Oncogene - Table of Contents alert Volume 29 Issue 4

ONCOGENE

January 2010 Volume 29 Number 4, pp 469 - 624

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British Journal of Cancer presents:
Breast cancer: Improved care through effective management of febrile neutropenia

An examination of the increasing use of intensive adjuvant regimens for breast
cancer, and the increased rates of febrile neutropenia associated with these
regimens.
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REVIEW
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Activation of the hedgehog-signaling pathway in human cancer and the clinical implications
L Yang, G Xie, Q Fan and J Xie
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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ORIGINAL ARTICLES
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Immunogenic death of colon cancer cells treated with oxaliplatin
A Tesniere, F Schlemmer, V Boige, O Kepp, I Martins, F Ghiringhelli, L Aymeric, M Michaud, L Apetoh, L Barault, J Mendiboure, J-P Pignon, V Jooste, P van Endert, M Ducreux, L Zitvogel, F Piard and G Kroemer
Abstract: http://links.ealert.nature.com/ctt?kn=69&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0

UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes
M Ming, W Han, J Maddox, K Soltani, C R Shea, D M Freeman and Y -Y He
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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Chromosomal rearrangements after ex vivo Epstein-Barr virus (EBV) infection of human B cells
S Lacoste, E Wiechec, A G dos Santos Silva, A Guffei, G Williams, M Lowbeer, K Benedek, M Henriksson, G Klein and S Mai
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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Knockdown of peroxisome proliferator-activated receptor-[beta] induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells
L Yang, B Olsson, D Pfeifer, J -I Jonsson, Z -G Zhou, X Jiang, B -A Fredriksson, H Zhang and X -F Sun
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0

BAG-1 overexpression attenuates luminal apoptosis in MCF-10A mammary epithelial cells through enhanced RAF-1 activation
L R Anderson, R L Sutherland and A J Butt
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis
J Zhang, Y Li, Q Liu, W Lu and G Bu
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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Serum protein signature may improve detection of ductal carcinoma in situ of the breast
J Solassol, P Rouanet, P J Lamy, C Allal, G Favre, T Maudelonde and A Mange
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species
J -J Lee, J -H Lee, Y -G Ko, S I Hong and J -S Lee
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition
A Lakshmikuttyamma, S A Scott, J F DeCoteau and C R Geyer
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim
J Konishi, F Yi, X Chen, H Vo, D P Carbone and T P Dang
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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LIM-kinase 2, a regulator of actin dynamics, is involved in mitotic spindle integrity and sensitivity to microtubule-destabilizing drugs
S T Po'uha, M S Y Shum, A Goebel, O Bernard and M Kavallaris
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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SHORT COMMUNICATIONS
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The Rap GTPases regulate the migration, invasiveness and in vivo dissemination of B-cell lymphomas
K B L Lin, P Tan, S A Freeman, M Lam, K M McNagny and M R Gold
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2
E Bourke, J A L Brown, S Takeda, H Hochegger and C G Morrison
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=34587564&r=MTc2ODI0Mjc1MwS2&b=2&j=NjYyNjY5NDMS1&mt=1&rt=0
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Pollutants plucked from air with copper
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Materials science: Membrane magic
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Biophysics: Joint effort bends membrane
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Fluid dynamics: Supersonic splash
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Cell mechanics and the cytoskeleton
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Strong crystal size effect on deformation twinning
Qian Yu, Zhi-Wei Shan, Ju Li, Xiaoxu Huang, Lin Xiao, Jun Sun & Evan Ma
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High-water-content mouldable hydrogels by mixing clay and a dendritic
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Kou Okuro, Kazushi Kinbara & Takuzo Aida
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Broken rotational symmetry in the pseudogap phase of a high-Tc
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R. Daou, J. Chang, David LeBoeuf, Olivier Cyr-Choiniere, Francis
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Many-body effects in electronic bandgaps of carbon nanotubes
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Portrait of the potential barrier at metal-organic nanocontacts
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Towards a quantum resistance standard based on epitaxial graphene
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High-reflectivity high-resolution X-ray crystal optics with diamonds
Yuri V. Shvyd'ko, Stanislav Stoupin, Alessandro Cunsolo,
Ayman H. Said, Xianrong Huang
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Laser cooling of solids to cryogenic temperatures
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Active magneto-plasmonics in hybrid metal�ferromagnet structures
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Multimeric small interfering ribonucleic acid for highly efficient
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Atomic structure of conducting nanofilaments in TiO2 resistive
switching memory
Deok-Hwang Kwon, Kyung Min Kim, Jae Hyuck Jang, Jong Myeong Jeon,
Min Hwan Lee, Gun Hwan Kim, Xiang-Shu Li, Gyeong-Su Park, Bora Lee,
Seungwu Han, Miyoung Kim & Cheol Seong Hwang
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Naturally occurring resonators in random lasing of [pi]-conjugated
polymer films
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An ultra-small, low-power, all-optical flip-flop memory on a silicon chip
Liu Liu, Rajesh Kumar, Koen Huybrechts, Thijs Spuesens, G�nther Roelkens,
Erik-Jan Geluk, Tjibbe de Vries, Philippe Regreny, Dries Van Thourhout,
Roel Baets, et al.
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International Stem Cell Corporation Announces Shareholder Conference Call

