Kidney International - Table of Contents alert Volume 77 Issue 6

KIDNEY INTERNATIONAL

March 2010 Volume 77 Number 6, pp 477 - 560

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IN THIS ISSUE
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In this Issue
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EDITORIAL
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Anemia trials: lessons for clinicians, politicians, and third-party payers
Lynda Szczech
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JOURNAL CLUB
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Journal Club
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COMMENTARIES
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Role of hyperpolarization-activated cation channels in pyeloureteric peristalsis
Richard J Lang
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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Acute kidney injury in sepsis: questions answered, but others remain
Paul Muntner and David G Warnock
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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Better nephrology for mice-and man
Matthew D Breyer and Zhonghua Qi
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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MINI REVIEWS
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Endothelial cells as vascular salt sensors
Hans Oberleithner, Kristina Kusche-Vihrog and Hermann Schillers
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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Novel aspects of complement in kidney injury
Mark B Vieyra and Peter S Heeger
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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ORIGINAL ARTICLES
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The pelvis-kidney junction contains HCN3, a hyperpolarization-activated cation channel that triggers ureter peristalsis
Romulo Hurtado, Gil Bub and Doris Herzlinger
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice
M Teresa Grande, Isabel Fuentes-Calvo, Miguel Arévalo, Fabiana Heredia, Eugenio Santos, Carlos Martínez-Salgado, Diego Rodriguez-Puyol, M Angela Nieto and José M López-Novoa
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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Major contribution of tubular secretion to creatinine clearance in mice
Christoph Eisner, Robert Faulhaber-Walter, Yaohui Wang, Asada Leelahavanichkul, Peter S T Yuen, Diane Mizel, Robert A Star, Josephine P Briggs, Mark Levine and Jurgen Schnermann
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival
Raghavan Murugan, Vijay Karajala-Subramanyam, Minjae Lee, Sachin Yende, Lan Kong, Melinda Carter, Derek C Angus and John A Kellum on behalf of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Investigators
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury
Edward D Siew, Michael E Matheny, T Alp Ikizler, Julie B Lewis, Randolph A Miller, Lemuel R Waitman, Alan S Go, Chirag R Parikh and Josh F Peterson
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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Long-term study of mycophenolate mofetil treatment in IgA nephropathy
Sydney C W Tang, Anthony W C Tang, Sunny S H Wong, Joseph C K Leung, Yiu Wing Ho and Kar Neng Lai
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease
Daniela V Barreto, Fellype C Barreto, Sophie Liabeuf, Mohammed Temmar, Horst-Dieter Lemke, Christophe Tribouilloy, Gabriel Choukroun, Raymond Vanholder and Ziad A Massy on behalf of the European Uremic Toxin Work Group (EUTox)
Abstract: http://links.ealert.nature.com/ctt?kn=90&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0
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NEPHROLOGY IMAGE
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Idiopathic renal arteriovenous fistulae
Hassane Izzedine, Alain Baumelou and Philippe Cluzel
http://links.ealert.nature.com/ctt?kn=83&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0

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MAKE YOUR DIAGNOSIS
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The Case | Cranial nerve palsy and acute renal failure after a `special drink'
Johann Morelle, Nada Kanaan and Philippe Hantson
http://links.ealert.nature.com/ctt?kn=80&m=34661315&r=MTc2MzAwNDQzNwS2&b=2&j=NjgwMTIxMjIS1&mt=1&rt=0

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Mol. Biol. Cell Table of Contents for 1 March 2010; Vol. 21, No. 5

		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Mol. Biol. Cell Table of Contents Alert

A new issue of Molecular Biology of the Cell is available online:

1 March 2010; Vol. 21, No. 5

The below Table of Contents is available online at: http://www.molbiolcell.org/content/vol21/issue5/?etoc

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Retrospective

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Binding to the Extracellular Matrix and Proteolytic Processing: Two Key Mechanisms Regulating Vascular Endothelial Growth Factor Action

Napoleone Ferrara

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Cell Cycle

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NPP-16/Nup50 Function and CDK-1 Inactivation Are Associated with Anoxia-induced Prophase Arrest in Caenorhabditis elegans

Vinita A. Hajeri, Brent A. Little, Mary L. Ladage, and Pamela A. Padilla

Cellular and genetic analysis supports the notion that NPP-16/NUP50 and CDK-1 function to reversibly arrest prophase blastomeres in Caenorhabditis elegans embryos exposed to anoxia. The anoxia-induced shift of cells from an actively dividing state to an arrested state reveals a previously uncharacterized prophase checkpoint in the C. elegans embryo.

Fate Specification and Tissue-specific Cell Cycle Control of the Caenorhabditis elegans Intestine

Alexandra Segref, Juan Cabello, Caroline Clucas, Ralf Schnabel, and Iain L. Johnstone

The Caenorhabditis elegans β-TrCP orthologue LIN-23 of maternal origin regulates a progressive decline of CDC-25.1 abundance over several embryonic cell-cycles and specifies cell number of one tissue, the embryonic intestine.

Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1

Mary E. Gagou, Pedro Zuazua-Villar, and Mark Meuth

H2AX phosphorylation at serine 139 (H2AX) is a sensitive indicator of DNA damage and replication stress. H2AX levels are strongly enhanced in cells treated with replication inhibitors in the absence Chk1. Our data suggest that this phosphorylation persists at stalled or abandoned replication forks but does not commit cells to death.

