Cord Blood America (OTC BB: CBAI) CEO Interview

Release #:812-73375-em-434148:

Cord Blood America (OTC BB: CBAI) CEO Interview CEO of Cord Blood America (OTCBB: CBAI) Reveals His Company Has Voracious Appetite for Growth, Expansion and Acquisitions LOS ANGELES, CA--(Marketwire - 01/05/10) - BioMedReports.Com, the news portal which covers Wall Street's biomedical sector and delivers financial and investment intelligence to a community of highly informed investors, has an exclusive interview with Matthew L. Schissler, the CEO of Cord Blood America (OTC.BB:CBAI - News), the small cap company that is preparing to open its seventeen thousand square foot state-of-the-art stem cell storage facility and laboratory in Las Vegas. In the interview, the CEO reveals that his company is focused on three core goals for 2010. "One of those three core goals is the diversification of revenue streams," says Schissler. "Not only will we have our own organic growth engine by processing and storing for our own company, but (yesterday) we announced that we have entered into a letter of agreement to process and store for another very successful stem cell company. "That's going to be the flavor for 2010 and onward -- diversification of revenue streams by using our new facility to its full capacity. The other goal is continued growth and we're going to be very focused on acquisitions. "In fact, I'll tell you that in 2010 we have a voracious appetite for acquisitions. With the economy the way it is, a lot of stem cell companies are struggling and we've been very fortunate to have our company go in the right direction by reducing debt and raising capital. We feel it's a very good time for us to make some acquisitions and so we're going to be very focused on that this year." The interview is available now at BioMedReports.Com: http://biomedreports.com/articles/most-popular/23349-ceo-of-cord-blood-america-otccbai-says-company-is-ready-to-grow.html Biotech investors interested in accessing the news portal's complete database of clinical trials and upcoming FDA decisions can access that information here: http://biomedreports.com/fda-calendar/fda-calendar.html About BioMedReports.Com BioMedReports.com is a news portal covering the biomedical news and financial sector. BioMedReports is not paid or compensated to report the news and developments of publicly traded companies. For more biomedical sector and investment news go to http://BioMedReports.com Contact: Media Contacts Only: Mary Davila Assistant Editor, BioMedReports.Com e-mail: Email Contact Tel: +1 323 472 4480 Fax: +1 888 210 3556

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Cell Research - Table of Contents alert Volume 20 Issue 1

CELL RESEARCH

January 2010 Volume 20 Number 1, pp 1 - 112

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RESEARCH HIGHLIGHT
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Mobilizing forces - CD4+ helper T cells script adaptive immunity
Frederick Masson and Gabrielle T Belz
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----------------------
REVIEWS
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Heterogeneity and plasticity of T helper cells
Jinfang Zhu and William E Paul
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34529925&r=MTc2MDE3NzA4MwS2&b=2&j=NjM3Mjg4NDIS1&mt=1&rt=0
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Quick to remember, slow to forget: rapid recall responses of memory CD8+ T cells
Joanna R DiSpirito and Hao Shen
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The nuclear signaling of NF-[kappa]B: current knowledge, new insights, and future perspectives
Fengyi Wan and Michael J Lenardo
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Complement and its role in innate and adaptive immune responses
Jason R Dunkelberger and Wen-Chao Song
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H5N1 influenza viruses: outbreaks and biological properties
Gabriele Neumann, Hualan Chen, George F Gao, Yuelong Shu and Yoshihiro Kawaoka
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ORIGINAL ARTICLES
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IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation
Juan Peng, Xuexian O Yang, Seon Hee Chang, Jiong Yang and Chen Dong
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Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death
signals via membrane nanotubes
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TRAF2-MLK3 interaction is essential for TNF-[alpha]-induced MLK3 activation
Gautam Sondarva, Chanakya N Kundu, Suneet Mehrotra, Rajakishore Mishra, Velusamy Rangasamy,
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The serine/threonine kinase LKB1 controls thymocyte survival through regulation of
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LETTER TO THE EDITOR
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Evidence for the involvement of ActA in maturation of the Listeria monocytogenes phagosome
Mathilde A Poussin and Howard Goldfine
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Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.

