July 2008 Volume 8 Number 7
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Immunotherapy and Biological Therapy Meeting
International Society for Biological Therapy of Cancer (iSBTc)
iSBTc 23rd Annual Meeting & Associated Programs
October 29 - November 2, 2008 San Diego, CA
Abstract Submission Deadline: July 21, 2008
For more information, visit http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFe0E7
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Before the roundworm, there was the silkmoth.
CDD's next Special Issue commemorates Richard
Lockshin in honor of his 70th birthday.
Featured review articles discuss the phylogeny and regulation of programmed
cell death in a variety of model organisms. Read a selection of FREE articles
from the Richard Lockshin issue online at CDD.
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0Bugw0Et
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This month's FEATURED article:
Banking on cord blood stem cells
Michael J. Sullivan
p555 | doi:10.1038/nrc2418
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByF70EM
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From the editors
p481 | doi:10.1038/nrc2338
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFf0E8
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RESEARCH HIGHLIGHTS
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Metastasis: Regressing to self-renewal
p483 | doi:10.1038/nrc2423
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFg0EA
Signalling: Survival of the sweetest
p484 | doi:10.1038/nrc2424
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFh0EB
Tumorigenesis: Combined effort
p484 | doi:10.1038/nrc2426
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFi0EC
IN THE NEWS
Weighing benefits and risks
p484 | doi:10.1038/nrc2435
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFj0ED
Cell cycle: Stop start
p485 | doi:10.1038/nrc2421
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFk0EE
Genetics: Looking at the big picture
p486 | doi:10.1038/nrc2422
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFl0EF
Tumour suppressor: Confirming DLC1
p486 | doi:10.1038/nrc2425
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFm0EG
TRIAL WATCH
Vaccinating the brain | Positively platinum
p486 | doi:10.1038/nrc2436
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFn0EH
IN BRIEF
Chemotherapy | Immunotherapy | DNA repair
p487 | doi:10.1038/nrc2430
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFo0EI
Tumorigenesis: Some HIFs are more equal than others
p488 | doi:10.1038/nrc2427
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFp0EJ
Senescence: Hold that thought
p488 | doi:10.1038/nrc2429
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFq0EK
Tumorigenesis: Too much of a good thing
p489 | doi:10.1038/nrc2428
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFr0EL
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PROGRESS
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Targeting the oncogene and kinome chaperone CDC37
Phillip J. Gray, Jr, Thomas Prince, Jinrong Cheng, Mary Ann Stevenson and Stuart K. Calderwood
p491 | doi:10.1038/nrc2420
CDC37 is oncogenic because it stabilizes the structures of mutated or overexpressed oncogenic kinases. Targeting this chaperone activity, on which many tumours depend, is therefore an attractive option for broad-based therapy.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFs0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFt0EN
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REVIEWS
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Recurrent gene fusions in prostate cancer
Chandan Kumar-Sinha, Scott A. Tomlins and Arul M. Chinnaiyan
p497 | doi:10.1038/nrc2402
Gene fusions have long been known to have an important role in leukaemias, but they have recently been identified in a majority of prostate cancers. Understanding their role in this disease could lead to better targeted therapies.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFv0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFw0EQ
Living on a break: cellular senescence as a DNA-damage response
Fabrizio d'Adda di Fagagna
p512 | doi:10.1038/nrc2440
Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour suppressive function. This Review discusses the evidence indicating that DNA damage and the engagement of the DNA-damage response pathways are common to both ageing and cancer.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFx0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFy0ES
MYB function in normal and cancer cells
Robert G. Ramsay and Thomas J. Gonda
p523 | doi:10.1038/nrc2439
The transcription factor MYB seems to have key roles as a regulator of epithelial stem and progenitor cells. Therefore, MYB is an oncogene that is involved in some human leukaemias, and could also be involved in epithelial cancers such as colorectal cancer and breast cancer.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByFz0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByF10EG
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PERSPECTIVES
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OPINION
Revisiting the biological roles of PAI2 (SERPINB2) in cancer
David R. Croucher, Darren N. Saunders, Sergei Lobov and Marie Ranson
p535 | doi:10.1038/nrc2400
Of the two main urokinase plasminogen activator inhibitors, high tumour levels of the type 1 inhibitor promote tumour progression, whereas high levels of the type 2 inhibitor decrease tumour growth and metastasis. What might be the basis of this paradoxical action?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByF20EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByF30EI
OPINION
Exploring the role of cancer stem cells in radioresistance
Michael Baumann, Mechthild Krause and Richard Hill
p545 | doi:10.1038/nrc2419
Cancer stem cell content and the intrinsic radiosensitivity of cancer stem cells is thought to vary between tumours, thereby affecting their radiocurability. What do we know about cancer stem cells in radioresistance and how might this information be used?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByF40EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByF50EK
SCIENCE AND SOCIETY
Banking on cord blood stem cells
Michael J. Sullivan
p555 | doi:10.1038/nrc2418
The controversy surrounding private, for-profit umbilical cord blood banks continues unabated. What is the scientific rationale for banking your child's cord blood for its potential future use against malignancy? Michael sullivan investigates.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByF60EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByF70EM
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CORRESPONDENCE
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Correspondence: BCR-ABL and CDKN2A: a dropped connection
Richard T. Williams and Charles J. Sherr
p563 | doi:10.1038/nrc2368-c1
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByF80EN
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AUTHOR REPLY
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Author Reply: Cell-cycle deregulation in progressive CML
Michael Savona and Moshe Talpaz
p563 | doi:10.1038/nrc2368-c2
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0ByGA0EX
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Nature Reviews Stem Cell Collection
Free online access
Stem-cell research has a history of more than 20 years, and has made some outstanding contributions to our understanding of haematopoiesis and embryology. The Nature Reviews journals present a Stem Cell Collection, which includes Research Highlights, Reviews and Perspectives articles from Nature Reviews Cancer, Nature Reviews Immunology and Nature Reviews Molecular Cell Biology.
All these articles will be available free online for six months at:
http://ealerts.nature.com/cgi-bin24/DM/y/elnN0Xztnp0Hja0Bqfi0Ea
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