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World Stem Cell Summit 2010

Monday, March 3, 2008

EMBO Reports Table of Contents March 2008, Volume 9, Number 3, pp 207 - 300.

EMBO REPORTS TABLE OF CONTENTS

March 2008 Volume 9 Number 3, pp 207-300
(c) Copyright 2008 by the European Molecular Biology Organization
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60rc0EP


Visit EMBO reports online to browse the content of the current
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Scientific reports.

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Contents: Volume 9, Number 3 (March 2008)

---------------------
EDITORIAL
---------------------


Language barriers.
Frank Gannon
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo110ER

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SCIENCE AND SOCIETY
---------------------

VIEWPOINTS

Hedgehogs, humans and high-school science. The benefits of involving high-school students in university research.
Giulio Pavesi, Antonio Siccardi, Giovanna Viale, Cinzia Grazioli, Tiziana Calciolari, Maria Luisa Tenchini & Paolo Plevani
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo120ES


Six senses in the literature. The bleak sensory landscape of biomedical texts.
Raul Rodriguez-Esteban & Andrey Rzhetsky
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo130ET


How do we ask for money? A view of funding for basic research.
Juan-Manuel Schvartzman & Jorge-Bernardo Schvartzman
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo140EU

ANALYSES

First do no harm. Improving drug safety through legislation and independent research.
Mark Greener
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo150EV


Not so simple after all. A renaissance of research into prokaryotic evolution and cell structure.
Philip Hunter
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo160EW

BOOK REVIEW

Enhancing evolution: the next step?.
Sarah Chan
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo170EX

---------------------
REVIEWS
---------------------

MEETING REPORTS

A journey into the nucleus. Conference on Nuclear Structure and Dynamics.
Irina Solovei, Philippe Pasero & Neus Visa
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo180EY


Are cancer and ageing different sides of the same coin? Conference on Cancer and Ageing.
Graham Pawelec & Rafael Solana
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2A0Ei


Fly neurobiology: development and function of the brain. Meeting on the Neurobiology of Drosophila.
Michael D Gordon, Andrea Manzo & Kristin Scott
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2B0Ej

LITERATURE REPORT

NLRX1: friend or foe?.
Etienne Meylan & Jurg Tschopp
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2C0Ek

REVIEW

Second meiotic arrest and exit in frogs and mice.
Anthony C.F. Perry & Marie-Hélène Verlhac
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2D0El
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2E0Em

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SCIENTIFIC REPORTS
---------------------


DNA-damage response control of E2F7 and E2F8.
L Panagiotis Zalmas, Xiujie Zhao, Anne L Graham, Rebecca Fisher, Carmel Reilly, Amanda S Coutts & Nicholas B La Thangue
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2F0En
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2G0Eo


Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.
Soda Balla Diop, Karine Bertaux, Dasari Vasanthi, Ali Sarkeshik, Benjamin Goirand, Denise Aragnol, Nicholas S Tolwinski, Michael D Cole, Jacques Pradel, John R Yates III, Rakesh K Mishra, Yacine Graba & Andrew J Saurin
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2H0Ep
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2I0Eq


Regulation of an inducible promoter by an HP1[beta][ndash]HP1[gamma] switch.
Bogdan Mateescu, Brigitte Bourachot, Christophe Rachez, Vasily Ogryzko & Christian Muchardt
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2J0Er
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2K0Es


The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.
Markus Haindl, Thomas Harasim, Dirk Eick & Stefan Muller
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2L0Et
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2M0Eu


Ribosomal proteins are targets for the NEDD8 pathway.
Dimitris P Xirodimas, Anders Sundqvist, Akihiro Nakamura, Linnan Shen, Catherine Botting & Ronald T Hay
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2N0Ev
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2O0Ew


BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.
Adele Adamo, Paolo Montemauri, Nicola Silva, Jordan D Ward, Simon J Boulton & Adriana La Volpe
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2P0Ex
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2Q0Ey


NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-[kappa]B and JNK pathways by inducing reactive oxygen species production.
Ivan Tattoli, Leticia A Carneiro, Muguette Jéhanno, Joao G Magalhaes, Youmin Shu, Dana J Philpott, Damien Arnoult & Stephen E Girardin
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2R0Ez
http://ealerts.nature.com/cgi-bin24/DM/y/ejTI0Xztnp0Hh60Bo2S0E1


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Sunday, March 2, 2008

Keyword News: [stem cell]

Yahoo! Alerts Yahoo! News - My Alerts - Edit Alert
Sunday, March 2, 2008 10:31 PM PST

Adult Stem Cell Changes Underlie Rare Genetic Disease Associated With Accelerated Aging
Science Daily Sun, 02 Mar 2008 2:34 PM PST
Adult stem cells may provide an explanation for the cause of a Hutchinson-Gilford Progeria Syndrome, a rare disease that causes premature aging in children. These findings, the first to indicate a biological basis for the clinical features of HGPS, also known as progeria, may also provide new insights into the biological mechanisms of normal aging.