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ESRC CASE Studentship:Revealing the Economic Value of Adventurous Off-Road Cycling as a Tourism Product: a Case-Study of South West England

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ESRC CASE Studentship:The Socio-cultural Impacts of Museums in the Local Community: an Investigation of the Royal Albert Memorial Museum, Exeter.

University of Bath
Structure and morphology of cryoprotected systems

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High resolution mapping of atmospheric water vapour using remote sensing over arid regions of North Africa

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Queen's University Belfast/ESRCPhD Research Studentship

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Using Mixing in Sludge Digesters to Maximise Energy Output

University College London
Investigating the Signature of Adaptive Radiation: A Study of East African Great Lake Catfish

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Convergence or Homology of Larvae in Animal Evolution

University College London
Developmental Regulation of the Growth of Sexual Traits in Stalk-Eyed Flies

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Population Genomics of the Fission Yeast

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Atomic and functional characterisation of the interactions between H3K4 demethylase JARID1 and the oncogenic DNA binding complex LMO2-Ldb1-SCL/TAL1-E47; relevance in normal and malignant haematopoiesis

Imperial College London
Ikaros as a tumour suppressor

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Mol. Biol. Cell Table of Contents for 1 January 2010; Vol. 21, No. 1

		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Mol. Biol. Cell Table of Contents Alert

A new issue of Molecular Biology of the Cell is available online:

1 January 2010; Vol. 21, No. 1

The below Table of Contents is available online at: http://www.molbiolcell.org/content/vol21/issue1/?etoc

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Editorial

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Are You Being Served?

David G. Drubin

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Retrospective

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It's the Data!

David Botstein

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ASCB Award Essays

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A Tale of Mother and Daughter

Yukiko M. Yamashita

A Developmental Journey and Lessons Learned Along the Way

Janet Rossant

It's a Wonderful Life: A Career as an Academic Scientist

Ronald D. Vale

Walking Along the Serendipitous Path of Discovery

Peter Walter

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Articles

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Mobility, Microtubule Nucleation and Structure of Microtubule-organizing Centers in Multinucleated Hyphae of Ashbya gossypii   A Highlights from MBoC Selection Claudia Lang, Sandrine Grava, Tineke van den Hoorn, Rhonda Trimble, Peter Philippsen, and Sue L. Jaspersen We used live imaging and EM to study migration of multiple nuclei in A. gossypii. Three types of nuclear movements, oscillation, rotation, and bypassing, depend on cytoplasmic microtubules while a fourth type, co-transport with the cytoplasmic stream, does not. Nuclear MTOCs emanating perpendicular and tangential cMTs lead cMT-dependent movements

Receptor Type Protein Tyrosine Phosphatase-Kappa Mediates Cross-Talk between Transforming Growth Factor-Beta and Epidermal Growth Factor Receptor Signaling Pathways in Human Keratinocytes

Yiru Xu, Dustin Baker, TaiHao Quan, Joseph J. Baldassare, John J. Voorhees, and Gary J. Fisher

EGFR signaling pathways are major mitogenic pathways, while TGF-β signaling pathways are anti-proliferative in primary human keratinocytes. TGF-β induces protein tyrosine phosphatase-kappa (RPTP-), a negative regulator of EGFR function. TGF-β indirectly inhibits EGFR-dependent signaling and proliferation via up-regulation of RPTP-.

Retrograde Neurotrophic Signaling Requires a Protein Interacting with Receptor Tyrosine Kinases via C2H2 Zinc Fingers   A Highlights from MBoC Selection Xiaoqin Fu, Keling Zang, Zhiwei Zhou, Louis F. Reichardt, and Baoji Xu NTRAP is a novel protein that interacts with Trk receptors through its C2H2 zinc fingers in a kinase-dependent manner. It is associated with signaling endosomes in neurons. Down-regulation of NTRAP inhibits NGF-induced signaling within endosomes and neurite outgrowth in PC12 cells, and it also decreases retrograde neurotrophic signaling in cultured sensory neurons.

