Cord Blood America (OTC BB: CBAI) Las Vegas Update

Release #:812-70381-em-434148:

Cord Blood America (OTC BB: CBAI) Las Vegas Update Cord Blood America Opens Las Vegas Cryogenic Laboratory; Consolidates Offices in Nevada LAS VEGAS, Sept. 30 /PRNewswire-FirstCall/ -- Cord Blood America, Inc. (OTC Bulletin Board: CBAI - News), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com ) focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally, said today that it is opening its new Corporate headquarters and cryogenic research and storage laboratory in Las Vegas, as planned, the first week of October. Matthew Schissler, founder and CEO, said the 17,000 square foot facility is perhaps the one of the largest cryogenic storage facility in the U.S. "Our goal is to ensure CBAI becomes one of the largest cryogenic storage companies in the world," Cord Blood America's founder said. "The new facility will significantly reduce the cost of sales while increasing gross profits, because we no longer have to outsource the storage and because of its proximity to one of the nation's busiest airports," Mr. Schissler said. "It allows us to expand our arsenal, storing other stem cells such as adipose tissue and peripheral blood stem cells. Also, we will explore wholesale storage contracts with other companies for a profit, as well as store other medical necessities including plasma or tissue. Having the new facility will move CBAI away from being strictly a business to consumer sales company of cord blood stem cell storage. CBAI will have the ability to offer multiple consumer storage products, while adding additional business- to-business revenue streams, with possibly an additional layer of research and development." "We anticipate processing of stem cells in the new lab to commence sometime in the fourth quarter of 2009. We are confident that this new facility will assist Cord Blood America to become a giant in the cryogenic storage sector," Mr. Schissler said. About Cord Blood America Cord Blood America (OTC Bulletin Board: CBAI - News) is the parent company of CorCell, which facilitates umbilical cord blood stem cell preservation for expectant parents and their children. Its mission is to be the most respected stem cell preservation company in the industry. Collected through a safe and non-invasive process, cord blood stem cells offer a powerful and potentially life-saving resource for treating a growing number of ailments, including cancer, leukemia, blood, and immune disorders. To find out more about Cord Blood America, Inc. (OTC Bulletin Board: CBAI - News), visit our website at www.corcell.com. For investor information, visit www.cordblood-america.com. Forward-Looking Statements Some statements made in this press release are forward-looking statements, which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. We use words such as "anticipate,'' "believe,'' "expect,'' "future,'' "intend,'' "plan,'' and similar expressions to identify forward-looking statements. These statements including those related to the growth of the industry, new stem cell treatments, and the Company's performance, are only predictions and are subject to certain risks, uncertainties and assumptions. Additional risks are identified and described in the Company's public filings with the Securities and Exchange Commission. Statements made herein are as of the date of this press release and should not be relied upon as of any subsequent date. The Company's past performance is not necessarily indicative of its future performance. The Company does not undertake, and the Company specifically disclaims any obligation to update any forward-looking statements to reflect occurrences, developments, events, or circumstances after the date of such statement.   CONTACT: Paul Knopick E & E Communications 949/707-5365 pknopick@eandecommunications.com

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Nature Reviews Nephrology - Table of Contents alert Volume 5 Issue 10

NATURE REVIEWS NEPHROLOGY

October 2009 Volume 5 Number 10

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=====================================================================

Editorial: The renal complications of HIV
Susan J. Allison
p545 | doi:10.1038/nrneph.2009.152
http://links.ealert.nature.com/ctt?kn=38&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Chronic kidney disease: Hemodialysis and transplantation do not preclude
influenza vaccination
p547 | doi:10.1038/nrneph.2009.120
http://links.ealert.nature.com/ctt?kn=6&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

Biomarkers: Rapid urine test for kidney disease
p548 | doi:10.1038/nrneph.2009.121
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IN BRIEF
Polycystic kidney disease | Genetics | Dialysis | Biomarkers
p548 | doi:10.1038/nrneph.2009.136
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Chronic kidney disease: Association of FGF23 with left ventricular hypertrophy
p549 | doi:10.1038/nrneph.2009.132
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Transplantation: Dialysis does not increase mortality in patients with
ESRD and heart attack
p549 | doi:10.1038/nrneph.2009.133
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Chronic kidney disease: Parathyroid hormone measurements not useful for
the assessment of bone turnover
p550 | doi:10.1038/nrneph.2009.134
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Transplantation: Low pregnancy rates in kidney transplant recipients
p550 | doi:10.1038/nrneph.2009.135
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----------------------
NEWS AND VIEWS
----------------------
Dialysis: Vascular access: not enough light at the end of the tunnel?
Raymond Vanholder, Francis Verbeke and Wim Van Biesen
p551 | doi:10.1038/nrneph.2009.144
Graft stenosis, which can lead to thrombosis, is a major problem in
hemodialysis patients with arteriovenous grafts. Does anti-aggregation
with dipyridamole and aspirin help to prolong the primary patency of
vascular access grafts?
http://links.ealert.nature.com/ctt?kn=13&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