Adult stem cell changes underlie rare genetic disease associated with accelerated aging
EurekAlert! Sun, 02 Mar 2008 10:17 AM PST
Adult stem cells may provide an explanation for the cause of a Hutchinson-Gilford Progeria Syndrome (HGPS), a rare disease that causes premature aging in children, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH). These findings, the first to indicate a biological basis for the clinical features of HGPS, also known as progeria, may ...

Adult stem cell changes underlie rare genetic disease associated with accelerated aging
PhysOrg Sun, 02 Mar 2008 10:40 AM PST
Adult stem cells may provide an explanation for the cause of a Hutchinson-Gilford Progeria Syndrome (HGPS), a rare disease that causes premature aging in children, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health. These findings, the first to indicate a biological basis for the clinical features of HGPS, also known as progeria, may also ...

Brazil's Church Lobbies On Stem Cells
FOX 29 Lake Charles Sun, 02 Mar 2008 9:33 AM PST
BRASILIA, Brazil -- Brazilian church officials urged the Supreme Court on Friday to reject embryonic stem cell research in the world's largest Roman Catholic country, a week before the justices rule on banning such research.

Blood Drive Benefits Tot With Rare Cancer
FOX 4 News Kansas City Sun, 02 Mar 2008 7:12 PM PST
One boy's battle with a rare and deadly cancer has inspired an entire community to help see that he survives. Trisha Putthoff said her son Gabe has seen plenty of pain since being diagnosed with a rare form of kidney cancer. Gabe has endured surgeries, chemotherapy and bone marrow and stem cell transplants.

Profiles of Success in Texas Panhandle: Patience paves path for oncologist
Amarillo Globe-News Sun, 02 Mar 2008 0:55 AM PST
[My education enables me to make a difference in the lives of cancer patients. Not only am I the only physician-scientist in Amarillo, I am also doing what I enjoy most: providing state-of-the-art care, including stem cell transplants, to cancer patients with leukemia, lymphoma, and myeloma, and also conducting research to discover a vaccine for the treatment of cancer. My medical education has ...




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Newsletter: 3 stem cell patents issued last week

View this newletter online to get all the info!

3 stem cell patents issued last week



Dear manoj kumar valluru,

Last week 3 patents of relevance to the area of stem cells were issued.

1. # 7,335,490 (Patent Spotlight), teaches how to stimulate cardiac regeneration by administration of a specially made type of erythropoietin.

2. # 7,335,641 teaches the use of a molecule similar to KGF-2 for stimulation of hair growth.

3. # 7,335,230 covers an implantable device that is useful for regeneration of connective tissue.


In The News

Embryonic Stem Cell Homing

Friday February 29th, 2008 @ 15:52:20 EST

Boston, MA -

Administration of bone marrow derived stem cells to patients post-infarct has demonstrated positive clinical results in double blind trials. Additionally, Osiris Therapeutics has reported intravenous administration of allogeneic mesenchymal stem cells increases cardiac function in similar patient populations.

A recent study (Malek et al. Successful implantation of intravenously administered stem cells correlates with severity of inflammation in murine myocarditis. Pflugers Arch. 2006 Jun;452:268-75) asked the question of whether intravenous administration of embryonic stem cells may be beneficial in viral induced heart failure. The scientists first demonstrated that after viral (encephalomyocarditis virus) infection there is a gradient of inflammatory cytokines produced, with peak serum concentrations at day 14 post infection. This is interesting since coxsackie b3 viral infection induces mobilization of mesenchymal stem cells on day 3 post infection

The investigators then performed intravenous injection of GFP-marked mouse embryonic stem cells at different timepoints. Cells injected at day 14 had the highest rate of incorporation in comparison to other time-points. Additionally injection at day 14 induced the highest rate of regenerative activity.

These data have very interesting implications on the migratory mechanisms of embryonic stem cells. Do ES cells have CXCR-4 on them?

