealerts.nature.com/cgi-bin24/DM/y/eiXb0Xztnp0HjT0Zzu0EL
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2008 Nature Publishing Group
=====================================================================