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Corrections

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Correction for Conserved Actin Cysteine Residues Are Oxidative Stress Sensors That Can Regulate Cell Death in Yeast

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Membrane Trafficking

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Glycolipid Trafficking in Drosophila Undergoes Pathway Switching in Response to Aberrant Cholesterol Levels

Ralf Hortsch, Esther Lee, Nandanan Erathodiyil, Sarita Hebbar, Steffen Steinert, Jun Yu Lee, Doreen See Kin Chua, and Rachel Kraut

The uptake and trafficking behavior of a fluorescent glycosphingolipid analog is described in Drosophila neurons, opening the door to analysis of models of neurodegenerative lipid storage diseases. The study also documents "hijacking," whereby a lactosyl ceramide analog diverts the route of another cargo present at the membrane simultaneously.

Intracellular Targeting Signals and Lipid Specificity Determinants of the ALA/ALIS P₄-ATPase Complex Reside in the Catalytic ALA -Subunit

Rosa L. López-Marqués, Lisbeth R. Poulsen, Susanne Hanisch, Katharina Meffert, Morten J. Buch-Pedersen, Mia K. Jakobsen, Thomas Günther Pomorski, and Michael G. Palmgren

Phospholipid flipping across cellular membranes contributes to vesicle biogenesis in eukaryotes and involves flippases (P₄-ATPases). However, the minimal composition of the flippase machinery remains to be determined. We demonstrate that cellular targeting and lipid specificity of P₄-ATPases require the -subunit but are independent of the β-subunit.

Numb Independently Antagonizes Sanpodo Membrane Targeting and Notch Signaling in Drosophila Sensory Organ Precursor Cells

Xin Tong, Diana Zitserman, Ilya Serebriiskii, Mark Andrake, Roland Dunbrack, and Fabrice Roegiers

How Numb regulates Notch signaling following asymmetric cell division is unclear. Numb directly binds and blocks membrane localization of Sanpodo, a protein essential for Notch signaling in Drosophila. Uncoupling Sanpodo from Numb results in accumulation of Sanpodo at the membrane, but this surprisingly does not appear to promote Notch signaling.

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Nuclear Functions

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Nuclear Translocation of β-Actin Is Involved in Transcriptional Regulation during Macrophage Differentiation of HL-60 Cells

Yong Zhong Xu, Thusanth Thuraisingam, David Anderson de Lima Morais, Marek Rola-Pleszczynski, and Danuta Radzioch

The functional significance of nuclear translocation of β-actin remains unclear. Here, we demonstrate that PMA induces β-actin accumulation in the nucleus and binding to various target genes with different functions. We also find that accumulated nuclear β-actin is involved in recruitment of RNA polymerase II and in transcription regulation.

Distinct and Temporal Roles of Nucleosomal Remodeling and Histone Deacetylation in the Repression of the hTERT Gene

Shuwen Wang, Chunguang Hu, and Jiyue Zhu

Transcriptional silencing of the hTERT gene during HL60 cell differentiation was a biphasic process. The initial repression was accompanied by the loss of c-Myc binding and disappearance of a nucleosome-free region at the core promoter. The subsequent nucleosomal remodeling and histone modifications at the promoter stabilized this repression.

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Retraction

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Retraction for Old Yellow Enzyme Protects the Actin Cytoskeleton from Oxidative Stress

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Signaling

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The Late Endosome is Essential for mTORC1 Signaling   A Highlights from MBoC Selection Rory J. Flinn, Ying Yan, Sumanta Goswami, Peter J. Parker, and Jonathan M. Backer Recent work suggests a link between endocytic trafficking and mTORC1 signaling. This paper demonstrates a specific requirement for the integrity of the late endosomal compartment for amino acid and insulin-stimulated mTORC1 signaling to downstream effectors.

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Nature 25 February 2010 Volume 463 Number 7284 pp999-1112

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EDITORIALS
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Simplification is essential p999
The new European research commissioner deserves political support
from member states of the European Union to drastically reduce
the dead weight of Brussels bureaucracy.
doi:10.1038/463999a
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Bridges, not barriers pp999-1000
Industry talent should be welcomed into academia, not seen as a
corrupting influence.
doi:10.1038/463999b
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An absurd law p1000
Turkey's government is about to pass legislation that could cripple
the country's biological research.
doi:10.1038/4631000a
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RESEARCH HIGHLIGHTS
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Energy: Carbon from the mountains p1002
doi:10.1038/4631002a
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Neuroscience: Baby blues p1002
doi:10.1038/4631002b
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Particle physics: Dazzling dysprosium p1002
doi:10.1038/4631002c
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Molecular imaging: Tumour glows out p1002
doi:10.1038/4631002d
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Evolutionary biology: On the invasion front p1002
doi:10.1038/4631002e
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Cell biology: Lost in the mail pp1002-1003
doi:10.1038/4631002f
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Organic chemistry: Catalysts cooperate p1003
doi:10.1038/4631003a
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Biology: Colour-blind p1003
doi:10.1038/4631003b
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Genetics: Male regulator switched p1003
doi:10.1038/4631003c
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Developmental biology: Heads or tails p1003
doi:10.1038/4631003d
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JOURNAL CLUB
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Journal club p1003
Luke Harmon
doi:10.1038/4631003e
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NEWS
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News briefing: 25 February 2010 pp1004-1005
The week in science.
doi:10.1038/4631004a
http://links.ealert.nature.com/ctt?kn=216&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

'Seek, test and treat' slows HIV p1006
Studies in several nations show that treating people before they
fall ill can curb the spread of disease.
Erika Check Hayden
doi:10.1038/4631006a
http://links.ealert.nature.com/ctt?kn=259&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Reserves 'win–win' for fish and fishermen p1007
Marine protection areas could offer fisheries a boost.
Rex Dalton
doi:10.1038/4631007a
http://links.ealert.nature.com/ctt?kn=257&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Did design flaws doom the LHC? pp1008-1009
Catastrophic failure that caused accelerator shutdown was not a
freak accident, says project physicist.
Geoff Brumfiel
doi:10.1038/4631008a
http://links.ealert.nature.com/ctt?kn=255&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Pebble-bed nuclear reactor gets pulled pp1008-1009
South Africa cuts funding for energy technology project.
Linda Nordling
doi:10.1038/4631008b
http://links.ealert.nature.com/ctt?kn=252&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