Ask a question OR leave your comments.

Read more StemCellPatents.com News


This Week's Patent Spotlight

Use of erythropoietin for the preventive or curative treatment of cardiac failure

Patent Number: 7,335,490

The use of erythropoietin for non-hematopoietic purposes has been increasing in the last couple of years. One obvious example is the Canadian company Stem Cell Therapeutics (sss.v) which is using erythropoietin together with human chorionic gonadotropin for treatment of patients post-stroke. Other uses of erthrypoietin include direct stimulation of neurite outgrowth

The current patent covers the use of a specific type of recombinant erythropoietin for treatment of a patient with heart failure. Specifically the patent claims a recombinant erthyropoietin that is produced in an "isolated host cell expressing at least the Early Region 1A (E1A) protein of an adenovirus, wherein said host cell is a cell as deposited under European Collection of Animal Cell Cultures (ECACC) no. 96022940".

In the summary of the invention the inventors make an interesting discussion. Essentially they state that EPO has conventionally been used for the treatment of anemia and that some of the anemic patients had heart failure. Specifically, the inventors discuss a type of heart failure that is actually associated with anemia. When the EPO was used to treat the anemia an increased heart performance was observed. Accordingly the inventors asked whether non-hematopoietic modulating effects of EPO could be at work, which it seems like they were.

The examples in the patent include:

1. Detection of EPO receptor in human and rat heart tissue

2. Anti-apoptotic effects of EPO in the ischemia reperfusion rat model

3. Inhibition of apoptosis in chronic ischemia models

Ask a question OR leave your comments.



LATEST JOBS


Patent Proscecution Technology Specialist or Scientific Advisor
Posted July 28 | Crescent Strategic Resources

Attorney- Patent Litigation Associate
Posted July 28 | Crescent Strategic Resources

Stem Cell Technicians & Research Scientists
Posted July 1 | Steenblock Research Institute, Inc.

Stem Cell Biologist
Posted March 19 | The Institute of Cellular Medicine

View the StemCellPatents.com Job Board



RECENTLY ADDED PATENTS
Connective tissue substitutes, method of preparation and uses thereof
Method for stimulating hair follicle cell proliferation
Use of erythropoietin for the preventive or curative treatment of cardiac failure
Compositions and treatments for myelosuppression by ex vivo activated immune cells
Hematopoietic stem cells treated by in vitro fucosylation and methods of use
Methods for inducing differentiation of pluripotent cells
Fish produced by nuclear transfer from cultured cells
N-phenyl-3-pyrimidine-amine derivatives
Buffy coat tube and float system and method
Decellularized bone marrow extracellular matrix
View all 1263 Stem Cell Patents on StemCellPatents.com


LATEST NEWS
Embryonic Stem Cell Homing
Friday February 29th, 2008 @ 15:52:20 EST | Ask a question OR leave your comments

Boston, MA - Administration of bone marrow derived stem cells to patients "post-infarct has... [Read more]

Viral Inflammation Mobilizes Stem Cells
Friday February 29th, 2008 @ 14:55:23 EST | Ask a question OR leave your comments

Shanghai, China - It is known that various stem cell types, including... [Read more]

IL-18 in the Heart
Sunday February 17th, 2008 @ 02:36:25 EST | 1 Comment

Indianapolis, Indiana - It is safe to say that the actual implimentation of stem cell therapy... [Read more]

Acidic mesenchymal stem cells
Saturday February 16th, 2008 @ 19:51:40 EST | Ask a question OR leave your comments

Los Angeles, CA - Tissue injury is known to cause mobilization of various types of stem cells... [Read more]

Pancreatic Cancer Stem Cells
Monday February 4th, 2008 @ 04:39:46 EST | Ask a question OR leave your comments

Wuhan, China - The concept of cancer stem cells has been around for a while. One could say... [Read more]

Read more StemCellPatents.com News


We thank-you again for supporting StemCellPatents.com




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[StemCells] Cartilage repair

Does anyone have information on stem cell use in
repairing and regrowing cartilage?

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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Saturday, March 1, 2008

Keyword News: [stem cell]

Yahoo! Alerts Yahoo! News - My Alerts - Edit Alert
Saturday, March 1, 2008 10:31 PM PST

Senate slashes stem-cell funds
Baltimore Sun Sat, 01 Mar 2008 8:03 AM PST
State senators slashed Gov. Martin O'Malley 's spending plan for stem-cell research to less than one-fourth of last year's funding level, eliciting an outcry from advocates, who say that such a budget cut would cripple the pioneering work in Maryland.