Release #:1468-74258-rl-434148:

International Stem Cell Corporation Announces Shareholder Conference Call ISCO Chairman Kenneth Aldrich to Discuss "State of the Company" International Stem Cell Corporation (OTCBB:ISCO), a California-based biotechnology company creating human stem cell lines from unfertilized eggs, today announced that it is has scheduled a conference call for February 5, 2010 at 10:00 a.m. PST. ISCO Chairman Mr. Kenneth Aldrich will discuss both the present status of the company and its vision for the coming year. The dial-in number for participants is 1 (800) 774-6070 and the pass code ID is 8273 225#. An alternate dial-in number is 1 (630) 691-2753 and the pass code will be the same for both numbers. A replay of the call will be available via the Investor Relations link on the company's web site at: http://www.internationalstemcell.com. ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB) International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO's core technology, parthenogenesis, results in the creation of parthenogenetic human stem cells from unfertilized eggs (oocytes). Like embryonic stem cells (ESCs), hpSCs are pluripotent (i.e. have the capacity to become almost any cell type in the body), yet avoid ethical issues associated with use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO's website, www.internationalstemcell.com. To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0. FORWARD-LOOKING STATEMENTS: Statements pertaining to anticipated future financial and/or operating results, future growth in research, technology, clinical development and potential joint venture and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements. Key Words: Stem Cells, Biotechnology, Parthenogenesis International Stem Cell Corporation Kenneth C. Aldrich, Chairman 760-940-6383 kaldrich@intlstemcell.com Or International Stem Cell Corporation Jeffrey Janus, Sr. VP, Operations President & CEO, Lifeline Cell Technology 760-940-6383 jjanus@intlstemcell.com

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Nature 28 January 2010 Volume 463 Number 7280 pp401-578

NATURE

28 January 2010 Volume 463 Number 7280, pp 401 - 578

Visit Nature online to browse the journal.

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----------------------
EDITORIALS
----------------------
Learning to share p401
By opening up its database of potential malaria drugs, GlaxoSmithKline
has blazed a path that other pharmaceutical companies should follow.
doi:10.1038/463401a
http://links.ealert.nature.com/ctt?kn=93&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Valid concerns pp401-402
The reporting of candidate biomarkers for disease must be rigorous
to drive translational research.
doi:10.1038/463401b
http://links.ealert.nature.com/ctt?kn=102&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

False alarms p402
British scientists must adopt a positive tone if they hope to
protect their gains in funding.
doi:10.1038/463402a
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----------------------
RESEARCH HIGHLIGHTS
----------------------
Genetics: Protein's billion-year history p404
doi:10.1038/463404a
http://links.ealert.nature.com/ctt?kn=66&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Material science: Speedy silk imprinting p404
doi:10.1038/463404b
http://links.ealert.nature.com/ctt?kn=71&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Biomaterials: Super snail shells p404
doi:10.1038/463404c
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Regenerative biology: New nerve cells connect p404
doi:10.1038/463404d
http://links.ealert.nature.com/ctt?kn=82&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Vascular biology: Hearty hormones pp404-405
doi:10.1038/463404e
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Astronomy: Hot spectra p405
doi:10.1038/463405a
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Neurobiology: Prions at work p405
doi:10.1038/463405b
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Atmospheric science: Stronger storms p405
doi:10.1038/463405c
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Cancer biology: Weighted cancer risk p405
doi:10.1038/463405d
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----------------------
JOURNAL CLUB
----------------------
Journal club p405
Jay Shendure
doi:10.1038/463405e
http://links.ealert.nature.com/ctt?kn=117&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
NEWS
----------------------
News briefing: 28 January 2010 pp406-407
The week in science
doi:10.1038/463406a
http://links.ealert.nature.com/ctt?kn=156&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Icy hunt for old air pp408-409
Antarctic drilling project aims for a definitive record of climate.
Chaz Firestone
doi:10.1038/463408a
http://links.ealert.nature.com/ctt?kn=266&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Altered microbe makes biofuel p409
Bacterium could work directly on grass or crop waste.
Jeff Tollefson
doi:10.1038/463409a
http://links.ealert.nature.com/ctt?kn=263&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Debt crisis threatens UK science pp410-411
As Britain's researchers face fierce budget cuts, Nature finds out
how labs are preparing for hard times.
Geoff Brumfiel
doi:10.1038/463410a
http://links.ealert.nature.com/ctt?kn=261&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Stem-cell line given the nod p411
NIH moves to approve cells in limbo after rule change.
Brendan Borrell
doi:10.1038/463411a
http://links.ealert.nature.com/ctt?kn=259&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Lawsuit rekindles gene-patent debate p413
Criticism of exclusive licences puts university policies in the
spotlight.
Brendan Borrell
doi:10.1038/463413a
http://links.ealert.nature.com/ctt?kn=299&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