Analyzing the Effects of Delaying Aster Separation on Furrow Formation during Cytokinesis in the Caenorhabditis elegans Embryo   A Highlights from MBoC Selection Lindsay Lewellyn, Julien Dumont, Arshad Desai, and Karen Oegema Signaling by the centrosomal asters and spindle midzone coordinately directs formation of the cytokinetic furrow. By analyzing the effects of altering inter-aster distance in the C. elegans embryo, Lewellyn et al. show that signaling by the separated asters couples furrow formation to anaphase onset and restricts furrowing to a single site.

Hsp90 Nuclear Accumulation in Quiescence Is Linked to Chaperone Function and Spore Development in Yeast

Hugo Tapia and Kevin A. Morano

The protein chaperone Hsp90 and its co-chaperone Sba1/p23 are found to accumulate in the nucleus of haploid yeast cells as glucose is exhausted and in sporulating diploids. Novel and existing Hsp90 mutants exhibit defects in nuclear translocation and spore development, linking these two phenomena.

Na⁺/H⁺ Exchanger Regulatory Factor 1 Overexpression-dependent Increase of Cytoskeleton Organization Is Fundamental in the Rescue of F508del Cystic Fibrosis Transmembrane Conductance Regulator in Human Airway CFBE41o- Cells

Maria Favia, Lorenzo Guerra, Teresa Fanelli, Rosa Angela Cardone, Stefania Monterisi, Francesca Di Sole, Stefano Castellani, Mingmin Chen, Ursula Seidler, Stephan Joel Reshkin, Massimo Conese, and Valeria Casavola

NHERF1 overexpression increases functional apical expression of F508del CFTR in CFBE41o- cells. Here, we show that this occurs via the formation of the multiprotein complex NHERF1-phosphoezrin-actin, which provides a regulated linkage between F508del CFTR and the actin cytoskeleton resulting in an increased F508del CFTR stability in the membrane.

Age-dependent Preferential Dense-Core Vesicle Exocytosis in Neuroendocrine Cells Revealed by Newly Developed Monomeric Fluorescent Timer Protein   A Highlights from MBoC Selection Takashi Tsuboi, Tetsuya Kitaguchi, Satoshi Karasawa, Mitsunori Fukuda, and Atsushi Miyawaki Using a newly developed protein-based fluorescent timer, mK-GO, which changes color with a predictable time course, we show that Rab27A effectors, rabphilin and Slp4-a, regulate age-dependent exocytosis of secretory vesicles in PC12 cells, and suggest that coordinate functions of the effectors are required for regulated secretory pathway.

Phosphatidylinositol 3,4,5-trisphosphate Localization in Recycling Endosomes Is Necessary for AP-1B–dependent Sorting in Polarized Epithelial Cells

Ian C. Fields, Shelby M. King, Elina Shteyn, Richard S. Kang, and Heike Fölsch

The authors show that PI(3,4,5)P3 in recycling endosomes is needed for AP-1B recruitment and AP-1Bdependent sorting to the basolateral membrane. Interestingly, AP-1B expression itself triggers the formation of PI(3,4,5)P3 in this location.

A Novel Mouse HSF3 Has the Potential to Activate Nonclassical Heat-Shock Genes during Heat Shock   A Highlights from MBoC Selection Mitsuaki Fujimoto, Naoki Hayashida, Takuma Katoh, Kouji Oshima, Toyohide Shinkawa, Ramachandran Prakasam, Ke Tan, Sachiye Inouye, Ryosuke Takii, and Akira Nakai HSF1 is a master regulator of the heat-shock response in mammalian cells, whereas in avian cells, HSF3, which was considered as an avian-specific factor, is required for the expression of classical heat-shock genes. Here, the authors identify mouse HSF3, and demonstrate that it has the potential to activate only nonclassical heat-shock genes.