German paper chase to end p1009
Funding agency cuts number of publications needed for grant
applications.
Quirin Schiermeier
doi:10.1038/4631009a
http://links.ealert.nature.com/ctt?kn=288&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Cosmic-ray theory unravels p1011
Astrophysicists ponder whether ultrahigh-energy particles really
do come from the centre of galaxies.
Eric Hand
doi:10.1038/4631011a
http://links.ealert.nature.com/ctt?kn=285&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

A land without Google? pp1012-1013
A survey by Nature reveals how Chinese scientists could be affected
by the stand-off between their government and the search-engine giant.
Jane Qiu reports.
doi:10.1038/4631012a
http://links.ealert.nature.com/ctt?kn=282&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
NEWS FEATURE
----------------------
Earth science: The climate machine pp1014-1016
A new generation of sophisticated Earth models is gearing up for its
first major test. But added complexity may lead to greater
uncertainty about the future climate,
finds Olive Heffernan.
doi:10.1038/4631014a
http://links.ealert.nature.com/ctt?kn=269&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
CORRESPONDENCE
----------------------
Research thrives on integration of natural and social sciences p1018
Erik Fisher, Simon Biggs, Stuart Lindsay and Jie Zhao
doi:10.1038/4631018a
http://links.ealert.nature.com/ctt?kn=36&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Rigid animal-rights views not useful to ethics debate p1018
Rob Campbell
doi:10.1038/4631018b
http://links.ealert.nature.com/ctt?kn=38&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

New NMR machines are set to boost biomedical potential p1018
Jeffrey C. Hoch
doi:10.1038/4631018c
http://links.ealert.nature.com/ctt?kn=31&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Skewed assessment values have stifled textbook-writing p1018
Tristram D. Wyatt
doi:10.1038/4631018d
http://links.ealert.nature.com/ctt?kn=34&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Futures perfect -- food for thought and welcome light relief p1018
Robin Thompson
doi:10.1038/4631018e
http://links.ealert.nature.com/ctt?kn=55&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
OPINION
----------------------
Globe still in grip of addiction pp1020-1021
After five years, the World Health Organization's tobacco-control
treaty is starting to have an effect, but we need to tackle the
smoking epidemic in the developing world,
say Jonathan M. Samet and Heather L. Wipfli.
doi:10.1038/4631020a
http://links.ealert.nature.com/ctt?kn=53&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
BOOKS AND ARTS
----------------------
Theft or innovation? pp1022-1023
A history of intellectual-property rights reveals how the pirating
of ideas and goods has transformed science publishing, drug
development and software, explains Michael Gollin.
Michael Gollin reviews Piracy: The Intellectual Property Wars from
Gutenberg to Gates by Adrian Johns
doi:10.1038/4631022a
http://links.ealert.nature.com/ctt?kn=51&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Stamps celebrate Royal Society scientists p1023
doi:10.1038/4631023b
http://links.ealert.nature.com/ctt?kn=49&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Symmetry and hubris pp1023-1024
W. F. Bynum reviews Francis Crick: Hunter of Life's Secrets
by Robert Olby
doi:10.1038/4631023a
http://links.ealert.nature.com/ctt?kn=47&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

How lateral thinking saved lives p1024
Martin Kemp is struck by the surreal quality of a home-made iron lung.
Martin Kemp
doi:10.1038/4631024a
http://links.ealert.nature.com/ctt?kn=8&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Q&A: Georgina Ferry on writing biography p1025
Acclaimed biographer Georgina Ferry has chronicled the lives of two
Nobel prizewinning chemists, Dorothy Hodgkin and Max Perutz. In the
fourth in our series of five interviews with authors who each write
science books for a different audience, Ferry reveals how detachment
is needed to turn an attic's worth of personal letters into a
compelling story.
Nicola Jones
doi:10.1038/4631025a
http://links.ealert.nature.com/ctt?kn=11&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Applied mathematics: The statistics of style pp1027-1028
A mathematical method has been developed that distinguishes between
the paintings of Pieter Bruegel the Elder and those of his imitators.
But can the approach be used to spot imitations of works by any artist?
Bruno A. Olshausen and Michael R. DeWeese
doi:10.1038/4631027a
http://links.ealert.nature.com/ctt?kn=2&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Cell biology: A brake on lipid synthesis pp1028-1029
Although sphingolipids are vital cellular components, the path to
their production is paved with toxic intermediates. Orm proteins
allow cells to form these lipids without killing themselves in
the process.
Fikadu G. Tafesse and Joost C. M. Holthuis
doi:10.1038/4631028a
http://links.ealert.nature.com/ctt?kn=4&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Low-temperature physics: Surprise in the strong regime pp1029-1031
The finding that the normal phase of an ultracold gas of fermionic
atoms in the strongly interacting regime is close to a Fermi liquid
isn't quite what theorists expected for these systems.
Yong-il Shin
doi:10.1038/4631029a
http://links.ealert.nature.com/ctt?kn=7&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