What will the next solar cycle bring? p414
Orbiting mission will probe the Sun's activity, including flares
that can disrupt electricity grids.
Lizzie Buchen
doi:10.1038/463414a
http://links.ealert.nature.com/ctt?kn=297&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Aid fund faces cash crunch p415
Fight against tuberculosis, malaria and AIDS under threat
from success.
Declan Butler
doi:10.1038/463415a
http://links.ealert.nature.com/ctt?kn=294&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Correction p415
doi:10.1038/463415b
http://links.ealert.nature.com/ctt?kn=279&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
NEWS FEATURES
----------------------
Literature mining: Speed reading pp416-418
Scientists are struggling to make sense of the expanding scientific
literature. Corie Lok asks whether computational tools can do the
hard work for them.
Corie Lok
doi:10.1038/463416a
http://links.ealert.nature.com/ctt?kn=285&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Planetary science: A whiff of mystery on Mars pp420-421
The surprising discovery of methane in Mars's atmosphere could be a
sign of life there. Researchers are now working out how to find its
source,
reports Katharine Sanderson.
doi:10.1038/463420a
http://links.ealert.nature.com/ctt?kn=267&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Translational research: Talking up translation pp422-423
Alan Ashworth took a cancer drug from Petri dish to patients in near
record speed. Daniel Cressey meets a biologist who is evangelical
about translational research.
Daniel Cressey
doi:10.1038/463422a
http://links.ealert.nature.com/ctt?kn=269&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
CORRESPONDENCE
----------------------
Local priorities can be too parochial for biodiversity p424
Reed F. Noss
doi:10.1038/463424a
http://links.ealert.nature.com/ctt?kn=38&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Psychiatry: medicine benefits from cultural and personal insights p424
Ellen Rubinstein
doi:10.1038/463424b
http://links.ealert.nature.com/ctt?kn=33&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Psychiatry: Brazil debates dismantling all mental hospitals p424
Alvaro Machado Dias
doi:10.1038/463424c
http://links.ealert.nature.com/ctt?kn=35&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Mind the gap: future depends on sciences and humanities p425
Adrian D. Manning and Joern Fischer
doi:10.1038/463425a
http://links.ealert.nature.com/ctt?kn=29&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Mind the gap: social sciences can reveal community needs p425
Chris Morris
doi:10.1038/463425b
http://links.ealert.nature.com/ctt?kn=31&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Safeguarding the integrity of protein archive p425
Helen M. Berman et al.
doi:10.1038/463425c
http://links.ealert.nature.com/ctt?kn=55&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Science friction as fantasy irritates religious sensibilities p425
Denis Alexander
doi:10.1038/463425d
http://links.ealert.nature.com/ctt?kn=53&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
OPINION
----------------------
Research on global sun block needed now pp426-427
Geoengineering studies of solar-radiation management should begin
urgently, argue David W. Keith, Edward Parson and M. Granger Morgan
-- before a rogue state decides to act alone.
David W. Keith, Edward Parson and M. Granger Morgan
doi:10.1038/463426a
http://links.ealert.nature.com/ctt?kn=51&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
BOOKS AND ARTS
----------------------
On the shoulders of giants p429
A volume of essays celebrating 350 years of Britain's Royal Society
highlights the continuing gulf between science and the public,
says John Gribbin.
John Gribbin reviews Seeing Further: The Story of Science and the
Royal Society by Bill Bryson
doi:10.1038/463429a
http://links.ealert.nature.com/ctt?kn=49&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Brainy reads p430
Joanne Baker
doi:10.1038/463430b
http://links.ealert.nature.com/ctt?kn=47&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Deciphering the printed word pp430-431
John Gabrieli reviews Reading in the Brain: The Science and
Evolution of a Human Invention by Stanislas Dehaene
doi:10.1038/463430a
http://links.ealert.nature.com/ctt?kn=8&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Across the cultural divide p431
Richard Taylor reviews The Neural Imagination: Aesthetic and
Neuroscientific Approaches to the Arts by Irving Massey
doi:10.1038/463431a
http://links.ealert.nature.com/ctt?kn=11&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Tricks of the stage p432
A restored imperial theatre in China reveals how Western techniques
of visual perspective brought by the Jesuits were adopted by an
eighteenth-century Chinese emperor, explains Martin Kemp.
Martin Kemp
doi:10.1038/463432a
http://links.ealert.nature.com/ctt?kn=2&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Biomechanics: Barefoot running strikes back pp433-434
Detailed analyses of foot kinematics and kinetics in barefoot and shod
runners offer a refined understanding of bipedalism in human evolution.
This research will also prompt fresh studies of running injuries.
William L. Jungers
doi:10.1038/463433a
http://links.ealert.nature.com/ctt?kn=4&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Immunology: The expanding TH2 universe pp434-435
TH2 growth factors, which are involved in allergy and in defence
against parasites, are produced by many different cell types,
including a newly identified population found in fat-associated
lymph clusters in the abdomen.
Warren Strober
doi:10.1038/463434a
http://links.ealert.nature.com/ctt?kn=7&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Organometallic chemistry: Carbon-carbon bonds get a break pp435-436
As a rule of thumb, carbon-carbon bonds are not easily broken. But
a tungsten complex has been found to break a particularly strong
carbon-carbon bond, opening up fresh opportunities for organic
synthesis.
Alan S. Goldman
doi:10.1038/463435a
http://links.ealert.nature.com/ctt?kn=26&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