State Senate panel votes for cuts to higher education, stem cell research
The Capital Sat, 01 Mar 2008 8:29 AM PST
A Maryland Senate subcommittee voted yesterday for cuts in higher education, stem cell research and inpatient hospital costs as lawmakers brace for unfavorable revenue projections next week.

Stem Cell Therapy International to merge with Histostem
PharmaBiz Sat, 01 Mar 2008 0:42 AM PST
Stem Cell Therapy International, Inc. and Histostem, Co., Ltd., have signed a Memorandum of Understanding (MoU) for their companies to merge subject to further discussions with respect to operational details and the signing of the definitive agreement.

Stem Cell Trial Offers Hope For Patients With Severe Ischemic Heart Disease
Science Daily Sat, 01 Mar 2008 8:35 PM PST
Patients with ischemic heart disease, a serious condition that occurs when the heart's arteries become clogged with cholesterol plaque, may have new options if they have exhausted traditional cardiovascular therapies. A newclinical trial is using patients' own stem cells to improve circulation in hearts damaged by inadequate blood flow, by promoting the growth of new, microscopic blood vessels. ...

Brazil's Church Lobbies on Stem Cells
Las Vegas Sun Sat, 01 Mar 2008 2:08 AM PST
Sat, Mar 1, 2008 (2:04 a.m.) Brazilian church officials urged the Supreme Court on Friday to reject embryonic stem cell research in the world's largest Roman Catholic country, a week before the justices rule on banning such research.

S Korean scientist caught faking breathrough research
AFP via Yahoo! News Sat, 01 Mar 2008 10:03 AM PST
A South Korean scientist who once said he wanted to be as famous as now-disgraced stem cell expert Hwang Woo-Suk has been caught faking his study, news reports here said Saturday.

Week in Review
Milwaukee Journal Sentinel Sat, 01 Mar 2008 7:39 PM PST
BIOTECHNOLOGYStem cell challenge deniedWisconsin's role in the commercialization of embryonic stem cell research received a boost from the U.S. patent office, which rejected a challenge to a key patent held by the Wisconsin...

Senate Panel Cuts University Funds, Putting Tuition Freeze in Jeopardy
Washington Post Fri, 29 Feb 2008 11:42 PM PST
A Maryland Senate budget panel cut nearly $7 million in state funding yesterday for the University System of Maryland, a move that could jeopardize a proposed tuition freeze this fall. The panel also reduced state spending on stem cell research next year from $23 million to $5 million.

Scientist caught faking research
Gulf Times Sat, 01 Mar 2008 8:57 PM PST
SEOUL: A South Korean scientist who once said he wanted to be as famous as now-disgraced stem cell expert Hwang Woo-Suk has been caught faking his study, news reports here said yesterday.




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[StemCells] File - Recurring Monthly Moderator Note


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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[Tissue-Engineering] Lectureship/Senior Lectureship in Cell Biology, Leeds Dental Institute

Faculty of Medicine and Health
Leeds Dental Institute
Lectureship/Senior Lectureship in Cell Biology

Leeds Dental Institute, as part of a continuing planned expansion, is
seeking to appoint a new Lecturer/Senior Lecturer in Cell Biology to
join the Basic Dental Sciences Group within the Department of Oral
Biology. Key criteria are the potential/ability to carry out high
quality research and teaching. The Institute's three established
interdisciplinary research themes in the Basic Dental Sciences are
Biomineralisation, Infection and Immunity and Biomaterials but a new
initiative in Skeletal Tissue Engineering and Stem Cell Therapies is
a rapidly expanding area. Applicants with research strengths in cell
biology who are keen to interact in these areas are welcome.

Visit our website
http://www.leeds.ac.uk/dental/research/research.html for further
information.

Informal enquiries may be made to Professor Jennifer Kirkham, Head of
Oral Biology and Director of Research; email j.kirkham@leeds.ac.uk
tel +44 (0)113 343 6156.

Application packs are available from Pauline Findlay on tel. +44 (0)
113 343 8277 or email n.p.findlay@leeds.ac.uk or online by visiting
http://www.leeds.ac.uk and click on jobs.

University Grade 8 (£33,779 - £40,335 p.a.) or University Grade 9
(£41,545 - £48,161 p.a.) depending upon experience and research
output

Job ref 314188 Closing date 11 March 2008

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