50 & 100 years ago p1030
doi:10.1038/4631030a
http://links.ealert.nature.com/ctt?kn=29&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Regenerative medicine: Cell reprogramming gets direct pp1031-1032
In a feat of biological wizardry, one type of differentiated cell
has been directly converted into another, completely distinct type.
Notably, the approach does not require a stem-cell intermediate stage.
Cory R. Nicholas and Arnold R. Kriegstein
doi:10.1038/4631031a
http://links.ealert.nature.com/ctt?kn=27&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Climate change: Tropical cyclones in the mix pp1032-1033
What was responsible for the unusual climatic conditions that
prevailed during the early Pliocene, 5 million to 3 million years
ago? Modelling studies point to intense tropical-cyclone activity
as a possible answer.
Ryan L. Sriver
doi:10.1038/4631032a
http://links.ealert.nature.com/ctt?kn=18&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Geomicrobiology: Sediment reactions defy dogma pp1033-1034
Redox reactions in widely spatially separated layers of marine
sediments are coupled to each other. This suggests that bacteria
mediate the flow of electrons between the layers -- an idea that
would previously have been dismissed.
Kenneth H. Nealson
doi:10.1038/4631033a
http://links.ealert.nature.com/ctt?kn=293&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
BRIEF COMMUNICATIONS ARISING
----------------------
Location of corneal epithelial stem cells ppE10-E11
Tung-Tien Sun, Scheffer C. Tseng and Robert M. Lavker
doi:10.1038/nature08805
Abstract: http://links.ealert.nature.com/ctt?kn=275&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=300&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Majo et al. reply pE11
Francois Majo et al.
doi:10.1038/nature08806
Abstract: http://links.ealert.nature.com/ctt?kn=277&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=309&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Direct conversion of fibroblasts to functional neurons by defined
factors pp1035-1041
Mouse and human fibroblasts can be reprogrammed to a pluripotent
state with a combination of four transcription factors. Here, mature
differentiated cells are directed, via a combination of a few
transcription factors (distinct from those described for generating
iPS cells), to form functional neurons in vitro, without having to
revert the fibroblasts to an embryonic state.
Thomas Vierbuchen et al.
doi:10.1038/nature08797
Abstract: http://links.ealert.nature.com/ctt?kn=279&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=260&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Reprogramming towards pluripotency requires AID-dependent DNA
demethylation pp1042-1047
To elucidate regulatory mechanisms involved in reprogramming to
generate pluripotent cells from somatic cells, this study generates
interspecies heterokaryons (fused mouse ES cells and human fibroblasts)
that induce reprogramming efficiently, rapidly and without cell
division. SiRNA-mediated knockdown reveals that AID is required for
active DNA demethylation and initiation of nuclear reprogramming
towards pluripotency in human somatic cells.
NIdhi Bhutani et al.
doi:10.1038/nature08752
Abstract: http://links.ealert.nature.com/ctt?kn=280&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=270&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Orm family proteins mediate sphingolipid homeostasis pp1048-1053
Mutations near the ORMDL3 gene have been associated with childhood
asthma. Here, in yeast, Orm proteins are shown to function in
sphingolipid homeostasis; alterations in this control result in
misregulation of sphingolipid production and accumulation of toxic
metabolites. This raises the testable hypothesis that misregulation
of sphingolipids may directly contribute to the development of asthma.
David K. Breslow et al.
doi:10.1038/nature08787
Abstract: http://links.ealert.nature.com/ctt?kn=295&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=278&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
LETTERS
----------------------
WASP-12b as a prolate, inflated and disrupting planet from tidal
dissipation pp1054-1056
WASP-12b is a planet of 1.4 Jupiter masses that orbits at a mean
distance of only 3.1 stellar radii from its star; its orbital period
is 1.1 days, and its radius (1.79 times that of Jupiter) is
unexpectedly large. An analysis of its properties now reveals that
the planet is losing mass to its host star at a rate of ~10-7 Jupiter
masses per year, and that dissipation of the star's tidal perturbation
in the planet's convective envelope provides the energy source for
its large volume.
Shu-lin Li, N. Miller, Douglas N. C. Lin and Jonathan J. Fortney
doi:10.1038/nature08715
Abstract: http://links.ealert.nature.com/ctt?kn=290&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=240&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Exploring the thermodynamics of a universal Fermi gas pp1057-1060
In principle, it is possible to simulate some astrophysical phenomena
inside the highly controlled environment of an atomic physics
laboratory: previous work on the thermodynamics of a two-component
Fermi gas (a system suited for such studies) led to thermodynamic
quantities averaged over the trap. Now a general experimental method
is reported that yields the equation of state of a uniform gas,
providing new physical insights and enabling a detailed comparison
with existing theories.
S. Nascimbène et al.
doi:10.1038/nature08814
Abstract: http://links.ealert.nature.com/ctt?kn=292&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=235&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Simultaneous phase and size control of upconversion nanocrystals
through lanthanide doping pp1061-1065
Many technological materials are intentionally 'doped' with foreign
elements to impart new and desirable properties, a classic example
being the doping of semiconductors to tune their electronic behaviour.
Here lanthanide doping is used to control the growth of nanocrystals,
allowing for simultaneous tuning of the size, crystallographic phase
and optical properties of the hybrid material.
Feng Wang et al.
doi:10.1038/nature08777
Abstract: http://links.ealert.nature.com/ctt?kn=301&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=232&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Tropical cyclones and permanent El Niño in the early Pliocene epoch
pp1066-1070
Palaeoclimate data show that 3-5 million years ago in the early
Pliocene the equatorial Pacific experienced persistent warm, El Nino
conditions. Here a hurricane model and a coupled climate model show
a feedback between sea surface temperature and frequent hurricanes
that could account for such conditions.
Alexey V. Fedorov, Christopher M. Brierley and Kerry Emanuel
doi:10.1038/nature08831
Abstract: http://links.ealert.nature.com/ctt?kn=303&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=110&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Electric currents couple spatially separated biogeochemical processes
in marine sediment pp1071-1074
It has been previously demonstrated that some microbes are capable of
extracellular electron transport through so-called nanowires or
electron shuttles. Here it is demonstrated that this may be a
significant process in the marine sediment.
Lars Peter Nielsen et al.
doi:10.1038/nature08790
Abstract: http://links.ealert.nature.com/ctt?kn=296&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=119&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Fossilized melanosomes and the colour of Cretaceous dinosaurs and birds
pp1075-1078
Here the presence of melanosomes -- characteristic bodies that give
feathers their colour -- is demonstrated in feathers and feather-like
structures of fossil early birds and dinosaurs from the Early
Cretaceous Jehol Group of China. Not only is it shown that the
feather-like structures of dinosaurs such as Sinosauropteryx really
are akin to feathers, it is also possible to speculate in an informed
way about their colour.
Fucheng Zhang et al.
doi:10.1038/nature08740
Abstract: http://links.ealert.nature.com/ctt?kn=299&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=117&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Arthropod relationships revealed by phylogenomic analysis of nuclear
protein-coding sequences pp1079-1083
The evolutionary interrelationships of arthropods has long been a
matter of dispute. A new phylogeny applies an arsenal of techniques
to more than 41,000 base pairs of DNA from 75 arthropod species. The
results support the idea that insects are land-living crustaceans,
that crustaceans comprise a diverse assemblage of at last three
distinct arthropod types, and that myriapods (millipedes and centipedes)
comprise the closest relatives of this great 'pancrustacean' group.
Jerome C. Regier et al.
doi:10.1038/nature08742
Abstract: http://links.ealert.nature.com/ctt?kn=308&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Ancient animal microRNAs and the evolution of tissue identity
pp1084-1088
Recent work suggests that microRNAs might have been important in
the evolution of complexity in multicellular animals. Here it is
shown that the most ancient known microRNA, miR-100, was initially
active in neurosecretory cells around the mouth. Other highly
conserved varieties were first present in specific tissues and organ
systems. Thus, microRNA expression was initially restricted to an
ancient set of ancient animal cell types and tissues.
Foteini Christodoulou et al.
doi:10.1038/nature08744
Abstract: http://links.ealert.nature.com/ctt?kn=310&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Neural evidence for inequality-averse social preferences pp1089-1091
Social science hypotheses suggest that humans prefer more equality
in outcome distributions because the knowledge of inequality reduces
the reward experience. Here, functional MRI was used to test directly
for inequality-averse social preferences in the brain during monetary
transfers between pairs of participants and an experimenter. The
results indicate that the brain's reward circuitry is sensitive to
distribution inequality and is actively modulated relative to context.
Elizabeth Tricomi, Antonio Rangel, Colin F. Camerer and
John P. O'Doherty
doi:10.1038/nature08785
Abstract: http://links.ealert.nature.com/ctt?kn=305&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=176&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

