Mol. Biol. Cell MBC In Press for 5 Aug 2009

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Mol. Biol. Cell Online MBC In Press Alert

New Molecular Biology of the Cell MBC In Press articles have been made available
(for the period 29 Jul 2009 to 5 Aug 2009):

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Articles

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Hierarchical Inactivation of a Synthetic Human Kinetochore by a Chromatin Modifier

Stefano Cardinale, Jan H. Bergmann, David Kelly, Megumi Nakano, Manuel M. Valdivia, Hiroshi Kimura, Hiroshi Masumoto, Vladimir Larionov, and William C. Earnshaw

mTrs130 Is a Component of a Mammalian TRAPPII Complex, a Rab1 GEF that Binds to COPI Coated Vesicles

Akinori Yamasaki, Shekar Menon, Sidney Yu, Jemima Barrowman, Timo Meerloo, Viola Oorschot, Judith Klumperman, Ayano Satoh, and Susan Ferro-Novick

Function and Assembly of DNA looping, Clustering and Microtubule Attachment Complexes within a Eukaryotic Kinetochore

Marybeth Anderson, Julian Haase, Elaine Yeh, and Kerry Bloom

Autocatalytic Processing of m-AAA Protease Subunits in Mitochondria

Mirko Koppen, Florian Bonn, Sarah Ehses, and Thomas Langer

Glycogen Synthase Kinase-3 and Omi/HtrA2 Induce Annexin A2 Cleavage followed by Cell Cycle Inhibition and Apoptosis

Chi-Yun Wang, Yee-Shin Lin, Wu-Chou Su, Chia-Ling Chen, and Chiou-Feng Lin

Reciprocal Efficiency of RNQ1 and Polyglutamine Detoxification in the Cytosol and Nucleus

Peter M. Douglas, Daniel W. Summers, Hong-Yu Ren, and Douglas M. Cyr

Udu Deficiency Activates DNA Damage Checkpoint

Chiaw-Hwee Lim, Shang-Wei Chong, and Yun-Jin Jiang

Bacterial Sec Protein Transport Is Rate-limited by Precursor Length: A Single Turnover Study

Fu-Cheng Liang, Umesh K. Bageshwar, and Siegfried M. Musser

Regulation of Cell Death by Recycling Endosomes and Golgi Membrane Dynamics via a Pathway Involving Src-Family Kinases, Cdc42 and Rab11a

Marie-Claude Landry, Andréane Sicotte, Claudia Champagne, and Josée N. Lavoie

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Nature 6 August 2009 Volume 460 Number 7256 pp667-772

NATURE

6 August 2009 Volume 460 Number 7256, pp 667 - 772

Visit Nature online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=127&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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Agent-based modelling

Three pieces in this week's Nature discuss the use of agent-based
modelling. Joshua M. Epstein discusses how agent-based computational
modelling is playing a central part in mapping the possible spread
of H1N1, and designing policies for its mitigation. Also, J. Doyne
Farmer and Duncan Foley consider how (and why) the world's economy
needs agent-based modelling.
http://links.ealert.nature.com/ctt?kn=236&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

http://links.ealert.nature.com/ctt?kn=228&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

