Nature Cell Biology contents: February 2010 Volume 12 Number 2, pp 101 - 199

NATURE CELL BIOLOGY

February 2010 Volume 12 Number 2, pp 101 - 199

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----------------------
EDITORIAL
----------------------
Mentoring matters p101
doi:10.1038/ncb0210-101
Mentoring enhances the experience of mentees; however, mentors and their
institutions will also reap the rewards of a mentorship culture.
http://links.ealert.nature.com/ctt?kn=20&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

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NEWS AND VIEWS
----------------------
Tipping the scale: muscle versus fat pp102 - 104
Matthew S. Rodeheffer
doi:10.1038/ncb0210-102
Adipocytes and scar tissue form during skeletal muscle degeneration.
Two new studies reveal that adipocytes and fibroblasts in skeletal
muscle derive from a population of bipotent progenitors that reside
within muscle, but are not derived from the muscle lineage. These
progenitor cells also have a surprising role in stimulating the
restoration of muscle mass during regeneration.
http://links.ealert.nature.com/ctt?kn=16&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

Mitochondria get a Parkin' ticket pp104 - 106
Philipp Wild and Ivan Dikic
doi:10.1038/ncb0210-104
Recent studies have revealed a prominent role of mitochondrial
dysfunction in the development of one of the most common neurodegenerative
disorders, Parkinson's disease. The ubiquitin ligase Parkin and the protein
kinase PINK1, whose mutations are associated with Parkinson's disease,
function in a pathway that links ubiquitylation with selective autophagy
of damaged mitochondria.
http://links.ealert.nature.com/ctt?kn=12&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

Cohesin and Cdk1: an anaphase barricade pp106 - 108
Keith T. Jones
doi:10.1038/ncb0210-106
Separation of sister chromatids at anaphase in metazoan cells requires
only the cleavage of the kleisin subunit of centromeric cohesin,
but efficient poleward movement of separated sisters requires the
associated loss in Cdk1 activity. Activation of the anaphase-promoting
complex/cyclosome ensures these events are coordinated.
http://links.ealert.nature.com/ctt?kn=11&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

Research highlights p109
doi:10.1038/ncb0210-109
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ARTICLES
----------------------
DNA zip codes control an ancient mechanism for gene targeting to
the nuclear periphery pp111 - 118
Sara Ahmed et al.
doi:10.1038/ncb2011
In budding yeast, many inducible genes translocate to the nuclear
periphery when activated. Sequence motifs have now been identified
in promoters, which target genes to the nuclear periphery and
contribute to gene activation
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
pp119 - 131
Sven Geisler et al.
doi:10.1038/ncb2012
The E3 ubiquitin ligase Parkin mediates the clearance of depolarized
mitochondria through the autophagy pathway. PINK1 kinase activity is
required for Parkin translocation to depolarized mitochondria where
Parkin generates polyubiquitin chains on the voltage-dependent anion
channel (VDAC1) to recruit the autophagic adaptor p62/SQSTM1.
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

Histone deacetylase and Cullin3-RENKCTD11 ubiquitin ligase interplay
regulates Hedgehog signalling through Gli acetylation pp132 - 142
Gianluca Canettieri et al.
doi:10.1038/ncb2013
Hedgehog signalling and activation of its downstream effectors Gli1/2
is deregulated in tumorigenesis. Hedgehog-induced HDAC1 is shown to
activate Gli1/2 through its deacetylation. This effect is negatively
regulated by the Cullin3/RENKCTD11 ubiquitin ligase, a Gli antagonist
that is often lost in human medulloblastoma.
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=96&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

Mesenchymal progenitors distinct from satellite cells contribute to
ectopic fat cell formation in skeletal muscle pp143 - 152
Akiyoshi Uezumi et al.
doi:10.1038/ncb2014
Ectopic adipocytes in skeletal muscle are observed in several disorders,
but their origin is unclear. PDGFRalpha+ mesenchymal progenitors are
identified as responsible for ectopic adipogenesis, which is inhibited
by the presence of satellite cell-derived myofibres.
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

Muscle injury activates resident fibro/adipogenic progenitors that
facilitate myogenesis pp153 - 163
Aaron W. B. Joe et al.
doi:10.1038/ncb2015
Following skeletal muscle damage, a population of resident fibro/adipogenic
progenitors (FAP) initiates proliferation, resulting in the generation
of ectopic white fat but not myofibres. FAPs enhance the differentiation
of the myogenic progenitors involved in muscle regeneration.
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

----------------------
LETTERS
----------------------
The Nup107-160 complex and gamma-TuRC regulate microtubule polymerization
at kinetochores pp164 - 169
Ram Kumar Mishra et al.
doi:10.1038/ncb2016
The gamma-tubulin ring complex (gamma-TuRC) nucleates microtubules.
The nuclear pore subcomplex Nup107-160 is found to interact and cooperate
with gamma-TuRC to nucleate microtubules at kinetochores, thereby
promoting spindle assembly.
Abstract: http://links.ealert.nature.com/ctt?kn=27&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=93&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

