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World Stem Cell Summit 2010

Saturday, January 19, 2008

Journal of Investigative Dermatology Contents Volume 128 pp. 247 - 492

JOURNAL OF INVESTIGATIVE DERMATOLOGY

February 2008 Volume 128 Number 2, pp 247 - 492

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Journal of Investigative Dermatology (JID) is the official journal of
the Society for Investigative Dermatology
and the European Society for Dermatological Research. JID, published
in print and online, provides an international forum for the
publication of high-quality, original articles. JID features
information on all aspects of cutaneous biology and skin disease.
Visit the journal online at http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BSsT0Eh to view the
latest research and access selected articles FREE of charge!

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The Journal of Investigative Dermatology features timely,peer-reviewed
contributions highlighting experimental, theoretical, and clinical
aspects in cutaneous biology and skin disease. If you can't access the
articles below, recommend a site licence to your librarian by visiting
http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BSup0ED

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EDITORIALS
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Clinical Snippets
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIL0EI
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIM0EJ

Research Snippets
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIN0EK
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIO0EL

Editors' Picks
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIP0EM
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIQ0EN

----------------------
JOURNAL CLUB
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Topical Nicotinamide Prevents UV Immunosuppression
Nancy Kim, Aparche Yang and Robert S Kirsner
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIR0EO
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIS0EP

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MEETING REPORTS
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Langerhans Cells at the Interface of Medicine, Science, and Industry
Miriam Merad, Nikolaus Romani and Gwendalyn Randolph
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIT0EQ
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIU0ER

Report from the 4th International Workshop for the Study of Itch
Gil Yosipovitch and E Carstens
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIV0ES
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIW0ET

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COMMENTARIES
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Adulterated Effects of Nitric Oxide-Generating Donors
Klaus-D Kroncke and Christoph V Suschek
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIX0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIY0EV
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIZ0EW

Neuroimmune Communication in Skin: Far from Peripheral
Sven Hendrix
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIa0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIb0Ee
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIc0Ef

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ORIGINAL ARTICLES
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APPENDAGES
Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla
Cells Causes Apoptosis in Follicular Keratinocytes
Mi Hee Kwack, Young Kwan Sung, Eun Jung Chung, Sang Uk Im, Ji Seop
Ahn, Moon Kyu Kim and Jung Chul Kim
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlId0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIe0Eh
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIf0Ei

Mice Expressing a Mutant Krt75 (K6hf) Allele Develop Hair and Nail
Defects Resembling Pachyonychia Congenita
Jiang Chen, Karin Jaeger, Zhining Den, Peter J Koch, John P Sundberg
and Dennis R Roop
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIg0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIh0Ek
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIi0El

CELL BIOLOGY
TGF-[beta]1 Slows the Growth of Pathogenic Myofibroblasts through a
Mechanism Requiring the Focal Adhesion Protein, Hic-5
Ganary Dabiri, David A Tumbarello, Christopher E Turner and Livingston
Van De Water
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIj0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIk0En
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIl0Eo

CLINICAL RESEARCH
Temperature-Induced Changes in Structural and Physicochemical
Properties of Vernix Caseosa
Robert Rissmann, Hendrik W W Groenink, Gert S Gooris, Marion H M
Oudshoorn, Wim E Hennink, Maria Ponec and Joke A Bouwstra
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIm0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIn0Eq
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIo0Er

Increased Expression of the Orphan Nuclear Receptor NURR1 in Psoriasis
and Modulation following TNF-[alpha] Inhibition
Marina O'Kane, Trevor Markham, Alice N McEvoy, Ursula Fearon, Doug J
Veale, Oliver FitzGerald, Brian Kirby and Evelyn P Murphy
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIp0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIq0Et
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIr0Eu

GENETICS
The [ldquo]Bald Mill Hill[rdquo] Mutation in the Mouse Is Associated
with an Abnormal, Mislocalized HR bmh Protein
Maud-Virginie Brancaz-Bouvier, Eric J G Folco, Dimitri Salameire,
Yannick Romero, Rabah Iratni and Stefan Nonchev
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIs0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIt0Ew
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIu0Ex

Detection of an Intragenic Deletion Expands the Spectrum of CTSC
Mutations in Papillon-Lefevre Syndrome
Thomas Jouary, Cyril Goizet, Isabelle Coupry, Isabelle
Redonnet-Vernhet, Thierry Levade, Ingrid Burgelin, Annick Toutain,
Emmanuel Delaporte, Claire Douillard, Didier Lacombe, Alain Taieb and
Benoit Arveiler
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIv0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIw0Ez
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIx0E1

