Signaling Gateway - 3 July 2008
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0M40Ea
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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DNA DAMAGE: ATM AND DAMAGE RECOVERY ARE JOINED AT THE HIPK
The ATM and ATR kinases block Siah-1-mediated ubiquitination of HIPK2
during the DNA damage response.
Original research paper: Nature Cell Biology 10, 812-824 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0vP0Ej
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0HIE0Ez
S6K1
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBA0Ek
The S6 kinases are members of the AGC family of serine/threonine
protein kinases and are involved in the regulation of cell growth,
survival and metabolism. Short and long versions of S6 kinase 1 (S6K1)
are produced from a single messenger RNA and have been termed S6K1S
(p70 S6K1) and S6K1L (p85 S6K1), respectively. S6 kinases have gained
attention as downstream effectors of the mammalian Target of
Rapamycin (mTOR).
Also published this week:
S6K2
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBB0El
PI4KIIalpha
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBC0Em
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BUuz0Ev
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Selected Updates
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PROTEIN DEGRADATION: CATCHING UBIQUITIN
The proteasome subunit Rpn13 is a high-affinity receptor for ubiquitin
that recognizes its substrates through a novel ubiquitin-binding domain.
Original research paper: Nature 453, 481-488 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBD0En
SIGNALLING: SURVIVAL OF THE SWEETEST
EGFR promotes cell survival in a kinase-independent fashion by
preventing autophagy and maintaining a basal level of intracellular
glucose, thus explaining the disappointing response rates to EGFR
inhibitors in cancer patients.
Original research paper: Cancer Cell 13, 385-393 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBE0Eo
CANCER GENETICS: LOOKING AT THE BIG PICTURE
A new, large-scale mutagenesis screen in different mouse backgrounds
identifies candidate oncogenes and tumor suppressors, and reveals the
networks that link them together.
Original research paper: Cell 133, 727-741 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBF0Ep
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0vO0Ei
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Research Library
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RhoA AND MICROTUBULE DYNAMICS CONTROL CELL–BASEMENT MEMBRANE
INTERACTION IN EMT DURING GASTRULATION
Nature Cell Biology 10, 765-775 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBG0Eq
A Gata6-Wnt PATHWAY REQUIRED FOR EPITHELIAL STEM CELL DEVELOPMENT AND
AIRWAY REGENERATION
Nature Genetics 40, 862-870 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBH0Er
MAPPING AND QUANTIFYING MAMMALIAN TRANSCRIPTOMES BY RNA-Seq
Nature Methods 5, 621-628 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBI0Es
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Signaling News
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NATURE REVIEWS MOLECULAR CELL BIOLOGY FOCUS ON LIPIDS
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0Bl5Y0Eh
Lipids are important signaling molecules in cancer and inflammation,
and in cardiovascular, neurodegenerative and metabolic diseases. A
complex protein-lipid signaling network that comprises
phosphoinositides, sphingolipids, steroids and other lipid-derived
mediators has been uncovered in recent years. This FREE Focus contains
research highlights, reviews that provide a snapshot of lipid biology
and an accompanying 'Targeting lipid signaling in disease' poster.
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BlsB0EM
More News
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0Crw0ER
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Gateway Updates
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NATURE PROTOCOLS: RECIPES FOR RESEARCHERS
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W04a70Ep
Nature Protocols is a comprehensive online resource of laboratory
protocols, including authoritative, peer-reviewed protocols and an
interactive Protocols Network.
This month's featured protocols include:
Purification of matrix metalloproteinases by column chromatography
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0Byy40ER
Generation of human-induced pluripotent stem cells
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0ByzI0En
An optimized procedure for whole-mount in situ hybridization on mouse
embryos and embryoid bodies
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0ByzM0Er
Sign up to receive the table of contents e-alert for Nature Protocols.
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W02Bg0E5
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Signaling Job of the Week
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Tenure-track Faculty Positions
Employer: University of Cincinnati
Location: Cincinnati, OH
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BzBJ0Et
The newly created Department of Cancer and Cell Biology at the
University of Cincinnati College of Medicine invites applications for
several tenure-track faculty positions in the area of cell signaling
in relation to cancer. Individuals recruited for full and associate
professor positions are expected to lead internationally recognized
and well-funded research programs. Assistant professor candidates
must have an outstanding publication record and demonstrated
potential to secure external grant funding.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0BnjC0EG
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/el2e0Xztnp0H2W0vqs0ED
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