Planar polarization of node cells determines the rotational axis of
node cilia pp170 - 176
Masakazu Hashimoto et al.
doi:10.1038/ncb2020
Mouse node cilia are posteriorly tilted to generate a leftward fluid
flow and left/right asymmetry in the embryo, but how the tilt comes
about was not known. The basal bodies of node cilia gradually shift
from a central position towards the posterior side of node cells in
a dishevelled and non-canonical Wnt signalling-dependent manner and
follow a shift in Dvl localization to the posterior.
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

53BP1-dependent robust localized KAP-1 phosphorylation is essential
for heterochromatic DNA double-strand break repair pp177 - 184
Angela T. Noon et al.
doi:10.1038/ncb2017
The ATM signalling mediator proteins 53BP1 and KAP-1 are required for
heterochromatic double-strand break DNA repair. 53BP1 aids Mre11,
NBS1 and ATM accumulation at heterochromatic breaks, leading to
localized phosphorylation of KAP-1 by ATM.
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=81&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei
pp185 - 192
Raquel A. Oliveira et al.
doi:10.1038/ncb2018
Whether cohesion-independent forces hold chromosomes together in
metaphase is a debated issue. Artificial cleavage of cohesin is
sufficient to induce chromosome disjunction in Drosophila syncytical
embryos but cdk1 inactivation is required for normal subsequent
chromosome separation.
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication
by a KSHV microRNA pp193 - 199
Xiufen Lei et al.
doi:10.1038/ncb2019
The role of Kaposi's sarcoma-associated herpesvirus microRNAs in viral
infection and replication remains unclear. A viral cluster containing
14 microRNAs is shown to negatively regulate viral replication by
targeting the the NF-kappaB inhibitor IkappaBalpha and thereby decreasing
NF-kappaB signalling.
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

----------------------
CORRIGENDUM
----------------------
Phosphorylation of STIM1 underlies suppression of store-operated
calcium entry during mitosis p199
Jeremy T. Smyth et al.
doi:10.1038/ncb0210-199
http://links.ealert.nature.com/ctt?kn=30&m=34595104&r=MTc2NDEyMTk0MQS2&b=2&j=NjY0NDc5NDES1&mt=1&rt=0

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EMBO Reports - Table of Contents alert Volume 11 Issue 2, pp 73 - 139

EMBO REPORTS

February 2010 Volume 11 Number 2, pp 73 - 139

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organization of centers and ends.

Focus on Telomeres and Centromeres in full
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UPFRONT
----------------------
EDITORIAL
Race to the top
Howy Jacobs discusses the lack of non-white students and researchers in molecular biology in Europe and how to ensure that a career in biology appeals to all Europeans.Howy Jacobs discusses the lack of non-white students and researchers in molecular biology in Europe and how to ensure that a career in biology appeals to all Europeans.
Howy Jacobs
doi:10.1038/embor.2009.280
http://links.ealert.nature.com/ctt?kn=82&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

MEETING POINT
Sisters dancing in meiosis
The EMBO Conference on Meiosis held last September highlighted the dynamic aspects of this process, including the variability of hotspots for break formation, switches between partners during repair, and the dynamics of sister chromatid cohesion.
Willy M. Baarends and Raphael Mercier
doi:10.1038/embor.2009.277
http://links.ealert.nature.com/ctt?kn=33&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

The reverse logic of multivesicular endosomes
The conference on ‘Endocytic machineries in control of cell signaling and tissue morphogenesis’ held last October highlighted advances in our understanding of endocytic trafficking. A centerpiece was the amazing plasticity and sorting options of the maturing late endosome compartment.
Linton M. Traub
doi:10.1038/embor.2009.281
http://links.ealert.nature.com/ctt?kn=30&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

OPINION
Perfect time or perfect crime?
Do we need to be afraid of synthetic biology? Not yet, Antoine Danchin argues: we still need more knowledge before we are able to reconstruct life.Do we need to be afraid of synthetic biology? Not yet, Antoine Danchin argues: we still need more knowledge before we are able to reconstruct life.
Antoine Danchin
doi:10.1038/embor.2009.275
http://links.ealert.nature.com/ctt?kn=69&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

Gene therapy: back on track?
Fulvio Mavilio assesses the current state of affairs of gene therapy and how over-regulation might be stifling its progress and, thus, patient access to novel therapies.Fulvio Mavilio assesses the current state of affairs of gene therapy and how over-regulation might be stifling its progress and, thus, patient access to novel therapies.
Fulvio Mavilio
doi:10.1038/embor.2009.284
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SCIENCE & SOCIETY
----------------------
OUTLOOK
Striking a balance
Sharon Long, a plant scientists who advised Barack Obama during his presidential election campaign, talks about green biotechnology and the role of scientists in political decision-making.Sharon Long, a plant scientists who advised Barack Obama during his presidential election campaign, talks about green biotechnology and the role of scientists in political decision-making.
Holger Breithaupt and Samuel Caddick
doi:10.1038/embor.2009.285
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System crash
Laurent Segalat draws worrying parallels between the causes of the recent crash of the global financial system and current developments in academic science.Laurent Segalat draws worrying parallels between the causes of the recent crash of the global financial system and current developments in academic science.
Laurent Segalat
doi:10.1038/embor.2009.278
http://links.ealert.nature.com/ctt?kn=18&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

