Stem Cell: July 2008

Thursday, July 31, 2008

Keyword News: [stem cell]

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Thursday, July 31, 2008 11:32 PM PDT

ALS research takes step forward with stem-cell reprogramming
The Kansas City Star Thu, 31 Jul 2008 8:46 PM PDT
Stem-cell scientists reported Thursday in the journal Science that they had turned skin cells from two elderly patients with amyotrophic lateral sclerosis into motor neurons. Those are the nerve cells that become damaged in ALS.

NY Stem Cell Foundation plays critical funding role in major new ALS research announced today
EurekAlert! Thu, 31 Jul 2008 11:21 AM PDT
NEW YORK, NY (July 31, 2008) – In a breakthrough discovery, Dr. Kevin Eggan, Chief Scientific Officer of The New York Stem Cell Foundation and Principal Faculty Member of the Harvard Stem Cell Institute, has produced human stem cell lines from the cells of patients afflicted with a version of amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease.

S Korea bars disgraced cloning hero from human stem-cell work
Khaleej Times Thu, 31 Jul 2008 10:53 PM PDT
Seoul - South Korean cloning researcher Hwang Woo Sook was barred Friday from returning to human stem-cell research, two years after a scandal over manipulated data in studies in which Hwang had claimed to be the first to clone human stem cells.

Stanford fruit-fly study adds weight to theories about another type of adult stem cell
EurekAlert! Thu, 31 Jul 2008 11:21 AM PDT
STANFORD, Calif. - It turns out that an old dog - or at least an old fruit-fly cell - can learn new tricks. Researchers at the Stanford University School of Medicine have found that mature, specialized cells naturally regress to serve as a kind of de facto stem cell during the fruit-fly life cycle.

Harvard, Columbia Researchers Make Stem Cell Breakthrough
The Harvard Crimson Thu, 31 Jul 2008 11:19 AM PDT
Scientists from Harvard and Columbia announced Thursday the creation of the first patient-specific stem cell line from humans afflicted with a genetic disease, a key step in the push to create therapies for a wide variety of illnesses by replacing diseased tissue with tissue generated by stem cells.

Egg shortage hits stem cell studies / Research slowed by California's ban on paying donors
San Francisco Chronicle Thu, 31 Jul 2008 0:42 AM PDT
Facing a human egg shortage they say is preventing medical breakthroughs, scientists and biotech entrepreneurs are pushing the country's top funders of stem cell research to rethink rules that prohibit paying women for eggs. "You need to have enough...

Invitrogen Licenses Stem Cell Line From Buck Institute
BioresearchOnline Thu, 31 Jul 2008 9:10 AM PDT
Invitrogen Corporation (NASDAQ:IVGN), a provider of essential life science technologies for research, production and diagnostics, has licensed an engineered stem cell line from the Buck Institute for Age Research

Stem-cell researchers say egg shortage slows progress
San Jose Mercury News Thu, 31 Jul 2008 2:08 AM PDT
Facing a human egg shortage they say is preventing medical breakthroughs, scientists and biotech entrepreneurs are pushing the country's top funders of stem-cell research to rethink rules that prohibit paying women for eggs.

S Korea Rejects Research Bid By Disgraced Stem Cell Scientist
Nasdaq Thu, 31 Jul 2008 0:33 AM PDT
SEOUL (AFP)--South Korea won't allow disgraced cloning expert Hang Woo-suk to resume human stem cell research, the Yonhap news agency reported Thursday.

Scientists Reach Stem-Cell Milestone
Time Magazine Thu, 31 Jul 2008 11:54 AM PDT
Researchers create the first nerve cells out of reprogrammed stem cells, using a technique that bypasses the destruction of embryos

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[StemCells] iPS makes makes ALS study possible in new ways

Harvard-Columbia team creates neurons from ALS patient's skin cells
New key to understanding and treating ALS, and a step toward
personalized regenerative medicine
NEW YORK – Harvard and Columbia scientists have for the first time
used a new technique to transform an ALS (amyotrophic lateral
sclerosis, or Lou Gehrig's disease) patient's skin cells into motor
neurons, a process that may be used in the future to create tailor-
made cells to treat the debilitating disease. The research – led by
Kevin Eggan, Ph.D. of the Harvard Stem Cell Institute – will be
published July 31 in the online version of the journal Science.

This is the first time that skin cells from a chronically-ill patient
have been reprogrammed into a stem cell-like state, and then coaxed
into the specific cell types that would be needed to understand and
treat the disease.

Though cell replacement therapies are probably still years away, the
new cells will solve a problem that has hindered ALS research for
years: the inability to study a patient's motor neurons in the
laboratory.

