Nature Cell Biology contents: April 2009 Volume 11 Number 4, pp 363 - 508

NATURE CELL BIOLOGY

April 2009 Volume 11 Number 4, pp 363 - 508

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EDITORIALS
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UK research funding p363
Is the UK still committed to basic biology research?
doi:10.1038/ncb0409-363a
http://links.ealert.nature.com/ctt?kn=13&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Turning points p363
A series of essays describing pivotal events in the careers of cell biologists.
doi:10.1038/ncb0409-363b
http://links.ealert.nature.com/ctt?kn=40&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

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TURNING POINTS
----------------------
Coming in from the cold: how answering a postcard can launch a
scientific career p364
Gottfried Schatz
doi:10.1038/ncb0409-364
http://links.ealert.nature.com/ctt?kn=12&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

----------------------
REVIEW
----------------------
Spindle orientation during asymmetric cell division pp365 - 374
Karsten H. Siller and Chris Q. Doe
doi:10.1038/ncb0409-365
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=54&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Double JMY: making actin fast pp375 - 376
The assembly of actin networks is dependent on nucleation-promoting
factors. A new study identifies JMY as a protein containing two separate
nucleation-promoting activities that shuttles between the nucleus and the
cytoplasm and promotes cell migration. These observations indicate that
JMY is an important factor controlling actin dynamics in motile cells.
David W. Roadcap and James E. Bear
doi:10.1038/ncb0409-375
http://links.ealert.nature.com/ctt?kn=120&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Skp2: caught in the Akt pp377 - 379
To control cell proliferation, signal transduction needs to regulate the
cell-cycle machinery. Recent findings show that Akt -- a major
kinase that coordinates diverse signalling pathways -- phosphorylates
Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key
cell-cycle regulators. Akt1-dependent phosphorylation activates
SCF-Skp2 through multiple mechanisms.
Karin Ecker and Ludger Hengst
doi:10.1038/ncb0409-377
http://links.ealert.nature.com/ctt?kn=104&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Targeting protein ubiquitylation: DDB1 takes its RING off pp379 - 381
Ubiquitin E3 ligases of the RING and HECT families are distinct not
only in their catalytic mechanisms but also in targeting substrates.
Now it seems that one heterodimeric complex can target substrates
to both types of E3 ligase.
Sarah Jackson and Yue Xiong
doi:10.1038/ncb0409-379
http://links.ealert.nature.com/ctt?kn=86&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

SOC: now also store-operated cyclase pp381 - 382
Depletion of Ca2+ from intracellular stores has long been known to signal
to and activate plasma membrane 'store-operated' channels. We now
learn that store depletion also controls the formation of cyclic AMP (cAMP)
through the regulation of adenylyl cyclase (A-Cyclase). These findings
substantially broaden the scope and biological significance of Ca2+
store-regulated signalling.
James W. Putney, Jr
doi:10.1038/ncb0409-381
http://links.ealert.nature.com/ctt?kn=123&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Research highlights p383
doi:10.1038/ncb0409-383
http://links.ealert.nature.com/ctt?kn=20&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate
autophagy at different stages pp385 - 396
Beclin 1 is an essential mediator of mammalian autophagy that has
anti-tumour activity. Beclin 1 associates with Atg14L and Rubicon to
regulate autophagosome formation and maturation, respectively.
Kohichi Matsunaga et al.
doi:10.1038/ncb1846
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and
impairs APCCdh1-mediated Skp2 destruction pp397 - 408
Skp2 is a known component of the SCF ubiquitin ligase that targets the
cell-cycle regulator p27. Akt kinase phosphorylates Skp2 and regulates
its stability and cytoplasmic localization.
Daming Gao et al.
doi:10.1038/ncb1847
Abstract: http://links.ealert.nature.com/ctt?kn=102&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=98&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase
pp409 - 419
The kinase DYRK2 regulates the assembly of a ubiquitin ligase complex in
a phosphorylation-independent manner, while also phosphorylating the target
for the ligase. Thus, ligase assembly and target ubiquitylation appear to be
physically linked processes.
Subbareddy Maddika and Junjie Chen
doi:10.1038/ncb1848
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Phosphorylation-dependent regulation of cytosolic localization and oncogenic
function of Skp2 by Akt/PKB pp420 - 432
Skp2 is a known component of the SCF ubiquitin ligase that ubiquitylates the
cell-cycle regulator p27. Akt kinase directly phosphorylates Skp2 and regulates
SCF complex assembly and ligase activity, Skp2 cytoplasmic localization and
Skp2-dependent regulation of cell proliferation and migration.
Hui-Kuan Lin et al.
doi:10.1038/ncb1849
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Store-operated cyclic AMP signalling mediated by STIM1 pp433 - 442
The ER Ca2+ sensor protein STIM1 regulates cAMP signalling by coupling
the changes in luminal ER Ca2+ content to adenylyl cyclase activity.
Konstantinos Lefkimmiatis et al.
doi:10.1038/ncb1850
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

