July 2008 Volume 9 Number 7
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Cell Signaling Review Series and Web Focus -
brought to you by Cell Research
Since March 2008, Cell Research has featured many articles about the
recent advances in cell signaling. This review series and accompanying web
focus highlights articles from Cell Research as well as Nature and explores
the context of stem cell self-renewal and differentiation, cancer and other
human diseases.
Access the Cell Signaling Review Series and Web Focus today to view select articles FREE of charge.
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This month's FEATURED article:
Ras oncogenes: split personalities
Antoine E. Karnoub & Robert A. Weinberg
p517 | doi:10.1038/nrm2438
http://foxtrot.nature.com/nrm/journal/v9/n7/abs/nrm2438.html
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From the editors
p495 | doi:10.1038/nrm2444
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBS0EK
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RESEARCH HIGHLIGHTS
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Small RNAs: United in silence
p496 | doi:10.1038/nrm2429
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBT0EL
WEB WATCH
Science sans frontiers
p497 | doi:10.1038/nrm2437
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBU0EM
Protein folding: Chaperone embrace
p497 | doi:10.1038/nrm2441
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBV0EN
Protein degradation: Catching ubiquitin
p498 | doi:10.1038/nrm2431
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBW0EO
Cell signalling: How to lead a double life
p498 | doi:10.1038/nrm2436
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBX0EP
Mechanisms of disease: A structural unwinding
p499 | doi:10.1038/nrm2442
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBY0EQ
Cell morphology: Breaking the spatial code
p500 | doi:10.1038/nrm2433
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBZ0ER
Reverse transcription: Do the flip
p501 | doi:10.1038/nrm2432
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBa0EY
IN BRIEF
Cytoskeleton | Stem cells | Chromatin
p501 | doi:10.1038/nrm2440
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBb0EZ
AN INTERVIEW WITH...
Harold Varmus
p502 | doi:10.1038/nrm2435
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBc0Ea
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REVIEWS
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Mediators of reprogramming: transcription factors and transitions through mitosis
Dieter Egli, Garrett Birkhoff and Kevin Eggan
p505 | doi:10.1038/nrm2439
Animal cloning demonstrates that the genome of a differentiated cell can be reprogrammed
to support the development of an entire organism and allow the derivation of pluripotent
stem cells. Is there a common mechanism for programming and reprogramming developmental
states? And what factors are required?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBe0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBf0Ed
Ras oncogenes: split personalities
Antoine E. Karnoub and Robert A. Weinberg
p517 | doi:10.1038/nrm2438
Extensive research over the past 30 years has revealed the involvement of Ras not only
in tumorigenesis but also in many developmental disorders. The complexity of the molecular
and cell biological mechanisms of action of Ras proteins indicates that much remains to be learnt.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBg0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBh0Ef
Cytochrome c: functions beyond respiration
Yong-Ling P. Ow, Douglas R. Green, Zhenyue Hao and Tak W. Mak
p532 | doi:10.1038/nrm2434
Cytochrome c is primarily known for its function in the mitochondria as a key participant
in the life-supporting function of ATP synthesis. Yet, cytochrome c also has a prominent
role in apoptotic pathways and participates in non-apoptotic processes during development.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBi0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBj0Eh
Mechanisms of membrane fusion: disparate players and common principles
Sascha Martens and Harvey T. McMahon
p543 | doi:10.1038/nrm2417
Although fusion proteins that function in different membrane-fusion events can be structurally
diverse, their functional activities are often similar. Fusion proteins bring the two membranes
into sufficiently close proximity and inject energy into the fusion process.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBk0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBl0Ej
A gene regulatory network orchestrates neural crest formation
Tatjana Sauka-Spengler and Marianne Bronner-Fraser
p557 | doi:10.1038/nrm2428
The neural crest is a migratory population of cells that is unique to vertebrate embryos and
that forms numerous derivatives, such as melanocytes, peripheral neurons and glia, and the
craniofacial skeleton. Formation of the neural crest is mediated through a multimodule
gene regulatory network.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBm0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBn0El
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PERSPECTIVES
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OPINION
Extra-chromosomal elements and the evolution of cellular DNA replication machineries
Adam T. McGeoch and Stephen D. Bell
p569 | doi:10.1038/nrm2426
Although DNA replication is fundamental to the propagation of cellular life, the
bacterial replication machinery is distinct from that used by archaea and eukaryotes.
What has been the role of lateral gene transfer by extra-chromosomal elements in
shaping the replication machinery during evolution?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBo0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBp0En
OPINION
Endosomal sorting and signalling: an emerging role for sorting nexins
Peter J. Cullen
p574 | doi:10.1038/nrm2427
Sorting nexins are associated with the early endosomal network and have important
functions in endocytosis, sorting and signalling. But how do specific sorting nexins
regulate tubular-based endosomal sorting and how do other sorting nexins coordinate
sorting with endosomal signalling events?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBq0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBr0Ep
Corrigendum: In Brief: Nuclear envelope
doi:10.1038/nrm2445
http://ealerts.nature.com/cgi-bin24/DM/y/elkn0Xztnp0Hjf0ByBd0Eb
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