February 2008 Volume 9 Number 2, pp 107 - 216
Visit Nature Immunology online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0iXc0E3
Please note that you need to be a subscriber to enjoy full text
access to Nature Immunology online. To purchase a subscription,
please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0bKq0Ew
Alternatively, to recommend a subscription to your library,
please visit
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0BTLW0EP
=====================================================================
Fame. Fortune. A T-shirt. My Transfection Space,
on Invitrogen's web site, lets scientists share
transfection work successes using Invitrogen products.
Selected featured scientists win a $500 meeting stipend;
each submitter gets a T-shirt. Share your story at:
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0BlhW0EH
=====================================================================
Sweet Spots in Biology: The Functional Glycomics Gateway
A free, comprehensive and regularly updated resource for functional glycomics research,
brought to you by the Consortium for Functional Glycomics and Nature Publishing Group.
- research highlights
- news & events
- databases, data & reagents
- glycan-binding proteins
- carbohydrate structures
- glycan expression profiles
and more. Free online at http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0BjjL0E5
Sign-up for monthly email
alerts today!
=====================================================================
----------------------
EDITORIAL
----------------------
Prelude to a good story p107
Authors should provide a cover letter that explains 'in their words'
why the new work should be published in a top-tier journal.
doi:10.1038/ni0208-107
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0BlhX0EI
----------------------
COMMENTARY
----------------------
Connecting immunology research to public health: Cuban
biotechnology pp109 - 112
Agustin Lage
doi:10.1038/ni0208-109
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0BlhY0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0BlhZ0EK
----------------------
ESSAY
----------------------
The cysteinyl leukotrienes: Where do they come from? What are they?
Where are they going? pp113 - 115
K Frank Austen
doi:10.1038/ni0208-113
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blha0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhb0ES
----------------------
NEWS AND VIEWS
----------------------
Lymphocyte transmigration in the brain: a new way
of thinking pp117 - 118
Lymphocytes depend on endothelial adhesion molecules such as ICAM-1
and VCAM-1, upregulated with inflammation, to facilitate
transmigration across junctional barriers. New data show that ALCAM
replaces VCAM-1 in the CNS during the development
of neuroinflammatory diseases such as multiple sclerosis.
Boris P-L Lee and Beat A Imhof
doi:10.1038/ni0208-117
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhc0ET
Stress gets under your skin pp119 - 120
The prevailing paradigms ascribe the initiation of immune
surveillance to the detection of foreign or inflammatory
'danger' signals. However, new work indicates that immune
cells can detect early signs of cellular dysregulation
that precede tumorigenesis, even in the absence of non-self
signals and/or inflammation.
Daniel M Andrews and Mark J Smyth
doi:10.1038/ni0208-119
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhd0EU
What turns on Foxp3? pp121 - 122
Inducible regulatory T cells respond to TGF-beta by upregulating
Foxp3 expression. Tone and colleagues identify an enhancer site in
Foxp3 that binds transcription factors Smad3 and NFAT, suggesting
a means by which TGF-beta regulates Foxp3 expression.
Harald von Boehmer and Jens Nolting
doi:10.1038/ni0208-121
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhe0EV
CD160 and BTLA: LIGHTs out for CD4+ T cells pp122 - 124
The T cell costimulatory protein LIGHT and coinhbitory protein
BTLA share a common ligand, HVEM. Now CD160 is also shown to
bind HVEM and deliver a potent inhibitory signal to CD4 T cells.
Jonathan Kaye
doi:10.1038/ni0208-122
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhf0EW
IL-17 drives germinal center B cells? pp124 - 126
The inflammatory cytokine interleukin 17, normally considered
a T cell-associated factor, is now reported to be the central
participant driving the development of germinal center-derived
autoantibodies in a model disease setting.
David Tarlinton
doi:10.1038/ni0208-124
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhg0EX
Research Highlights p127
doi:10.1038/ni0208-127
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhh0EY
----------------------
REVIEW
----------------------
Of lineage and legacy: the development of mammalian hematopoietic
stem cells pp129 - 136
Elaine Dzierzak and Nancy A Speck
doi:10.1038/ni1560
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhi0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhj0Ea
----------------------
ARTICLES
----------------------
Activated leukocyte cell adhesion molecule promotes leukocyte
trafficking into the central nervous system pp137 - 145
Romain Cayrol et al.
doi:10.1038/ni1551
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhk0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhl0Ec
Acute upregulation of an NKG2D ligand promotes rapid reorganization
of a local immune compartment with pleiotropic effects on
carcinogenesis pp146 - 154
Jessica Strid et al.
doi:10.1038/ni1556
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhm0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhn0Ee
Direct priming of antiviral CD8+ T cells in the peripheral
interfollicular region of lymph nodes pp155 - 165
Heather D Hickman et al.
doi:10.1038/ni1557
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blho0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhp0Eg
Interleukin 17-producing T helper cells and interleukin 17
orchestrate autoreactive germinal center development in
autoimmune BXD2 mice pp166 - 175
Hui-Chen Hsu et al.
doi:10.1038/ni1552
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhq0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhr0Ei
CD160 inhibits activation of human CD4+ T cells through
interaction with herpesvirus entry mediator pp176 - 185
Guifang Cai et al.
doi:10.1038/ni1554
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhs0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blht0Ek
'Tuning' of type I interferon-induced Jak-STAT1 signaling by
calcium-dependent kinases in macrophages pp186 - 193
Lu Wang et al.
doi:10.1038/ni1548
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhu0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhv0Em
Smad3 and NFAT cooperate to induce Foxp3 expression through its
enhancer pp194 - 202
Yukiko Tone et al.
doi:10.1038/ni1549
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhw0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhx0Eo
Transcription factor EBF restricts alternative lineage options
and promotes B cell fate commitment independently of
Pax5 pp203 - 215
Jagan M R Pongubala et al.
doi:10.1038/ni1555
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhy0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blhz0Eq
----------------------
CORRIGENDUM
----------------------
Akirins are highly conserved nuclear proteins required for
NF-kappaB-dependent gene expression in drosophila and mice p216
Akira Goto et al.
doi:10.1038/ni0208-216
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blh10Ed
=====================================================================
Fondation IPSEN, Nature Medicine and Nature Immunology present:
Multiple Sclerosis: From Pathogenesis to Therapy
June 6, 2008
Espace Charles Louis Havas, Neuilly-sur-Seine, France
This mini-symposium will address open questions in multiple sclerosis research, with the goal of identifying future directions that may lead to therapy.
Attendance at this meeting is free on application. To apply and for more information visit:
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Blh20Ee
=====================================================================
You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your nature.com
account at:
http://ealerts.nature.com/cgi-bin24/DM/y/eiig0Xztnp0HjR0Zzu0Ef
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration
department:
registration@nature.com
For print subscription enquiries, please contact our subscription
department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York
| NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2008 Nature Publishing Group
=====================================================================