----------------------
LETTERS
----------------------
Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to
the plus ends of actin filaments pp443 - 450
Actin filaments in stereocilia on the surface of inner ear sensory hair
cells are continually renewed. Myosin IIIa transports the actin-binding/
bundling protein espin to stereocilia tips and cooperates with espin in
actin filament elongation.
Felipe T. Salles et al.
doi:10.1038/ncb1851
Abstract: http://links.ealert.nature.com/ctt?kn=101&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

p53-cofactor JMY is a multifunctional actin nucleation factor pp451 - 459
JMY, originally discovered as a binding partner of the p53 co-activator
p300, is an actin-nucleating protein, assembling filaments both by
activation of the Arp2/3 complex and through an Arp2/3-independent
mechanism.
J. Bradley Zuchero et al.
doi:10.1038/ncb1852
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Characterization of the interface between normal and transformed
epithelial cells pp460 - 467
How a transformed cell interacts with normal cells remains unclear.
Most RasV12-transformed cells in an epithelial monolayer are extruded
apically in a manner regulated by ROCK, Myosin II and Cdc42, but
some cells invade the basal matrix via a mechanism requiring PI3 kinase.
Catherine Hogan et al.
doi:10.1038/ncb1853
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Distinct regulation of autophagic activity by Atg14L and Rubicon
associated with Beclin 1-phosphatidylinositol-3-kinase complex
pp468 - 476
Beclin 1 is an essential mediator of mammalian autophagy that has
anti-tumour activity. Two proteins that interact with Beclin 1 have been
newly identified and their analysis shows that distinct Beclin 1 complexes
regulate autophagosome formation and maturation, respectively.
Yun Zhong et al.
doi:10.1038/ncb1854
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

A mechanism for chromosome segregation sensing by the NoCut checkpoint
pp477 - 483
In yeast, anaphase defects can trigger activation of the NoCut checkpoint,
resulting in delayed cytokinesis. The Ilp1/aurora kinase localizes to the
spindle midzone and monitors chromatin segregation, thus acting as a
chromatin sensor.
Manuel Mendoza et al.
doi:10.1038/ncb1855
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Modularity of MAP kinases allows deformation of their signalling pathways
pp484 - 491
During evolution, MAP kinases repeatedly changed substrate specificities
and interaction partners. Because of their modular design, they can be
experimentally re-designed to achieve rewiring of the signalling network.
Areez Mody, Joan Weiner and Sharad Ramanathan
doi:10.1038/ncb1856
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=125&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

STAT3 inhibition of gluconeogenesis is downregulated by SirT1 pp492 - 500
Yongzhan Nie et al.
doi:10.1038/ncb1857
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis
reveals an rpL11-translation-dependent mechanism of p53 induction pp501 - 508
Depletion of ribosomal protein S6 leads to upregulation of p53 and cell cycle
arrest. Surprisingly, p53 induction is not due to nucleolar disruption and Mdm2
inhibition, but rather the selective translation of a class of mRNAs including
ribosomal protein L11.
Stefano Fumagalli et al.
doi:10.1038/ncb1858
Abstract: http://links.ealert.nature.com/ctt?kn=124&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