A Novel c-Jun N-terminal Kinase (JNK)-binding Protein WDR62 Is Recruited to Stress Granules and Mediates a Nonclassical JNK Activation

Tanya Wasserman, Ksenya Katsenelson, Sharon Daniliuc, Tal Hasin, Mordechay Choder, and Ami Aronheim

WDR62 is a novel JNK-binding protein. WDR62 potentiates JNK kinase activity but inhibits AP-1 transcription. Cells transfected with WDR62 display cytoplasmic granular localization. WDR62 is localized to stress granule and activated JNK to processing bodies following arsenite treatment. WDR62 may mediate mRNA fate following stress.

Novel Role of ATPase Subunit C Targeting Peptides Beyond Mitochondrial Protein Import   A Highlights from MBoC Selection Cristofol Vives-Bauza, Jordi Magrané, Antoni L. Andreu, and Giovanni Manfredi Mammals have three isoforms of F1F0-ATP synthase subunit c, only differing by their mitochondrial targeting peptides. Here, we show that these isoforms are non-redundant, because of different functions conferred by the targeting peptides, which in addition to mediating protein import, play a yet undiscovered role in respiratory chain maintenance.

The E3 Ubiquitin Ligases Hrd1 and gp78 Bind to and Promote Cholera Toxin Retro-Translocation

Kaleena M. Bernardi, Jeffrey M. Williams, Marjolein Kikkert, Sjaak van Voorden, Emmanuel J. Wiertz, Yihong Ye, and Billy Tsai

Cholera toxin intoxicates cells by trafficking from the cell surface to the endoplasmic reticulum (ER) where the toxic CTA1 peptide subsequently retro-translocates to the cytosol to induce toxicity. In this study, we uncovered the ER membrane components Hrd1 and gp78 as crucial players in the ER-to-cytosol transport of CTA1.

Sec3-containing Exocyst Complex Is Required for Desmosome Assembly in Mammalian Epithelial Cells

Nicholas J. Andersen and Charles Yeaman

In epithelial cells, Sec3 associates with Exocyst complexes enriched at desmosomes and centrosomes, distinct from Sec6/8 complexes at the apical junctional complex. RNAi-mediated suppression of Sec3 alters trafficking of desmosomal cadherins and impairs desmosome morphology and function, without noticeable effect on adherens junctions.

Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

Farida Korobova and Tatyana Svitkina

The high resolution structure of the cytoskeleton in dendritic spines and their precursors, dendritic filopodia, was characterized by platinum replica electron microscopy. The unexpected features of the actin architecture of these protrusions dramatically change the existing paradigm of cytoskeletal organization of elongated membrane protrusions.

Rad4 Regulates Protein Turnover at a Postubiquitylation Step

Yue Li, Jing Yan, Ikjin Kim, Chang Liu, Keke Huo, and Hai Rao

Rad4 was previously known only as a key repair factor that directly recognizes DNA damage and initiates DNA repair. Here, we demonstrate that Rad4 also regulates ubiquitylated substrate turnover. Substrates in rad4 mutant cells are ubiquitylated, indicating that Rad4 regulates a postubiquitylation event.

Actin-binding Protein-1 Interacts with WASp-interacting Protein to Regulate Growth Factor-induced Dorsal Ruffle Formation

Christa L. Cortesio, Benjamin J. Perrin, David A. Bennin, and Anna Huttenlocher

The authors show that the mammalian actin binding protein-1 (mAbp1) is required for PDGF-induced dorsal ruffle formation. mAbp1 interacts directly with WASp Interacting Protein (WIP) through its SH3 domain, and this interaction is important for regulating dorsal ruffle formation.

Growth-limiting Intracellular Metabolites in Yeast Growing under Diverse Nutrient Limitations

Viktor M. Boer, Christopher A. Crutchfield, Patrick H. Bradley, David Botstein, and Joshua D. Rabinowitz

We find that the metabolome of nutrient-limited yeast varies dramatically with the limiting nutrient's identity. Low glutamine is a hallmark of nitrogen limitation, ATP of phosphorus limitation, and pyruvate of carbon limitation. The availability of these metabolites can quantitatively account for the nutrient-limited yeast's growth rate.