Biopsy: Observation time after kidney biopsy: when to discharge?
Christina M. Yuan, Rahul M. Jindal and Kevin C. Abbott
p552 | doi:10.1038/nrneph.2009.147
How long should we monitor patients for evidence of significant bleeding
after percutaneous native kidney biopsy? Both cost and safety must be
rigorously considered before recommending a new standard of care.
http://links.ealert.nature.com/ctt?kn=49&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

Transplantation: Kidney or kidney-pancreas transplant for the uremic
diabetic?
David E. R. Sutherland, Angelika C. Gruessner and David M. Radosevich
p554 | doi:10.1038/nrneph.2009.149
Uremic diabetics have better survival rates with a kidney transplant than
on dialysis. Adding a pancreas graft induces insulin independence and if
the graft survives for >1 year, risk-adjusted registry analyses show
improved patient and graft survival. Overall, however, as survival is
similar for kidney-pancreas and kidney transplants alone from deceased
pancreas donors, many questions remain.
http://links.ealert.nature.com/ctt?kn=51&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

Trombotic microangiopathy: Can liver-kidney transplantation cure aHUS?
Hae Il Cheong
p556 | doi:10.1038/nrneph.2009.148
Atypical hemolytic uremic syndrome often progresses to end-stage renal
disease and recurs after kidney transplantation, even with empiric plasma
therapy. Guidelines on the treatment of this devastating disease have now
been published, following a consensus conference in Bergamo, Italy.
http://links.ealert.nature.com/ctt?kn=43&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

Glomerular disease: The Oxford classification-predicting progression
of IgAN
Frank Eitner and Jurgen Floege
p557 | doi:10.1038/nrneph.2009.150
The new Oxford classification of IgA nephropathy has been developed as
a pathological classification system to reliably predict the risk of
disease progression. Future studies need to demonstrate the value of
this classification in directing individualized therapeutic decisions
for patients with IgA nephropathy.
http://links.ealert.nature.com/ctt?kn=45&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

Sepsis: Clearing the blood in sepsis
Jean-Louis Vincent
p559 | doi:10.1038/nrneph.2009.146
The recent EUPHAS trial was stopped early because of reduced mortality
in patients with sepsis treated with polymyxin B hemoperfusion. So should
we rush to offer this technique to all patients with sepsis? Not quite
so fast.
http://links.ealert.nature.com/ctt?kn=40&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

Diagnosis: Should renal biopsies be performed in the very elderly?
J. Ashley Jefferson and Charles E. Alpers
p561 | doi:10.1038/nrneph.2009.145
As the population ages, more elderly people are developing kidney disease.
Nephrologists are often reluctant to perform renal biopsy in elderly
patients, but in many cases, the diagnostic benefits of this procedure
outweigh the risks.
http://links.ealert.nature.com/ctt?kn=57&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

=====================================================================
Focus on: HIV and the kidney
----------------------
REVIEWS
----------------------
The nephrotoxic effects of HAART
Hassane Izzedine, Marianne Harris and Mark A. Perazella
p563 | doi:10.1038/nrneph.2009.142
Highly active antiretroviral therapy (HAART) has a variety of adverse renal
effects. Patients receiving HAART can develop acute kidney injury, which
can progress to chronic kidney disease. HAART also contributes indirectly
to kidney disease by increasing the risk of diabetes and hypertension.
This Review describes the epidemiology, mechanisms and diagnosis of
HAART-related kidney damage, with an emphasis on the preventive management
of risk factors such as intravascular volume depletion and pharmacological
interactions.
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

Controversies in the pathogenesis of HIV-associated renal diseases
Leslie A. Bruggeman and Peter J. Nelson
p574 | doi:10.1038/nrneph.2009.139
The two most common forms of HIV-related renal disease are HIV-associated
nephropathy and a collection of immunoglobulin-related glomerulonephritides
known as HIV immune complex kidney diseases. In this Review, Bruggeman
and Nelson discuss the pathogenesis of these two diseases focusing on
topics that remain points of controversy, such as mechanisms of infection
within the kidney, modeling of disease in rodents, the contribution of
host immune responses, and the source of the proliferating glomerular
epithelial cell.
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

Renal transplantation in patients with HIV
Lynda A. Frassetto, Clara Tan-Tam and Peter G. Stock
p582 | doi:10.1038/nrneph.2009.140
The presence of HIV has historically been viewed as a contraindication
to transplantation because of the risks associated with immunosuppression
in patients who are already immunocompromised, the lack of long-term
outcomes data to justify the use of a limited supply of donor organs, and
the possibility of viral transmission to surgical staff. Frassetto and
colleagues examine the issues surrounding kidney transplantation in patients
with HIV and describe a range of strategies that optimize outcomes in
these individuals.
Abstract: http://links.ealert.nature.com/ctt?kn=17&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

HIV and kidney disease in sub-Saharan Africa
June Fabian and Saraladevi Naicker
p591 | doi:10.1038/nrneph.2009.141
Studies in Africa have reported differing prevalence rates of renal disease
in HIV; however, extrapolation of US statistics suggests that between 770,000
and 2.6 million people in sub-Saharan Africa could have HIV-associated
nephropathy. This Review provides a global overview of HIV-related kidney
disease to set the scene for a detailed analysis of this issue in Africa.
The authors proffer advice on how to prevent or slow progression of renal
disease and outline options for renal replacement therapy.
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