----------------------
ERRATUM
----------------------
Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex
at the plasma membrane during planar epithelial polarization p508
Matias Simons et al.
doi:10.1038/ncb0409-508
http://links.ealert.nature.com/ctt?kn=83&m=32242963&r=MTc2NDEyMTk0MQS2&b=2&j=NDcwNTY0NjMS1&mt=1&rt=0

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Kidney International - Table of Contents alert Volume 75 Issue 8

KIDNEY INTERNATIONAL

April 2009 Volume 75 Number 8, pp 761 - 868

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World Congress of Nephrology
Milan, May 22nd - 26th

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----------------------
IN THIS ISSUE
----------------------
In this Issue
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----------------------
JOURNAL CLUB
----------------------
Journal Club
http://links.ealert.nature.com/ctt?kn=93&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

----------------------
COMMENTARIES
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The diversity of PKD1 alleles: implications for disease pathogenesis and genetic counseling
Richard N Sandford
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

The goddess of the waters
Harry van Goor and Henri G D Leuvenink
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Regulation of renal arteriolar tone by adenosine: novel role for type 2 receptors
Tracy D Bell and William J Welch
Abstract: http://links.ealert.nature.com/ctt?kn=96&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Left ventricular hypertrophy in renal disease: beyond preload and afterload
Eberhard Ritz
Abstract: http://links.ealert.nature.com/ctt?kn=36&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

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MINI REVIEWS
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Melamine nephrotoxicity: an emerging epidemic in an era of globalization
Vivek Bhalla, Paul C Grimm, Glenn M Chertow and Alan C Pao
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Childhood urinary stones induced by melamine-tainted formula: how much we know, how much we don't know
Jie Ding
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

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ORIGINAL ARTICLES
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Ischemic and non-ischemic acute kidney injury cause hepatic damage
Fereshteh Golab, Mehri Kadkhodaee, Maryam Zahmatkesh, Mehdi Hedayati, Hossein Arab, Rebecca Schuster, Kamyar Zahedi, Alex B Lentsch and Manoocher Soleimani
Abstract: http://links.ealert.nature.com/ctt?kn=108&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Activation of A2 adenosine receptors dilates cortical efferent arterioles in mouse
Rozh H Al-Mashhadi, Ole Skott, Paul M Vanhoutte and Pernille B Hansen
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure
Andrew M Siedlecki, Xiaohua Jin and Anthony J Muslin
Abstract: http://links.ealert.nature.com/ctt?kn=95&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia-reperfusion injury
Minjae Kim, Sean W C Chen, Sang Won Park, Mihwa Kim, Vivette D D'Agati, Jay Yang and H Thomas Lee
Abstract: http://links.ealert.nature.com/ctt?kn=102&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
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Oligosaccharide composition is similar in drusen and dense deposits in membranoproliferative glomerulonephritis type II
Yvonne B D'souza, Carolyn J P Jones, Colin D Short, Ian S D Roberts and Richard E Bonshek
Abstract: http://links.ealert.nature.com/ctt?kn=83&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
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Lymphatic vessels develop during tubulointerstitial fibrosis
Izumi Sakamoto, Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Akiho Sawai, Akio Tanaka, Shoichi Maruyama, Yoshifumi Takei, Yukio Yuzawa and Seiichi Matsuo
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Mutations of NPHP2 and NPHP3 in infantile nephronophthisis
Kalman Tory, Caroline Rousset-Rouviere, Marie-Claire Gubler, Vincent Moriniere, Audrey Pawtowski, Celine Becker, Claude Guyot, Sophie Gie, Yaacov Frishberg, Hubert Nivet, Georges Deschenes, Pierre Cochat, Marie-France Gagnadoux, Sophie Saunier, Corinne Antignac and Remi Salomon
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease
Sandro Rossetti, Vickie J Kubly, Mark B Consugar, Katharina Hopp, Sushmita Roy, Sharon W Horsley, Dominique Chauveau, Lesley Rees, T Martin Barratt, William G van't Hoff, W Patrick Niaudet, Vicente E Torres and Peter C Harris
Abstract: http://links.ealert.nature.com/ctt?kn=114&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

----------------------
THE RENAL CONSULT
----------------------
A case of nephrocalcinosis
Leal C Herlitz, Robert Bruno, Jai Radhakrishnan and Glen S Markowitz
http://links.ealert.nature.com/ctt?kn=1&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