50 & 100 years ago p436
doi:10.1038/463436b
http://links.ealert.nature.com/ctt?kn=18&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Cell biology: Stability in times of stress pp436-438
Damaged lysosomes, the principal degradative organelles, can kill
a cell. A stress-induced protein controls lysosome stability,
providing a potential target to treat lysosome-related diseases
and cancer.
Ibolya Horvath and Laszlo Vigh
doi:10.1038/463436a
http://links.ealert.nature.com/ctt?kn=16&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Carbon cycle: Degrees of climate feedback pp438-439
A probabilistic analysis of climate variation during the period
AD 1050-1800 refines available estimates of the influence of
temperature change on the concentration of carbon dioxide in the
atmosphere.
Hugues Goosse
doi:10.1038/463438a
http://links.ealert.nature.com/ctt?kn=304&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Fluid dynamics: Supersonic splash p439
Andrew Mitchinson
doi:10.1038/463439b
http://links.ealert.nature.com/ctt?kn=313&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Biophysics: Joint effort bends membrane pp439-440
The curvature of cellular membranes is generated by proteins and
lipids. A synthetic experimental system allows the interplay
between protein- and lipid-generated bending mechanisms to be
studied directly.
Michael M. Kozlov
doi:10.1038/463439a
http://links.ealert.nature.com/ctt?kn=309&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
NEWS AND VIEWS Q&A
----------------------
Physics: Quantum computing pp441-443
The race is on to build a computer that exploits quantum mechanics.
Such a machine could solve problems in physics, mathematics and
cryptography that were once thought intractable, revolutionizing
information technology and illuminating the foundations of physics.
But when?
Emanuel Knill
doi:10.1038/463441a
http://links.ealert.nature.com/ctt?kn=320&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
INSIGHT
----------------------
EDITORIAL
Building a Cell p445
Deepa Nath, Ritu Dhand and Angela K. Eggleston
doi:10.1038/463445a
http://links.ealert.nature.com/ctt?kn=317&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

REVIEW ARTICLE
Towards building a chromosome segregation machine pp446-456
Kerry Bloom and Ajit Joglekar
doi:10.1038/nature08912
Abstract: http://links.ealert.nature.com/ctt?kn=319&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=272&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Expansion of the eukaryotic proteome by alternative splicing pp457-463
Timothy W. Nilsen and Brenton R. Graveley
doi:10.1038/nature08909
Abstract: http://links.ealert.nature.com/ctt?kn=321&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=286&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

The endocytic matrix pp464-473
Giorgio Scita and Pier Paolo Di Fiore
doi:10.1038/nature08910
Abstract: http://links.ealert.nature.com/ctt?kn=316&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=288&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Chromatin remodelling during development pp474-484
Lena Ho and Gerald R. Crabtree
doi:10.1038/nature08911
Abstract: http://links.ealert.nature.com/ctt?kn=218&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=245&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Cell mechanics and the cytoskeleton pp485-492
Daniel A. Fletcher and R. Dyche Mullins
doi:10.1038/nature08908
Abstract: http://links.ealert.nature.com/ctt?kn=219&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=238&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Systemic signals regulate ageing and rejuvenation of blood stem cell
niches pp495-500
Age-associated changes in stem cell supportive niche cells are shown
to deregulate normal haematopoiesis by causing haematopoietic stem
cell dysfunction. Age-dependent defects in niche cells are systemically
regulated and can be reversed by exposure to a young circulation or by
neutralization of the conserved longevity regulator, insulin-like
growth factor-1, in the marrow microenvironment.
Shane R. Mayack, Jennifer L. Shadrach, Francis S. Kim and Amy J. Wagers
doi:10.1038/nature08749
Abstract: http://links.ealert.nature.com/ctt?kn=220&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=232&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Targeting Bcr-Abl by combining allosteric with ATP-binding-site
inhibitors pp501-506
GNF-2 is a recently discovered, selective allosteric Bcr-Abl inhibitor.
Solution NMR, X-ray crystallography, mutagenesis and hydrogen exchange
mass spectrometry are now used to show that GNF-2 binds to the
myristate-binding site of Abl, leading to changes in the structural
dynamics of the ATP-binding site. The results show that the combination
of allosteric and ATP-competitive inhibitors can overcome resistance to
either agent alone.
Jianming Zhang et al.
doi:10.1038/nature08675
Abstract: http://links.ealert.nature.com/ctt?kn=221&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=115&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Structure of a bacterial homologue of vitamin K epoxide reductase pp507-512
The [gamma]-carboxylation of many blood coagulation factors relies
on the generation of vitamin K hydroquinone by the enzyme vitamin K
epoxide reductase (VKOR), of which the anticoagulant warfarin is an
inhibitor. Here, the X-ray crystal structure of a bacterial homologue
of VKOR is presented; the results have implications for the mechanism
of action of mammalian VKOR and explain how mutations can cause warfarin
resistance.
Weikai Li et al.
doi:10.1038/nature08720
Abstract: http://links.ealert.nature.com/ctt?kn=214&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=124&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
LETTERS
----------------------
A relativistic type Ibc supernova without a detected [gamma]-ray
burst pp513-515
Long duration [gamma]-ray bursts mark the explosive death of some
massive stars and are a rare sub-class of type Ibc supernovae.
To date, central-engine-driven supernovae have been discovered
exclusively through their [gamma]-ray emission, yet it is expected
that a larger population goes undetected. The discovery of luminous
radio emission from the seemingly ordinary type Ibc supernova SN 2009bb,
which requires a substantial relativistic outflow powered by a central
engine, is now reported.
A. M. Soderberg et al.
doi:10.1038/nature08714
Abstract: http://links.ealert.nature.com/ctt?kn=215&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

