Signaling Gateway - 27 June 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0M40E2
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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IGF BINDING PROTEINS: MAKE ANOTHER LITTLE PIECE OF MY HEART NOW, BABY
Insulin-like growth-factor-binding protein 4 (IGFBP-4) promotes
cardiac development by binding to Wnt co-receptors and inhibiting
canonical Wnt signaling.
Original research paper: Nature advance online publication 4 June 2008
(doi:10.1038/nature07027)
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0vP0EC
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0HIE0ES
GAB1
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZl0EJ
Gab1 (Grb2-associated binder-1) is a member of the Gab family of
scaffold and adaptor proteins and connects a broad range of growth
factor and cytokine signals to intracellular signaling pathways. Gab1
is tyrosine phosphorylated upon recruitment to multiple receptor
tyrosine kinases and non-tyrosine kinase receptors, and provides a
link to the activation of multiple downstream signaling pathways. The
signals initiated downstream from Gab1 have been shown to have
important roles in cellular proliferation, migration, scattering,
angiogenesis, survival, morphogenesis and development.
Also published this week:
Rcan1-4
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZm0EK
AP-3 beta3A
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZn0EL
AP-3 delta
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZo0EM
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0BUuz0EO
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Selected Updates
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GENE EXPRESSION: PIONEERING RESEARCH
mTOR and S6 protein kinase-1 (S6K1) help assemble an efficient
initiation complex during the first round of translation on newly
spliced mRNAs.
Original research paper: Cell 133, 303-313 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZp0EN
CELL POLARITY: APC THROWS THE ANCHOR
APC (adenomatous polyposis coli) anchors over 50 mRNAs - including
Rab13 and Pkp4 (plakophilin 4) - to microtubule plus ends at the
pseudopodial tips of migrating cells.
Original research paper: Nature 453, 115-119 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZq0EO
MOLECULARLY TARGETED THERAPY: JAK2 INHIBITOR RESTORES BALANCE IN
POLYCYTHAEMIA VERA
A highly specific ATP-competitive Janus kinase 2 (JAK2) inhibitor
shows promise for treating myeloproliferative disorders such as
polycythemia vera, essential thrombocythemia and myelofibrosis.
Original research paper: Cancer Cell 13, 311-320 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZr0EP
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0vO0EB
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Research Library
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STIM1 SIGNALLING CONTROLS STORE-OPERATED CALCIUM ENTRY REQUIRED FOR
DEVELOPMENT AND CONTRACTILE FUNCTION IN SKELETAL MUSCLE
Nature Cell Biology 10, 688-697 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZs0EQ
INTERNAL DYNAMICS CONTROL ACTIVATION AND ACTIVITY OF THE
AUTOINHIBITED VAV DH DOMAIN
Nature Structural & Molecular Biology 15, 613-618 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZt0ER
A Cdc7 KINASE INHIBITOR RESTRICTS INITIATION OF DNA REPLICATION AND
HAS ANTITUMOR ACTIVITY
Nature Chemical Biology 4, 357-365 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZu0ES
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Signaling News
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ANESTHETICS WORSEN POST-OPERATIVE PAIN
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByLK0EW
General anesthetics induce unconsciousness by activating GABA
receptors. However, anesthetics can also stimulate TRP channels such
as TRPA1 and TRPV1, which activate pain-sensing nerves throughout
the body and may contribute to post-operative pain and inflammation.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0Crw0Es
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Gateway Updates
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NATURE PRECEDINGS: PRE-PUBLICATION RESEARCH AND PRELIMINARY FINDINGS
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0BVUp0Eh
Nature Precedings is one year old! Over the past year, researchers
in a variety of disciplines have posted nearly 500 documents to the
site. Recent pre-print manuscripts include:
CD14 modulates PI3K/Akt/p38-MAPK licensing of negative regulators of
TLR signaling to restrain chronic inflammation
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZv0ET
Pancreas islets in metabolic signaling - focus on the beta-cell
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZw0EU
Enforced expression of PPP1R13L increases tumorigenesis and invasion
through p53-dependent and p53-independent mechanisms
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZx0EV
Search for documents or browse by subject category to stay
informed of the latest research in your field.
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0BiO60Ew
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Signaling Job of the Week
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Research Directors and Group Leaders
Employer: University of Copenhagen
Location: Copenhagen, Denmark
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0ByZy0EW
The Novo Nordisk Foundation Center for Protein Research at the
University of Copenhagen seeks talented and innovative scientists to
serve as Research Directors and Group Leaders when the Center opens
in 2009. Successful candidates will carry out independent research as
well as integrated, collaborative projects. Researchers with
experience in studying signaling pathways, protein degradation and
post-translational modifications are especially encouraged to apply.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0BnjC0Eh
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0vqs0Ee
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http://ealerts.nature.com/cgi-bin24/DM/y/eltz0Xztnp0H2W0dIO0E5
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