An essential role for XBP-1 in host protection against immune activation
in C. elegans pp1092-1095
The unfolded protein response, known to contribute to the defence
against infectious agents and toxins, is shown here to protect
Caenorhabditis elegans larvae against detrimental effects of the
innate immune response to infection with Pseudomonas aeruginosa.
The findings establish innate immunity as a physiologically relevant
inducer of ER stress during C. elegans development.
Claire E. Richardson, Tristan Kooistra and Dennis H. Kim
doi:10.1038/nature08762
Abstract: http://links.ealert.nature.com/ctt?kn=223&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=178&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Tbx3 improves the germ-line competency of induced pluripotent stem cells
pp1096-1100
The transcription factor Tbx3 is shown to significantly improve the
quality of induced pluripotent stem (iPS) cells. Tbx3 binding sites
in embryonic stem cells are present in genes involved in pluripotency
and reprogramming factors. Furthermore, there are intrinsic
qualitative differences in iPS cells generated by different methods
in terms of their pluripotency, thus highlighting the need to
rigorously characterize iPS cells beyond in vitro studies.
Jianyong Han et al.
doi:10.1038/nature08735
Abstract: http://links.ealert.nature.com/ctt?kn=224&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=182&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Genome-wide erasure of DNA methylation in mouse primordial germ cells
is affected by AID deficiency pp1101-1105
The extent of epigenetic reprogramming in mammalian primordial germ
cells (PGCs) and in early embryos, and its molecular mechanisms, are
poorly understood. DNA methylation profiling in PGCs now reveals a
genome-wide erasure of methylation, with female PGCs being less
methylated than male ones. A deficiency of the cytidine deaminase AID
interferes with the genome-wide erasure of DNA methylation, indicating
that AID has a critical function in epigenetic reprogramming.
Christian Popp et al.
doi:10.1038/nature08829
Abstract: http://links.ealert.nature.com/ctt?kn=225&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=215&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
CORRIGENDA
----------------------
The sequence and de novo assembly of the giant panda genome p1106
Ruiqiang Li et al.
doi:10.1038/nature08846
http://links.ealert.nature.com/ctt?kn=207&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Dense packings of the Platonic and Archimedean solids p1106
S. Torquato and Y. Jiao
doi:10.1038/nature08847
http://links.ealert.nature.com/ctt?kn=205&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
NATUREJOBS
----------------------
News
Mixed budget outlook for young scientists p1108
Biomedical researchers face fewer competing grants in 2011.
Karen Kaplan
doi:10.1038/nj7284-1108a
http://links.ealert.nature.com/ctt?kn=134&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Prospects
Salary boost p1108
Negotiating for a pay rise can be a smooth, fruitful process if you
follow a few guidelines, says Deb Koen.
Deb Koen
doi:10.1038/nj7284-1108b
http://links.ealert.nature.com/ctt?kn=138&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Careers Q&A
Zhenrong Zhang p1109
In January, Zhenrong Zhang obtained her first faculty position as an
assistant professor, at Baylor University in Waco, Texas. She will
set up Baylor's first scanning tunnelling microscopy lab.
Virginia Gewin
doi:10.1038/nj7284-1109a
http://links.ealert.nature.com/ctt?kn=136&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

In Brief
Postdocs waltz to Vienna p1109
Life-sciences initiative targets young scientists.
doi:10.1038/nj7284-1109b
http://links.ealert.nature.com/ctt?kn=148&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