FEATURE
Hitting the right spot
Philip Hunter explores how recent technological and conceptual developments are helping clinicians improve the efficacy and safety of radiotherapy against obstinate cancers.Philip Hunter explores how recent technological and conceptual developments are helping clinicians improve the efficacy and safety of radiotherapy against obstinate cancers.
Philip Hunter
doi:10.1038/embor.2009.286
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Lost in translation
The public increasingly expect that the research they pay for will produce tangible results. The resultant emphasis on translational research may come at the expense of funding for basic research, which continues to worry many scientists.The public increasingly expect that the research they pay for will produce tangible results. The resultant emphasis on translational research may come at the expense of funding for basic research, which continues to worry many scientists.
Kristen Minogue and Howard Wolinsky
doi:10.1038/embor.2009.282
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REVIEWS
----------------------
REVIEW
Integrin-TGF-[beta] crosstalk in fibrosis, cancer and wound healing
There is increasing evidence of a crosstalk between integrins and TGF-[beta] signaling in normal physiology and numerous pathological processes, including systemic sclerosis, pulmonary fibrosis, chronic obstructive pulmonary disease and cancer. Margadant and Sonnenberg explore this crosstalk and asses the possibility of targeting integrins to interfere with TGF-[beta] signalling as a new option for the treatment of these diseases.There is increasing evidence of a crosstalk between integrins and TGF-[beta] signaling in normal physiology and numerous pathological processes, including systemic sclerosis, pulmonary fibrosis, chronic obstructive pulmonary disease and cancer. Margadant and Sonnenberg explore this crosstalk and asses the possibility of targeting integrins to interfere with TGF-[beta] signalling as a new option for the treatment of these diseases.
Coert Margadant and Arnoud Sonnenberg
doi:10.1038/embor.2009.276
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

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SCIENTIFIC REPORTS
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Polyadenylation and degradation of incomplete RNA polymerase I transcripts in mammalian cells
Pestov and colleagues demonstrate that polyadenylation acts as a surveillance mechanism for aberrant RNA Polymerase I transcripts in mammals and find a role for the noncanonical poly(A) polymerase PAPD5 and the exosome in this process. The authors also show that polyadenylated truncated pre-rRNA species accumulate when cells are treated with low doses of actinomycin D, thus revealing a previously unknown property of a drug commonly utilized to block rRNA synthesis.Pestov and colleagues demonstrate that polyadenylation acts as a surveillance mechanism for aberrant RNA Polymerase I transcripts in mammals and find a role for the noncanonical poly(A) polymerase PAPD5 and the exosome in this process. The authors also show that polyadenylated truncated pre-rRNA species accumulate when cells are treated with low doses of actinomycin D, thus revealing a previously unknown property of a drug commonly utilized to block rRNA synthesis.
Natalia Shcherbik, Minshi Wang, Yevgeniya R Lapik, Leena Srivastava & Dimitri G Pestov
doi:10.1038/embor.2009.271
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0
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Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast
Allshire and colleagues demonstrate that transitivity occurs in fission yeast. Their study implies that RDRPRdp1 can synthesize RNA from targeted RNA templates in vivo, generating secondary siRNAs not homologous a hairpin trigger.Allshire and colleagues demonstrate that transitivity occurs in fission yeast. Their study implies that RDRPRdp1 can synthesize RNA from targeted RNA templates in vivo, generating secondary siRNAs not homologous a hairpin trigger.
Femke Simmer, Alessia Buscaino, Isabelle C Kos-Braun, Alexander Kagansky, Abdelhalim Boukaba, Takeshi Urano, Alastair R W Kerr & Robin C Allshire
doi:10.1038/embor.2009.273
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0
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Transfer-messenger RNA controls the translation of cell-cycle and stress proteins in Streptomyces
The van Wezel group shows that the translation of some mRNAs, encoding stress and cell cycle control proteins, is dependant on tmRNA, though transcription is unaffected. Their data unveil a surprisingly dedicated functionality for tmRNA: promoting the translation of the mRNA that it targets at the expense of sacrificing the first nascent protein.The van Wezel group shows that the translation of some mRNAs, encoding stress and cell cycle control proteins, is dependant on tmRNA, though transcription is unaffected. Their data unveil a surprisingly dedicated functionality for tmRNA: promoting the translation of the mRNA that it targets at the expense of sacrificing the first nascent protein.
Sharief Barends, Martin Zehl, Sylwia Bialek, Ellen de Waal, Bjørn A Traag, Joost Willemse, Ole Nørregaard Jensen, Erik Vijgenboom & Gilles P van Wezel
doi:10.1038/embor.2009.255
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