=====================================================================

----------------------
CASE STUDY
----------------------
Lupus activation with cerebritis following pegylated interferon in a
hemodialysis patient
Sanjay Kumar Agarwal, Charanjeet Lal and Sabahat Husain Zaidi
p599 | doi:10.1038/nrneph.2009.137
Interferon, which is widely used to treat chronic hepatitis C virus
infection, plays a critical role in the pathogenesis and perpetuation
of certain autoimmune diseases, including systemic lupus erythematosus.
In this Case Study, Agarwal and colleagues present the case of a patient
on hemodialysis who experienced systemic lupus erythematosus exacerbation
with cerebritis following treatment of her hepatitis C virus infection
with pegylated interferon monotherapy.
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=34085806&r=MTc2NDE4ODIzOQS2&b=2&j=NTg2NzAwNjcS1&mt=1&rt=0

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Nature Methods Contents: October 2009 Volume 6 pp 687 - 781

NATURE METHODS

October 2009 Volume 6 Number 10, pp 687 - 781

Visit Nature Methods online to browse the journal.

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=====================================================================

----------------------
SPECIAL FEATURE
----------------------
Five Year Anniversary Special
Nature Methods celebrates its five year anniversary with commentaries
discussing the impact and progress of methodological developments
in the life sciences. We also include a fun selection of papers and
covers from our pages.
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----------------------
EDITORIAL
----------------------
Special Feature: Five Year Anniversary Special
In celebration of methods p687
doi:10.1038/nmeth1009-687
As evidenced by the cake adorning the cover, Nature Methods is five
years old. To celebrate this anniversary, we look at methodological
development and its role in scientific inquiry.
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----------------------
CORRESPONDENCE
----------------------
Online image analysis software for photoactivation localization
microscopy pp689 - 690
Per Niklas Hedde et al.
doi:10.1038/nmeth1009-689
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My5C: web tools for chromosome conformation capture
tudies pp690 - 691
Bryan R Lajoie, Nynke L van Berkum, Amartya Sanyal and Job Dekker
doi:10.1038/nmeth1009-690
http://links.ealert.nature.com/ctt?kn=149&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Two photons as exciting as one p693
Natalie de Souza
doi:10.1038/nmeth1009-693
Channelrhodopsin-2 can be efficiently activated by infrared
two-photon excitation light and stimulates action potentials in
cultured neurons.
http://links.ealert.nature.com/ctt?kn=136&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

'Blue' lighting cell signaling research pp694 - 695
Irene Kaganman
doi:10.1038/nmeth1009-694a
By fusing a light-sensitive domain of an oat plant protein to Rac1,
researchers created a genetically encoded protein fusion that can
be reversibly activated with blue light and control cell movement-an
attractive alternative to current caging tools.
http://links.ealert.nature.com/ctt?kn=140&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

A leader anyone can follow pp694 - 695
Michael Eisenstein
doi:10.1038/nmeth1009-694b
The development of leader sequences that stimulate mRNA translation
in a species-independent manner could offer new possibilities for
eukaryotic protein production and proteomic research.
http://links.ealert.nature.com/ctt?kn=13&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

News in brief p695
doi:10.1038/nmeth1009-695
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Illuminating lipids p696
Allison Doerr
doi:10.1038/nmeth1009-696
Visualization of choline-containing phospholipids in cells and
in vivo is made possible by the metabolic incorporation of a
choline analog with an alkyne handle for click chemistry-based
labeling.
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Engineering bacteria in yeast p698
Nicole Rusk
doi:10.1038/nmeth1009-698
Bacterial genomes shuttled into yeast can be easily altered before
transplantation back into bacteria.
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----------------------
HISTORICAL COMMENTARIES
----------------------
Special Feature: Five Year Anniversary Special
Technical matters: method, knowledge and infrastructure in
twentieth-century life science pp701 - 705
Angela N H Creager and Hannah Landecker
doi:10.1038/nmeth1009-701
Conceptual breakthroughs in science tend to garner accolades and
attention. But, as the invention of tissue culture and the
development of isotopic tracers show, innovative methods open up
new fields and enable the solution of longstanding problems.
http://links.ealert.nature.com/ctt?kn=26&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

Special Feature: Five Year Anniversary Special
Seeing things: from microcinematography to live cell
imaging pp707 - 709
Hannah Landecker
doi:10.1038/nmeth1009-707
From histology to microcinematography, from cytochemistry to live
cell imaging, the history of visualization technology in the life
sciences may be understood as a series of cycles of action and
reaction between static and dynamic modes of representing life.
http://links.ealert.nature.com/ctt?kn=118&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

----------------------
COMMENTARIES
----------------------
Special Feature: Five Year Anniversary Special
Is sequencing enlightenment ending the dark age of the
transcriptome? pp711 - 713
Piero Carninci
doi:10.1038/nmeth1009-711
Sequencing-based technologies for RNA discovery are playing
a key role in deciphering the transcriptome and hold the potential
to provide us with a census of RNAs and their functions.
http://links.ealert.nature.com/ctt?kn=120&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

