Signaling Gateway - 20 June 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0M40Ew
*********************************************************************
Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
*********************************************************************
In Signaling Update this week:
------------------------
Featured Article
------------------------
POST-TRANSLATIONAL MODIFICATIONS: THE ACTIVE TGF-BETA RECEPTOR IS
SUMOYLATED
Transforming growth factor-beta receptor type I is sumoylated,
which regulates Smad3 activation and affects invasion and metastasis.
Original research paper: Nature Cell Biology 10, 654-664 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0vP0E6
------------------------
Signaling Survey
------------------------
SIGNALING GATEWAY SURVEY: WHAT DO YOU THINK?
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bvd80ET
The Signaling Gateway team invites you to complete a brief online
survey on the usability of the site for the chance to win a FREE iPod
Touch or two-year subscription to Nature. Your feedback will help
ensure that we continue to present content and information that meet
your needs. To complete the survey and enter the prize draw, please
click here.
------------------------
Molecule Pages
------------------------
The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0HIE0EN
PINK1
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bx750Eh
PTEN-induced kinase 1 (PINK1) is a serine/threonine kinase that is
primarily localized to the mitochondria in eukaryotic cells.
Loss-of-function mutations in the PINK1 gene have been
correlated with early-onset parkinsonism. Other mutations in PINK1
are associated with recessively inherited forms of familial
Parkinson's disease. Protein overexpression and gene-knockdown
studies suggest that PINK1 has a critical anti-apoptotic function
that prevents mitochondrial depolarization/permeablization in
response to various cellular insults, including proteosomal
inhibition and oxidative stress.
search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0BUuz0EJ
-------------------
Selected Updates
-------------------
CELL SIGNALLING: DYNAMIC REDISTRIBUTION
Wnt5a signals through Rab4 and RhoB to control cell orientation,
polarity and directional movement.
Original research paper: Science. 320, 365-369 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bx760Ei
METASTASIS: WHICH WAY TO THE LUNGS?
TGFbeta-mediated upregulation of the cytokine angiopoietin-like
protein 4 (ANGPTL4) disrupts endothelial cell contacts, which
contributes to lung metastasis of primary breast cancers.
Original research paper: Cell 133, 66-77 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bx770Ej
SYSTEMS BIOLOGY: REWIRING E. COLI
By adding new connections between unrelated genes to a gene network,
researchers can investigate network robustness and evolvability.
Original research paper: Nature 452, 840-845 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bx780Ek
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0vO0E5
------------------------
Research Library
------------------------
SYNERGISTIC RESPONSE TO ONCOGENIC MUTATIONS DEFINES GENE CLASS
CRITICAL TO CANCER PHENOTYPE
Nature 453, 1112-1116 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bx8A0Eu
THE RECEPTOR TYROSINE KINASE FLT3 IS REQUIRED FOR DENDRITIC CELL
DEVELOPMENT IN PERIPHERAL LYMPHOID TISSUES
Nature Immunology 9, 676-683 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bx8B0Ev
DEVELOPMENTAL AXON PRUNING MEDIATED BY BDNF-P75NTR–DEPENDENT AXON
DEGENERATION
Nature Neuroscience 11, 649-658
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bx8C0Ew
------------------------
Signaling News
------------------------
LAB DISINFECTANT HARMS MOUSE FERTILITY
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bxvw0Eq
Two chemicals widely used in cleaning agents cause birth defects and
fertility problems in mice whose cages have been in contact with
them, according to Patricia Hunt at Washington State University in
Pullman. The quaternary ammonium compounds ADBAC (n-alkyl dimethyl
benzyl ammonium chloride) and DDAC (didecyl dimethyl ammonium
chloride) were identified after a search for what was causing a
massive drop-off in mouse fertility after Hunt moved her research
animals to Pullman from Case Western Reserve Medical School.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Crw0En
-------------------------
Gateway Updates
-------------------------
THE FUNCTIONAL GLYCOMICS GATEWAY - JUNE UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0BKHW0En
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Sepsis, coagulation, metastasis: Endogenous lectin receptors unveiled
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0BxZ70EK
Glycosylation and development: A frog hops into the gap
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0BxZ80EL
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0BJYw0Eb
-----------------------------
Signaling Job of the Week
-----------------------------
Science Manager and Postdoc positions
Employer: Otto von Guericke University Magdeburg
Location: Magdeburg, Germany
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bx8D0Ex
The Institute of Experimental Internal Medicine at the Otto von
Guericke University Magdeburg is seeking a science manager and a
post-doc or PhD student. The science manager will contribute to
patent and grant applications and help develop innovative research
strategies. The post-doc or PhD student will study cell biology
and/or systems biology. Projects at the Institute are centered on
inflammation and tumor biology with a focus on molecular mechanisms
of signal transmission and mathematical models of signal processes.
For more information, please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0Bx8E0Ey
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0BnjC0Ec
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0vqs0EZ
======================================================================
Genentech is proud to be a corporate sponsor of the UCSD-Nature Signaling Gateway.
Genentech is a leading biotechnology company that discovers,
develops, manufactures and commercializes biotherapeutics
for significant unmet medical needs. Fifteen of the currently
approved biotechnology products stem from or are based on
Genentech science. Genentech manufactures and commercializes
ten biotechnology products directly in the United States.
The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0dIO0Ez
=====================================================================
As a registered user of the Nature Publishing Group web sites, you
were selected to receive this message in the genuine belief that it
would be of interest to you.
If you no longer wish to receive news and announcements from Nature
Publishing Group or wish to unsubscribe from the Signaling Update
email alert please update your online Nature.com account details here:
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0BCGZ0Eh
For further technical assistance or any other enquiries, please click here:
http://ealerts.nature.com/cgi-bin24/DM/y/eljC0Xztnp0H2W0mg0EL
Nature's world-wide offices:
London . Paris . Munich . New Delhi . Tokyo . Melbourne . San Diego .
San Francisco . Washington . New York . Boston
(c) 2008 Nature Publishing Group
---------------------------------------------------------------------
