July 2008 Volume 6 Number 7
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This month's FEATURED article:
Advances in bacterial promoter recognition and its control by factors that do not bind DNA
Shanil P. Haugen, Wilma Ross & Richard L. Gourse
p507 | doi:10.1038/nrmicro1912
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXV0Ep
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In this issue
p495 | doi:10.1038/nrmicro1938
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXI0Ec
Editorial: Les 120 ans de l'institut Pasteur
p496 | doi:10.1038/nrmicro1942
This Editorial highlights the legacy of Louis Pasteur, one of the founding
fathers of microbiology, and the Institute he founded 120 years ago.
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXJ0Ed
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RESEARCH HIGHLIGHTS
----------------------
Bacterial secretion: Structural snapshot
p497 | doi:10.1038/nrmicro1943
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXK0Ee
Cellular microbiology: Collaring the pocket
p498 | doi:10.1038/nrmicro1933
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXL0Ef
Antibiotics: Spot the difference
p498 | doi:10.1038/nrmicro1937
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXM0Eg
IN BRIEF
Phage biology | Innate immunity | Techniques and applications
p498 | doi:10.1038/nrmicro1944
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXN0Eh
Evolution: What's on the menu?
p499 | doi:10.1038/nrmicro1940
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXO0Ei
HIV: Do the flip
p500 | doi:10.1038/nrmicro1934
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXP0Ej
Biofilms: New hide-out for TB?
p500 | doi:10.1038/nrmicro1945
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXQ0Ek
Cellular microbiology: HO1 tips the balance
p501 | doi:10.1038/nrmicro1936
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXR0El
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NEWS AND ANALYSIS
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GENOME WATCH
Vive la difference
Nicholas R. Thomson
p502 | doi:10.1038/nrmicro1929
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXT0En
DISEASE WATCH
In the News
p504 | doi:10.1038/nrmicro1946
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXS0Em
----------------------
REVIEWS
----------------------
Advances in bacterial promoter recognition and its control by factors that do not bind DNA
Shanil P. Haugen, Wilma Ross and Richard L. Gourse
p507 | doi:10.1038/nrmicro1912
Structures of RNA polymerase enzymes have advanced our understanding of transcription initiation
in all kingdoms of life. This Review discusses bacterial promoter structure, recent advances in
our understanding of the successive promoter-RNA polymerase complexes that contribute to the kinetics
of transcription initiation and unconventional regulators that target RNA polymerase, but not DNA,
for the control of transcription initiation in bacteria.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXU0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXV0Ep
Systems biology of persistent infection: tuberculosis as a case study
Douglas Young, Jaroslav Stark and Denise Kirschner
p520 | doi:10.1038/nrmicro1919
In the first of a series of articles that focus on systems biology in microorganisms, Douglas Young
and colleagues describe how systems biology provides a new and integrative tool that can be used to
probe host-pathogen interactions during persistent infection, using Mycobacterium tuberculosis as an example.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXW0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXX0Er
Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded
Roberto Cattaneo, Tanner Miest, Elena V. Shashkova and Michael A. Barry
p529 | doi:10.1038/nrmicro1927
Oncolytic viruses can be reprogrammed into vectors for use in cancer therapy by combining three
types of modification: targeting, arming and shielding. Roberto Cattaneo and colleagues discuss
the principles of virus reprogramming using adenovirus, a DNA virus with a naked icosahedral
capsid, and measles virus, an enveloped RNA virus with a helical capsid, as the main examples.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXY0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXZ0Et
Viral infection and iron metabolism
Hal Drakesmith and Andrew Prentice
p541 | doi:10.1038/nrmicro1930
In recent years, the interactions between viruses and cellular metabolism have become a topic
of great interest. Viral infections that disrupt liver function can be accompanied by changes
in iron homeostasis, and iron loading of the liver can exacerbate chronic viral disease.
Here, Hal Drakesmith and Andrew Prentice consider some examples of how viruses such as HIV-1,
hepatitis C virus and arenaviruses manipulate cellular iron metabolism.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXa0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXb0E2
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PERSPECTIVES
----------------------
INNOVATION
Ibis T5000: a universal biosensor approach for microbiology
David J. Ecker et al.
p553 | doi:10.1038/nrmicro1918
The Ibis T5000 couples nucleic acid amplification to high-performance electrospray mass
spectrometry and base-composition analysis and enables the identification and quantification
of all known bacteria, all major groups of pathogenic fungi and the major families of viruses
that cause disease in humans and animals. Here, Ecker and colleagues describe this new technology.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXc0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXd0E4
OPINION
Microbial endemism: does phosphorus limitation enhance speciation?
Valeria Souza, Luis E. Eguiarte, Janet Siefert and James J. Elser
p559 | doi:10.1038/nrmicro1917
Using examples from the Cuatro Cienegas basin in Mexico, Souza et al. argue that the occurrence
of strong ecosystem nutrient limitation, especially by phosphorus, encourages local microbial
endemism because it reduces horizontal gene transfer among locally adapting microbial lineages.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXe0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXf0E6
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CORRESPONDENCE
----------------------
Correspondence: Networking for infectious-disease emergencies in Europe
Giuseppe Ippolito, Carla Nisii and Maria R. Capobianchi
p564 | doi:10.1038/nrmicro1896-c1
http://ealerts.nature.com/cgi-bin24/DM/y/elYL0Xztnp0Hje0BxXg0E7
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