Special Feature: Five Year Anniversary Special
Engineered fluorescent proteins: innovations and
applications pp713 - 717
Michael W Davidson and Robert E Campbell
doi:10.1038/nmeth1009-713
Despite expansion of the fluorescent protein and optical highlighter
palette into the orange to far-red range of the visible spectrum,
achieving performance equivalent to that of EGFP has continued to
elude protein engineers.
http://links.ealert.nature.com/ctt?kn=113&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

Special Feature: Five Year Anniversary Special
Comparative analysis to guide quality improvements in
proteomics pp717 - 719
Matthias Mann
doi:10.1038/nmeth1009-717
The potential of mass spectrometry-based proteomics to advance
biology and biomedicine is nearly unlimited but so is its potential
for generating bad data. Apart from the pursuit of technological
progress in protocols and instruments, stringent comparative
analyses of different approaches are critical for fully developing
the discipline.
http://links.ealert.nature.com/ctt?kn=115&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

Special Feature: Five Year Anniversary Special
From information to knowledge: new technologies for defining
gene function pp721 - 723
Sean R Collins, Jonathan S Weissman and Nevan J Krogan
doi:10.1038/nmeth1009-721
A wide range of methodology will be needed to bridge the gap
between genome sequence and mechanistic understanding in biology.
Recent advances in high-throughput genetic screening address
this task.
http://links.ealert.nature.com/ctt?kn=109&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

----------------------
FIVE YEARS OF METHODS
----------------------
Special Feature: Five Year Anniversary Special
Five years of Methods pp724 - 725
doi:10.1038/nmeth1009-724
http://links.ealert.nature.com/ctt?kn=153&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Staging worms for next-generation analysis pp727 - 728
L Ryan Baugh
doi:10.1038/nmeth1009-727
Automated stage-specific sorting of Caenorhabditis elegans embryos
enables next-generation molecular and biochemical analysis of
development.
http://links.ealert.nature.com/ctt?kn=148&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

---------------------
BRIEF COMMUNICATIONS
----------------------
Nanoscale 3D cellular imaging by axial scanning transmission
electron tomography pp729 - 731
Martin F Hohmann-Marriott et al.
doi:10.1038/nmeth.1367
Using an axial detector, scanning transmission electron microscopy
allows three-dimensional tomographic reconstruction of
micrometer-thick sections of biological samples, at a resolution
comparable to that obtained on thin sections.
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=139&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

Somatic cell nuclear transfer in zebrafish pp733 - 735
Kannika Siripattarapravat et al.
doi:10.1038/nmeth.1369
Technical modifications of existing methods lead to a somatic cell
nuclear transfer method in the zebrafish, which yields adult cloned
fish with healthy offspring that carry donor traits.
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

Genetically encoded FRET sensors to monitor intracellular Zn2+
homeostasis pp737 - 740
Jan L Vinkenborg et al.
doi:10.1038/nmeth.1368
A series of genetically encoded fluorescent sensors for intracellular
Zn2+ with binding affinities spanning the picomolar and nanomolar
ranges show that cytosolic Zn2+ is buffered at ~0.4 nM. Targeting
of the sensors to insulin-containing secretory granules indicates a
free Zn2+ concentration between 1 and 100 muM in these organelles.
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

Proteomics strategy for quantitative protein interaction profiling in
cell extracts pp741 - 744
Kirti Sharma et al.
doi:10.1038/nmeth.1373
Quantitative information is necessary to determine which protein
interactions are the most relevant in a cellular context. A defined
set of affinity purification experiments combined with quantitative
mass spectrometry analysis allows the determination of dissociation
constants for all protein targets interacting with an introduced
ligand.
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Direct PCR from plant tissues
http://links.ealert.nature.com/ctt?kn=1&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

Finnzymes' Phire Plant Direct PCR Kit allows DNA amplification
directly from plant tissues such as leaves and seeds. No DNA isolation is
required prior to PCR. Short and simple protocols allow results in as
little as 30 minutes.

Take the direct route from sample to results: Finnzymes Direct PCR.
http://links.ealert.nature.com/ctt?kn=1&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

=====================================================================

----------------------
ARTICLES
----------------------
Large-scale sorting of C. elegans embryos reveals the dynamics
of small RNA expression pp745 - 751
Marlon Stoeckius et al.
doi:10.1038/nmeth.1370
Fluorescence-activated cell sorting of worm embryos promises to
replace manual sorting of staged embryos and yields large populations
highly enriched in specific developmental stages, allowing
high-throughput genomic analysis.
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=143&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

A Flp-nick system to study repair of a single protein-bound nick
in vivo pp753 - 757
Ida Nielsen et al.
doi:10.1038/nmeth.1372
By targeting a mutant Flp recombinase that forms a covalent
protein-DNA complex to a single FRT site placed anywhere in
the yeast genome, the authors can study repair pathways activated
by a single genomic insult as well as events at the site of damage.
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

An approach for extensibly profiling the molecular states of cellular
subpopulations pp759 - 765
Lit-Hsin Loo et al.
doi:10.1038/nmeth.1375
Computational compensation for the loss of information from a
cellular marker visualized in one fluorescence channel increases
the number of markers that can be used to study a population of
cells. This should allow a more detailed molecular understanding
of heterogeneity in a cellular population.
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

Tn-seq: high-throughput parallel sequencing for fitness and genetic
interaction studies in microorganisms pp767 - 772
Tim van Opijnen, Kip L Bodi and Andrew Camilli
doi:10.1038/nmeth.1377
High-throughput sequencing of Mariner transposon insertion libraries
is used for quantitative studies of fitness and of genetic
interactions in Streptococcus pneumoniae. The approach should allow
similar studies in several microorganismal species.
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Nature Methods is 5 years old!!!