Regulation of antigen-receptor gene assembly in hagfish
Nagawa and colleagues demonstrate that VLR gene assembly in agnathans occurs mainly in a monoallelic manner and is achieved through feedback inhibition by a functional VLR. Yet, in some cases the authors found diallelic assembly to have taken place. In many of such cases, one allele was functional whereas the other was defective.Nagawa and colleagues demonstrate that VLR gene assembly in agnathans occurs mainly in a monoallelic manner and is achieved through feedback inhibition by a functional VLR. Yet, in some cases the authors found diallelic assembly to have taken place. In many of such cases, one allele was functional whereas the other was defective.
Natsuko Kishishita, Tatsuya Matsuno, Yoshimasa Takahashi, Hiroyuki Takaba, Hirofumi Nishizumi & Fumikiyo Nagawa
doi:10.1038/embor.2009.274
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway
Castanier and colleagues report that mitochondrial dynamics play a role in innate anti-viral immunity by regulating the RIG-I-like receptor (RLR)/MAVS pathway. The authors show that RLR activation promotes elongation of mitochondria, which enhances signalling downstream of MAVS and favours the binding of MAVS to STING, an ER protein involved in the RLR pathway. Their finding that MAVS associates with Mfn1, a protein of the mitochondrial fusion machinery, suggests that MAVS regulates mitochondrial dynamics to facilitate the mitochondria/ER association required for signal transduction.Castanier and colleagues report that mitochondrial dynamics play a role in innate anti-viral immunity by regulating the RIG-I-like receptor (RLR)/MAVS pathway. The authors show that RLR activation promotes elongation of mitochondria, which enhances signalling downstream of MAVS and favours the binding of MAVS to STING, an ER protein involved in the RLR pathway. Their finding that MAVS associates with Mfn1, a protein of the mitochondrial fusion machinery, suggests that MAVS regulates mitochondrial dynamics to facilitate the mitochondria/ER association required for signal transduction.
Celine Castanier, Dominique Garcin, Aime Vazquez and Damien Arnoult
doi:10.1038/embor.2009.258
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

----------------------
CORRECTIONS
----------------------
CORRIGENDUM
Me, myself and I. The genetics and molecular biology behind self-incompatibility and the avoidance of inbreeding in plants
Philip Hunter
doi:10.1038/embor.2009.287
http://links.ealert.nature.com/ctt?kn=49&m=34595109&r=MTc2MDI0MTQ4MQS2&b=2&j=NjY0NDgwNDcS1&mt=1&rt=0

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Cell Research - Table of Contents alert Volume 20 Issue 2

CELL RESEARCH

February 2010 Volume 20 Number 2, pp 113 - 245

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New to NPG: Cell Death & Disease
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----------------------
RESEARCH HIGHLIGHTS
----------------------
Histone code in the cross-talk during DNA damage signaling
Thomas Vaissiere and Zdenko Herceg
http://links.ealert.nature.com/ctt?kn=32&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0

Novel molecular insights into the mechanism of GO removal by MutM
Guo-Min Li
http://links.ealert.nature.com/ctt?kn=41&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0

Slaying RAS with a synthetic lethal weapon
Archana Bommi-Reddy and William G Kaelin
http://links.ealert.nature.com/ctt?kn=43&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0

UnTTrapping the ends: A new player in overcoming protein linked DNA damage
Karim Bahmed, Karin C Nitiss and John L Nitiss
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----------------------
REVIEW
----------------------
PPARs: diverse regulators in energy metabolism and metabolic diseases
Yong-Xu Wang
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0
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----------------------
ORIGINAL ARTICLES
----------------------
A GPCR/secretase complex regulates [beta]- and [gamma]-secretase specificity for A[beta]
production and contributes to AD pathogenesis
Lin Teng, Jian Zhao, Feifei Wang, Lan Ma and Gang Pei
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0

Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4
Chengyang Huang, Yang Xiang, Yanru Wang, Xia Li, Longyong Xu, Ziqi Zhu, Ting Zhang, Qingqing Zhu,
Kejing Zhang, Naihe Jing and Charlie Degui Chen
Abstract: http://links.ealert.nature.com/ctt?kn=60&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0
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Structural insights into a novel histone demethylase PHF8
Lin Yu, Yang Wang, Shuo Huang, Jianjun Wang, Zengqin Deng, Qi Zhang, Wei Wu, Xingliang Zhang,
Zhao Liu, Weimin Gong and Zhongzhou Chen
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0
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ATF4 regulates lipid metabolism and thermogenesis
Chunxia Wang, Zhiying Huang, Ying Du, Ying Cheng, Shanghai Chen and Feifan Guo
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0
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Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during
early development of zebrafish
Hao Yuan, Jun Zhou, Min Deng, Xi Liu, Morgane Le Bras, Hugues de The, Sai Juan Chen, Zhu Chen,
Ting Xi Liu and Jun Zhu
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0
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High-coverage proteome analysis reveals the first insight of protein modification systems in
the pathogenic spirochete Leptospira interrogans
Xing-Jun Cao, Jie Dai, Hao Xu, Song Nie, Xiao Chang, Bao-Yu Hu, Quan-Hu Sheng, Lian-Shui Wang,
Zhi-Bin Ning, Yi-Xue Li, Xiao-Kui Guo, Guo-Ping Zhao and Rong Zeng
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Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activity
Min Luo, Zhiyong Lu, He Sun, Kehu Yuan, Quancang Zhang, Sha Meng, Fangxun Wang, Hongchun Guo,
Xiaofang Ju, Yuqing Liu, Tao Ye, Zhigang Lu and Zhonghe Zhai
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0
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Endocytosis of Fc[alpha]R is clathrin and dynamin dependent, but its cytoplasmic domain is not required
Min Peng, Na Yin and Wei Zhang
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0
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----------------------
LETTERS TO THE EDITOR
----------------------
Netrin-1 signaling mediates NO-induced glial precursor migration and accumulation
Hongwei Chen, Qiang Wei, Jing Zhang, Chuangkun Xu, Tao Tan and Weizhi Ji
http://links.ealert.nature.com/ctt?kn=75&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0

Activation of JNK signaling links lgl mutations to disruption of the cell polarity and
epithelial organization in Drosophila imaginal discs
Mingwei Zhu, Tianchi Xin, Shunyan Weng, Yin Gao, Yingjie Zhang, Qi Li and Mingfa Li
http://links.ealert.nature.com/ctt?kn=67&m=34595093&r=MTc2MDE3NzA4MwS2&b=2&j=NjY0NDc3OTcS1&mt=1&rt=0

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Laboratory Investigation - Table of Contents alert Volume 90 Issue 2

LABORATORY INVESTIGATION

February 2010 Volume 90 Number 2, pp 142 - 343

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Still the #1 journal in Dermatology*

Journal of Investigative Dermatology (JID) continues to publish the latest,
most important research in cutaneous biology and skin disease.

Read a full issue FREE online:
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*2008 Journal Citation Report (Thomson Reuters, 2009)

----------------------
INSIDE LI
----------------------
Inside Lab Invest
http://links.ealert.nature.com/ctt?kn=21&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

----------------------
RESEARCH ARTICLES
----------------------
Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma
cells independent of PTEN status
Xuan Zhou, Yu Ren, Lynette Moore, Mei Mei, Yongping You, Peng Xu, Baoli Wang, Guangxiu Wang,
Zhifan Jia, Peiyu Pu, Wei Zhang and Chunsheng Kang
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic
injury via inhibiting the JNK-signaling pathway
Jing Pan, Jing Qian, Yu Zhang, Jianfang Ma, Gang Wang, Qin Xiao, Shengdi Chen and Jianqing Ding
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

Complement system becomes activated by the classical pathway in intracranial aneurysm walls
Riikka Tulamo, Juhana Frosen, Sami Junnikkala, Anders Paetau, Marko Kangasniemi, Jose Pelaez,
Juha Hernesniemi, Mika Niemela and Seppo Meri
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=41&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

The role of hypoxia and neurogenic genes (Mash-1 and Prox-1) in the developmental
programming and maturation of pulmonary neuroendocrine cells in fetal mouse lung
Suzanne McGovern, Jie Pan, Guillermo Oliver, Ernest Cutz and Herman Yeger
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
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Epstein-Barr virus facilitates the malignant potential of immortalized epithelial cells:
from latent genome to viral production and maintenance
Jian-Hong Lu, Yun-Lian Tang, Hai-Bo Yu, Jian-Hua Zhou, Chun-Yan Fu, Xi Zeng, Zheng-Yuan Yu,
Hong-Ling Yin, Ming-Hua Wu, Jun-Yi Zhang, Xiao-Ling Li and Gui-Yuan Li
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

Morphological differences during in vitro chondrogenesis of bone marrow-, synovium-MSCs,
and chondrocytes
Shizuko Ichinose, Takeshi Muneta, Hideyuki Koga, Yuko Segawa, Motoki Tagami,
Kunikazu Tsuji and Ichiro Sekiya
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

Runx2 regulates survivin expression in prostate cancer cells
Minyoung Lim, Chen Zhong, Shangxin Yang, Adam M Bell, Michael B Cohen and Pradip Roy-Burman
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome
Ting Li, Yun Su, Yuping Mei, Qixin Leng, Bingjie Leng, Zhenqiu Liu, Sanford A Stass and Feng Jiang
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats
fed a methionine-choline-deficient diet
Yong-ping Mu, Tomohiro Ogawa and Norifumi Kawada
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury
Kun Wang, Ivan Damjanov and Yu-Jui Yvonne Wan
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=9&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