ALS is caused by the degeneration and death of motor neurons, the
nerve cells which convey nerve impulses from the spinal cord to each
of the body's muscles. The death of motor neurons leads to paralysis
of these muscles, including those involved in swallowing and
breathing, and ultimately leads to death of the patient. The disease
affects about 30,000 people in the United States.

"Up until now, it's been impossible to get access to the neurons
affected by ALS and, although everyone was excited by the potential
of the new technology, it was uncertain that we would be able to
obtain them from patients' skin cells," says co-author Chris
Henderson, Ph.D., professor of pathology, neurology and neuroscience,
co-director of the Center for Motor Neuron Biology and Disease at
Columbia, and senior scientific advisor of the Project A.L.S./
Jenifer Estess Laboratory for Stem Cell Research. "Our paper now
shows that we can generate hundreds of millions of motor neurons that
are genetically identical to a patient's own neurons. This will be an
immense help as we try to uncover the mechanisms behind this disease
and screen for drugs that can prolong life."

The motor neurons were created using a new technique that reprograms
human adult skin cells into cells that resemble embryonic stem (ES)
cells. The technique used to make these cells – called induced
pluripotent stem (iPS) cells – was a major advance in the field that
was first reported last November by researchers in Japan and
Wisconsin. Those studies used skin cells from healthy adults, but it
remained unknown whether iPS cells could be created with cells from
chronically-ill patients and then transformed into neurons. The
Columbia-Harvard team, in this paper, showed this was possible using
an ALS patient's skin cells.

Columbia clinician-researchers Wendy Chung, M.D., Ph.D., Herbert
Irving Assistant Professor of Pediatrics in Medicine, and Hiroshi
Mitsumoto, M.D., D.Sc., the Wesley J. Howe Professor of Neurology at
Columbia, obtained skin cells from an 82-year-old ALS patient. In the
Project A.L.S. laboratory, Columbia researchers Dr. Henderson and
Hynek Wichterle, Ph.D., assistant professor of pathology, and
colleagues cultured the cells and contributed expertise needed for
identifying iPS cell-derived motor neurons. Finally, Harvard
researchers, led by Kevin Eggan of the Harvard Stem Cell Institute,
successfully used the new technique to reprogram the skin cells into
iPS cells and differentiate them into motor neurons.

Scientists had originally hoped to create neurons and other adult
cells using "therapeutic cloning," in which DNA from a patient is
inserted into a donated egg to create embryonic stem cells. That
technique, however, has still not been successful in humans, and is
also hindered by a shortage of donated eggs.

If the iPS technique holds its promise in producing neurons and other
cells for research, it will probably replace the "therapeutic
cloning" approach, Dr. Henderson says, but there are still lots of
questions about the iPS-derived neurons.

"We don't know yet how similar they are to the motor neurons in ALS
patients," he says. "While the cells exhibit many properties that are
typical of motor neurons, we don't yet know whether they will be
prone to degeneration that will allow us to mimic the disease in the
culture dish and therefore to screen potential drugs."

Researchers at Columbia and Harvard are already collaborating to
investigate the cells with the ultimate goal of determining how they
differ from a healthy person's motor neurons.

"Project A.L.S. has always maintained that collaboration between
scientists is the answer to understanding and treating this disease,"
Valerie Estess, founder and research director, Project A.L.S. "We are
thrilled to have catalyzed the Harvard-Columbia collaboration that
led to this discovery."

"Therapeutic use of the cells is probably a long way off," Dr.
Henderson says. "Right now there are safety issues with iPS cells,
including a risk of cancer. We also don't know how to reintroduce
cells into a sick adult in a way that will be beneficial. All these
hurdles need to be overcome first before we can think about using the
cells to treat disease, but we can start immediately to evaluate them
as a tool for drug discovery."

###

The Columbia and Harvard researchers were supported by the Harvard
Stem Cell Institute, Project A.L.S., the SMA Foundation, MDA Wings
Over Wall Street, the Claire and Leonard Tow Charitable Foundation,
the Spina, Drago and Bowen Families, Ride for Life and the New York
Stem Cell Foundation.