And in a News Feature Mark Buchanan reports on whether agent-based
computer models could prevent another financial crisis.
http://links.ealert.nature.com/ctt?kn=8&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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EDITORIALS
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A model approach p667
More development work is needed to help computer simulations inform
economic policy.
doi:10.1038/460667a
http://links.ealert.nature.com/ctt?kn=341&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Science under attack p667
Congress should stop playing politics with the peer-review process.
doi:10.1038/460667b
http://links.ealert.nature.com/ctt?kn=314&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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RESEARCH HIGHLIGHTS
----------------------
Evolution: Arboreal ascent p668
doi:10.1038/460668a
http://links.ealert.nature.com/ctt?kn=309&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Exoplanets: Avoiding shrinkage p668
doi:10.1038/460668b
http://links.ealert.nature.com/ctt?kn=303&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Cancer biology: HPV's unexpected effect p668
doi:10.1038/460668c
http://links.ealert.nature.com/ctt?kn=266&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Materials science: Foam finesse p668
doi:10.1038/460668d
http://links.ealert.nature.com/ctt?kn=245&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Neuroscience: Learning experience p668
doi:10.1038/460668e
http://links.ealert.nature.com/ctt?kn=334&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Genetics: Context is king pp668-669
doi:10.1038/460668f
http://links.ealert.nature.com/ctt?kn=343&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Water management: Colorado be dammed p669
doi:10.1038/460669a
http://links.ealert.nature.com/ctt?kn=372&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Invertebrate immunity: Infection in real time p669
doi:10.1038/460669b
http://links.ealert.nature.com/ctt?kn=357&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Chemical biology: 800 million strong p669
doi:10.1038/460669c
http://links.ealert.nature.com/ctt?kn=115&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Structural biology: Get into the groove p669
doi:10.1038/460669d
http://links.ealert.nature.com/ctt?kn=121&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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JOURNAL CLUB
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Journal club p669
Douglas Kell
doi:10.1038/460669e
http://links.ealert.nature.com/ctt?kn=102&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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NEWS
----------------------
US joins China in climate talks p670
But the two-day meeting was long on mutual understanding while being
notably short on targets.
Jeff Tollefson
doi:10.1038/460670a
http://links.ealert.nature.com/ctt?kn=162&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Greek scientists fight research shake-up p671
Protests greet plans to dismantle multidisciplinary institutions.
Alison Abbott
doi:10.1038/460671a
http://links.ealert.nature.com/ctt?kn=182&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Snapshot: The guts of a dying star p671
Swirling gas sets pulsar spinning in supercomputer simulation.
Lizzie Buchen
doi:10.1038/460671b
http://links.ealert.nature.com/ctt?kn=210&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Who speaks for science in Europe? pp672-673
Questions remain over whether researchers have a coherent enough voice
to influence European science policy. Natasha Gilbert reports.
Natasha Gilbert
doi:10.1038/460672a
http://links.ealert.nature.com/ctt?kn=105&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Spain unveils its eye on the sky p674
World's largest optical telescope inaugurated.
Govert Schilling
doi:10.1038/460674a
http://links.ealert.nature.com/ctt?kn=103&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Joint Mars plans come together p675
US and Europe schedule rovers and orbiters for the red planet.
Eric Hand
doi:10.1038/460675a
http://links.ealert.nature.com/ctt?kn=64&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Grant scores leave applicants in limbo p676
Top-rated research must wait until September for NIH funding decision.
Meredith Wadman
doi:10.1038/460676a
http://links.ealert.nature.com/ctt?kn=57&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

India embarks on push to become a solar power p677
doi:10.1038/460677a
http://links.ealert.nature.com/ctt?kn=316&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Lab worker charged with destroying protein crystals p677
doi:10.1038/460677b
http://links.ealert.nature.com/ctt?kn=320&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Plummeting silicon prices may boost solar sales p677
doi:10.1038/460677c
http://links.ealert.nature.com/ctt?kn=331&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

US report backs distinction between science and policy p677
doi:10.1038/460677d
http://links.ealert.nature.com/ctt?kn=43&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Chikyu showcases riser drilling for deep-sea research p677
doi:10.1038/460677e
http://links.ealert.nature.com/ctt?kn=38&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Corrections p677
doi:10.1038/460677f
http://links.ealert.nature.com/ctt?kn=79&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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COLUMN
----------------------
Sending out an SOS p679
An Obama gambit on space policy highlights the benefits and risks of
turning to outside experts.
David Goldston explains.
doi:10.1038/460679a
http://links.ealert.nature.com/ctt?kn=94&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

----------------------
NEWS FEATURE
----------------------
Economics: Meltdown modelling pp680-682
Could agent-based computer models prevent another financial crisis?
Mark Buchanan reports.
doi:10.1038/460680a
http://links.ealert.nature.com/ctt?kn=62&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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CORRESPONDENCE
----------------------
Helping young scientists to speak for themselves p683
Christina Astin
doi:10.1038/460683a
http://links.ealert.nature.com/ctt?kn=72&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Flu: no sign so far that the human pandemic is spread by pigs p683
Bernard Vallat
doi:10.1038/460683b
http://links.ealert.nature.com/ctt?kn=347&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Small but effective moves towards a greener China pp683-684
Wanxin Li
doi:10.1038/460683c
http://links.ealert.nature.com/ctt?kn=69&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Mystery ape: other fossils suggest that it's no mystery at all p684
Dennis A. Etler
doi:10.1038/460684a
http://links.ealert.nature.com/ctt?kn=55&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Mystery ape: a call for taxonomic rigour p684
Kevin Padian
doi:10.1038/460684b
http://links.ealert.nature.com/ctt?kn=77&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Human uniqueness and the denial of death p684
Ajit Varki
doi:10.1038/460684c
http://links.ealert.nature.com/ctt?kn=59&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