Detergent-resistant microdomains mediate activation of host cell signaling in response to
attaching-effacing bacteria
Grace Shen-Tu, David B Schauer, Nicola L Jones and Philip M Sherman
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

----------------------
TECHNICAL REPORT
----------------------
Rapid quantification of DNA methylation by measuring relative peak heights in direct
bisulfite-PCR sequencing traces
Minghong Jiang, Yuhao Zhang, Jing Fei, Xinxia Chang, Weiwei Fan, Xueqing Qian, Tianbao Zhang and Daru Lu
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

----------------------
ABSTRACT
----------------------
SPP Annual Meeting Abstracts
http://links.ealert.nature.com/ctt?kn=17&m=34594751&r=MTc2Mjk0MzQ4MgS2&b=2&j=NjY0NDI1MjES1&mt=1&rt=0

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NATURE REVIEWS CLINICAL ONCOLOGY

February 2010 Volume 7 Number 2

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British Journal of Cancer presents:

NEW SUPPLEMENT

Diagnosing Cancer Earlier: Evidence for a National Awareness and Early
Diagnosis Initiative

Late diagnosis is generally accepted as a key factor in poor cancer
survival rates. Researchers from many disciplines here set out the
evidence and the enormous potential benefits of further identifying
and tackling the root causes.

View the supplement at:
http://links.ealert.nature.com/ctt?kn=58&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

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EDITORIAL
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Breast cancer screening and mortality
Vincent T. DeVita, Jr
p65 | doi:10.1038/nrclinonc.2009.232
http://links.ealert.nature.com/ctt?kn=25&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

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RESEARCH HIGHLIGHTS
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Hematology: Nilotinib as first-line therapy for Ph+ CML
p67 | doi:10.1038/nrclinonc.2009.228
http://links.ealert.nature.com/ctt?kn=29&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Genetics: Four-gene signature predicts survival in NSCLC
p68 | doi:10.1038/nrclinonc.2009.225
http://links.ealert.nature.com/ctt?kn=11&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

S-100B predicts survival in melanoma
p68 | doi:10.1038/nrclinonc.2009.226
http://links.ealert.nature.com/ctt?kn=15&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Medical oncology: Carcinoembryonic antigen mRNA expression-a marker for
early pancreatic cancer recurrence?
p69 | doi:10.1038/nrclinonc.2009.227
http://links.ealert.nature.com/ctt?kn=18&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Chemotherapy: Satraplatin delays progression in prostate cancer
p69 | doi:10.1038/nrclinonc.2009.230
http://links.ealert.nature.com/ctt?kn=90&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Immunotherapy: Predicting HSCT outcome in patients with neuroblastoma
p70 | doi:10.1038/nrclinonc.2009.224
http://links.ealert.nature.com/ctt?kn=93&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Hematology: Promising new agent for B-cell lymphoma
p70 | doi:10.1038/nrclinonc.2009.229
http://links.ealert.nature.com/ctt?kn=82&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