*** Related Teleconference: A teleconference related to the
forthcoming Science paper, "Induced pluripotent stem cells generated
from patients with ALS can be differentiated into motor neurons," by
Dr. Eggan and colleagues is planned for 12 noon, U.S. Eastern Time,
Wednesday, 30 July. All information released during the
teleconference will remain under embargo until 2:00 p.m. U.S. ET
Thursday, July 31. NB: The teleconference will be recorded and posted
on the web, and by calling in you are consenting to be recorded. Call
in numbers are as follows: From the United States: 1-800-311-9410.
From outside the United States: 1334-232-7224. The password
is "stemcell"

The final roster of speakers has yet to be determined, but will at a
minimum include Kevin Eggan of the Harvard Stem Cell Institute, and
Chris Henderson of Columbia University. The embargoed press briefing
is being organized by the Harvard Stem Cell Institute and Columbia
University, in cooperation with Science ***

Columbia University Medical Center is home to the Eleanor and Lou
Gehrig MDA/ALS Center, which cares for over 300 ALS patients each
year, the Center for Motor Neuron Biology and Disease, with more than
40 scientists working to uncover the cause of ALS and other motor
neuron diseases, and the Project A.L.S./Jenifer Estess/Laboratory for
Stem Cell Research. In recent years, CUMC scientists have discovered
that motor neurons may be degenerating in ALS in response to a toxin
released by neighboring cells; developed ways to turn embryonic stem
cells into motor neurons; and uncovered how motor neurons mature and
find their way to their target muscles (most recently in a paper
published this week in Cell by Thomas Jessell, Ph.D., the Claire Tow
Professor of Neuroscience, Biochemistry & Molecular Biophysics and
Investigator, Howard Hughes Medical Institute). This progress and the
present article moves Columbia scientists and their colleagues closer
to their long-term goal of finding a cure for this dreaded disease.
Columbia University investigators in the Naomi Berrie Diabetes Center
are also collaborating with Dr. Eggan and others in the Harvard Stem
Cell Institute on similar experiments on skin cells taken from
patients with diabetes. In January 2008, Columbia University received
$2.5 million from New York State's Empire State Stem Cell Board, an
agency created by the state legislature to support stem cell
research.

Columbia University Medical Center provides international leadership
in basic, pre-clinical and clinical research, in medical and health
sciences education, and in patient care. The medical center trains
future leaders and includes the dedicated work of many physicians,
scientists, public health professionals, dentists, and nurses at the
College of Physicians & Surgeons, the Mailman School of Public
Health, the College of Dental Medicine, the School of Nursing, the
biomedical departments of the Graduate School of Arts and Sciences,
and allied research centers and institutions. Established in 1767,
Columbia's College of Physicians & Surgeons was the first institution
in the country to grant the M.D. degree and is among the most
selective medical schools in the country. Columbia University Medical
Center is home to the largest medical research enterprise in New York
City and state, and one of the largest in the United States. For more
information, please visit www.cumc.columbia.edu.

Public release date: 31-Jul-2008
Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center

http://www.eurekalert.org/pub_releases/2008-07/cumc-htc072808.php

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Article: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1sw0Ee

Fat redistribution and adipocyte transformation in uninephrectomized rats
Hai-Lu Zhao, Yi Sui, Jing Guan, Lan He, Xun Zhu, Rong-Rong Fan, Gang Xu, Alice P S Kong, Chung Shun Ho, Fernand M M Lai, Dewi K Rowlands, Juliana C N Chan and Peter C Y Tong
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1sx0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1sy0Eg

PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney
Ruimin Gu, Yan Jin, Yuanyuan Zhai, Lei Yang, Chengbiao Zhang, Wennan Li, lijun Wang, Shumin Kong, Yunhong Zhang, Baofeng Yang and Wen-Hui Wang
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1sz0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1s10EU

Effect of apelin on glomerular hemodynamic function in the rat kidney
Annette Hus-Citharel, Nadine Bouby, Alain Frugiere, Laurence Bodineau, Jean-Marie Gasc and Catherine Llorens-Cortes
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1s20EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1s30EW

The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease
Kevin S Eardley, Chandrashekhar Kubal, Daniel Zehnder, Marcus Quinkler, Julia Lepenies, Caroline O Savage, Alec J Howie, Kirrenjit Kaur, Mark S Cooper, Dwomoa Adu and Paul Cockwell
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1s40EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1s50EY

Gender differences in predictors of the decline of renal function in the general population
Nynke Halbesma, Auke H Brantsma, Stephan J L Bakker, Desiree F Jansen, Ronald P Stolk, Dick De Zeeuw, Paul E De Jong and Ronald T Gansevoort
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1s60EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1s70Ea

Myocardial fatty acid imaging identifies a group of hemodialysis patients at high risk for cardiac death after coronary revascularization
Masato Nishimura, Toshiko Tokoro, Masasya Nishida, Tetsuya Hashimoto, Hiroyuki Kobayashi, Satoru Yamazaki, Ryo Imai, Koji Okino, Hakuo Takahashi and Toshihiko Ono
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1s80Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tA0El