Hydrogen Sulfide Increases Hypoxia-inducible Factor-1 Activity Independently of von Hippel–Lindau Tumor Suppressor-1 in C. elegans

Mark W. Budde and Mark B. Roth

In C. elegans, hydrogen sulfide (H2S) exposure results in Hif-1 stabilization. hif-1 is required for survival in H2S and constitutive HIF-1 stabilization confers resistance to H2S. H2S-induced HIF-1 reporter activity appears to be independent of VHL-1, whereas VHL-1 is required for hypoxic regulation of HIF-1 reporter activity.

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Nature Reviews Rheumatology - Table of Contents alert Volume 6 Issue 1

NATURE REVIEWS RHEUMATOLOGY

January 2010 Volume 6 Number 1

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----------------------
RESEARCH HIGHLIGHTS
----------------------
Metabolic bone diseases: Teriparatide or alendronate for
glucocorticoid-induced osteoporosis therapy?
p1 | doi:10.1038/nrrheum.2009.241
http://links.ealert.nature.com/ctt?kn=24&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

TREG cell therapy
p2 | doi:10.1038/nrrheum.2009.244
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Rheumatoid arthritis: RASFs identified as culprits in the spread of RA
p2 | doi:10.1038/nrrheum.2009.246
http://links.ealert.nature.com/ctt?kn=20&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Rheumatoid arthritis: Inducing immune tolerance in RA: clinical and
immunologic efficacy
p3 | doi:10.1038/nrrheum.2009.242
http://links.ealert.nature.com/ctt?kn=18&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Adenovirus alleviates arthritis
p3 | doi:10.1038/nrrheum.2009.243
http://links.ealert.nature.com/ctt?kn=28&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Genetics: Genes associated with BMD and osteoporotic fracture: a meta-analysis
p3 | doi:10.1038/nrrheum.2009.248
http://links.ealert.nature.com/ctt?kn=95&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Experimental arthritis: Targeting the complement alternative pathway
p4 | doi:10.1038/nrrheum.2009.247
http://links.ealert.nature.com/ctt?kn=93&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

IN BRIEF
Rheumatoid arthritis | Bone | Connective tissue diseases
p4 | doi:10.1038/nrrheum.2009.251
http://links.ealert.nature.com/ctt?kn=41&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Correction: Osteoimmunology and the effects of the immune system on bone
p4 | doi:10.1038/nrrheum.2009.280
http://links.ealert.nature.com/ctt?kn=87&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Pulmonary arterial hypertension: A role for Notch3 in PAH
p5 | doi:10.1038/nrrheum.2009.245
http://links.ealert.nature.com/ctt?kn=26&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Metabolic bone diseases: Cathepsin K inhibition for osteoporosis
p5 | doi:10.1038/nrrheum.2009.250
http://links.ealert.nature.com/ctt?kn=32&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Biomarkers: Elevated microparticle levels in primary Sjogren's syndrome
p6 | doi:10.1038/nrrheum.2009.249
http://links.ealert.nature.com/ctt?kn=34&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

