January 2008 Volume 9 Number 1, pp 1 - 105
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EDITORIAL
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Stepping up to the plate p1
Picking up where pharmaceutical companies have left off, new academic
science coalitions are using innovative techniques to hunt for new
antibiotics.
doi:10.1038/ni0108-1
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjM0EQ
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COMMENTARY
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Mentoring and networking: how to make it work pp3 - 5
Mentoring and networking are critical components for success
in science. Here the importance and steps required for good
mentoring and networking are described.
Laura Haynes, Sherrill L Adams and Jeremy M Boss
doi:10.1038/ni0108-3
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjN0ER
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NEWS AND VIEWS
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Akirins versus infection pp7 - 9
Over 20 years have passed since the discovery of NF-kappaB and its
signaling pathways, yet additional participants continue to be
identified. The highly conserved protein Akirin is such an example.
Bruce Beutler and Eva Marie Y Moresco
doi:10.1038/ni0108-7
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjO0ES
IRF1: a deus ex machina in TH1 differentiation pp9 - 10
The cytokines IFN-gamma and IL-12, along with the transcription
factors STAT4 and T-bet, are necessary for driving TH1 development.
Fresh data now indicate that the transcription factor IRF1 is also
essential in this process.
Derya Unutmaz and Jan Vilcek
doi:10.1038/ni0108-9
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjP0ET
Antigens take the shuttle pp11 - 12
Splenic marginal zone B cells take up blood-borne antigens. These
B cells are now reported to continuously transport antigens to the
follicles, a process that ensures efficient delivery of blood-borne
antigens to follicular dendritic cells.
Georg Kraal
doi:10.1038/ni0108-11
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjQ0EU
Bring out your dead pp12 - 14
Phagocytosis of apoptotic cells by macrophages occurs through
recognition of specific molecules on the surfaces of apoptotic
cells by receptors on macrophages. Three recent studies add to
the understanding of this process.
David A Hume
doi:10.1038/ni0108-12
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjR0EV
Research Highlights p15
doi:10.1038/ni0108-15
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjS0EW
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REVIEW
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Semaphorins and their receptors in immune cell
interactions pp17 - 23
Kazuhiro Suzuki, Atsushi Kumanogoh and Hitoshi Kikutani
doi:10.1038/ni1553
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjT0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjU0EY
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ARTICLES
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Unique functions of the type II interleukin 4 receptor identified
in mice lacking the interleukin 13 receptor alpha1
chain pp25 - 33
Thirumalai R Ramalingam et al.
doi:10.1038/ni1544
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjV0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjW0Ea
The contribution of transcription factor IRF1 to the
interferon-gamma-interleukin 12 signaling axis and TH1
versus TH-17 differentiation of CD4+ T cells pp34 - 41
Shin-ichi Kano et al.
doi:10.1038/ni1538
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjX0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjY0Ec
The sphingosine 1-phosphate receptor 1 causes tissue retention
by inhibiting the entry of peripheral tissue T lymphocytes into
afferent lymphatics pp42 - 53
Levi G Ledgerwood et al.
doi:10.1038/ni1534
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0BjjZ0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjja0Ek
Follicular shuttling of marginal zone B cells facilitates antigen
transport pp54 - 62
Guy Cinamon et al.
doi:10.1038/ni1542
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjb0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjc0Em
CD19 is essential for B cell activation by promoting B cell
receptor-antigen microcluster formation in response to
membrane-bound ligand pp63 - 72
David Depoil et al.
doi:10.1038/ni1547
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjd0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjje0Eo
Suppression of immunoglobulin E-mediated allergic responses
by regulator of G protein signaling 13 pp73 - 80
Geetanjali Bansal et al.
doi:10.1038/ni1533
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjf0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjg0Eq
Essential function for the calcium sensor STIM1 in mast cell
activation and anaphylactic responses pp81 - 88
Yoshihiro Baba et al.
doi:10.1038/ni1546
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjh0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjji0Es
Defective mast cell effector functions in mice lacking the CRACM1
pore subunit of store-operated calcium release-activated calcium
channels pp89 - 96
Monika Vig et al.
doi:10.1038/ni1550
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjj0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjk0Eu
Akirins are highly conserved nuclear proteins required for
NF-kappaB-dependent gene expression in drosophila
and mice pp97 - 104
Akira Goto et al.
doi:10.1038/ni1543
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjl0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjm0Ew
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ERRATUM
----------------------
Erratum: Pathogen subversion of cell-intrinsic innate immunity p105
Craig R Roy and Edward S Mocarski
doi:10.1038/ni0108-105a
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjn0Ex
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CORRIGENDA
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Corrigendum: The MAPK-activated kinase Rsk controls an acute
Toll-like receptor signaling response in dendritic cells and is
activated through two distinct pathways p105
Rossana Zaru et al.
doi:10.1038/ni0108-105b
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjo0Ey
Corrigendum: Comprehensive epigenetic profiling identifies multiple
distal regulatory elements directing transcription of the gene
encoding interferon-gamma p105
Jamie R Schoenborn et al.
doi:10.1038/ni0108-105c
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjp0Ez
Corrigendum: Suppression of autoimmune inflammation of the central
nervous system by interleukin 10 secreted by interleukin
27-stimulated T cells p105
Denise C Fitzgerald et al.
doi:10.1038/ni0108-105d
http://ealerts.nature.com/cgi-bin24/DM/y/eiEb0Xztnp0HjR0Bjjq0E1
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