January 2008 Volume 22 Number 1, pp 1 - 229
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SPOTLIGHT EDITORIAL
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Introduction to 'A special spotlight review series on
BCR-ABL-negative myeloproliferative neoplasms'
A Tefferi and S N Constantinescu
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSK0EC
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SPOTLIGHT REVIEWS
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Introduction to 'Spotlight on myeloproliferative neoplasms'
C N Muller-Berat Killmann
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSL0ED
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SPOTLIGHT REVIEWS
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The history of myeloproliferative disorders: before and after Dameshek
A Tefferi
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSM0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSN0EF
Classification and diagnosis of myeloproliferative neoplasms: The 2008
World Health Organization criteria and point-of-care diagnostic
algorithms
A Tefferi and J W Vardiman
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSO0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSP0EH
JAK2 inhibitor therapy in myeloproliferative disorders: rationale,
preclinical studies and ongoing clinical trials
A Pardanani
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSQ0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSR0EJ
Current status of reduced-intensity allogeneic stem cell
transplantation using alternative donors
Y-B Chen and T R Spitzer
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSS0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlST0EL
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REVIEWS
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Recent advances in adult T-cell leukemia therapy: focus on a new
anti-transferrin receptor monoclonal antibody
C Callens, I C Moura, Y Lepelletier, S Coulon, A Renand, M Dussiot, D
Ghez, M Benhamou, R C Monteiro, A Bazarbachi and O Hermine
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSU0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSV0EN
Lymphoma microenvironment: culprit or innocent?
B Herreros, A Sanchez-Aguilera and M A Piris
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSW0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSX0EP
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ORIGINAL ARTICLES
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Time-course-dependent microvascular alterations in a model of myeloid
leukemia in vivo
C Schaefer, M Krause, I Fuhrhop, M Schroeder, P Algenstaedt, W
Fiedler, W Ruther and N Hansen-Algenstaedt
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSY0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSZ0ER
MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia:
development of a model for rapid therapeutic assessment
M C Stubbs, Y M Kim, A V Krivtsov, R D Wright, Z Feng, J Agarwal, A L
Kung and S A Armstrong
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSa0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSb0EZ
Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor
cell transformation
S Agrawal, S Koschmieder, N Baumer, N G P Reddy, W E Berdel, C
Muller-Tidow and H Serve
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSc0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSd0Eb
Development of ET, primary myelofibrosis and PV in mice expressing
JAK2 V617F
K Shide, H K Shimoda, T Kumano, K Karube, T Kameda, K Takenaka, S Oku,
H Abe, K S Katayose, Y Kubuki, K Kusumoto, S Hasuike, Y Tahara, K
Nagata, T Matsuda, K Ohshima, M Harada and K Shimoda
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSe0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSf0Ed
Harmonization of BCR-ABL mRNA quantification using a uniform
multifunctional control plasmid in 37 international laboratories
M C Muller, P Erben, G Saglio, E Gottardi, C G Nyvold, T Schenk, T
Ernst, S Lauber, J Kruth, R Hehlmann and A Hochhaus
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSg0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSh0Ef
Organ-injury-induced reactivation of hemangioblastic precursor cells
B Dekel, S Metsuyanim, A M Garcia, C Quintero, M J Sanchez and S
Izraeli
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSi0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSj0Eh
Disruption of ETV6 in intron 2 results in upregulatory and insertional
events in childhood acute lymphoblastic leukaemia
G R Jalali, Q An, Z J Konn, H Worley, S L Wright, C J Harrison, J C
Strefford and M Martineau
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSk0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSl0Ej
Prognostic significance of molecular-cytogenetic abnormalities in
pediatric T-ALL is not explained by immunophenotypic differences
M van Grotel, J P P Meijerink, E R van Wering, A W Langerak, H B
Beverloo, J G C A M Buijs-Gladdines, N B Burger, M Passier, E M van
Lieshout, W A Kamps, A J P Veerman, M M van Noesel and R Pieters
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSm0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSn0El
Hyperdiploid karyotypes in acute myeloid leukemia define a novel
entity: a study of 38 patients from the Groupe Francophone de
Cytogenetique Hematologique (GFCH)
I Luquet, J L Lai, C Barin, L Baranger, C Bilhou-Nabera, E Lippert, C
Gervais, P Talmant, P Cornillet-Lefebvre, C Perot, N Nadal, M J
Mozziconacci, M Lafage-Pochitaloff, V Eclache, F Mugneret, C Lefebvre,
C Herens, F Speleman, H Poirel, I Tigaud, C Cabrol, P Rousselot, S
Daliphard, M Imbert, R Garand, F Genevieve, R Berger and C Terre
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSo0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSp0En
Synergistic antileukemic effects between ABT-869 and chemotherapy
involve downregulation of cell cycle-regulated genes and
c-Mos-mediated MAPK pathway
J Zhou, M Pan, Z Xie, S-L Loh, C Bi, Y-C Tai, M Lilly, Y-P Lim, J-H
Han, K B Glaser, D H Albert, S K Davidsen and C-S Chen
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSq0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSr0Ep
Proapoptotic activity and chemosensitizing effect of the novel Akt