In Brief
Science courses at risk p1109
Growing budget deficit raises alarm for US higher education.
doi:10.1038/nj7284-1109c
http://links.ealert.nature.com/ctt?kn=145&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

In Brief
Biotech beats recession p1109
Outlook seems relatively sunny in California.
doi:10.1038/nj7284-1109d
http://links.ealert.nature.com/ctt?kn=162&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
FUTURES
----------------------
Distraction p1112
A fine romance.
Julian Tang
doi:10.1038/4631112a
http://links.ealert.nature.com/ctt?kn=211&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

----------------------
Advance Online Publication
----------------------
24 February 2010
Compensatory evolution in mitochondrial tRNAs navigates valleys of
low fitness
Margarita V. Meer, Alexey S. Kondrashov, Yael Artzy-Randrup and
Fyodor A. Kondrashov
doi:10.1038/nature08691
Abstract: http://links.ealert.nature.com/ctt?kn=159&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=159&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Antagonistic coevolution accelerates molecular evolution
Steve Paterson et al.
doi:10.1038/nature08798
Abstract: http://links.ealert.nature.com/ctt?kn=156&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=156&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

An intrinsic vasopressin system in the olfactory bulb is involved
in social recognition
Vicky A. Tobin et al.
doi:10.1038/nature08826
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=151&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

21 February 2010
Metabolic streamlining in an open-ocean nitrogen-fixing cyanobacterium
H. James Tripp et al.
doi:10.1038/nature08786
Abstract: http://links.ealert.nature.com/ctt?kn=172&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=172&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Targeted deletion of the 9p21 non-coding coronary artery disease risk
interval in mice
Axel Visel et al.
doi:10.1038/nature08801
Abstract: http://links.ealert.nature.com/ctt?kn=168&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=168&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Mad2-induced chromosome instability leads to lung tumour relapse after
oncogene withdrawal
Rocio Sotillo, Juan-Manuel Schvartzman, Nicholas D. Socci and Robert Benezra
doi:10.1038/nature08803
Abstract: http://links.ealert.nature.com/ctt?kn=165&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=165&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

Sister chromosome pairing maintains heterozygosity in parthenogenetic
lizards
Aracely A. Lutes et al.
doi:10.1038/nature08818
Abstract: http://links.ealert.nature.com/ctt?kn=263&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=263&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

ITPA gene variants protect against anaemia in patients treated for
chronic hepatitis C
Jacques Fellay et al.
doi:10.1038/nature08825
Abstract: http://links.ealert.nature.com/ctt?kn=271&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=271&m=34654702&r=MjA1NTkxMDA2MAS2&b=2&j=Njc5MDY0NDES1&mt=1&rt=0

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Latest PhD Studentships - 23 February 2010

Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.

University of Birmingham
Artificial Intelligence Approaches to Figurative Language

University of Birmingham
New Strategies for Natural Product Synthesis

University of Birmingham
Novel Transformations for the Synthesis of Nitrogen Heterocycles

Cardiff University
PRESIDENT'S SCHOLARSHIPS: Demand management through smart meters

University of Sheffield
Identification and manipulation of signalling pathways that control growth and differentiation of human auditory stem cells using small molecules

Cardiff University
PRESIDENT'S SCHOLARSHIPS: Control of a 1 MW variable speed wind turbine

Cardiff University
PRESIDENT'S SCHOLARSHIPS: Characterisation studies of particulate matter from gas turbine and internal combustion engines

University of East Anglia
Mechanisms by which anthocyanins and their metabolites reduce cardiovascular risk

Cardiff University
PRESIDENT'S SCHOLARSHIPS: Carbon nanotube reinforced soft magnetic alloy composites

University of Birmingham
Early development of children's eating behaviours: the interaction between parental feeding practices and child characteristics.

University of Birmingham
The texts, images, manuscripts and literary legacy of the Anglo-Saxons

University of East Anglia
Development of Glycosyltransferase Inhibitors as Novel Anti-Infective Agents

University of East Anglia
Examining hydrogeological conditions in the Chalk aquifer system of East Anglia using stable isotopes and noble gases

University of East Anglia
Coastal Megacities and their atmospheric implications

University of East Anglia
Ultrafast Dynamics in the condensed phase and proteins

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RSCI February Special Edition

Your February 2010 Special Edition of the RSCI Newsletter is here!

In this Newsletter we cover:

THE EMBRYONIC STEM CELL HOAX:

A HISTORY OF THE GERON SCANDAL

 

For six years, the American people’s understanding of stem cells has been overwhelmed by rampant misinformation and deception. We were led to believe the future of medicine lies in Embryonic Stem Cells (ESC) and that Repair (adult) Stem Cells (RSC) are “snake oil.” 

 

These skewed stories of ESC hope and RSC failure intentionally misled the American people in general and forced spinal cord patients to pay for the false-hope of ESC treatments in order to line the pockets of the  ESC promoters. 

 

Only Don Margolis, founder of the Repair Stem Cell Institute, had the wisdom to see through this ruse and the courage to expose this national campaign of deception. 