To celebrate the 5-year anniversary of Nature Methods launch, the October 2009 issue will contain a special feature highlighting critical methods developments and their importance in biological research.

Visit http://links.ealert.nature.com/ctt?kn=82&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0 for access.

=====================================================================

----------------------
TECHNOLOGY FEATURE
----------------------
Getting inside their minds pp773 - 781
Michael Eisenstein
doi:10.1038/nmeth1009-773
Neuroscientists are taking advantage of powerful new tools for
fluorescence imaging that enable detailed visualization of the
structure and activity of neuronal circuits within the living brain.
http://links.ealert.nature.com/ctt?kn=101&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

----------------------
APPLICATION NOTES
----------------------
Optimized library preparation method for next-generation sequencing
Fraz Syed, Haiying Grunenwald and Nicholas Caruccio
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=41&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

In vivo real-time optical coherence tomography imaging of Drosophila
for cardiovascular research
Jon Holmes
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34085723&r=MTc2NjExMzUwMAS2&b=2&j=NTg2Njg1MzkS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Method of the Year 2009
Help Nature Methods select the breakthrough laboratory method of the year for 2009.
To cast your vote and nominate candidate methods visit:
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Nature Reviews Clinical Oncology - Table of Contents alert Volume 6 Issue 10

NATURE REVIEWS CLINICAL ONCOLOGY

October 2009 Volume 6 Number 10

Visit Nature Reviews Clinical Oncology online to browse the journal.

Now available at
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=========================== ADVERTISEMENT ===========================

AACR Conference:
Advances in Breast Cancer Research: Genetics, Biology and Clinical
Applications
October 13-16, 2009 - San Diego, CA
Carlos L. Arteaga, Lewis A. Chodosh, and Kornelia Polyak, Chairpersons

Presenting discoveries in genetics, cell biology, and molecular biology
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=========================== ADVERTISEMENT ===========================

Focus on p53 - 30 years on

To celebrate the past 30 years of research on p53, Nature Reviews Cancer
presents a Focus issue of specially-commissioned articles that discuss
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=====================================================================

----------------------
EDITORIAL
----------------------
The Holy Grail of biomarkers
Lisa Hutchinson and Vincent T. DeVita Jr
p553 | doi:10.1038/nrclinonc.2009.145
http://links.ealert.nature.com/ctt?kn=21&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Immunotherapy: HPV-16/18 vaccine is highly effective against cervical
infection
p555 | doi:10.1038/nrclinonc.2009.134
http://links.ealert.nature.com/ctt?kn=24&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Medical oncology: Vascular normalization predicts response to cediranib
p556 | doi:10.1038/nrclinonc.2009.137
http://links.ealert.nature.com/ctt?kn=8&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Overdiagnosis with mammography?
p556 | doi:10.1038/nrclinonc.2009.138
http://links.ealert.nature.com/ctt?kn=10&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Chemotherapy: Metastatic breast cancer-optimal front-line therapy
p557 | doi:10.1038/nrclinonc.2009.135
http://links.ealert.nature.com/ctt?kn=13&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Surgery: Rectal cancer-treatment on the less invasive side
p557 | doi:10.1038/nrclinonc.2009.136
http://links.ealert.nature.com/ctt?kn=95&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