A mildly relativistic radio jet from the otherwise normal type Ic
supernova 2007gr pp516-518
Type Ic supernovae have drawn attention since 1998 owing to their
sparse association with long duration [gamma]-ray bursts (GRBs).
Although the GRB central engine generates ultra-relativistic jets,
no relativistic outflows have yet been found in type Ib/c supernovae
explosions. Here, radio observations reveal a mildly relativistic
expansion in a nearby type Ic supernova, SN 2007gr.
Z. Paragi et al.
doi:10.1038/nature08713
Abstract: http://links.ealert.nature.com/ctt?kn=216&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Broken rotational symmetry in the pseudogap phase of a high-Tc
superconductor pp519-522
In the study of high-transition-temperature (high-Tc) copper oxide
superconductors, a fundamental question is what symmetries are broken
when the pseudogap phase sets in below a temperature T*. A large
in-plane anisotropy of the Nernst effect is now observed in a high-Tc
copper oxide superconductor that sets in precisely at T* throughout
the doping phase diagram. It is concluded that the pseudogap phase is
an electronic state that strongly breaks four-fold rotational symmetry.
R. Daou et al.
doi:10.1038/nature08716
Abstract: http://links.ealert.nature.com/ctt?kn=217&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Cleaving carbon-carbon bonds by inserting tungsten into unstrained
aromatic rings pp523-526
The transformation of petroleum-derived feedstocks into useful chemicals
often requires controllable cleavage of C-H or C-C bonds. There are many
examples of achieving this through the oxidative addition of C-H bonds
to metal centres, but analogous transformations of C-C bonds are rare.
Here, using a tungsten centre and exploiting the formation of an unusual
chelating ligand, a strong C-C bond is cleaved; other metal centres with
suitable ancillary ligands could perform the same function.
Aaron Sattler and Gerard Parkin
doi:10.1038/nature08730
Abstract: http://links.ealert.nature.com/ctt?kn=223&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=185&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Ensemble reconstruction constraints on the global carbon cycle
sensitivity to climate pp527-530
Anthropogenic global warming is likely to be amplified by positive
feedback from the global carbon cycle; however, the magnitude of
the climate sensitivity of the global carbon cycle, and thus of its
positive feedback strength, is under debate. By combining a probabilistic
approach with an ensemble of proxy-based temperature reconstructions
and pre-industrial CO2 data from three ice cores, this climate
sensitivity is now shown to be much smaller than previously thought.
David C. Frank et al.
doi:10.1038/nature08769
Abstract: http://links.ealert.nature.com/ctt?kn=224&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=175&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Foot strike patterns and collision forces in habitually barefoot versus
shod runners pp531-535
Although humans have engaged in long-distance running either barefoot
or with minimal footwear for most of human evolutionary history, the
modern running shoe was not invented until the 1970s. Here, runners
who habitually run in sports shoes are shown to run differently to
those who habitually run barefoot, with the latter often landing on
the fore-foot rather than the rear-foot. This strike pattern may have
evolved to protect from some of the impact-related injuries now
experienced by runners.
Daniel E. Lieberman et al.
doi:10.1038/nature08723
Abstract: http://links.ealert.nature.com/ctt?kn=226&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=180&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Chimpanzee and human Y chromosomes are remarkably divergent in structure
and gene content pp536-539
Little is known about the recent evolution of the Y chromosome because
only the human Y chromosome has been fully sequenced. The sequencing
of the male-specific region of the Y chromosome (MSY) in the chimpanzee
and comparison between the MSYs of the two species now reveals that
they differ radically in sequence structure and gene content, indicating
rapid evolution over the past 6 million years.
Jennifer F. Hughes et al.
doi:10.1038/nature08700
Abstract: http://links.ealert.nature.com/ctt?kn=244&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=181&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Innate production of TH2 cytokines by adipose tissue-associated
c-Kit+Sca-1+ lymphoid cells pp540-544
Innate immune responses are important in the early phases of infection;
for example, natural killer cells are innate lymphocytes that rapidly
exhibit cytotoxic activities against virus-infected cells and produce
various cytokines. Here, a new type of innate lymphocyte is found in
a novel lymphoid structure associated with adipose tissues in the
peritoneal cavity. These cells, termed FALC (fat-associated lymphoid
cluster) cells, produce TH2 cytokines and support B1 cells.
Kazuyo Moro et al.
doi:10.1038/nature08636
Abstract: http://links.ealert.nature.com/ctt?kn=246&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=199&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Interaction between RasV12 and scribbled clones induces tumour growth
and invasion pp545-548
In human tumours, complex cell interactions in the tumour and its
microenvironment are thought to have an important role in tumorigenesis
and cancer progression. In a genetically well-defined model system
in Drosophila, clones of cells bearing different mutations are now
shown to cooperate to promote tumour growth and invasion. This
interaction involves JNK signalling propagation and JNK-induced
upregulation of JAK/STAT-activating cytokines.
Ming Wu, Jose Carlos Pastor-Pareja and Tian Xu
doi:10.1038/nature08702
Abstract: http://links.ealert.nature.com/ctt?kn=239&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=196&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated
lysosomal pathology pp549-553
Heat shock protein 70 (Hsp70) is a molecular chaperone which, by
inhibiting lysosomal membrane permeabilization, promotes the survival
of stressed cells. Hsp70 is now shown to stabilize lysosomes by
binding to an anionic phospholipid, BMP, resulting in stimulation of
acid sphingomyelinase (ASM) activity. Notably, the decreased ASM
activity and lysosomal stability seen in patients with Niemann-Pick
disease can be corrected by treatment with recombinant Hsp70.
Thomas Kirkegaard et al.
doi:10.1038/nature08710
Abstract: http://links.ealert.nature.com/ctt?kn=241&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=157&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