----------------------
OPINION
----------------------
The economy needs agent-based modelling pp685-686
The leaders of the world are flying the economy by the seat of their
pants, say J. Doyne Farmer and Duncan Foley. There is, however, a
better way to help guide financial policies.
J. Doyne Farmer and Duncan Foley
doi:10.1038/460685a
http://links.ealert.nature.com/ctt?kn=45&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Modelling to contain pandemics p687
Agent-based computational models can capture irrational behaviour,
complex social networks and global scale -- all essential in
confronting H1N1, says Joshua M. Epstein.
Joshua M. Epstein
doi:10.1038/460687a
http://links.ealert.nature.com/ctt?kn=52&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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BOOKS AND ARTS
----------------------
In Retrospect: Lamarck's treatise at 200 pp688-689
Fifty years before On the Origin of Species, a confusing, tiresome
and prescient book laid the foundations of modern evolutionary
theory, write Dan Graur, Manolo Gouy and David Wool.
Dan Graur, Manolo Gouy and David Wool review Philosophie Zoologique
(Zoological Philosophy) by Jean Baptiste Lamarck
doi:10.1038/460688a
http://links.ealert.nature.com/ctt?kn=194&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

A passion for birds p689
Devorah Bennu reviews Life List: A Woman's Quest for the World's
Most Amazing Birds by Olivia Gentile
doi:10.1038/460689a
http://links.ealert.nature.com/ctt?kn=342&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Playing the con game of academe p690
Rachel Ivie reviews Lives in Science: How Institutions Affect
Academic Careers by Joseph C. Hermanowicz
doi:10.1038/460690a
http://links.ealert.nature.com/ctt?kn=221&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Me, environmentalist p691
Colin Martin reviews Tarzan! Or Rousseau Among the Waziri by
doi:10.1038/460691a
http://links.ealert.nature.com/ctt?kn=226&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Ecology reading p691
Joanne Baker
doi:10.1038/460691b
http://links.ealert.nature.com/ctt?kn=232&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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NEWS AND VIEWS
----------------------
Demography: Babies make a comeback pp693-694
The population of some wealthy countries is shrinking because of a
declining birth rate. It comes as a surprise, and one with policy
implications, that after a certain point of development that trend
can reverse.
Shripad Tuljapurkar
doi:10.1038/460693a
http://links.ealert.nature.com/ctt?kn=212&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Galaxy formation: Too small to ignore pp694-695
A study of one galaxy's dynamics backs up previous claims that
surprisingly compact galaxies existed in the early Universe. But
how such objects blew up in size to form present-day galaxies
remains a puzzle.
Karl Glazebrook
doi:10.1038/460694a
http://links.ealert.nature.com/ctt?kn=184&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Archaeology: The earliest musical tradition pp695-696
Music is a ubiquitous element in our daily lives, and was probably
just as important to our early ancestors. Fragments of ancient
flutes reveal that music was well established in Europe by about
40,000 years ago.
Daniel S. Adler
doi:10.1038/460695a
http://links.ealert.nature.com/ctt?kn=252&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Structural biology: Aerial view of the HIV genome pp696-698
A bird's-eye view of the higher-order structure of HIV-1's entire RNA
genome reveals new motifs in surprising places. Structural biologists
can now zoom in on these regions to explore their functions further.
Hashim M. Al-Hashimi
doi:10.1038/460696a
http://links.ealert.nature.com/ctt?kn=256&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