ER-[alpha]36 and resistance to tamoxifen
p558 | doi:10.1038/nrclinonc.2009.132
http://links.ealert.nature.com/ctt?kn=98&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Medical oncology: PSA is best outcome predictor
p558 | doi:10.1038/nrclinonc.2009.133
http://links.ealert.nature.com/ctt?kn=88&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Chemotherapy: Topotecan or treosulfan-that is the question
Maurie Markman
p559 | doi:10.1038/nrclinonc.2009.144
Meier and coauthors found that topotecan improved progression-free and
overall survival compared with treosulfan in patients with recurrent
ovarian cancer following platinum and taxane-based therapy. Although
these results are promising, the optimum treatment strategy for patients
with recurrent ovarian cancer still remains to be determined.
http://links.ealert.nature.com/ctt?kn=91&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Chemotherapy: Optimizing irinotecan regimens for colorectal cancer
Kein-Leong Yim and David Cunningham
p560 | doi:10.1038/nrclinonc.2009.140
Second-line irinotecan regimens are efficacious in patients with advanced
colorectal cancer who experience disease progression on first-line
oxaliplatin-based chemotherapy. Bidard et al. investigated the impact
of treatment with dose-dense irinotecan on improving survival in such
patients and aimed to optimize the irinotecan combination chemotherapy
platform.
http://links.ealert.nature.com/ctt?kn=92&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Chemotherapy: Irinotecan or etoposide as front-line therapy for SCLC?
Faye M. Johnson and Bonnie S. Glisson
p562 | doi:10.1038/nrclinonc.2009.141
The results of a large, randomized, North American trial (SWOG S0124)
that compared etoposide and cisplatin with irinotecan and cisplatin
for patients with extensive small-cell lung cancer have failed to
confirm the benefit observed with irinotecan that was demonstrated
in an earlier Japan Clinical Oncology Group study (JCOG 9511).
http://links.ealert.nature.com/ctt?kn=7&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Chemotherapy: Adjuvant chemotherapy in older patients with breast cancer
Agnes Jager, Jaap Verweij and Stefan Sleijfer
p563 | doi:10.1038/nrclinonc.2009.142
A prospective, randomized trial has shown that standard adjuvant
chemotherapy is superior to capecitabine in the treatment of women with
breast cancer aged 65 years or older; on the basis of the results of
this study, capecitabine cannot be recommended in this setting.
http://links.ealert.nature.com/ctt?kn=3&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Hematology: Thalidomide maintenance in multiple myeloma
Jacob P. Laubach, Paul G. Richardson and Kenneth C. Anderson
p565 | doi:10.1038/nrclinonc.2009.131
Thalidomide is frequently used in patients with newly diagnosed and
relapsed multiple myeloma, but its role as maintenance therapy following
autologous stem-cell transplantation has been an area of uncertainty.
In this article we consider the efficacy of thalidomide maintenance
therapy in multiple myeloma.
http://links.ealert.nature.com/ctt?kn=5&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Radiotherapy: IMRT reduces xerostomia and potentially improves QoL
Avraham Eisbruch
p567 | doi:10.1038/nrclinonc.2009.143
Xerostomia and reduced quality of life are common occurrences in patients
treated with radiation to the salivary gland for head and neck
squamous-cell carcinoma. This article discusses outcomes after
intensity-modulated radiation therapy and three-dimensional conventional
radiotherapy among patients with head and neck squamous-cell carcinoma.
http://links.ealert.nature.com/ctt?kn=16&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
Article series: Antiangiogenic Clinical Strategies
An overview of small-molecule inhibitors of VEGFR signaling
S. Percy Ivy, Jeannette Y. Wick and Bennett M. Kaufman
Published online: 08 September 2009
p569 | doi:10.1038/nrclinonc.2009.130
The VEGFR small-molecule inhibitors of angiogenesis show promise for
oncology patients. These rationally designed inhibitors are being tailored
for use in specific malignancies and will have a pivotal role in
personalized medicine. The authors discuss the potential of these agents
for treating tumors such as metastatic renal-cell carcinoma, GIST and
hepatocellular carcinoma.
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Role of cancer stem cells in pancreatic ductal adenocarcinoma
Gregory Sergeant, Hugo Vankelecom, Lies Gremeaux and Baki Topal
Published online: 18 August 2009
p580 | doi:10.1038/nrclinonc.2009.127
With greater understanding of the biology of pancreatic cancer a role
for cancer stem cells is becoming clear. The authors of this Review
discuss the current knowledge on pancreatic cancer stem cells and their
potential use as targets in therapeutic regimens.
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Src kinases as therapeutic targets for cancer
Lori C. Kim, Lanxi Song and Eric B. Haura
p587 | doi:10.1038/nrclinonc.2009.129
Src family kinases have been extensively studied and found to be central
mediators in multiple signaling pathways that are important in oncogenesis.
Preclinical studies have shown that SFK inhibitors can suppress tumor
growth and metastases. The authors of this Review discuss the potential
use of these agents to target cancer in humans.
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

Neurological adverse effects caused by cytotoxic and targeted therapies
David Schiff, Patrick Y. Wen and Martin J. van den Bent
Published online: 25 August 2009
p596 | doi:10.1038/nrclinonc.2009.128
With the development of new chemotherapy and targeted agents, neurotoxicity
has become increasingly important as a cause of dose-limiting toxicity.
The authors review the important and unusual neurotoxicities related to
chemotherapy and targeted agents approved since January 1999.
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

----------------------
CASE STUDY
----------------------
Breast cancer in a BRCA2 mutation carrier with a history of prostate
cancer
Seema Panchal, Orli Shachar, Frances O'Malley, Pavel Crystal, Jaime
Escallon, Juanita Crook, Anita Bane and Louise Bordeleau
p604 | doi:10.1038/nrclinonc.2009.116
This case study discusses a patient initially diagnosed with high-risk
prostate cancer who underwent androgen deprivation therapy. The patient
subsequently presented with ductal carcinoma in situ and was found to
be a BRCA2 mutation carrier with a strong family history of breast cancer.
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=34082529&r=MTc2NDg2OTc4MQS2&b=2&j=NTg2MjQ2MTIS1&mt=1&rt=0

