January 2008 Volume 6 Number 1
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This month's FEATURED article:
The biology and future prospects of antivirulence therapies
Lynette Cegelski, Garland R. Marshall, Gary R. Eldridge & Scott J. Hultgren
p17 | doi:10.1038/nrmicro1818
http://www.nature.com/nrmicro/journal/v6/n1/full/nrmicro1818.html
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In this issue
p1 | doi:10.1038/nrmicro1831
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bjey0EN
Editorial: The value of vaccines
p2 | doi:10.1038/nrmicro1834
Our ability to control infectious diseases is continuously being eroded by antimicrobial resistance, the decline in industrial antibiotic development and increasing development timelines from discovery to market. There has never been a better time to rediscover the value of vaccination.
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bjez0EO
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RESEARCH HIGHLIGHTS
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HIV: Infection, superinfection and (lack of) protection
p3 | doi:10.1038/nrmicro1829
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bje10EB
Microbial physiology: How low can you grow?
p4 | doi:10.1038/nrmicro1825
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bje20EC
RNA: Extending the network of sRNA control
p4 | doi:10.1038/nrmicro1826
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bje30ED
Host response: IgA -- peacemaker in the gut
p4 | doi:10.1038/nrmicro1828
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bje40EE
IN BRIEF
Bacterial pathogenesis | Molecular ecology | Bacterial secretion
p5 | doi:10.1038/nrmicro1832
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bje50EF
Bacterial development: Moving in the right direction
p6 | doi:10.1038/nrmicro1823
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bje60EG
Virus structure: One of a kind!
p6 | doi:10.1038/nrmicro1827
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bje70EH
Bacterial virulence: The cycle of success for Legionella
p7 | doi:10.1038/nrmicro1822
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0Bje80EI
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NEWS AND ANALYSIS
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GENOME WATCH
A poultry existence
Helena Seth-Smith
p8 | doi:10.1038/nrmicro1830
The two poultry pathogens discussed in this month's Genome Watch are closely related to well-characterized organisms that infect humans, so scrutinizing their genomes could reveal factors that determine host-specificity.
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfA0ES
DISEASE WATCH
In the News
p9 | doi:10.1038/nrmicro1833
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfB0ET
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PROGRESS
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The versatility of Shigella effectors
Michinaga Ogawa et al.
p11 | doi:10.1038/nrmicro1814
Shigella use a type III secretion system to deliver effector proteins into the host-cell cytoplasm, where they can usurp host-cell functions and signalling pathways. In this Progress article, Chihiro Sasakawa and colleagues highlight the most recent advances in our understanding of the exact functions of the many Shigella type III-secreted effectors.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfC0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfD0EV
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REVIEWS
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The biology and future prospects of antivirulence therapies
Lynette Cegelski, Garland R. Marshall, Gary R. Eldridge and Scott J. Hultgren
p17 | doi:10.1038/nrmicro1818
Targeting bacterial virulence is an alternative approach to antimicrobial therapy. This Review considers recent efforts towards antivirulence-based drug discovery in the framework of marketable drugs, and discusses what challenges remain and the factors that are crucial to developing the antivirulence therapeutic approach.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfE0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfF0EX
Getting organized -- how bacterial cells move proteins and DNA
Martin Thanbichler and Lucy Shapiro
p28 | doi:10.1038/nrmicro1795
Bacteria have evolved several different mechanisms to target protein complexes, membrane vesicles and DNA to specific positions within the cell. Here, Thanbichler and Shapiro highlight key mechanisms of cellular organization in bacteria, with an emphasis on the role of polymeric protein assemblies in the directed movement and positioning of macromolecular complexes.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfG0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfH0EZ
Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis
James C. Sacchettini, Eric J. Rubin and Joel S. Freundlich
p41 | doi:10.1038/nrmicro1816
Why do we seem to be losing the fight against tuberculosis? In this Review, James Sacchettini, Eric Rubin and Joel Freundlich review the recent and ongoing efforts to produce new antitubercular drugs and the properties of current investigational agents.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfI0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfJ0Eb
Salmonellae interplay with host cells
Andrea Haraga, Maikke B. Ohlson and Samuel I. Miller
p53 | doi:10.1038/nrmicro1788
Salmonellae cause systemic diseases by invading and replicating inside epithelial cells and macrophages. Two functionally distinct type III secretion systems that are encoded on Salmonella pathogenicity islands 1 and 2 transfer Salmonella spp. effector proteins into host cells. The dynamic molecular interplay between these bacterial effectors and host responses is discussed in this Review.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfK0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfL0Ed
An integrated model of the recognition of Candida albicans by the innate immune system
Mihai G. Netea, Gordon D. Brown, Bart Jan Kullberg and Neil A. R. Gow
p67 | doi:10.1038/nrmicro1815
Recognition of fungi by the innate immune system depends on 'tasting' several pathogen-associated molecular patterns in the fungal cell wall. In this Review, the authors pull together the available in vitro and in vivo data to propose an integrated model for Candida albicans recognition by the innate immune system.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfM0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfN0Ef
Kiss and spit: the dual roles of Toxoplasma rhoptries
John C. Boothroyd and Jean-Francois Dubremetz
p79 | doi:10.1038/nrmicro1800
John C. Boothroyd and Jean-Francois Dubremetz review the roles of the apical rhoptry organelles in cell invasion by Apicomplexan parasites such as Toxoplasma gondii and Plasmodium spp. They propose a model in which an expansion of host range might have been the selective pressure for rhoptry-protein evolution.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfO0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfP0Eh
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CORRESPONDENCE
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Correspondence: From 'perfect mix' to 'potion magique' -- regulatory T cells and anti-inflammatory cytokines as adjuvant targets
Jagadeesh Bayry, Darren R. Flower, David F. Tough and Srini V. Kaveri
doi:10.1038/nrmicro1681-c1
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfQ0Ei
Correspondence: From 'perfect mix' to 'potion magique' -- regulatory T cells and anti-inflammatory cytokines as adjuvant targets: reply from Guy
Bruno Guy
doi:10.1038/nrmicro1681-c2
http://ealerts.nature.com/cgi-bin24/DM/y/eiEa0Xztnp0Hje0BjfR0Ej
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