July 2008 Volume 10 Number 7, pp 753 - 874
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EDITORIALS
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Birthday precedings p753
As some of the new 'web 2.0'-enabled publishing ventures mature, we
take stock of their utility to the community
doi:10.1038/ncb0708-753a
http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Bynu0EF
Signalling links p753
Our papers now link directly to relevant Molecule Page database entries
at the Signaling Gateway
doi:10.1038/ncb0708-753b
http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Bynv0EG
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NEWS AND VIEWS
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Cdh1: a master G0/G1 regulator pp755 - 757
APC/CCdh1 controls the G0 and G1 phases of the cell cycle. Using a
conditional knockout of the Cdh1 coding gene Fizzy-related (Fzr),
a new study demonstrates that Cdh1 is essential for viability and that
it functions as a tumour suppressor by preventing genomic instability.
Jeffrey R. Skaar and Michele Pagano
doi:10.1038/ncb0708-755
http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Bynw0EH
Breaking down EMT pp757 - 759
Epithelial-mesenchymal transition, in which epithelial cells lose their
polarity and become motile mesenchymal cells, occurs during development
and marks a key step in tumour progression towards metastasis. Most
studies of this process have focused on the disassembly of adherens
junctions, but regulation of basement membrane breakdown by a pathway
involving RhoA and microtubules may be equally important.
Romain Levayer and Thomas Lecuit
doi:10.1038/ncb0708-757
http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Bynx0EI
UVRAG reveals its second nature pp759 - 761
UVRAG, a known regulator of autophagosome formation, also promotes
autophagosome maturation by recruiting the fusion machinery of the
late endosome.
Karolina Peplowska, Margarita Cabrera and Christian Ungermann
doi:10.1038/ncb0708-759
http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Byny0EJ
Opposing roles for glypicans in Hedgehog signalling pp761 - 763
Glypican members of the heparan sulphate proteoglycan family regulate
several developmental signalling pathways, such as those involving
Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite effects of
glypicans on Hedgehog signalling and show how their core protein
domains and GPI anchor contribute to their versatile biological
functions.
Dong Yan and Xinhua Lin
doi:10.1038/ncb0708-761
http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Bynz0EK
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RESEARCH HIGHLIGHTS
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Research highlights p764
doi:10.1038/ncb0708-764
http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Byn10E6
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ARTICLES
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RhoA and microtubule dynamics control cell-basement membrane interaction
in EMT during gastrulation pp765 - 775
Yukiko Nakaya, Erike W. Sukowati, Yuping Wu and Guojun Sheng
doi:10.1038/ncb1739
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Byn20E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Byn30E8
Beclin1-binding UVRAG targets the class C Vps complex to coordinate
autophagosome maturation and endocytic trafficking pp776 - 787
Chengyu Liang et al.
doi:10.1038/ncb1740
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Byn40EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Byn50EB
A three-step pathway comprising PLZF/miR-146a/CXCR4 controls
megakaryopoiesis pp788 - 801
Catherine Labbaye et al.
doi:10.1038/ncb1741
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Byn60EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Byn70ED
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
pp802 - 811
Irene Garci-Higuera et al.
doi:10.1038/ncb1742
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0Byn80EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoA0EO
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint
kinases ATM and ATR pp812 - 824
Melanie Winter et al.
doi:10.1038/ncb1743
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoB0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoC0EQ
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused
by BubR1 insufficiency pp825 - 836
Darren J. Baker et al.
doi:10.1038/ncb1744
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoD0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoE0ES
TAZ controls Smad nucleocytoplasmic shuttling and regulates human
embryonic stem-cell self-renewal pp837 - 848
Xaralabos Varelas et al.
doi:10.1038/ncb1748
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoF0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoG0EU
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LETTERS
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WAVE and Arp2/3 jointly inhibit filopodium formation by entering
into a complex with mDia2 pp849 - 857
Petra Beli, Debora Mascheroni, Dalu Xu and Metello Innocenti
doi:10.1038/ncb1745
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoH0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoI0EW
Spindle-localized CPE-mediated translation controls meiotic chromosome
segregation pp858 - 865
Carolina Eliscovich, Isabel Peset, Isabelle Vernos and Raul Mendez
doi:10.1038/ncb1746
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoJ0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoK0EY
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates
apoptosis pp866 - 873
Nilkantha Sen et al.
doi:10.1038/ncb1747
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoL0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoM0Ea
----------------------
ERRATUM
----------------------
Erratum p874
doi:10.1038/ncb0708-874
http://ealerts.nature.com/cgi-bin24/DM/y/elyk0Xztnp0HjD0ByoN0Eb
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