50 & 100 years ago p697
doi:10.1038/460697a
http://links.ealert.nature.com/ctt?kn=279&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Biogeochemistry: Carbonate rocks deconstructed pp698-699
The ratios of stable isotopes, especially isotopes of carbon and
oxygen, have tales to tell about Earth's history. Post-depositional
alteration of the carbonate rocks being studied may radically alter
the story.
Michael A. Arthur
doi:10.1038/460698a
http://links.ealert.nature.com/ctt?kn=209&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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PROGRESS
----------------------
Beyond the myth of the supernova-remnant origin of cosmic rays
pp701-704
Yousaf Butt
doi:10.1038/nature08127
Abstract: http://links.ealert.nature.com/ctt?kn=165&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=168&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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ARTICLES
----------------------
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
pp705-710
Evidence for a single microRNA (miRNA) that can efficiently differentiate
multipotent stem cells into a specific lineage or regulate direct
reprogramming of cells into an alternative cell fate has been elusive.
Two miRNAs, miR-145 and miR-143, are now shown to be co-transcribed in
multipotent cardiac progenitors before becoming localized to smooth
muscle cells. miR-145 was found to be necessary for myocardin-induced
reprogramming of adult fibroblasts and sufficient to induce
differentiation of multipotent neural crest stem cells.
Kimberly R. Cordes et al.
doi:10.1038/nature08195
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=337&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Architecture and secondary structure of an entire HIV-1 RNA genome
pp711-716
Single-stranded RNA viruses are responsible for the common cold,
cancer, AIDS and other serious health threats. The genomes of these
viruses form conserved secondary structures that have functional
and regulatory roles, but most potential regulatory elements in
viral RNA genomes remain uncharacterized. Here however, the
structure of an entire HIV-1 genome at single nucleotide resolution
is reported.
Joseph M. Watts et al.
doi:10.1038/nature08237
Abstract: http://links.ealert.nature.com/ctt?kn=345&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=293&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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LETTERS
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A high stellar velocity dispersion for a compact massive galaxy at
redshift z = 2.186 pp717-719
The oldest and most luminous galaxies in the early Universe are
surprisingly compact, having stellar masses similar to present-day
elliptical galaxies but much smaller sizes. This suggests that massive
galaxies have grown in size by a factor of about five over the past
ten billion years, leading to the expectation that the stars in these
galaxies have much higher velocities than those in present-day galaxies
of the same mass. Here, the stellar velocity dispersion for a compact
massive galaxy at redshift z = 2.186 is indeed found to be very high.
Pieter G. van Dokkum, Mariska Kriek and Marijn Franx
doi:10.1038/nature08220
Abstract: http://links.ealert.nature.com/ctt?kn=297&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Observed variations of methane on Mars unexplained by known atmospheric
chemistry and physics pp720-723
Recent observations of methane on Mars suggest that methane concentrations
are locally enhanced and change with the seasons. However, methane has a
photochemical lifetime of several centuries, and is therefore expected to
have a spatially uniform distribution on the planet. Here, using a global
climate model of Mars with coupled chemistry reveals that photochemistry
as currently understood cannot explain these variations in Martian methane.
Franck Lefevre and Francois Forget
doi:10.1038/nature08228
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=323&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Observation of strong coupling between a micromechanical resonator and
an optical cavity field pp724-727
Achieving coherent quantum control over massive mechanical resonators
via coupling to electrons or photons is a current research goal. Here,
unambiguous evidence for strong coupling of cavity photons to a
mechanical resonator is reported, paving the way for full quantum
optical control of nano- and micromechanical devices.
Simon Groblacher, Klemens Hammerer, Michael R. Vanner and
Markus Aspelmeyer
doi:10.1038/nature08171
Abstract: http://links.ealert.nature.com/ctt?kn=329&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=190&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

The late Precambrian greening of the Earth pp728-732
The low 13C/12C ratio in some Neoproterozoic carbonates is considered
to be evidence of carbon cycle perturbations unique to the Precambrian.
Here, all published oxygen and carbon isotope data for Neoproterozoic
marine carbonates are compiled. The combined isotope systematics are
found to be identical to those of well-understood Phanerozoic examples,
suggesting an influx of photosynthetic carbon rather than perturbations
to the carbon cycle -- and implying an explosion of photosynthesizing
communities on late Precambrian land surfaces.
L. Paul Knauth and Martin J. Kennedy
doi:10.1038/nature08213
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=131&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Fluid and deformation regime of an advancing subduction system at
Marlborough, New Zealand pp733-736
Newly forming subduction zones on Earth can provide insights into the
evolution of major fault zone geometries from shallow levels to deep
in the lithosphere, and into the role of fluids in promoting rock
failure by several modes. The acquisition of a transect of
magnetotelluric soundings across the Marlborough strike-slip fault
system of the northern South Island of New Zealand now implicates three
distinct processes connecting fluid generation along the upper mantle
plate interface to rock deformation in the crust as the subduction
zone develops.
Philip E. Wannamaker et al.
doi:10.1038/nature08204
Abstract: http://links.ealert.nature.com/ctt?kn=164&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=169&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