IN BRIEF
Vasculitis syndromes | Rheumatoid arthritis | Imaging | Epidemiology
p6 | doi:10.1038/nrrheum.2009.252
http://links.ealert.nature.com/ctt?kn=51&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Connective tissue diseases: A nonsurgical therapy for Dupuytren disease
Ardeshir Bayat
p7 | doi:10.1038/nrrheum.2009.255
Surgery is the current mainstay of treatment for Dupuytren disease but
is associated with potentially serious complications and a high rate of
recurrence. A phase III study of enzymatic fasciotomy promises advances
towards effective nonsurgical treatment of this debilitating disorder.
http://links.ealert.nature.com/ctt?kn=3&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Therapy: Optimum therapy in septic arthritis: to cut or not to cut?
Max Field
p8 | doi:10.1038/nrrheum.2009.256
Septic arthritis kills 10-15% of patients, despite advances in medical
treatment over the past 50 years. Is it time to revisit the question of
whether, in addition to medical treatment, joint surgery is necessary?
http://links.ealert.nature.com/ctt?kn=40&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Therapy: Hydroxychloroquine in SLE: old drug, new perspectives
Thomas Dorner
p10 | doi:10.1038/nrrheum.2009.235
Antimalarial agents have long been used in the treatment of autoimmune
diseases, despite uncertainty regarding the exact mechanisms underlying
their various effects. Growing evidence that these drugs offer protection
from major infections could stimulate more research into these mechanisms,
with possible implications for therapy.
http://links.ealert.nature.com/ctt?kn=7&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Psychology: Emotional disclosure in RA: does it work?
Joan L. Duda and Jet J. C. S. Veldhuijzen van Zanten
p11 | doi:10.1038/nrrheum.2009.254
What is the psychological and clinical effectiveness of a home-based
emotional disclosure intervention? Results from a randomized, controlled
trial of such an intervention in patients with rheumatoid arthritis could
have implications for the future of therapeutic research and clinical
practice.
http://links.ealert.nature.com/ctt?kn=13&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
Lupus nephritis: lessons from murine models
Anne Davidson and Cynthia Aranow
Published online: 01 December 2009
p13 | doi:10.1038/nrrheum.2009.240
Treatment of renal disease associated with systemic lupus erythematosus
remains inadequate despite advances in our understanding of the disease
pathogenesis. As discussed in this Review, clinical trials are underway
for a number of therapeutic agents shown to be successful in murine lupus.
In addition, insights gleaned from animal studies could lead to new
strategies for the treatment of lupus nephritis in humans.
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

The role of microparticles in the pathogenesis of rheumatic diseases
Christian Beyer and David S. Pisetsky
Published online: 01 December 2009
p21 | doi:10.1038/nrrheum.2009.229
Microparticles, which are membrane-bound vesicles that are released from
cells during cell activation and apoptosis, are emerging as important
mediators of intercellular communication in the context of rheumatic
disease. Levels of microparticles are increased in the blood of patients
with rheumatic diseases, suggesting a role for microparticles not only in
disease pathogenesis, but also as potential biomarkers in these diseases.
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Update on gout: new therapeutic strategies and options
Robert Terkeltaub
p30 | doi:10.1038/nrrheum.2009.236
The epidemiology and clinical profile of gout have changed considerably
over the past two decades. In this context, advances in our understanding
of the pathogenesis of hyperuricemia and gouty inflammation, and
developments in therapeutic options for patients with gout are discussed
in this Review.
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Type I interferons: crucial participants in disease amplification in
autoimmunity
John C. Hall and Antony Rosen
p40 | doi:10.1038/nrrheum.2009.237
Mounting evidence indicates a role for interferons in the pathogenesis
of systemic autoimmunity. This Review focuses on the role of the type I
interferon pathway in the development of systemic autoimmune diseases,
describing the mechanisms by which these cytokines are produced and how
they exert their effects in both the normal antiviral immune response and
in autoimmune disease.
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

Mechanical signals as anabolic agents in bone
Engin Ozcivici, Yen Kim Luu, Ben Adler, Yi-Xian Qin, Janet Rubin, Stefan
Judex and Clinton T. Rubin
p50 | doi:10.1038/nrrheum.2009.239
A reduction in mechanical loading of the skeleton resulting from aging
or a sedentary lifestyle can confer an increased risk of fracture through
reductions in bone quantity and quality. Not only are mechanical signals
crucial in defining and maintaining bone mass, but they also have the
potential-in a high-frequency, low-intensity form-to be used in the
treatment of osteoporosis.
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=34527231&r=MTc2NDQ4MTc5OAS2&b=2&j=NjM2MjEzMTgS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

FOCUS ON TOLERANCE BREAKDOWN

A variety of cellular and molecular mechanisms are required to maintain
immune tolerance to self. Nature Immunology presents a series of specially
commissioned articles that discuss these mechanisms, as well as events
that can precipitate tolerance breakdown and lead to autoimmunity. The
web focus also includes highlights of recent research findings.