 

Read about:
• The Embryonic Stem Cell Hoax

• Don Margolis’ Exposure of the $100 Billion Scam
• Geron’s History of Misrepresentation
• The Failure of ESC to Produce Treatments

• The Exodus of the Top ESC Scientists from ESC to RSC

• 22 Articles of Spinal Cord Injury Patients Who Benefitted from RSC

Click the following link to view our February 2010, Special Edition:

http://www.repairstemcells.org/Newsletters/NL022010.htm

Be sure to check out the latest in Repair Stem Cell Science by visiting our 3 web sites:
www.repairstemcells.org
www.donmargolis.com
www.quipnation.com/StemCellBlog

Stem Cells Accepted Articles for February 19th

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Copyright © 2009 AlphaMed Press Published on behalf of AlphaMed Press This Publication Alert is being sent to individuals who requested receipt of this information. For additional details, see the bottom of this message. Stem Cells Express (Accepted Articles) Editorial Law, Ethics, Religion, and Clinical Translation in the 21st Century  -  A Discussion with Derek Hei (p N/A) Susan Rainey Daher, Majlinda Lako, Alan O. Trounson Accepted Article Online: Feb 17 2010 11:56AM DOI: 10.1002/stem.323 Embryonic Stem Cells/Induced Pluripotent Stem Cells No Evidence for Clonal Selection due to Lentiviral Integration Sites in Human Induced Pluripotent Stem Cells (p N/A) Thomas Winkler, Amy Cantilena, Jean-Yves Métais, Xiuli Xu, Anh-Dao Nguyen, Bhavesh Borate, Jessica E. Antosiewicz-Bourget, Tyra G. Wolfsberg, James A.Thomson, Cynthia E. Dunbar Accepted Article Online: Feb 17 2010 11:56AM DOI: 10.1002/stem.322 Induced pluripotent stem cells (iPSCs) generate both retinal ganglion cells and photoreceptors: Therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration (p N/A) Sowmya Parameswaran, Sudha Balasubramanian, Norbert Babai, Fang Qiu, James D. Eudy, Wallace B Thoreson, Iqbal Ahmad Accepted Article Online: Feb 17 2010 11:56AM DOI: 10.1002/stem.320 This message is sent to subscribers and alert registrants for Stem Cells. To UNSUBSCRIBE from future mailings go to The Stem Cells Express Alert list. If you have any questions or concerns about this message, please contact lwoo@wiley.com. Do not reply directly to this message. Wiley InterScience is a division of:      John Wiley & Sons, Inc.  |  111 River Street  |  Hoboken, NJ 07030      Phone: 800-225-5945  |  Fax: 800-605-2665  |  www.wiley.com

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Publication Alert - Stem Cells - February 2010