New flutes document the earliest musical tradition in southwestern
Germany pp737-740
The existence of complex musical instruments is accepted to be an
indication of fully modern behaviour and advanced symbolic
communication. The discovery of bone and ivory flutes that are
around 35,000 years old at Hohle Fels in southwestern Germany now
demonstrates the presence of a well-established musical tradition
at the time when modern humans colonized Europe.
Nicholas J. Conard, Maria Malina and Susanne C. Munzel
doi:10.1038/nature08169
Abstract: http://links.ealert.nature.com/ctt?kn=155&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=240&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Advances in development reverse fertility declines pp741-743
The increasing wealth of nations is accompanied by a fall in fertility
such that in many developed and developing nations fertility rates
have dropped below replacement value (less than 2.1 children per
woman). Rapid population ageing, and in some cases the prospect of
significant population decline, present difficult social and political
problems. However, it is now shown that above a certain degree of
economic development fertility begins to rise once again.
Mikko Myrskyla, Hans-Peter Kohler and Francesco C. Billari
doi:10.1038/nature08230
Abstract: http://links.ealert.nature.com/ctt?kn=135&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=143&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Common variants conferring risk of schizophrenia pp744-747
Here, in the first of three papers on the genetics of schizophrenia,
a genome-wide association study of single nucleotide polymorphisms
using data from several large genome-wide scans reveals significant
associations to individual loci that implicate perturbations in
immunity, brain development, memory and cognition in the
predisposition to schizophrenia.
Hreinn Stefansson et al.
doi:10.1038/nature08186
Abstract: http://links.ealert.nature.com/ctt?kn=170&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=154&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Common polygenic variation contributes to risk of schizophrenia and
bipolar disorder pp748-752
In the second of three papers on the genetics of schizophrenia, a
large genome-wide association study looking at common genetic variants
underlying the risk of schizophrenia implicates the major
histocompatibility complex -- and thus, immunity -- and provides
molecular genetic evidence for a substantial polygenic component to
the risk of schizophrenia. The latter involves thousands of common
alleles of very small effect that also contribute to the risk of
bipolar disorder.
The International Schizophrenia Consortium
doi:10.1038/nature08185
Abstract: http://links.ealert.nature.com/ctt?kn=363&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=366&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Common variants on chromosome 6p22.1 are associated with schizophrenia
pp753-757
In the third of three papers looking at the genetics of schizophrenia,
a genome-wide association study using the Molecular Genetics of
Schizophrenia case-control data set followed by a meta-analysis
further implicates the major histocompatibility complex. The study
also reveals that although common schizophrenia susceptibility alleles
can be detected, there are probably few or no single common loci with
large effects.
Jianxin Shi et al.
doi:10.1038/nature08192
Abstract: http://links.ealert.nature.com/ctt?kn=339&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=348&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Switch in FGF signalling initiates glial differentiation in the
Drosophila eye pp758-761
Glial cells have an essential role in the building and wiring of
nervous systems. They generally migrate over long distances before
they initiate differentiation, but the molecular pathways coordinating
the switch from glial migration to glial differentiation are largely
unknown. The study of glial cells in the Drosophila eye disc now
implicates fibroblast growth factor (FGF) signalling proteins in
this process.
Sigridur Rut Franzdottir et al.
doi:10.1038/nature08167
Abstract: http://links.ealert.nature.com/ctt?kn=325&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=307&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Proteome-wide cellular protein concentrations of the human pathogen
Leptospira interrogans pp762-765
Absolute protein concentration measurements of a considerable
fraction of the proteome have, until now, only been derived from
genetically altered Saccharomyces cerevisiae cells, using a
technique that is not directly portable from yeast to other species.
A mass-spectrometry-based method is now used to determine the
absolute protein abundance for a significant fraction of the
proteome of the human pathogen Leptospira interrogans.
Johan Malmstrom et al.
doi:10.1038/nature08184
Abstract: http://links.ealert.nature.com/ctt?kn=311&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=317&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

----------------------
CORRIGENDUM
----------------------
Warming of the Antarctic ice-sheet surface since the 1957 International
Geophysical Year p766
Eric J. Steig et al.
doi:10.1038/nature08286
http://links.ealert.nature.com/ctt?kn=287&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

----------------------
Naturejobs
----------------------
Prospects
Back to first principles p769
We need more physician innovators, not just more physician scientists,
writes Justin Chakma.
doi:10.1038/nj7256-769a
http://links.ealert.nature.com/ctt?kn=270&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Postdoc journal
Footloose and freelance? p769
Taking the plunge into freelance writing.
Joanne Isaac
doi:10.1038/nj7256-769b
http://links.ealert.nature.com/ctt?kn=251&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

In Brief
Postdocs join union p769
Rutgers University becomes one of a handful of US universities with
unionized postdocs.
doi:10.1038/nj7256-769c
http://links.ealert.nature.com/ctt?kn=243&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Help for service economy p769
Harnessing UK science could boost banking and other sectors.
doi:10.1038/nj7256-769d
http://links.ealert.nature.com/ctt?kn=74&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

Spotlight on UK energy p769
International panel to review UK research on renewable and
sustainable energy.
doi:10.1038/nj7256-769e
http://links.ealert.nature.com/ctt?kn=26&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

----------------------
FUTURES
----------------------
Expatriate p772
Contact has been made.
Julian Tang
doi:10.1038/460772a
http://links.ealert.nature.com/ctt?kn=96&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

----------------------
Advance Online Publication
----------------------
02 August 2009
Adult mice generated from induced pluripotent stem cells near-final version
Michael J. Boland et al.
doi:10.1038/nature08310
Abstract: http://links.ealert.nature.com/ctt?kn=189&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=148&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