----------------------
LETTERS TO THE EDITOR
----------------------
`Labile hypertension' can be due to autonomic nervous system failure
Satish R Raj, James M Luther, Kyoko Sato and Andre Diedrich
http://links.ealert.nature.com/ctt?kn=31&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Response to `"Labile hypertension" can be due to autonomic nervous system failure'
Aldo J Peixoto and Tausif Zar
http://links.ealert.nature.com/ctt?kn=110&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Death or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depression
Christopher G Brown
http://links.ealert.nature.com/ctt?kn=59&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Response to `Death or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depression'
S Susan Hedayati, Hayden B Bosworth, Libbie P Briley, Richard Sloane, Carl Pieper, Paul L Kimmel and Lynda A Szczech
http://links.ealert.nature.com/ctt?kn=78&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Bilirubin as a predictor of albuminuria and atherosclerosis in type 2 diabetic patients: misleading data
Theodore I Kassimatis and Dimitrios-Anestis Moutzouris
http://links.ealert.nature.com/ctt?kn=60&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Response to `Bilirubin as a predictor of albuminuria and atherosclerosis in type 2 diabetic patients: misleading data'
Michiaki Fukui and Naoto Nakamura
http://links.ealert.nature.com/ctt?kn=39&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Relationship between serum bilirubin and kidney function in non-diabetic and diabetic individuals
Giovanni Targher, Giacomo Zoppini, Gian Cesare Guidi and Giuseppe Lippi
http://links.ealert.nature.com/ctt?kn=84&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

Response to `Relationship between serum bilirubin and kidney function in non-diabetic and diabetic individuals'
Michiaki Fukui and Naoto Nakamura
http://links.ealert.nature.com/ctt?kn=26&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

----------------------
MAKE YOUR DIAGNOSIS
----------------------
The Case | Acute kidney injury in a patient with P. carinii pneumonia
Vimal K Derebail, JulieAnne G McGregor, Romulo E Colindres, Harsharan K Singh and Abhijit V Kshirsagar
http://links.ealert.nature.com/ctt?kn=14&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

----------------------
NEPHROLOGY IMAGES
----------------------
Calcium channel blocker-induced chylous ascites in peritoneal dialysis
Yu-Tzu Tsao and Wei-Liang Chen
http://links.ealert.nature.com/ctt?kn=67&m=32242294&r=MTc2MzAwNDQzNwS2&b=2&j=NDcwNTIxMzYS1&mt=1&rt=0

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NATURE REVIEWS RHEUMATOLOGY

April 2009 Volume 5 Number 4

Visit Nature Reviews Rheumatology online to browse the journal.

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----------------------
EDITORIAL
----------------------
Bias, conflict of interest and publishing
Peter E. Lipsky
p175 | doi:10.1038/nrrheum.2009.52
http://links.ealert.nature.com/ctt?kn=37&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Connective tissue diseases: Undoing the damage caused by systemic sclerosis
p177 | doi:10.1038/nrrheum.2009.56
http://links.ealert.nature.com/ctt?kn=104&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

IN BRIEF
Bone diseases | Autoimmunity | Experimental arthritis | Rheumatoid arthritis
p178 | doi:10.1038/nrrheum.2009.44
http://links.ealert.nature.com/ctt?kn=67&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Rheumatoid arthritis: Predicting RA progression
p178 | doi:10.1038/nrrheum.2009.57
http://links.ealert.nature.com/ctt?kn=106&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Experimental arthritis: Exploiting IL-6 trans signaling targets
collagen-induced arthritis
p179 | doi:10.1038/nrrheum.2009.58
http://links.ealert.nature.com/ctt?kn=24&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Rheumatoid arthritis: Anti-MCV antibodies-a promising new biomarker for RA
p179 | doi:10.1038/nrrheum.2009.59
http://links.ealert.nature.com/ctt?kn=2&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

IL-3 prevents inflammatory arthritis
p180 | doi:10.1038/nrrheum.2009.60
http://links.ealert.nature.com/ctt?kn=92&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Rheumatoid arthritis: Do steroids increase metabolic syndrome risk?
p180 | doi:10.1038/nrrheum.2009.61
http://links.ealert.nature.com/ctt?kn=91&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