For more information, visit
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Cord Blood America (OTC BB: CBAI) Announces Major New Stem Cell Storage Agreement

Release #:812-73328-em-434148:

Cord Blood America (OTC BB: CBAI) Announces Major New Stem Cell Storage Agreement Cord Blood America Announces Cord Blood Stem Cell Processing and Storage Agreement With BioCells, a South American Company   LAS VEGAS, Jan. 4 /PRNewswire-FirstCall/ -- Cord Blood America, Inc. (OTC Bulletin Board: CBAI), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com) focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally, said today that it has signed a Letter of Intent to process and store cord blood specimens for BioCells, Inc., headquartered in Argentina, and its affiliates in Peru, Colombia, Bolivia, Panama and Puerto Rico.   "This is an excellent example of how our new laboratory and storage facility in Las Vegas allows us to significantly diversify our business model," said Matthew Schissler, co-founder and CEO.  "BioCells is already the second largest stem cell storage company in Argentina with annual revenues of 1.5M (USD). The company has 12 locations throughout the country and has recently expanded internationally to both Uruguay and Paraguay. We are confident this will be an excellent working relationship, beneficial to both companies. We will be processing and storing for BioCells' affiliates in Peru, Colombia, Bolivia, Panama and Puerto Rico."   "It is a revenue generator we have not had in the past.  Not only do we have our own organic sales engine, our new lab can now generate gross profit by processing and storage agreements with other successful stem cell companies," Mr. Schissler commented. "BioCells has proven to be a tremendous company and we are fortunate to have entered into this letter of intent."   Cord Blood America recently announced a grand opening of its 17,000 square foot stem cell laboratory and headquarters in Las Vegas, near the city's international airport, on January 22, 2010.   The deal between Cord Blood America and BioCells is pending due diligence, and if it is completed successfully, anticipates the contract closing in the first quarter of 2010.   About Cord Blood America   Cord Blood America (OTC Bulletin Board: CBAI) is the parent company of CorCell, which facilitates umbilical cord blood stem cell preservation for expectant parents and their children. Its mission is to be the most respected stem cell preservation company in the industry. Collected through a safe and non-invasive process, cord blood stem cells offer a powerful and potentially life-saving resource for treating a growing number of ailments, including cancer, leukemia, blood, and immune disorders. To find out more about Cord Blood America, Inc. (OTC Bulletin Board: CBAI), visit our website at www.corcell.com. For investor information, visit www.cordblood-america.com.         CONTACT:       Paul Knopick       E & E Communications       949/707-5365       pknopick@eandecommunications.com   Forward-Looking Statements   Some statements made in this press release are forward-looking statements, which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. We use words such as "anticipate,'' "believe,'' "expect,'' "future,'' "intend,'' "plan,'' and similar expressions to identify forward-looking statements. These statements including those related to the growth of the industry, new stem cell treatments, and the Company's performance, are only predictions and are subject to certain risks, uncertainties and assumptions. Additional risks are identified and described in the Company's public filings with the Securities and Exchange Commission. Statements made herein are as of the date of this press release and should not be relied upon as of any subsequent date. The Company's past performance is not necessarily indicative of its future performance. The Company does not undertake, and the Company specifically disclaims any obligation to update any forward-looking statements to reflect occurrences, developments, events, or circumstances after the date of such statement.

My EANDE More Information

New Year Holiday Edition

Your New Year Holiday Special Edition of the RSCI Newsletter is here!

The first RSCI Newsletter of 2010 highlights RSCI Beneficiaries of Repair Stem Cell Treatments!

Patients with conditions:
• Cerebral Palsy (If you can even imagine helping a human born 16 weeks prematurely)
• Congestive Heart Failure
• Optic Nerve Disorder
• Brain Injury/Blindness

Read about their treatment experience, how their quality of life has been impacted and much, much more…

RSCI wishes you and yours a happy and prosperous 2010!

Click the following link to view our New Year Holiday Special Edition:

http://www.repairstemcells.org/Newsletters/NL010110.htm

Be sure to check out the latest in Repair Stem Cell Science by visiting our 3 web sites:
www.repairstemcells.org
www.donmargolis.com
www.quipnation.com/StemCellBlog