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NEWS AND VIEWS
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Targeted therapies: Optimal first-line therapy for NSCLC with EGFR
mutations
Joel W. Neal and Lecia V. Sequist
p71 | doi:10.1038/nrclinonc.2009.191
Activating mutations in EGFR are characteristic of patients with lung
cancer who have high sensitivity to EGFR tyrosine kinase inhibitors,
such as gefitinib and erlotinib. The randomized IPASS study by Mok and
colleagues confirmed that patients with EGFR mutations have a higher
response rate, longer progression-free survival and improved quality
of life when treated with first-line gefinitib instead of chemotherapy.
http://links.ealert.nature.com/ctt?kn=85&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Surgical oncology: Why biopsying metastatic breast cancer should be
routine
Anand Sharma, Tim Crook, Alastair Thompson and Carlo Palmieri
p72 | doi:10.1038/nrclinonc.2009.222
Currently, acquisition of tissue from presumed metastatic deposits in
breast cancer is not routine. Instead therapeutic decisions in this
setting are based on the features of the tumor at initial diagnosis.
As biopsies are diagnostic and changes can occur between the primary
and the secondary tumors, the routine biopsy of suspected metastatic
deposits needs to be considered. Such biopsies will also be key to
translational research, which will underpin future therapeutic advances.
http://links.ealert.nature.com/ctt?kn=86&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Chemotherapy: Cisplatin combinations in cervical cancer-which is best?
David O. Holtz and Charles J. Dunton
p74 | doi:10.1038/nrclinonc.2009.220
We reviewed the results of the Gynecological Oncology Group 204 (GOG-204)
randomized phase III trial, which investigated four cisplatin combination
chemotherapy regimens for the treatment of patients with recurrent or
metastatic cervical carcinoma. As the overall survival was similar
between all arms, treatment recommendations need to be tailored based
on toxic effects.
http://links.ealert.nature.com/ctt?kn=10&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Medical oncology: Treatment and management of malignant gliomas
Deric M. Park, Sith Sathornsumetee and Jeremy N. Rich
p75 | doi:10.1038/nrclinonc.2009.221
The considerable progress made in the field of clinical neuro-oncology
and the understanding of brain tumor biology is generating cautious
optimism. Treatment options for patients with glioblastoma multiforme
(GBM), the most common form of malignant gliomas, now include
anti-angiogenic therapy after failure of standard multi-modality
treatments. Furthermore, scientific advancements are providing new
insights into disease pathogenesis and point to novel therapeutic
approaches for a disease that traditionally lacked treatment options.
http://links.ealert.nature.com/ctt?kn=5&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Chemotherapy: Continued lack of progress in SCLC
Janakiraman Subramanian and Ramaswamy Govindan
p77 | doi:10.1038/nrclinonc.2009.223
Chemotherapy options for patients with extensive-stage small-cell lung
cancer (SCLC) are limited. A recent phase III trial assessed the combination
of carboplatin and pemetrexed but this regimen produced inferior survival
results compared with the standard carboplatin and etoposide regimen. The
combination of carboplatin and etoposide remains the standard first-line
chemotherapy option for the treatment of patients with extensive-stage SCLC.
http://links.ealert.nature.com/ctt?kn=7&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Chemotherapy: Dose-dense treatment for triple-negative breast cancer
Eitan Amir, Alberto Ocana, Orit Freedman, Mark Clemons and Bostjan Seruga
p79 | doi:10.1038/nrclinonc.2009.231
Dose-dense chemotherapy has been proposed to improve breast cancer
outcome due to its ability to prevent cancer cell repopulation; however,
little is known about which patients benefit most from such scheduling.
A pooled analysis of studies assessing dose-dense adjuvant chemotherapy
has shown that most of the therapeutic benefit derived from dose-dense
scheduling arises in patients with node-positive, triple-negative disease.
http://links.ealert.nature.com/ctt?kn=34&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Targeted therapies: Tailored treatment for ovarian cancer: are we there yet?
Cristiana Sessa and Gianluca Del Conte
p80 | doi:10.1038/nrclinonc.2009.233
First-line platinum and taxane chemotherapy improves the prognosis of
patients with epithelial ovarian cancer (EOC), however, about 80% of
patients relapse and long-term survival is poor. The development of drug
resistance is the main cause of treatment failure; therefore, the
identification of new compounds that interfere with tumor growth and
survival is a priority.
http://links.ealert.nature.com/ctt?kn=22&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

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REVIEWS
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The role of SRC-3 in human breast cancer
Ondrej Gojis, Bharath Rudraraju, Mihir Gudi, Katy Hogben, Sami Sousha,
Charles R. Coombes, Susan Cleator and Carlo Palmieri
Published online: 22 December 2009
p83 | doi:10.1038/nrclinonc.2009.219
Members of the nuclear receptor superfamily of transcription factors have
been implicated in a broad range of normal physiological and disease
processes. There is evidence in support of the involvement of these
co-regulators in breast cancer progression. The authors review the role
of steroid receptor coactivator-3, which is frequently amplified in breast
cancer, and discuss its role in breast cancer risk, outcome and response
to endocrine therapy in patients with breast cancer.
Abstract: http://links.ealert.nature.com/ctt?kn=65&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Genomic markers for decision making: what is preventing us from using markers?
Vicky M. Coyle and Patrick G. Johnston
Published online: 15 December 2009
p90 | doi:10.1038/nrclinonc.2009.214
There has been extensive research evaluating the clinical usefulness of
genomic biomarkers. High-throughput genomic technologies have revolutionized
genomic research but challenges in biomarker assessment include clinical
study design, reproducibility and interpretation of results. This Review
explores these challenges, focusing on microarray-based gene-expression
profiling, and highlights some common failings in study design that have
impacted on the clinical use of putative genomic markers.
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Molecular predictors of response to trastuzumab and lapatinib in breast
cancer
Francisco J. Esteva, Dihua Yu, Mien-Chie Hung and Gabriel N. Hortobagyi
Published online: 22 December 2009
p98 | doi:10.1038/nrclinonc.2009.216
Trastuzumab and lapatinib improve survival in patients with HER2-positive
breast cancer and there is great interest in developing diagnostic tests
that predict which patients are more likely to benefit from specific
HER2-directed therapies. This article discusses the predictive role of
HER2 mRNA, predictive markers for response to therapy and the mechanisms
for overcoming resistance in metastatic disease.
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

Intraperitoneal therapy for peritoneal tumors: biophysics and clinical
evidence
Wim P. Ceelen and Michael F. Flessner
Published online: 15 December 2009
p108 | doi:10.1038/nrclinonc.2009.217
It has been established that intraperitoneal drug administration is
advantageous in patients with tumors confined to the peritoneal cavity.
The authors of this Review discuss intraperitoneal drug delivery including
the optimal drug, dose and schedule.
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