A role for the elongator complex in zygotic paternal genome
demethylation pp554-558
After fertilization in mammals, the maternal and paternal genomes
undergo epigenetic reprogramming to prepare for the transition from
germ cell to somatic cell transcription programs. One of the events
that takes place is the demethylation of the paternal genome. To
identify the factors involved in this process, a live cell imaging
system is now used to monitor the paternal DNA methylation state in
zygotes; Elp3, a component of the elongator complex, is found to have
an important role.
Yuki Okada et al.
doi:10.1038/nature08732
Abstract: http://links.ealert.nature.com/ctt?kn=235&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=158&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Microbial production of fatty-acid-derived fuels and chemicals from
plant biomass pp559-562
The increasing cost of energy and concerns about the environment have
emphasized the need to find new sources of fuel, with the microbial
production of high-energy fuels a promising approach. Here, Escherichia
coli is engineered to produce more complex biofuels -- fatty esters
(biodiesel), fatty alcohols and waxes -- directly from simple sugars.
Some cells are further engineered to express hemicellulases, a step
towards producing these compounds directly from hemicellulose.
Eric J. Steen et al.
doi:10.1038/nature08721
Abstract: http://links.ealert.nature.com/ctt?kn=237&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=153&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

DNMT1 maintains progenitor function in self-renewing somatic tissue
pp563-567
Progenitor cells sustain the capacity of self-renewing tissues for
proliferation while suppressing cell cycle exit and terminal
differentiation. DNA methylation is one potential epigenetic mechanism
for the cellular memory needed to preserve the somatic progenitor state
through cell divisions. The DNA methyltransferase 1 and other regulators
of DNA methylation are now shown to be essential for epidermal progenitor
cell function.
George L. Sen et al.
doi:10.1038/nature08683
Abstract: http://links.ealert.nature.com/ctt?kn=231&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=171&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Self versus non-self discrimination during CRISPR RNA-directed immunity
pp568-571
Distinguishing self from non-self is a vital function for immune
systems to repel invaders without inducing autoimmunity. One system,
which protects bacteria and archaea from invasion by phage and plasmid
DNA, involves clustered, regularly interspaced, short palindromic repeat
(CRISPR) loci. Here, in Staphylococcus epidermidis, the mechanism of
CRISPR self/non-self discrimination is defined.
Luciano A. Marraffini and Erik J. Sontheimer
doi:10.1038/nature08703
Abstract: http://links.ealert.nature.com/ctt?kn=233&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=166&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
NATUREJOBS
----------------------
News
Self-doubt plagues female astronomers p574
Study seeks insight into astronomers' career paths.
Karen Kaplan
doi:10.1038/nj7280-574a
http://links.ealert.nature.com/ctt?kn=135&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Careers Q&A
Richard Zare p574
Chemist Richard Zare is winner of the 2010 Priestley Medal and the
2009 Presidential Award for Excellence in Science, Mathematics and
Engineering Mentoring.
Virginia Gewin
doi:10.1038/nj7280-574b
http://links.ealert.nature.com/ctt?kn=138&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

News
China's research rise p575
Number of domestic researchers draws level with Europe and the
United States.
Gene Russo
doi:10.1038/nj7280-575a
http://links.ealert.nature.com/ctt?kn=136&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