----------------------
PERSPECTIVES
----------------------
OPINION
Molecular imaging of solid tumors: exploiting the potential
Wim J. G. Oyen and Winette T. A. van der Graaf
p609 | doi:10.1038/nrclinonc.2009.139
Novel targeted therapies often result in disease stabilization rather
than tumor shrinkage, which are reflected by changes in the molecular
features of the tumor. Noninvasive procedures to measure such features
are urgently needed. The authors of this opinion article discuss the
role of PET and its impact on decisions about monitoring of systemic
cytotoxic and targeted therapy.
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Laboratory Investigation - Table of Contents alert Volume 89 Issue 10

LABORATORY INVESTIGATION

October 2009 Volume 89 Number 10, pp 1074 - 1187

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Laboratory Investigation - dedication to the publication of current
research that significantly advances the understanding of human
and experimental disease. Particular emphasis is given to
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INSIDE LAB INVEST
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Inside Lab Invest
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----------------------
RESEARCH ARTICLES
----------------------
Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune
demyelinating disease through estrogen receptor alpha (ER[alpha])
Stefan M Gold, Manda V Sasidhar, Laurie B Morales, Sienmi Du, Nancy L Sicotte,
Seema K Tiwari-Woodruff and Rhonda R Voskuhl
Abstract: http://links.ealert.nature.com/ctt?kn=17&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

Reprogramming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines
Arpita Chakravarti, Daniel Rusu, Nicolas Flamand, Pierre Borgeat and Patrice E Poubelle
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
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Identification of mesenchymal stromal cells in human lung parenchyma capable of
differentiating into aquaporin 5-expressing cells
Golnaz Karoubi, Lourdes Cortes-Dericks, Isabel Breyer, Ralph A Schmid and Andre E Dutly
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation
in epithelial ovarian cancer
Shahab Uddin, Maqbool Ahmed, Azhar R Hussain, Zeenath Jehan, Fouad Al-Dayel, Adnan Munkarah,
Prashant Bavi and Khawla S Al-Kuraya
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

Cholestasis downregulate hepcidin expression through inhibiting IL-6-induced phosphorylation
of signal transducer and activator of transcription 3 signaling
Ying-Hsien Huang, Jiin-Haur Chuang, Ya-Ling Yang, Chao-Cheng Huang, Chia-Ling Wu and Chao-Long Chen
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

Hepatic damage associated with dengue-2 virus replication in liver cells of BALB/c mice
Marciano Viana Paes, Henrique Leonel Lenzi, Ana Cristina Martins Nogueira, Gerard James Nuovo,
Angela Teixeira Pinhao, Ester Maria Mota, Carlos Alberto Basilio-de-Oliveira, Hermann Schatzmayr,
Ortrud Monika Barth and Ada Maria de Barcelos Alves
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

Therapeutic targeting of the PDGF and TGF-[beta]-signaling pathways in hepatic
stellate cells by PTK787/ZK22258
Yuqing Liu, Xiao Ming Wen, Eric Lik Hang Lui, Scott L Friedman, Wei Cui, Nancy Pei Shan Ho,
Lei Li, Tao Ye, Sheung Tat Fan and Hui Zhang
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=84&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

In vivo effect of imatinib on progression of cecal GIST-like tumors in exon
17-type c-kit knock-in mice
Takashi Ishikawa, Norihiro Nakai, Ning-Ning Liu, Kazuhiro Shiba, Koji Isozaki,
Ikuo Matsuda, Takashi Ito, Jiro Fujimoto, Katsuyoshi Hatakeyama, Tatsuo Kanda and Seiichi Hirota
Abstract: http://links.ealert.nature.com/ctt?kn=51&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

Osteopontin attenuation of dextran sulfate sodium-induced colitis in mice
Andre Paes Batista da Silva, Richard P Ellen, Esben S Sorensen, Harvey A Goldberg,
Ron Zohar and Jaro Sodek
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

----------------------
TECHNICAL REPORT
----------------------
IGH and IGK gene rearrangements as PCR targets for pediatric Burkitt's lymphoma
and mature B-ALL MRD analysis
Federica Lovisa, Lara Mussolin, Lilia Corral, Marta Pillon, Giovanni Cazzaniga,
Andrea Biondi and Angelo Rosolen
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

----------------------
CORRIGENDUM
----------------------
Functional evaluation of pallid mice with genetic emphysema
Mitsuteru Yoshida, Shoji Sakiyama, Koichiro Kenzaki, Hiroaki Toba, Kou Uyama,
Masatsugu Takehisa, Kazuya Kondo and Akira Tangoku
http://links.ealert.nature.com/ctt?kn=50&m=34081753&r=MTc2Mjk0MzQ4MgS2&b=2&j=NTg2MTgyNjMS1&mt=1&rt=0

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Latest PhD Studentships - 29 September 2009

Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.