An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients
Daniel P K Ng, Siti Nurbaya, Sandra H J Ye and Andrzej S Krolewski
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tB0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tC0En

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TECHNICAL NOTE
----------------------
Arteriovenous fistula in the rat tail: a new model of hemodialysis access dysfunction
Tao Lin, Catherine Horsfield and Michael G Robson
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tD0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tE0Ep

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THE RENAL CONSULT
----------------------
Paroxysmal hypertension in a 48-year-old woman
Jennifer Hunt and Julie Lin
http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tF0Eq

----------------------
LETTERS TO THE EDITOR
----------------------
Letter regarding /`advisory about gadolinium calls for caution in the treatment of uremic patients with lanthanum carbonate/'
Michael DL Smyth and Raymond D Pratt
http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tG0Er

Response to /`Advisory about gadolinium calls for caution in the treatment of uremic patients with lanthanum carbonate/'
Silvio Aime, Caterina Canavese and Piero Stratta
http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tH0Es

A wearable hemofilter for continuous ambulatory ultrafiltration
Stanley Shaldon and Michael Lysaght
http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tI0Et

Response to /`A wearable hemofilter for continuous ambulatory ultrafiltration/'
Victor Gura, Claudio Ronco and Andrew Davenport
http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tJ0Eu

----------------------
MAKE YOUR DIAGNOSIS
----------------------
The Case [mid] Renal failure after percutaneous closure of a perivalvular leak
Barbara Labban and Jai Radhakrishnan
http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tK0Ev

----------------------
NEPHROLOGY IMAGE
----------------------
Hyporeninemic hypoaldosteronism from secondary amyloidosis
Fumi Takemoto, Yoshifumi Ubara, Shinya Kaname, Hideyuki Katori, Naoki Sawa, Junichi Hoshino, Tatsuya Suwabe, Yasushi Higa, Shohei Nakanishi, Michio Nagata, Kenichi Ohashi and Kenmei Takaichi
http://ealerts.nature.com/cgi-bin24/DM/y/embk0Xztnp0Hiy0B1tL0Ew

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Articles for Kidney International are published online ahead of print through Advance Online Publication (AOP), meaning that the latest research reaches you in the timeliest way possible. Check the AOP webpage each week at www.nature.com/ki/journal/vaop/ncurrent to make sure that you are not left behind.

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Kidney International Table of Contents alert Volume 74 Issue s110

KIDNEY INTERNATIONAL

August 2008 Volume 74 Number S110, pp S1 - S24

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Ensure your access to Kidney International

----------------------
INTRODUCTION
----------------------
Introduction to the Canadian Society of Nephrology Clinical Practice Guidelines for the management of anemia associated with chronic kidney disease
Braden J Manns, Colin T White, Francois Madore, Louise M Moist, Scott W Klarenbach, Brendan J Barrett, Rob N Foley, Bruce F Culleton and Marcello Tonelli
http://ealerts.nature.com/cgi-bin24/DM/y/embi0Xztnp0Hiy0B1sJ0Er

----------------------
GUIDELINES
----------------------
Clinical Practice Guidelines for evaluation of anemia
Colin T White, Brendan J Barrett, Francois Madore, Louise M Moist, Scott W Klarenbach, Rob N Foley, Bruce F Culleton, Marcello Tonelli and Braden J Manns
http://ealerts.nature.com/cgi-bin24/DM/y/embi0Xztnp0Hiy0B1sK0Es

Clinical Practice Guidelines for assessment and management of iron deficiency
Francois Madore, Colin T White, Rob N Foley, Brendan J Barrett, Louise M Moist, Scott W Klarenbach, Bruce F Culleton, Marcello Tonelli and Braden J Manns
http://ealerts.nature.com/cgi-bin24/DM/y/embi0Xztnp0Hiy0B1sL0Et

Clinical Practice Guidelines for evidence-based use of erythropoietic-stimulating agents
Louise M Moist, Rob N Foley, Brendan J Barrett, Francois Madore, Colin T White, Scott W Klarenbach, Bruce F Culleton, Marcello Tonelli and Braden J Manns
http://ealerts.nature.com/cgi-bin24/DM/y/embi0Xztnp0Hiy0B1sM0Eu

Clinical Practice Guidelines for supplemental therapies and issues
Scott W Klarenbach, Louise M Moist, Rob N Foley, Brendan J Barrett, Francois Madore, Colin T White, Bruce F Culleton, Marcello Tonelli and Braden J Manns
http://ealerts.nature.com/cgi-bin24/DM/y/embi0Xztnp0Hiy0B1sN0Ev