July 2008 Volume 8 Number 7
Visit Nature Reviews Immunology online to browse the journal.
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This month's FEATURED article:
Deubiquitylation and regulation of the immune response
Shao-Cong Sun
p501 | doi:10.1038/nri2337
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHD0EX
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From the editors
p487 | doi:10.1038/nri2373
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHE0EY
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RESEARCH HIGHLIGHTS
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Macrophages: Re-educating macrophages
p488 | doi:10.1038/nri2365
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHF0EZ
Immune regulation: Gut responses tamed by friendly bacteria
p489 | doi:10.1038/nri2367
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHG0Ea
IN BRIEF
T cells | Immune regulation | B cells
p489 | doi:10.1038/nri2375
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHH0Eb
Innate immunity: iNKT cells catch your breath
p490 | doi:10.1038/nri2369
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHI0Ec
Mucosal immunology: Another piece of the puzzle
p490 | doi:10.1038/nri2371
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHJ0Ed
Immunological memory: Basophils boost B-cell memory
p490 | doi:10.1038/nri2372
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHK0Ee
IN BRIEF
Immunotherapy | Regulatory T cells | Antibody responses
p491 | doi:10.1038/nri2376
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHL0Ef
Immune regulation: TSLP: not just skin deep
p492 | doi:10.1038/nri2363
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHM0Eg
B cells: (micro)Restraint of AID
p492 | doi:10.1038/nri2364
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHN0Eh
Autoimmunity: NKT cells linked to immune tolerance breakdown
p493 | doi:10.1038/nri2370
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHO0Ei
Gene regulation: Timing is everything
p494 | doi:10.1038/nri2362
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHP0Ej
IN THE NEWS
Inflammation-cancer link confirmed
p494 | doi:10.1038/nri2374
http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHQ0Ek
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PROGRESS
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Multifunctional roles for MALT1 in T-cell activation
Margot Thome
p495 | doi:10.1038/nri2338
Recent research on MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1), a protein essential for nuclear factor-kB (NF-kB) activation, has uncovered new mechanisms by which MALT1 can orchestrate intracellular signalling events. Here, Margot Thome highlights recent progress which characterizes how the protease and scaffolding functions of MALT1 modulate T-cell activation.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHR0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHS0Em
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REVIEWS
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Deubiquitylation and regulation of the immune response
Shao-Cong Sun
p501 | doi:10.1038/nri2337
This Review describes the significant progress that has been made recently in our understanding of the immunoregulatory role of deubiquitylation. Shao-Cong Sun discusses the deubiquitylating enzymes, in particular CYLD and A20, that have been shown to modulate innate and adaptive immunity.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHD0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHT0En
Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
Janko Nikolich-Zugich
p512 | doi:10.1038/nri2318
A decline in T-cell immunity is a major cause of morbidity and mortality from infectious diseases in the elderly. Janko Nikolich-Zugich weighs up the relative roles of and the interplay between homeostatic factors and persistent viruses in immune senescence.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHU0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHV0Ep
How regulatory T cells work
Dario A. A. Vignali, Lauren W. Collison and Creg J. Workman
p523 | doi:10.1038/nri2343
Regulatory T cells (TReg cells) have a central role in immune regulation, but how do they work? In this Review, our current understanding of the suppressive mechanisms used by TReg cells is described and the relative contribution of these mechanisms to TReg-cell function is discussed.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHW0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHX0Er
Colony-stimulating factors in inflammation and autoimmunity
John A. Hamilton
p533 | doi:10.1038/nri2356
As discussed in this article, in addition to their role as haematopoietic-cell growth factors, colony-stimulating factors have broader roles in immunity, and targeting these factors might have therapeutic benefits in inflammation and autoimmunity.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHY0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHZ0Et
Unravelling the association of partial T-cell immunodeficiency and immune dysregulation
Adrian Liston, Anselm Enders and Owen M. Siggs
p545 | doi:10.1038/nri2336
Surprisingly, and somewhat counter-intuitively, partial T-cell immunodeficiencies are commonly associated with hyper-immune dysregulation. Here, the authors review the genetic basis of such immunodeficiencies and draw on mouse models to provide a potential explanation for the coexistence of immunodeficiency and autoimmunity.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHa0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHb0E2
Interferon-inducible antiviral effectors
Anthony J. Sadler and Bryan R. G. Williams
p559 | doi:10.1038/nri2314
Type I interferons (IFNs) provide the first line of defence against viral infection. As discussed in this Review, the IFN-induced antiviral effector proteins, such as ISG15, Mx proteins, ribonuclease L and protein kinase R, are important components of this response.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHc0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elpE0Xztnp0Hjd0ByHd0E4
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Nature Reviews Immunology Focus on Mucosal Immunology
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