IMMUNOLOGY/INFECTION
Dimethylfumarate Reduces Leukocyte Rolling in Vivo through Modulation
of Adhesion Molecule Expression
Simone A Rubant, Ralf J Ludwig, Sandra Diehl, Katja Hardt, Roland
Kaufmann, Josef M Pfeilschifter and Wolf-Henning Boehncke
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIy0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlIz0E3
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlI10Ep

Transglutaminase Autoantibodies in Dermatitis Herpetiformis and Celiac
Sprue
Eric V Marietta, Michael J Camilleri, Luis A Castro, Patricia K
Krause, Mark R Pittelkow and Joseph A Murray
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlI20Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlI30Er
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlI40Es

Anti-Inflammatory Activity of Sertaconazole Nitrate Is Mediated via
Activation of a p38-COX-2-PGE2 Pathway
Runa Sur, Jeffrey M Babad, Michelle Garay, Frank T Liebel and Michael
D Southall
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlI50Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlI60Eu
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlI70Ev

Molecular Analysis of Malassezia Microflora in Seborrheic Dermatitis
Patients: Comparison with Other Diseases and Healthy Subjects
Mami Tajima, Takashi Sugita, Akemi Nishikawa and Ryoji Tsuboi
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlI80Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJA0E7
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJB0E8

Topically Applied Nitric Oxide Induces T-Lymphocyte Infiltration in
Human Skin, but Minimal Inflammation
Megan Mowbray, Xuejing Tan, Paul S Wheatley, Russell E Morris and
Richard B Weller
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJC0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJD0EB
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJE0EC

KERATINOCYTES/EPIDERMIS
Microarray Analysis Demonstrates a Role for Slug in Epidermal
Homeostasis
Kimberly M Newkirk, Debra A MacKenzie, Alan P Bakaletz, Laurie G
Hudson and Donna F Kusewitt
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJF0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJG0EE
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJH0EF

Deficiency of PPAR[beta]//[delta] in the Epidermis Results in
Defective Cutaneous Permeability Barrier Homeostasis and Increased
Inflammation
Mao-Qiang Man, Grant D Barish, Matthias Schmuth, Debra Crumrine,
Yaacov Barak, Sandra Chang, Yan Jiang, Ronald M Evans, Peter M Elias
and Kenneth R Feingold
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJI0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJJ0EH
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJK0EI

Water Distribution and Natural Moisturizer Factor Content in Human
Skin Equivalents Are Regulated by Environmental Relative Humidity
Joke A Bouwstra, H Wouter W Groenink, Joop A Kempenaar, Stefan G
Romeijn and Maria Ponec
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJL0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJM0EK
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJN0EL

Upregulation of the Human Alkaline Ceramidase 1 and Acid Ceramidase
Mediates Calcium-Induced Differentiation of Epidermal Keratinocytes
Wei Sun, Ruijuan Xu, Wei Hu, Junfei Jin, Heather A Crellin, Jacek
Bielawski, Zdzislaw M Szulc, Bruce H Thiers, Lina M Obeid and Cungui
Mao
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJO0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJP0EN
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJQ0EO

MELANOCYTES/MELANOMA
Selective Amplification of Rare Mutations Using Locked Nucleic Acid
Oligonucleotides that Competitively Inhibit Primer Binding to
Wild-Type DNA
Reid P Oldenburg, Monica S Liu and Michael S Kolodney
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJR0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJS0EQ
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJT0ER

Bim Expression Is Reduced in Human Cutaneous Melanomas
Derek L Dai, Yemin Wang, Min Liu, Magdalena Martinka and Gang Li
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJU0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJV0ET
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJW0EU

In Vitro Expansion of Immature Melanoblasts and their Ability to
Repopulate Melanocyte Stem Cells in the Hair Follicle
Saori Yonetani, Mariko Moriyama, Chikako Nishigori, Masatake Osawa and
Shin-Ichi Nishikawa
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJX0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJY0EW
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJZ0EX

Clinical and Molecular Characterization of Patients at Risk for
Hereditary Melanoma in Southern Brazil
Patricia Ashton-Prolla, Lucio Bakos, Gerson Junqueira, Roberto
Giugliani, Sergio J Azevedo and David Hogg
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJa0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJb0Ef
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJc0Eg