In Brief
From lab to laundry p575
University benefits should include housework help, study suggests.
doi:10.1038/nj7280-575b
http://links.ealert.nature.com/ctt?kn=146&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

In Brief
Responsible work plans p575
Booklet offers tips to help animal researchers avoid action by
activists.
doi:10.1038/nj7280-575c
http://links.ealert.nature.com/ctt?kn=143&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

In Brief
India offers foreign grant p575
Bangalore institute uses fellowship to entice young international
researchers.
doi:10.1038/nj7280-575d
http://links.ealert.nature.com/ctt?kn=160&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
FUTURES
----------------------
Quinquereme of Nineveh p578
The perils of long-haul travel.
Chaz Brenchley
doi:10.1038/463578a
http://links.ealert.nature.com/ctt?kn=163&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

----------------------
Advance Online Publication
----------------------
27 January 2010
Fossilized melanosomes and the colour of Cretaceous dinosaurs
and birds
Fucheng Zhang et al.
doi:10.1038/nature08740
Abstract: http://links.ealert.nature.com/ctt?kn=278&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

The cells and peripheral representation of sodium taste in mice
Jayaram Chandrashekar et al.
doi:10.1038/nature08783
Abstract: http://links.ealert.nature.com/ctt?kn=287&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=287&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

Direct conversion of fibroblasts to functional neurons by defined
factors
Thomas Vierbuchen et al.
doi:10.1038/nature08797
Abstract: http://links.ealert.nature.com/ctt?kn=292&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=292&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

24 January 2010
Animal cryptochromes mediate magnetoreception by an unconventional
photochemical mechanism
Robert J. Gegear, Lauren E. Foley, Amy Casselman and Steven M. Reppert
doi:10.1038/nature08719
Abstract: http://links.ealert.nature.com/ctt?kn=303&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=303&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

A bony connection signals laryngeal echolocation in bats
Nina Veselka et al.
doi:10.1038/nature08737
Abstract: http://links.ealert.nature.com/ctt?kn=307&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=307&m=34584668&r=MjA1NTkxMDA2MAS2&b=2&j=NjYyMTczMDYS1&mt=1&rt=0

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Editors: Grant Gallagher, HUMIGEN - The Institute for
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2008 Impact Factor 4.006*
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February 2010 Volume 7 Number 2

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----------------------
RESEARCH HIGHLIGHTS
----------------------
Coronary artery disease: Niacin combined with statin treatment reduces
carotid intima-media thickness in patients at risk of heart disease
p59 | doi:10.1038/nrcardio.2009.236
http://links.ealert.nature.com/ctt?kn=3&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Heart failure: Benefits of dietary advice in patients with HFpSF
p60 | doi:10.1038/nrcardio.2009.238
http://links.ealert.nature.com/ctt?kn=6&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Temporal changes in SCD predictors
p60 | doi:10.1038/nrcardio.2009.240
http://links.ealert.nature.com/ctt?kn=15&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Acute coronary syndromes: Atorvastatin treatment 24 h before stenting
prevents periprocedural MI
p61 | doi:10.1038/nrcardio.2009.237
http://links.ealert.nature.com/ctt?kn=20&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Coronary artery disease: Cardiovascular risk is increasing among
middle-aged women
p61 | doi:10.1038/nrcardio.2009.239
http://links.ealert.nature.com/ctt?kn=10&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Predictor of mortality after PCI?
p61 | doi:10.1038/nrcardio.2009.241
http://links.ealert.nature.com/ctt?kn=14&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Cardiac resuscitation: Intravenous medical therapy during CPR-do we need
better drugs to realize long-term benefits?
p62 | doi:10.1038/nrcardio.2009.242
http://links.ealert.nature.com/ctt?kn=18&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Vascular disease: Benefits of raising HDL-cholesterol levels
p62 | doi:10.1038/nrcardio.2009.243
http://links.ealert.nature.com/ctt?kn=26&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Heart Failure: Hospital-at-home care for CHF-verdict, 'not proven'
Karen J. Hogg and John J. V. McMurray
p63 | doi:10.1038/nrcardio.2009.225
Tibaldi et al. have addressed the feasibility of 'hospital-at-home'
care as an alternative to hospitalization for elderly patients with
chronic heart failure. Although this study addresses an important subject,
and the results are intriguing, extrapolation to other settings may not
be easy. The study should, therefore, be regarded as hypothesis-generating
rather than definitive.
http://links.ealert.nature.com/ctt?kn=28&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Surgery: On-pump or off-pump CABG surgery-under the spotlight
Robert A. Guyton
p64 | doi:10.1038/nrcardio.2009.234
The ROOBY investigators found off-pump CABG surgery to be significantly
inferior to on-pump surgery with regard to 1 year mortality,
revascularization, or new myocardial infarction. This unexpected finding
could be related to the fact that most of the participating surgeons
were experienced in on-pump CABG surgery, but relatively inexperienced
in the off-pump procedure.
http://links.ealert.nature.com/ctt?kn=31&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Hypertension: Cardiac hypertrophy as a target of antihypertensive therapy
Alberto Zanchetti
p66 | doi:10.1038/nrcardio.2009.229
Two large trials were conducted to evaluate the effects of an
angiotensin-converting-enzyme inhibitor, an angiotensin-receptor blocker
or a combination of both in high cardiovascular risk patients. A decrease
in the prevalence of left ventricular hypertrophy (LVH) was reported,
but this did not translate into a prognostic benefit. New-onset LVH was
associated with an increase in cardiovascular events.
http://links.ealert.nature.com/ctt?kn=42&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Pharmacotherapy: Intracoronary streptokinase in acute myocardial infarction
Paul W. Armstrong
p67 | doi:10.1038/nrcardio.2009.230
Despite angiographically successful primary percutaneous coronary
intervention (PCI) in patients with ST-segment elevation myocardial
infarction, microcirculatory failure is common and leads to an increased
risk of morbidity and mortality. The administration of intracoronary
streptokinase immediately after PCI may improve outcomes and provides
a promising potential therapy for the future.
http://links.ealert.nature.com/ctt?kn=49&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Device therapy: Defibrillators-a shocking therapy for cardiomyopathy?
John G. F. Cleland and Laszlo Buga
p69 | doi:10.1038/nrcardio.2009.233
Defibrillators, with or without cardiac resynchronization therapy, can
reduce the rate of sudden death. However, shocks are unpleasant, often
unnecessary, and can damage myocardium or defibrillator leads, thereby
increasing morbidity and mortality and detracting from the benefits of
this therapy. Conservative programming of devices may reduce such risks.
http://links.ealert.nature.com/ctt?kn=47&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

