Distinct Mammalian Precursors Are Committed To Generate Neurons With
Defined Dendritic Projection Patterns
Article Date: 12 Nov 2007 - 17:00 PST
The mammalian brain contains a large number of different classes of
neurons that are connected in a specific manner. A long-standing
question is how such stereotyped connections emerge during the
assembly of the brain. In a new study published online this week in
the open-access journal PLoS Biology, Wolfgang Kelsch, Carlos Lois,
and colleagues investigated whether neonatal and adult brain stem
cells give rise to neurons whose connections can be influenced by the
partners that they encounter while maturing, or alternatively,
whether these connections are predetermined from the moment that a
neuron is born.
They observed the existence of distinct populations of precursor
cells committed to generating neurons with a specific pattern of
connections. Furthermore, the pattern of connections formed by these
neurons was largely independent of the environment in which the
neurons matured. These results have important implications for the
formation of neuronal circuits, as they indicate that the connections
of a new neuron can be determined in their precursors.
In particular, these observations suggest that for neuronal
replacement therapies to be successful, it will be necessary to
understand the genetic programs that control how stem cells are
prespecified to produce neurons with a stereotypic pattern of
connections.
Citation: Kelsch W, Mosley CP, Lin CW, Lois C (2007) Distinct
mammalian precursors are committed to generate neurons with defined
dendritic projection patterns. PLoS Biol 5(11): e300.
doi:10.1371/
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StemCells subscribers may also be interested in these sites:
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Cord Blood Registry
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The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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