05 August 2009
Developmental and species-divergent globin switching are driven
by BCL11A
Vijay G. Sankaran et al.
doi:10.1038/nature08243
Abstract: http://links.ealert.nature.com/ctt?kn=153&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=225&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

L1 retrotransposition in human neural progenitor cells
Nicole G. Coufal et al.
doi:10.1038/nature08248
Abstract: http://links.ealert.nature.com/ctt?kn=233&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=128&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

02 August 2009
Characterization of two classes of small molecule inhibitors of
Arp2/3 complex
B. J. Nolen et al.
doi:10.1038/nature08231
Abstract: http://links.ealert.nature.com/ctt?kn=132&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=140&m=33804924&r=MjA1NTkxMDA2MAS2&b=2&j=NTUxMDM4MDkS1&mt=1&rt=0

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Cord Blood America (OTC BB: CBAI): Major Debt Reduction

Release #:812-68863-em-434148:

Cord Blood America (OTC BB: CBAI): Major Debt Reduction Cord Blood America Retires $2.53M Obligation SANTA MONICA, Calif., Aug. 5 /PRNewswire-FirstCall/ -- Cord Blood America, Inc. (OTC Bulletin Board: CBAI - News), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com) focused on bringing the life saving potential of stem cells to families nationwide and internationally, said today it has retired $2.53M of long-term debt. "The two notes signed in February and March of 2007 respectively, between CBAI and the Shelter Island Opportunity Fund (SIOF), have been retired as of August 3, 2009. With this debt retirement, CBAI has only the put option agreement obligation with SIOF remaining on its balance sheet. Cord Blood America regards this as a key milestone on its path to being able to operate debt free," said Matthew Schissler, Cord Blood America Founder and CEO. "Shelter Island provided us with the capital to purchase CorCell, which is the first licensed family cord blood banking company in the United States. Using their financing allowed us to establish CBAI as one of the largest domestic stem cell storage companies. Our obligation was to pay the notes in full before the February 28, 2010 maturity date. We are happy to have met the obligation and have saved a significant amount of interest payments because of early payoff." "We have repeatedly said that decreasing debt would be one of our significant items to focus on in 2009," said Mr. Schissler. "Eliminating debt makes our financial balance sheet stronger and makes Cord Blood America a better investment. We are very pleased with this development." About Cord Blood America Cord Blood America (OTC Bulletin Board: CBAI - News) is the parent company of CorCell, which facilitates umbilical cord blood stem cell preservation for expectant parents and their children. Its mission is to be the most respected stem cell preservation company in the industry. Collected through a safe and non-invasive process, cord blood stem cells offer a powerful and potentially life-saving resource for treating a growing number of ailments, including cancer, leukemia, blood, and immune disorders. To find out more about Cord Blood America, Inc. (OTC Bulletin Board: CBAI - News), visit our website at www.corcell.com. For investor information, visit www.cordblood-america.com. Forward-Looking Statements Some statements made in this press release are forward-looking statements, which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. We use words such as "anticipate," "believe," "expect," "future," "intend," "plan," and similar expressions to identify forward-looking statements. These statements including those related to the growth of the industry, new stem cell treatments, and the Company's performance, are only predictions and are subject to certain risks, uncertainties and assumptions. Additional risks are identified and described in the Company's public filings with the Securities and Exchange Commission. Statements made herein are as of the date of this press release and should not be relied upon as of any subsequent date. The Company's past performance is not necessarily indicative of its future performance. The Company does not undertake, and the Company specifically disclaims any obligation to update any forward-looking statements to reflect occurrences, developments, events, or circumstances after the date of such statement.   CONTACT: Paul Knopick E & E Communications 949/707-5365 pknopick@eandecommunications.com

My EANDE More Information

The EMBO Journal - Table of Contents alert Volume 28 Issue 15

THE EMBO JOURNAL

05 August 2009 Volume 28 Number 15, pp 2143 - 2306

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=====================================================================

----------------------
EDITORIAL
----------------------
The middle and the end
Karin Hartmut and Dumstrei Vodermaier
doi:10.1038/emboj.2009.191
http://links.ealert.nature.com/ctt?kn=24&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

----------------------
HAVE YOU SEEN ...?
----------------------
Gene activation at the edge of the nucleus
Jonathan R Chubb
doi:10.1038/emboj.2009.148
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Irresistible curves
Jennifer R Juarez and William Margolin
doi:10.1038/emboj.2009.167
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
Silent chromatin at the middle and ends: lessons from yeasts
Marc Bühler and Susan M Gasser
doi:10.1038/emboj.2009.185
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