NEUROBIOLOGY
Cerebral Processing of Histamine-Induced Itch Using Short-Term
Alternating Temperature Modulation - An fMRI Study
Michael Valet, Florian Pfab, Till Sprenger, Andreas Woller, Claus
Zimmer, Heidrun Behrendt, Johannes Ring, Ulf Darsow and Thomas R Tolle
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJd0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJe0Ei
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJf0Ej

Further Exploring the Brain-Skin Connection: Stress Worsens Dermatitis
via Substance P-dependent Neurogenic Inflammation in Mice
Sanja Pavlovic, Maria Daniltchenko, Desmond J Tobin, Evelin Hagen,
Stephen P Hunt, Burghard F Klapp, Petra C Arck and Eva M J Peters
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJg0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJh0El
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJi0Em

PHOTOBIOLOGY
UV Radiation-Induced Immunosuppression Is Greater in Men and Prevented
by Topical Nicotinamide
Diona L Damian, Clare R S Patterson, Michael Stapelberg, Joohong Park,
Ross St C Barnetson and Gary M Halliday
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJj0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJk0Eo
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJl0Ep

Augmentation of UVB Radiation-Mediated Early Gene Expression by the
Epidermal Platelet-Activating Factor Receptor
Jeffrey B Travers, Howard J Edenberg, Qiwei Zhang, Mohammed
Al-Hassani, Qiaofang Yi, Sulochanadevi Baskaran and Raymond L Konger
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJm0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJn0Er
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJo0Es

STRUCTURE
Proportion of Skin Surface Area of Children and Young Adults from 2 to
18 Years Old
Mathieu Boniol, Jean-Pierre Verriest, Remy Pedeux and Jean-Francois
Dore
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJp0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJq0Eu
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJr0Ev

TUMOR BIOLOGY
CD158K//KIR3DL2 Transcript Detection in Lesional Skin of Patients with
Erythroderma Is a Tool for the Diagnosis of Sezary Syndrome
Nicolas Ortonne, Sabine Le Gouvello, Hicham Mansour, Catherine
Poillet, Nadine Martin, Marie-Helene Delfau-Larue, Karen Leroy,
Jean-Pierre Farcet, Martine Bagot and Armand Bensussan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJs0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJt0Ex
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJu0Ey

IL-21 Enhances Antitumor Responses without Stimulating Proliferation
of Malignant T Cells of Patients with Sezary Syndrome
Jessica S Yoon, Sarah M Newton, Maria Wysocka, Andrea B Troxel,
Stephen D Hess, Stephen K Richardson, Julie H Lin, Bernice M Benoit,
Monika Kasprzycka, Mariusz A Wasik and Alain H Rook
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJv0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJw0E1
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJx0E2

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LETTERS TO THE EDITOR
----------------------
CLINICAL RESEARCH
Changing the Labeling of Sunscreen, Will We Transform Sun Avoiders
into Sunscreen Users?
Mathieu Boniol, Jean Francois Dore and Philippe Autier
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJy0E3
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJz0E4

Response to [ldquo]Changing the Labeling of Sunscreen, Will We
Transform Sun Avoiders into Sunscreen Users?[rdquo]
Jean-Jacques Grob and Caroline Gaudy-Marqueste
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJ10Eq
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJ20Er

APPENDAGES
Murine Vibrissae Cultured in Serum-Free Medium Reinitiate Anagen
Jonghyeob Lee, Wei Wu and Raphael Kopan
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJ30Es
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJ40Et

IMMUNOLOGY/INFECTION
The Importance of Long-Term Monitoring to Evaluate the Microvascular
Response to Light-Based Therapies
Bernard Choi, Wangcun Jia, Jennifer Channual, Kristen M Kelly and
Justin Lotfi
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJ50Eu
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJ60Ev

Absence of PDGFRA Mutations in Primary Melanoma
John A Curtin, Daniel Pinkel and Boris C Bastian
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJ70Ew
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlJ80Ex

TUMOR BIOLOGY
The HTLV tax-Like Sequences in Cutaneous T-Cell Lymphoma Patients
Enrico Zendri, Elisabetta Pilotti, Marie Perez, Marco Turci, Silvana
Pinelli, Paola Ronzi, Marina Frontani, Tullio Faraggiana, Giuseppe De
Panfilis and Claudio Casoli
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlKA0E8
PDF: http://ealerts.nature.com/cgi-bin24/DM/y/eids0Xztnp0Hiw0BlKB0EA

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