inhibitor perifosine in acute myelogenous leukemia cells
V Papa, P L Tazzari, F Chiarini, A Cappellini, F Ricci, A M Billi, C
Evangelisti, E Ottaviani, G Martinelli, N Testoni, J A McCubrey and A
M Martelli
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSs0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSt0Er
Src-family kinases play an essential role in differentiation signaling
downstream of macrophage colony-stimulating factor receptors mediating
persistent phosphorylation of phospholipase C-[gamma]2 and MAP kinases
ERK1 and ERK2
C Bourgin-Hierle, S Gobert-Gosse, J Therier, M-F Grasset and G
Mouchiroud
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSu0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSv0Et
A novel nude mice model of human extranodal nasal type NK//T-cell
lymphoma
S Zhao, Q L Tang, M X He, F Yang, H Wang, W Y Zhang, W Jiang, X L
Wang, X M Mo, G D Li and W P Liu
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSw0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSx0Ev
Bortezomib is synergistic with rituximab and cyclophosphamide in
inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo
M Wang, X H Han, L Zhang, J Yang, J F Qian, Y K Shi, L W Kwak, J
Romaguera and Q Yi
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSy0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlSz0Ex
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LETTERS TO THE EDITOR
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Absence of microsatellite instability in human chronic lymphocytic
leukaemia B cells
F Praz, F Le Page, L Vallat, F Davi, F Nguyen-Khac, K Maloum, J Delic
and H Merle-Beral
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlS10Ek
Childcare in the first 2 years of life reduces the risk of childhood
acute lymphoblastic leukemia
M Kamper-Jorgensen, A Woodward, J Wohlfahrt, C S Benn, J Simonsen, H
Hjalgrim and K Schmiegelow
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlS20El
Quantitative assessment of the JAK2 V617F allele burden: equivalent
levels in peripheral blood and bone marrow
T S Larsen, N Pallisgaard, M B Moller and H C Hasselbalch
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlS30Em
Absence of nucleophosmin leukaemic mutants in B and T cells from AML
with NPM1 mutations: implications for the cell of origin of NPMc+ AML
M P Martelli, N Manes, V Pettirossi, A Liso, R Pacini, R Mannucci, T
Zei, N Bolli, F di Raimondo, G Specchia, I Nicoletti, M F Martelli and
B Falini
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlS40En
PI-PLC[beta]-1 and activated Akt levels are linked to azacitidine
responsiveness in high-risk myelodysplastic syndromes
M Y Follo, C Finelli, C Bosi, G Martinelli, S Mongiorgi, M Baccarani,
L Manzoli, W L Blalock, A M Martelli and L Cocco
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlS50Eo
The presence of a single PML-RARA isoform lacking exon 5 in
FISH-negative APL samples
O Ashur-Fabian, L Trakhtenbrot, D Dominissini, M Koren-Michowitz, A
Nagler, G Rechavi and N Amariglio
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlS60Ep
Transplantation of human peripheral blood CD34-positive cells in
combination with ex vivo generated megakaryocytes results in fast
platelet formation in NOD//SCID mice
M R Tijssen, P B van Hennik, F di Summa, J J Zwaginga, C E van der
Schoot and C Voermans
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlS70Eq
Genomic analysis of different clonal evolution in a twin pair with
t(12;21) positive acute lymphoblastic leukemia sharing the same
prenatal clone
S Bungaro, J Irving, R Tussiwand, R Mura, L Minto, C Molteni, M
Citterio, A Hall, A Biondi and G Cazzaniga
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlS80Er
Determination of IGHV gene mutational status in chronic lymphocytic
leukemia: bioinformatics advances meet clinical needs
F Davi, R Rosenquist, P Ghia, C Belessi and K Stamatopoulos
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlTA0E2
Reply to /`Rituximab in CD20 positive multiple myeloma/' by P Moreau
et al.
P T Greipp, P Kapoor, W G Morice, T E Witzig and P R Greipp
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlTB0E3
Analysis of the exon 12 and 14 mutations of the JAK2 gene in
Philadelphia chromosome-positive leukemia
M Inami, H Yamaguchi, S Hasegawa, Y Mitamura, F Kosaka, A Kobayashi, S
Kimura, K Dan and K Inokuchi
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlTC0E4
A PDGFRB-positive acute myeloid malignancy with a new
t(5;12)(q33;p13.3) involving the ERC1 gene
P Gorello, R La Starza, L Brandimarte, S M Trisolini, V Pierini, B
Crescenzi, M Z Limongi, M Nanni, E Belloni, C Tapinassi, E Gerbino, M
F Martelli, R Foa, G Meloni, P G Pelicci and C Mecucci
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlTD0E5
Different genomic imbalances in low- and high-grade HCV-related
lymphomas
C Matteucci, M Bracci, G Barba, M Carbonari, M Casato, M Visentini, A
Pulsoni, E Varasano, G Roti, R La Starza, B Crescenzi, M F Martelli, M
Fiorilli and C Mecucci
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlTE0E6
The high frequency of T regulatory cells in patients with B-cell
chronic lymphocytic leukemia is diminished through treatment with
thalidomide
K Giannopoulos, M Schmitt, P Wlasiuk, J Chen, A Bojarska-Junak, M
Kowal, J Rolinski and A Dmoszynska
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlTF0E7
Are surrogates of IGHV gene mutational status useful in B-cell chronic
lymphocytic leukemia? The example of Septin-10
D Benedetti, R Bomben, M Dal-Bo, D Marconi, A Zucchetto, M Degan, F
Forconi, G Del-Poeta, G Gaidano and V Gattei
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlTG0E8
Differential expression of Sonic hedgehog and Gli1 in hematological
malignancies
L-Y Bai, C-F Chiu, C-W Lin, N-Y Hsu, C-L Lin, W-J Lo and M-C Kao
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlTH0EA
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CORRIGENDUM
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Modulation of cell apoptosis by AIR
M C Turco, A Lamberti, R Bisogni, M F Romano, A Petrella, M Ammirante,
A Rosati, M Davenia, C Arra, E Spugnini, P Bonelli and S Venuta
http://ealerts.nature.com/cgi-bin24/DM/y/eigj0Xztnp0Hi20BlTI0EB
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