University of Edinburgh
"Integrated assessment of quality of supply in future electricity networks"

Northumbria University
Development of a Virtual Tool for testing the Health and Safety Emergency Plans of On-Shore Gas Infrastructure

Cardiff University
A natural plant derived therapeutic for the treatment of the hospital pathogen Clostridium difficile

University of Teesside
Methodologies for the development of plastic electronics

University of Teesside
Innovation in Science – using SMEs

University of Teesside
Highly Replicated Polymer Based Lab-on-Chip

Norwegian University of Science and Technology
1 PhD fellowship in Chemical Engineering, palladium based membranes in catalytic reactions

University of Worcester
False Performance: unethical behaviour in performance evaluation and work relationships

Durham University
Sub-micron three dimensional holographic lithography

University of Plymouth
Composite materials for application in marine renewable energy systems

Beatson Institute for Cancer Research
Regulation of p53 by ubiquitin-like protein modification

Lancaster University
Control of a dual arm robot used for nuclear decommissioning

Cranfield University
PhD studentship - Novel diagnostic/detection platform for healthcare application

The Open University
The Open University/Leverhulme Trust Research Project: Performing Memory in the 'new' South Africa

University of Hertfordshire
PhD Studentship: Natural fibre surface treatments for composites

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Signaling Update contents for 28 September 2009

*********************************************************************
Signaling Gateway - 28 September 2009
http://links.ealert.nature.com/ctt?kn=32&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0
*********************************************************************

Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
http://links.ealert.nature.com/ctt?kn=4&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

*********************************************************************
In Signaling Update this week:

------------------------
Featured Article
------------------------
INTEGRIN ADHESION SIGNALING: TUMORS DECLARE INDEPENDENCE

Integrin alphavbeta3 and c-Src interact to promote
anchorage-independent growth and tumor cell survival.

Original research paper: Nature Medicine advance online publication,
6 September 2009

http://links.ealert.nature.com/ctt?kn=21&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

-------------------
Selected Updates
-------------------
VIRAL IMMUNITY: ARE MEN AND WOMEN DIFFERENT?
Plasmacytoid dendritic cells produce more interferon-alpha (IFNalpha)
in response to HIV-1 in women than in men, which leads to higher
levels of CD8⁺ T-cell activation and might explain the
tendency for women to progress significantly faster to AIDS than men
with the same viral load.
Original research paper: Nature Med. 15, 955–959 (2009)
http://links.ealert.nature.com/ctt?kn=6&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

TUMOUR SUPPRESSORS: DIFFERENT ROADS TO INACTIVATION
Inhibition of protein kinase C (PKC) might be a strategy to treat
glioblastomas that do not harbor mutations in the NF1 tumor
suppressor gene, whereas glioblastomas with genetic inactivation of
NF1 may respond to mTOR inhibition.
Original research paper: Cancer Cell 16, 44–54 (2009)
http://links.ealert.nature.com/ctt?kn=5&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

MIGRATION: EXCHANGE TO MIGRATE
Activation of GABAA receptors in glial precursor NG2 cells regulates
cell migration in part by triggering a Ca2+ signaling pathway that
reverses the activity of the Na+-Ca2+ exchanger 1 (NCX1).
Original research paper: J. Cell Biol. 186, 113–128 (2009)
http://links.ealert.nature.com/ctt?kn=9&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

More Updates:
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------------------------
Research Library
------------------------
http://links.ealert.nature.com/ctt?kn=2&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

A DIMERIZATION-DEPENDENT MECHANISM DRIVES RAF CATALYTIC ACTIVATION
Nature 461, 542-545 (2009)
http://links.ealert.nature.com/ctt?kn=13&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

P53 ISOFORMS [DELTA]133P53 AND P53[BETA] ARE ENDOGENOUS REGULATORS OF
REPLICATIVE CELLULAR SENESCENCE
Nature Cell Biology 11, 1135-1142 (2009)
http://links.ealert.nature.com/ctt?kn=25&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

MODULAR SCANNING FCS QUANTIFIES RECEPTOR-LIGAND INTERACTIONS IN
LIVING MULTICELLULAR ORGANISMS
Nature Methods 6, 643-645 (2009)
http://links.ealert.nature.com/ctt?kn=26&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

------------------------
Signaling News
------------------------
PROTEIN BURNS ITS EVOLUTIONARY BRIDGES
http://links.ealert.nature.com/ctt?kn=11&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

The glucocorticoid receptor (GR) evolved more than 400 million years
ago from an ancestral receptor that was activated by a trio of
hormones (cortisol, aldosterone and deoxycorticosterone).
Researchers have now shown that mutations that impart selectivity to
cortisol cannot be reverted; suggesting that changes in protein
function or structure happening over the course of tens of millions
of years can prevent molecular turnarounds and render evolution
irreversible.

More news
http://links.ealert.nature.com/ctt?kn=1&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

-------------------------
Gateway Updates
-------------------------
NCI-NATURE PATHWAY INTERACTION DATABASE - SEPTEMBER UPDATE
http://links.ealert.nature.com/ctt?kn=17&m=34078434&r=MTc2ODc4NDI0MAS2&b=2&j=NTg1NjM5ODYS1&mt=1&rt=0

The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and
bioinformaticians to explore, visualize and mine signaling events.

This month's update features the p53 pathway and LKB1 signaling
events.

-----------------------------
Job of the Week
-----------------------------
Instructor
Employer: The University of Tennessee Health Science Center
Location: Memphis, Tennessee, USA
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An instructor faculty position is available at the Department of
Physiology in the University of Tennessee Health Science Center.
The successful applicant will examine the role of protein
phosphatase 2a in myocardial ischemia and reperfusion, and will be
responsible for supervising postdoctoral fellows, research associates
and graduate students.

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