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Stem Cells Published on behalf of AlphaMed Press This Publication Alert is being sent to individuals who requested receipt of this information. For additional details, see the bottom of this message. Current Issue STEM CELLS Volume 28, Issue 2, 2010. Online ISSN: 1549-4918 Print ISSN: 1066-5099 Copyright © 2010 AlphaMed Press.   Research Articles Pages: 177-180 Law, Ethics, Religion, and Clinical Translation in the 21st Century - A Discussion with Stephen Bellamy Majlinda Lako, Alan Trounson, Susan Daher Published Online: 13 Jan 2010 DOI: 10.1002/stem.304 Pages: 181-190 Gliosarcoma Stem Cells Undergo Glial and Mesenchymal Differentiation In Vivo Ana C. deCarvalho, Kevin Nelson, Nancy Lemke, Norman L. Lehman, Ali S. Arbab, Steven Kalkanis, Tom Mikkelsen Published Online: 23 Nov 2009 DOI: 10.1002/stem.264 Pages: 191-200 Heparan Sulfation-Dependent Fibroblast Growth Factor Signaling Maintains Embryonic Stem Cells Primed for Differentiation in a Heterogeneous State Fredrik Lanner, Kian Leong Lee, Marcus Sohl, Katarina Holmborn, Henry Yang, Johannes Wilbertz, Lorenz Poellinger, Janet Rossant, Filip Farnebo Published Online: 23 Nov 2009 DOI: 10.1002/stem.265 Pages: 201-212 KMT1E Mediated H3K9 Methylation Is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation Felix Lohmann, Joseph Loureiro, Hui Su, Qing Fang, Hong Lei, Tanya Lewis, Yi Yang, Mark Labow, En Li, Taiping Chen, Shilpa Kadam Published Online: 10 Dec 2009 DOI: 10.1002/stem.278 Pages: 213-220 Conversion of Ancestral Fibroblasts to Induced Pluripotent Stem Cells Ryoko Araki, Yuko Jincho, Yuko Hoki, Miki Nakamura, Chihiro Tamura, Shunsuke Ando, Yasuji Kasama, Masumi Abe Published Online: 17 Dec 2009 DOI: 10.1002/stem.282 Pages: 221-228 Oct4 and Klf4 Reprogram Dermal Papilla Cells into Induced Pluripotent Stem Cells Su-Yi Tsai, Carlos Clavel, Soo Kim, Yen-Sin Ang, Laura Grisanti, Dung-Fang Lee, Kevin Kelley, Michael Rendl Published Online: 14 Dec 2009 DOI: 10.1002/stem.281 Pages: 229-239 Generation of Histocompatible Androgenetic Embryonic Stem Cells Using Spermatogenic Cells Qingguo Zhao, Jianle Wang, Yu Zhang, Zhaohui Kou, Sheng Liu, Shaorong Gao Published Online: 17 Dec 2009 DOI: 10.1002/stem.283 Pages: 240-246 Human Embryonic Stem Cell Lines and Their Use in International Research Peter Löser, Jacqueline Schirm, Anke Guhr, Anna M. Wobus, Andreas Kurtz Published Online: 21 Dec 2009 DOI: 10.1002/stem.286 Pages: 247-257 A Unique Interplay Between Rap1 and E-Cadherin in the Endocytic Pathway Regulates Self-Renewal of Human Embryonic Stem Cells Li Li, Shuai Wang, Anna Jezierski, Lilian Moalim-Nour, Kanishka Mohib, Robin J. Parks, Saverio Francesco Retta, Lisheng Wang Published Online: 28 Dec 2009 DOI: 10.1002/stem.289 Pages: 258-267 Human CMP-N-Acetylneuraminic Acid Hydroxylase Is a Novel Stem Cell Marker Linked to Stem Cell-Specific Mechanisms Johanna Nystedt, Heidi Anderson, Tia Hirvonen, Ulla Impola, Taina Jaatinen, Annamari Heiskanen, Maria Blomqvist, Tero Satomaa, Jari Natunen, Juhani Saarinen, Petri Lehenkari, Leena Valmu, Jarmo Laine Published Online: 4 Nov 2009 DOI: 10.1002/stem.250 Pages: 268-278 Disruption of Bis Leads to the Deterioration of the Vascular Niche for Hematopoietic Stem Cells Kyung-rim Kwon, Ji-Yeon Ahn, Myung-Shin Kim, Joo-Young Jung, Jeong-Hwa Lee, Il-Hoan Oh Published Online: 18 Dec 2009 DOI: 10.1002/stem.285 Pages: 279-286 The Egf Receptor-Sox2-Egf Receptor Feedback Loop Positively Regulates the Self-Renewal of Neural Precursor Cells Qikuan Hu, Lirong Zhang, Jinhua Wen, Shuling Wang, Meiyu Li, Ruopeng Feng, Xiaolong Yang, Lingsong Li Published Online: 30 Oct 2009 DOI: 10.1002/stem.246 Pages: 287-296 A Genetic Strategy for Single and Combinatorial Analysis of miRNA Function in Mammalian Hematopoietic Stem Cells Eirini P. Papapetrou, James E. Korkola, Michel Sadelain Published Online: 12 Nov 2009 DOI: 10.1002/stem.257 Pages: 297-307 β-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes during Post-Traumatic Gliogenesis in the Adult Brain Bryan D. White, Ryan J. Nathe, Don O. Maris, Nghi K. Nguyen, Jamie M. Goodson, Randall T. Moon, Philip J. Horner Published Online: 3 Dec 2009 DOI: 10.1002/stem.268 Pages: 308-317 Cyclin C Regulates Human Hematopoietic Stem/Progenitor Cell Quiescence Yasuhiko Miyata, Yan Liu, Vladimir Jankovic, Goro Sashida, Jennifer May Lee, Jae-Hung Shieh, Tomoki Naoe, Malcolm Moore, Stephen D. Nimer Published Online: 4 Dec 2009 DOI: 10.1002/stem.270 Pages: 318-328 Toward Engineering a Human Neoendothelium with Circulating Progenitor Cells Josephine B. Allen, Sadiya Khan, Karen A. Lapidos, Guillermo A. Ameer Published Online: 9 Dec 2009 DOI: 10.1002/stem.275 Pages: 329-343 Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses Jong Kil Lee, Hee Kyung Jin, Shogo Endo, Edward H. Schuchman, Janet E. Carter, Jae-sung Bae Published Online: 10 Dec 2009 DOI: 10.1002/stem.277 Pages: 344-356 Functional Remodeling of Benign Human Prostatic Tissues In Vivo by Spontaneously Immortalized Progenitor and Intermediate Cells Ming Jiang, Douglas W. Strand, Suzanne Fernandez, Yue He, Yajun Yi, Andreas Birbach, Qingchao Qiu, Johannes Schmid, Dean G. Tang, Simon W. Hayward Published Online: 17 Dec 2009 DOI: 10.1002/stem.284 Pages: 357-364 MicroRNA-204 Regulates Runx2 Protein Expression and Mesenchymal Progenitor Cell Differentiation Jian Huang, Lan Zhao, Lianping Xing, Di Chen Published Online: 28 Dec 2009 DOI: 10.1002/stem.288 Pages: 365-375 Lnk Deletion Reinforces the Function of Bone Marrow Progenitors in Promoting Neovascularization and Astrogliosis Following Spinal Cord Injury Naosuke Kamei, Sang-Mo Kwon, Cantas Alev, Masakazu Ishikawa, Ayumi Yokoyama, Kazuyoshi Nakanishi, Kiyotaka Yamada, Miki Horii, Hiromi Nishimura, Satoshi Takaki, Atsuhiko Kawamoto, Masaaki Ii, Hiroshi Akimaru, Nobuhiro Tanaka, Shin-Ichi Nishikawa, Mitsuo Ochi, Takayuki Asahara Published Online: 26 Oct 2009 DOI: 10.1002/stem.243 Pages: 376-385 NF κB Activation in Embryonic Endothelial Progenitor Cells Enhances Neovascularization via PSGL-1 Mediated Recruitment: Novel Role for LL37 Achim Pfosser, Chiraz El-Aouni, Iris Pfisterer, Melanie Dietz, Franziska Globisch, Georg Stachel, Teresa Trenkwalder, Olaf Pinkenburg, Jan Horstkotte, Rabea Hinkel, Markus Sperandio, Antonis K. Hatzopoulos, Peter Boekstegers, Robert Bals, Christian Kupatt Published Online: 14 Dec 2009 DOI: 10.1002/stem.280 Pages: 386 Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function Valeria Sordi, Raffaella Melzi, Alessia Mercalli, Roberta Formicola, Claudio Doglioni, Francesca Tiboni, Giuliana Ferrari, Rita Nano, Karolina Chwalek, Eckhard Lammert, Ezio Bonifacio, Danielle Borg, Lorenzo Piemonti Published Online: 16 Feb 2010 DOI: 10.1002/stem.314 This message is sent to subscribers and alert registrants for Stem Cells. To UNSUBSCRIBE from future mailings go to The Stem Cells Express Alert list. If you have any questions or concerns about this message, please contact lwoo@wiley.com. Do not reply directly to this message. Wiley InterScience is a division of: John Wiley & Sons, Inc. | 111 River Street | Hoboken, NJ 07030 Phone: 800-225-5945 | Fax: 800-605-2665 | www.wiley.com >>   If you have trouble viewing this e-mail, you can see this message online   <<