----------------------
CASE STUDY
----------------------
T-cell lymphoproliferative disorder potentially induced by imatinib in
a patient with GIST
Mareike Verbeek, Falko Fend, Thomas Licht, Christian Meyer zum Buschenfelde,
Jens Stollfuss, Christian Peschel and Justus Duyster
p116 | doi:10.1038/nrclinonc.2009.218
A 71-year-old male patient was diagnosed with a KIT-positive gastrointestinal
stromal tumor (GIST). The patient received adjuvant imatinib but developed
several subcutaneous and intra-abdominal tumor lesions after 4 months
of treatment. A T-cell lymphoproliferative disorder was suspected. The
authors discuss the potential of imatinib to induce reversible clonal
T-cell proliferations in patients with GIST who develop new tumor
manifestations that are suspicious for relapse.
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34594733&r=MTc2NDg2OTc4MQS2&b=2&j=NjY0NDIzMTcS1&mt=1&rt=0

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Vision Research: Retinal Ganglion Cells, Abstract deadline 3 February 2010

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Committee... Location...  Submit an Abstract... Registration Info...  Sponsors...   Abstract Submission Deadline Approaching Deadline: 3 February 2010 INTRODUCTION This conference aims to bring together leading basic and clinical scientists to share the latest research on retinal ganglion cells and their roles in vision and disease. The goal is to take a comprehensive look at this critical and complex class of neurons, examining their development and establishment of axonal and dendritic connections, their diverse functions in processing signals from the outer retina and detecting light directly, how they are affected in glaucoma, optic nerve damage, and other disease conditions, and how our understanding of these processes can lead to novel therapeutic approaches. CALL FOR POSTERS Abstract submission deadline: 3 February 2010 As a satellite to the annual meeting of ARVO, the Association for Research in Vision and Ophthalmology, we are requested by ARVO, as co-sponsor, to stipulate that you do not present the same work at both the Vision Research conference and the ARVO main meeting. We would appreciate your assistance in complying with this stipulation. NB. Selected quality posters will be chosen to present a 10 minute oral presentation based on their poster and latest results. Abstracts are invited for poster presentations on the following symposium topics. Please submit abstracts using the Online Submission Form by 3 February 2010 according to the abstract preparation guidelines. Topics include Signal processing by retinal ganglion cells Photosensitive ganglion cells Ganglion cell development and axonal targeting Optic nerve damage and regeneration Mechanisms of ganglion cell death/animal models Pathogenesis/neuro-protection for ganglion cells Gene defects associated with ganglion cell disease Novel therapeutic approaches in glaucoma All abstracts will be refereed and a criterion of rejection will be lack of originality. A condition of submission is that, if accepted, the paper will be presented at the Thirteenth Annual Vision Research Conference by one of the authors. ONLINE REGISTRATION NOW OPEN! Registration fees For registrations received prior to the conference: Academic Registration Fee- $355 Industrial Registration Fee- $520 Student* Registration Fee- $220 For registrations received onsite: Onsite Academic Registration Fee- $414 Onsite Industrial Registration Fee- $580 Onsite Student* Registration Fee- $250 * Student registration fee applicable for undergraduate students or those studying towards a post-graduate qualification. Must be accompanied with a letter from your head of department attesting to your student status Registration includes Access to all conference sessions Access to poster areas Abstract book available at the conference and conference documentation Mid-session refreshments as scheduled in the conference program A Special issue of Vision Research containing original papers by the invited speakers, to be mailed to all registered delegates after the conference Please note: The registration fee does not include lunch on either conference day. Lunch options will be available for delegates on a cash basis.     ORGANISERS T. Wensel, Baylor College of Medicine, USA W. Baehr, University of Utah, USA S. Wu, Baylor College of Medicine, USA Organised and sponsored by Vision Research, Elseviers international journal for Functional Aspects of Vision. Co-sponsored by ARVO the Association for Research in Vision and Ophthalmology.   CONFERENCE SECRETARIAT Amy Hill, Elsevier, UK   LOCATION Fort Lauderdale, Florida, USA The conference will take place at the Greater Fort Lauderdale/Broward Country Convention Center, which is conveniently locating in the city, minutes from the many restaurants, shops and galleries of Las Olas Boulevard. It is also nearby beaches and a great base for many sightseeing tours, including trips to the Bahamas Islands, the Florida Everglades and the waterways of the "Venice of America".       Data Protection Notice: This e-mail has been sent to manojhind2001us1.stemcell@blogger.com from Elsevier Ltd., The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, registered in England with registered number 1982084, using smartFOCUS DIGITAL's technology and platform. To ensure delivery to your inbox (not bulk or junk folders), please click here to add our address to your safe senders list. You are receiving this e-mail because you are a registered user of ScienceDirect® and have consented to receive information about related products. If you do not wish to receive calls for papers for Elsevier Conferences, you can visit this page to Unsubscribe, enter your email address, and press the submit button and you will be unsubscribed. 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