NEW from Nature Reviews Cardiology: Molecular Imaging Series
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Reviews and Perspective articles from leading specialists in cardiovascular
imaging.

The Molecular Imaging Series covers every aspect of the visualization
of physiological and pathophysiological processes at the cellular and
molecular levels.With each issue of Nature Reviews Cardiology until
spring 2010, a molecular-imaging-focused paper will be published in
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----------------------
REVIEWS
----------------------
Emerging ventricular assist devices for long-term cardiac support
Rajan Krishnamani, David DeNofrio and Marvin A. Konstam
Published online: 12 January 2010
p71 | doi:10.1038/nrcardio.2009.222
In this Review, the authors discuss innovations in ventricular assist
devices technology as an alternative therapeutic option for patients
with advanced heart failure. In particular, they focus on the newer,
third-generation VADs that are currently being developed for mechanical
cardiac support.
Abstract: http://links.ealert.nature.com/ctt?kn=80&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Monocytes in atherosclerosis: subsets and functions
Kevin J. Woollard and Frederic Geissmann
Published online: 12 January 2010
p77 | doi:10.1038/nrcardio.2009.228
Plaque macrophages account for the majority of leukocytes in atherosclerotic
plaques, and are believed to differentiate from monocytes recruited from
circulating blood. In this Review, Dr. Woollard and Dr. Geissmann discuss
the heterogenous population of monocytes involved in the pathogenesis of
atherosclerosis.
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Effects of cardiac rehabilitation referral strategies on referral and
enrollment rates
Shannon Gravely-Witte, Yvonne W. Leung, Rajiv Nariani, Hala Tamim, Paul Oh,
Victoria M. Chan and Sherry L. Grace
Published online: 08 December 2009
p87 | doi:10.1038/nrcardio.2009.223
Cardiac rehabilitation can reduce cardiovascular risk factors and prevent
cardiac morbidity and mortality as part of a comprehensive
secondary-prevention strategy. However, evidence indicates that cardiac
rehabilitation programs are currently underutilized, primarily because
many patients are not referred to these programs by their health-care
providers. The authors of this Review examine how novel referral
strategies can help to improve cardiac rehabilitation referral and
enrollment rates.
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

Article series: Molecular Imaging
Imaging approaches for the study of cell-based cardiac therapies
Joe F. Lau, Stasia A. Anderson, Eric Adler and Joseph A. Frank
Published online: 22 December 2009
p97 | doi:10.1038/nrcardio.2009.227
A major obstacle in cardiac stem cell investigations is the ability to
monitor cell engraftment and survival following implantation within the
myocardium. In this Review, Dr. Lau and colleagues examine cardiac
cellular imaging modalities, including the combinatorial use of several
probes in multimodality imaging. Their discussion focuses on data from
the past 5 years.
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

The conundrum of detecting stable angina pectoris in the community setting
Mary Russell, Marie Williams, Esther May and Simon Stewart
Published online: 22 December 2009
p106 | doi:10.1038/nrcardio.2009.226
Stable angina pectoris is a major contributor to disability in patients
with coronary artery disease. Accurate identification of the extent and
distribution of stable angina pectoris could vastly improve management
and secondary prevention of underlying coronary artery disease. This
Review assesses the strengths and limitations of contemporary methods
for detection.
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=34583546&r=MTc2NDI1MzEzNAS2&b=2&j=NjYyMDQ3NzUS1&mt=1&rt=0

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