Signaling Gateway - 14 December 2007
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0M40E5
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0BiPP0ES
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In Signaling Update this week:
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Featured Article
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CANCER SIGNALING: MUC1 MUCKS UP APOPTOSIS
The glycoprotein MUC1 may support apoptosis evasion of cancer cells
by constitutive nuclear factor-kappaB (NF-kappaB) activation.
Original research paper: Nature Cell Biology 9, 1419-1427 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0vP0EF
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0HIE0EV
Luteinizing hormone receptor
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0BjaY0Et
The luteinizing hormone (LH) receptor (LHR) acts as a key regulator
of growth and differentiation in the ovary and testis, mediating the
cellular effects of the trophic pituitary LH and chorionic
gonadotrophin (CG) glycoprotein hormones. LH stimulates
steroid-producing gonadal cells, thus controlling local and peripheral
sex steroid concentrations. LHR was among the first G-protein-coupled
receptors for which independent coupling to more than one G-protein
family was shown.
Also published this week
AP-3 sigma1
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0BjaZ0Eu
AP-3 sigma2
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Bjaa0E2
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0BUuz0ER
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Molecule Pages Automated Data
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Each of the 4000 Molecule Pages in the database features an extensive
automated data section.
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0HIE0EV
Interactions
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Bjab0E3
The Interactions section of the automated data of each Molecule Page
contains links to public interaction databases including BIND, IntAct,
HPRD and BioGRID. A list of interacting proteins is provided for each
Molecule Page protein and its orthologs. The references are displayed
in a brief format and feature links to expanded information, species
information and relevant public databases.
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Selected Updates
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INNATE IMMUNITY: DUBA DIMS IFN PRODUCTION
DUBA (deubiquitylating enzyme A) negatively regulates the production
of the antiviral type I interferons IFNalpha and IFNbeta, supporting
an important role for reversible ubiquitylation in the regulation of
the innate immune system.
Original research paper: Science 318, 1628-1632 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Bjac0E4
IMMUNOMODULATORS: ENHANCING REGULATION
Histone deacetylase inhibitors (HDACis) inhibit the inflammation
response by increasing the number and suppression capacity of
regulatory T cells (Treg cells), which are key mediators of immune
tolerance.
Original research paper: Nature Med. 13, 1299-1307 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Bjad0E5
BACTERIAL VIRULENCE: THE INTEGRIN CONNECTION
The gastric pathogen Helicobacter pylori hijacks the host cell's
alpha5beta1 integrin receptor to inject the CagA oncoprotein into
gastric epithelial cells and ensure that it is phosphorylated by the
tyrosine kinase Src.
Original research paper: Nature 449, 862-866 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Bjae0E6
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0vO0EE
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Research Library
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A VIRAL microRNA FUNCTIONS AS AN ORTHOLOGUE OF CELLULAR miR-155
Nature 450, 1096-1099 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Bjaf0E7
NATURAL KILLER CELL TRAFFICKING IN VIVO REQUIRES A DEDICATED
SPHINGOSINE 1-PHOSPHATE RECEPTOR
Nature Immunology 8, 1337-1344 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Bjag0E8
Pim-1 REGULATES CARDIOMYOCYTE SURVIVAL DOWNSTREAM OF Akt
Nature Medicine 13, 1467-1475 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Bjah0EA
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Signaling News
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NATURE INSIGHT: PROTEINS TO PROTEOMES
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0BjTh0Ev
Proteins are the most diverse and versatile set of biological
macromolecules, having crucial roles in all biological processes.
This FREE Nature Insight covers some of the most vibrant areas of
research in the 'protein world', taking a journey from single protein
dynamics to functional proteomics and drug discovery, through some of
the latest technological developments in structural, cellular,
evolutionary and computational biology.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Crw0Ev
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - DECEMBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0BKHW0Ev
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Malaria infection: Heparan sulfate says open sesame
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0BjZO0Ec
Cell proliferation: Rafting through the lattice
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0BjZQ0Ee
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0BJYw0Ej
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Signaling Job of the Week
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Tenure Track Faculty Positions
Employer: Flanders Institute for Biotechnology
Location: Leuven, Belgium
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Bjai0EB
The Laboratory of Cancer Biology and Genetics (LCBG) at the National
Institutes of Health (NIH) invites applications for a tenure track
investigator position. The applicant should hold a Ph.D. and/or M.D.
degree and be prepared to develop an outstanding independent program
in critical areas of cancer biology such as cancer genetics, signaling,
metastasis, molecular pharmacology and mouse models of human cancer.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eiD80Xztnp0H2W0Ba6W0Ez
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