January 2008 Volume 10 Number 1, pp 1 - 109
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EDITORIAL
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German science reinvigorated p1
With a new national science academy, an 'excellence initiative',
a roadmap for clinical research and a beefed-up science budget,
2008 looks rosy for German science.
doi:10.1038/ncb0108-1
http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbD0EK
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NEWS AND VIEWS
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Motor-cargo release: CaMKII as a traffic cop pp3 - 5
The spatial and temporal regulation of motor-based transport is
essential to ensure precise cargo delivery in all cell types. New
light has been shed on mechanisms controlling cargo-motor interactions,
with the finding that NMDA-cargo is released from KIF17 kinesin
following motor phosphorylation by CaMKII near the synapse.
Shabeen Ally, Amber L. Jolly and Vladimir I. Gelfand
doi:10.1038/ncb0108-3
http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbE0EL
Thrilling transcription through threonine
phosphorylation pp5 - 6
Covalent modifications of histone tails are highly correlated
with different states of gene expression. Although the biological
significance of many such modifications has been elucidated, the
physiological role of Thr 11 phosphorylation on histone H3 (H3T11)
has remained elusive.
Luciano Di Croce and Ramin Shiekhattar
doi:10.1038/ncb0108-5
http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbF0EM
Epigenetic memory: H3.3 steps in the groove pp7 - 9
Successful animal cloning after nuclear transfer requires efficient
reprogramming to achieve totipotency. Erasure of pre-existing marks
is not always efficient and some genes can escape reprogramming
and maintain their original active transcriptional state. Ng
and Gurdon propose that the histone H3.3 variant is a key player
in this process.
Nicolas Lacoste and Genevieve Almouzni
doi:10.1038/ncb0108-7
http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbG0EN
Redox rescues virus from ER trap pp9 - 11
How viruses manage to resist physical and chemical stress and yet
open their protective coats during cell infection has been
a longstanding, fundamental question. A study with the DNA tumour
virus SV40 now shows that protein folding and quality-control factors
of the endoplasmic reticulum reshuffle disulfide bonds within
the viral capsid, providing a molecular mechanism for the exit of
infectious virions from the endoplasmic reticulum.
Christoph J. Burckhardt and Urs F. Greber
doi:10.1038/ncb0108-9
http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbH0EO
Cilia put a brake on Wnt signalling pp11 - 13
Two studies suggest that the primary cilium, a microtubule-based
structure protruding from the surface of most vertebrate cells, has
a role in restraining Wnt/beta-catenin signalling. These findings
have implications for the pathogenesis of a plethora of diseases
associated with abnormal cilia; however, the mechanism linking
Wnt signalling and cilia remains a mystery.
Xi He
doi:10.1038/ncb0108-11
http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbI0EP
Actin nucleation: bacteria get in-Spired pp13 - 15
Spir proteins nucleate actin polymerization by assembling a linear
actin oligomer along a cluster of four actin-binding WH2 domains,
and this process is enhanced by formins of the Cappuccino family.
The discovery of Spir-like proteins in bacteria indicates that
pathogens have adopted this mechanism to manipulate the host
actin cytoskeleton.
Margot E. Quinlan and Eugen Kerkhoff
doi:10.1038/ncb0108-13
http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbJ0EQ
Getting invasive with GEP100 and Arf6 pp16 - 18
When cancers spread, they detach from their neighbouring cells
and invade the surrounding tissues to reach blood or lymphatic
vessels. EGF receptors induce cancer invasion by directly activating
GEP100, one of several potential activators of the GTP-binding
protein Arf6.
Ferran Valderrama and Anne J. Ridley
doi:10.1038/ncb0108-16
http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbK0ER
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ARTICLES
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Disruption of KIF17-Mint1 interaction by
CaMKII-dependent phosphorylation: a molecular
model of kinesin-cargo release pp19 - 29
Laurent Guillaud, Richard Wong and Nobutaka Hirokawa
doi:10.1038/ncb1665
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbL0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbM0ET
ARF1 is directly involved in dynamin-independent
endocytosis pp30 - 41
Sudha Kumari and Satyajit Mayor
doi:10.1038/ncb1666
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbN0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbO0EV
Unified mode of centromeric protection by shugoshin
in mammalian oocytes and somatic cells pp42 - 52
Jibak Lee et al.
doi:10.1038/ncb1667
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbP0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbQ0EX
Phosphorylation of histone H3 at threonine 11 establishes
a novel chromatin mark for transcriptional regulation pp53 - 60
Eric Metzger et al.
doi:10.1038/ncb1668
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbR0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbS0EZ
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LETTERS
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Epithelial coating controls mesenchymal shape change
through tissue-positioning effects and reduction of
surface-minimizing tension pp61 - 69
Hiromasa Ninomiya and Rudolf Winklbauer
doi:10.1038/ncb1669
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbT0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbU0Eb
Kif3a constrains beta-catenin-dependent Wnt signalling
through dual ciliary and non-ciliary mechanisms pp70 - 76
Kevin C. Corbit et al.
doi:10.1038/ncb1670
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbV0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbW0Ed
Pax7 activates myogenic genes by recruitment
of a histone methyltransferase complex pp77 - 84
Iain W. McKinnell et al.
doi:10.1038/ncb1671
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbX0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbY0Ef
GEP100 links epidermal growth factor receptor signalling
to Arf6 activation to induce breast cancer invasion pp85 - 92
Masaki Morishige et al.
doi:10.1038/ncb1672
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0BkbZ0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0Bkba0En
Neuroepithelial progenitors undergo LGN-dependent
planar divisions to maintain self-renewability
during mammalian neurogenesis pp93 - 101
Daijiro Konno et al.
doi:10.1038/ncb1673
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0Bkbb0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0Bkbc0Ep
Epigenetic memory of an active gene state depends
on histone H3.3 incorporation into chromatin in the
absence of transcription pp102 - 109
Ray Kit Ng and J. B. Gurdon
doi:10.1038/ncb1674
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0Bkbd0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiTk0Xztnp0HjD0Bkbe0Er
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