A quantitative systems view of the spindle assembly checkpoint
Andrea Ciliberto and Jagesh V Shah
doi:10.1038/emboj.2009.186
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Taming the tiger by the tail: modulation of DNA damage responses by telomeres
David Lydall
doi:10.1038/emboj.2009.176
Abstract: http://links.ealert.nature.com/ctt?kn=93&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Concerted action of two cation filters in the aquaporin water channel
Binghua Wu, Christina Steinbronn, Magnus Alsterfjord, Thomas Zeuthen and Eric Beitz
doi:10.1038/emboj.2009.182
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration
Marie-Laure Rives, Claire Vol, Yugo Fukazawa, Norbert Tinel, Eric Trinquet, Mohammed Akli Ayoub, Ryuichi Shigemoto, Jean-Philippe Pin and Laurent Prézeau
doi:10.1038/emboj.2009.177
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Increased RNA polymerase availability directs resources towards growth at the expense of maintenance
Bertil Gummesson, Lisa U Magnusson, Martin Lovmar, Kristian Kvint, Örjan Persson, Manuel Ballesteros, Anne Farewell and Thomas Nyström
doi:10.1038/emboj.2009.181
Abstract: http://links.ealert.nature.com/ctt?kn=1&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1
Yuehua Wei, Chi Kwan Tsang and X F Steven Zheng
doi:10.1038/emboj.2009.179
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Transcriptional competence of the integrated HIV-1 provirus at the nuclear periphery
Mariacarolina Dieudonné, Paolo Maiuri, Chiara Biancotto, Anna Knezevich, Anna Kula, Marina Lusic and Alessandro Marcello
doi:10.1038/emboj.2009.141
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=113&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy
Isabelle Vergne, Esteban Roberts, Rasha A Elmaoued, Valérie Tosch, Mónica A Delgado, Tassula Proikas-Cezanne, Jocelyn Laporte and Vojo Deretic
doi:10.1038/emboj.2009.159
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Far-red light inhibits germination through DELLA-dependent stimulation of ABA synthesis and ABI3 activity
Urszula Piskurewicz, Veronika Tureková, Eric Lacombe and Luis Lopez-Molina
doi:10.1038/emboj.2009.170
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Localisation of DivIVA by targeting to negatively curved membranes
Rok Lenarcic, Sven Halbedel, Loek Visser, Michael Shaw, Ling Juan Wu, Jeff Errington, Davide Marenduzzo and Leendert W Hamoen
doi:10.1038/emboj.2009.129
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Exon, intron and splice site locations in the spliceosomal B complex
Elmar Wolf, Berthold Kastner, Jochen Deckert, Christian Merz, Holger Stark and Reinhard Lührmann
doi:10.1038/emboj.2009.171
Abstract: http://links.ealert.nature.com/ctt?kn=118&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=120&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2
Marcello Clerici, André Mourão, Irina Gutsche, Niels H Gehring, Matthias W Hentze, Andreas Kulozik, Jan Kadlec, Michael Sattler and Stephen Cusack
doi:10.1038/emboj.2009.175
Abstract: http://links.ealert.nature.com/ctt?kn=91&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Protein modifications: beyond the usual suspects
EMBO reports web focus
http://links.ealert.nature.com/ctt?kn=15&m=33801925&r=MTc2ODY3NTU2NQS2&b=2&j=NTUwNzU5NjAS1&mt=1&rt=0

Get a sense of the molecular diversity that exists within cells! This series of comprehensive and engaging reviews highlights the complexity of post-translational protein modifications. Leading experts analyze atypical ubiquitin-chain formation, ATGylation, polyglutamylation, neddylation, and Urmylation, and update our knowledge on poly(ADP-ribosyl)ation and O-GlcNAcylation. A complex but important topic to understand!

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International Stem Cell Corporation Issues Letter to Shareholders

Release #:1468-68801-rl-434148:

International Stem Cell Corporation Issues Letter to Shareholders Letter Describes Capital Funding, Strengthening of Senior Management Team, Agreement with Cytograft Tissue Engineering, Positive Results from Animal Trials, and Other Developments International Stem Cell Corporation (OTCBB:ISCO), the first company to perfect a method of creating human stem cells from unfertilized eggs, has issued a letter to its shareholders. To view the shareholder letter in its entirety, please follow the link to the company's website: http://www.internationalstemcell.com/shareholderletter.htm. In the letter, International Stem Cell CEO and Chairman, Kenneth Aldrich updates shareholders on the company's continued efforts to increase shareholder value related to its key initiatives and developments, which include: The Company continues to lead in the development of human parthenogenetic stem cell ("hpSC") research. ISCO has made major strides in deriving cells that may be useful in the treatment of liver disease and in the creation of human corneal tissue both as a potential therapeutic product for corneal disease and as an alternative to animal testing to assess the safety of drugs and consumer products. $5 million investment commitment with a biotechnology-focused fund announced in July; funding expected to be in tranches, with first $1.5 million expected in September. Additional $1 million tranche funded on schedule under previously announced preferred stock offering, and over $500,000 in private common stock sales funded during first 6 months of 2009 Senior management team strengthened to provide greater capacity and flexibility as company expands its therapeutic and commercial activities Positive early results reported in May from animal trials designed to improve photorefractive keratectomy (PRK), a form of corrective laser eye surgery that offers an improved alternative to LASIK March 2009 agreement with Cytograft Tissue Engineering to design custom cell culture medium to cultivate living human vascular grafts "Viewed from a scientific, political, managerial, and financial perspective, the past six months have been a vibrant and compelling time in our corporate history," says Mr. Aldrich. "The company remains committed to its vision of creating the means to manufacture, bank, and provide cells for patients that need them, on demand, at low cost, without the risk of immune rejection. We look forward to our shareholders reviewing this update, thank them for their steadfastness and support, and look forward to our shared work in the months and years ahead." ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB) International Stem Cell Corporation is a California biotechnology company focused on developing therapeutic and research products. ISCO's technology, Parthenogenesis, results in the creation of pluripotent human stem cell lines from unfertilized human eggs. ISCO scientists have created the first Parthenogenetic homozygous stem cell line (phSC-Hhom-4) that can be a source of therapeutic cells that will minimize immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. These advancements offer the potential to create the first true "Stem Cell Bank" and address ethical issues by eliminating the need to use or destroy fertilized embryos. ISCO also produces and markets specialized cells and growth media worldwide for therapeutic research through its subsidiary Lifeline Cell Technology. For more information, visit the ISCO website at: www.internationalstemcell.com. To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0. For more news and information on International Stem Cell Corporation please visit www.IRGnews.com/coi/ISCO where you can find the CEO's video, a fact sheet on the company, investor presentations, and more. FORWARD-LOOKING STATEMENTS: Statements pertaining to expected future financial and/or operating results, anticipated funding, future research, technology and clinical development plans and potential opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the completion of funding commitments, the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital,and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements. Key Words: Stem Cells, Biotechnology, Parthenogenesis International Stem Cell Corporation Kenneth C. Aldrich, Chairman, CEO kaldrich@intlstemcell.com 760-940-6383 or The Investor Relations Group 212-825-3210 Investor Relations: Adam S. Holdsworth aholdsworth@investorrelationsgroup.com or Media Relations: Laura Colontrelle lcolontrelle@investorrelationsgroup.com

My InvestorPass Market Data More Information

Deplomatic Delivery, p2

From: Professor Gariba Belo
Address Accra Ghana

Deplomatic Delivery,

This is to inform you that your funds have been approved on your name for immediate delivery to you.

For the purpose of clarification and processing, you are advised to reconfirm your Full Names, Direct Telephone Numbers, Physical Address with Zip Code so that there will be no error during the delivery of the funds to you in your country of residence.

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From: Professor Gariba Belo

Latest PhD Studentships - 4 August 2009

Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.

Imperial College London
PhD Studentship in Sustainable Energy Engineering

Nottingham Trent University
Ab Initio Studies of Defects in Metal Oxides

Nottingham Trent University
Microfluidic Photonic Devices

Nottingham Trent University
The role of the mitochondrial enzyme monoamine oxidase (MAO) in health and disease

Nottingham Trent University
The Systems Biology of Breast Cancer

Cranfield University
EngD studentship – Impact of compost application to arable soils on Nitrous Oxide (N20) emissions

Nottingham Trent University
Virulence traits in Cronobacter species (formerly Enterobacter sakazakii)

University of Warwick
Analysis of plant materials for molecules of pharmaceutical importance

Cranfield University
EPSRC Industrial CASE studentship – Reducing retail and household fresh produce waste using palladium promoted ethylene scrubbers

National University of Ireland, Maynooth
PhD Scholarship in the area of Clean-Slate Radio Architectures

National University of Ireland, Maynooth
PhD/MEng.Sc Scholarship in Geospatial Applications of Wireless Sensors

National University of Ireland, Maynooth
PhD Scholarship in Clean-Slate Radio Networks

National University of Ireland, Maynooth
PhD Scholarship in Low Cost Wireless Sensor Networks

University of Manchester
New Synthetic Routes to Organic Semiconductors

University of Surrey
PhD Studentship on Single-Thruster Attitude Control for Rapid and Safe Deployment of Planetary Penetrators

Many more projects have been added this week! Click here to view them all!

Kind regards,

The FindAPhD.com Team

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