Signaling Gateway - 10 December 2007
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0M40EA
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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COLLECTIVE CELL INVASION: FOLLOWING THE LEADER'S TRACKS
Stromal fibroblasts lead collective cell invasion by deforming the
extracellular matrix, thus creating channels that are exploited by
the carcinoma cells that follow behind.
Original research paper: Nature Cell Biology 9, 1392-1400 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0vP0EJ
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0HIE0EZ
Rpt3
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1g0EO
Rpt3 (regulatory particle aTpase 3) is the systematic name for one
of the six proteasomal ATPases (Rpt1–6) of the AAA family. Rpt3
functions as part of the 26S proteasome and/or other related
macromolecular complexes. These ATPases provide the energy necessary
for several functions of the 26S proteasome, such as unfolding of the
protein substrate and translocation of the substrate towards the
central catalytic chamber of the proteasome.
Also published this week
RdgB beta
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1h0EP
Rpt4
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1i0EQ
Rpt5
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1j0ER
Rpt6
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1k0ES
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0BUuz0EV
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Selected Updates
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INFLAMMATION: THE JNK DIET
JUN N-terminal kinase 1 (JNK1) promotes obesity-induced insulin
resistance by regulating lipid accumulation in hematopoetic cells and
promoting obesity-associated inflammation in non-hematopoetic cells.
Original research paper: Cell Metab. 6, 386-397 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1l0ET
CANCER GENOMICS: COMBING THE GENOME FOR CANCER GENES
Two studies evaluating gene mutation and copy-number variation in
tumors have found that many cancer-associated genes are specific to
relatively small subsets of tumors.
Original research paper: Science 318, 1108-1113 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1m0EU
MOLECULAR NEUROSCIENCE: FAT CHANCE OF SURVIVAL
Mice that lack VAC14, a key regulator of
phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) synthesis, develop
brain lesions with high levels of apoptosis, supporting an important
role for PI(3,5)P2 in neuronal survival.
Original research paper: Proc. Natl Acad. Sci. USA 104, 17518-17523
(2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1n0EV
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0vO0EI
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Research Library
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ADAPTIVE IMMUNITY MAINTAINS OCCULT CANCER IN AN EQUILIBRIUM STATE
Nature 450, 903-907 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi2m0EV
LOSS OF Trim24 (Tif1alpha) GENE FUNCTION CONFERS ONCOGENIC ACTIVITY
TO RETINOIC ACID RECEPTOR ALPHA
Nature Genetics 39, 1500-1506 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1p0EX
USING EXPRESSION PROFILING DATA TO IDENTIFY HUMAN microRNA TARGETS
Nature Methods 4, 1045-1049 (2007)
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1q0EY
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Signaling News
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SKIN CREAM TACKLES SKIN CANCERS IN MICE
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bicm0EK
A skin cream that can restore normal activity to mutated p53 proteins
has been shown to protect mice from skin cancer, and to reduce the
growth of cancers already present. If the compound does the same for
humans, it could one day be added to sunscreen as a cancer-fighting
ingredient.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Crw0Ez
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Gateway Updates
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THE CELL MIGRATION GATEWAY - DECEMBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0uLB0EK
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles:
Lamellipodium, lamella and cofilin: Keeping control of protrusion
efficiency
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bira0EN
Cdc42 and proton efflux: A positive loop to move forward
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1r0EZ
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0BJrg0Ew
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Signaling Job of the Week
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Tenure-track Investigator
Employer: The National Institutes of Health
Location: Bethesda, Maryland
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Bi1s0Ea
The Laboratory of Cancer Biology and Genetics (LCBG) at the National
Institutes of Health (NIH) invites applications for a tenure track
investigator position. The applicant should hold a Ph.D. and/or M.D.
degree and be prepared to develop an outstanding independent program
in critical areas of cancer biology such as cancer genetics, signaling,
metastasis, molecular pharmacology and mouse models of human cancer.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0Ba6W0E4
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http://ealerts.nature.com/cgi-bin24/DM/y/eh5L0Xztnp0H2W0dIO0ED
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