IN BRIEF
Autoimmunity | Rheumatoid arthritis | Experimental arthritis |
Spondyloarthropathies
p181 | doi:10.1038/nrrheum.2009.45
http://links.ealert.nature.com/ctt?kn=70&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Inflammation: SIGN here for anti-inflammatory activity!
p181 | doi:10.1038/nrrheum.2009.62
http://links.ealert.nature.com/ctt?kn=18&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Connective tissue diseases: Autoantibody profiles linked to ethnicity
in pediatric SLE
p182 | doi:10.1038/nrrheum.2009.32
http://links.ealert.nature.com/ctt?kn=100&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Rheumatoid arthritis: PlGF's role extends beyond angiogenesis
p182 | doi:10.1038/nrrheum.2009.35
http://links.ealert.nature.com/ctt?kn=45&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Vasculitis syndromes: Vasculitis therapy-between Scylla and Charybdis
Richard Watts
p183 | doi:10.1038/nrrheum.2009.46
Achieving effective maintenance therapy with minimal adverse effects for
patients with antineutrophil cytoplasmic autoantibody associated vasculitis
is a major challenge facing the vasculitis community. A study by Pagnoux
et al. shows that azathioprine and methotrexate have similar efficacy and
adverse event profiles when used for remission maintenance in these patients.
http://links.ealert.nature.com/ctt?kn=52&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Therapy: Are TNF inhibitors safe in pregnancy?
Monika Ostensen
p184 | doi:10.1038/nrrheum.2009.47
Tumor necrosis factor inhibitors are fast acting, highly effective and
well tolerated by the majority of patients, but their safety in pregnant
women remains a matter of debate. The latest research weighs in on the
issue.
http://links.ealert.nature.com/ctt?kn=54&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Therapy: Methotrexate guidelines: compromise to reach consensus
Joel M. Kremer
p186 | doi:10.1038/nrrheum.2009.41
Practice in relation to administration of methotrexate varies considerably
despite its prominent place in the treatment arsenal for various rheumatic
diseases. A multinational initiative has developed recommendations, based
on the literature and in consultation with a large panel of rheumatologists,
for use of this drug.
http://links.ealert.nature.com/ctt?kn=5&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Genetics: Unraveling the genetics of autoimmune disease
Timothy J. Vyse
p187 | doi:10.1038/nrrheum.2009.42
The ability to conduct genetic association studies on a genome-wide scale
has revolutionized approaches to reveal the genetic basis of autoimmune
diseases. A comparison by Zhernakova and colleagues of the known
susceptibility genes in 11 immune-related diseases reveals evidence for
shared gene effects and common pathogenetic mechanisms.
http://links.ealert.nature.com/ctt?kn=21&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Fibromyalgia: A new treatment option for fibromyalgia
Robert M. Bennett
p188 | doi:10.1038/nrrheum.2009.48
The FDA's approval of milnacipran reflects advances in the development
of drugs aimed at modulating pain circuitry in fibromyalgia.
http://links.ealert.nature.com/ctt?kn=103&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
A symptom-based approach to pharmacologic management of fibromyalgia
Chad S. Boomershine and Leslie J. Crofford
p191 | doi:10.1038/nrrheum.2009.25
In the context of a multidisciplinary approach to the management of
fibromyalgia, guidelines recommend that pharmacologic therapies be
individually tailored to a patient's symptoms but do not offer a method
of assessment. In this Review, the authors provide a rapid,
easily-remembered framework for the quantitation and pharmacologic
management of symptoms that is suitable for use in a busy clinical practice.
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Transforming growth factor [beta] as a therapeutic target in systemic sclerosis
John Varga and Boris Pasche
p200 | doi:10.1038/nrrheum.2009.26
In patients with systemic sclerosis, impaired activity of transforming
growth factor [beta] (TGF-[beta]) has a central role in the pathogenesis
of fibrosis, which leads to the progression of the disease and severe
organ damage. In this context, the authors discuss the mechanisms of
aberrant TGF-[beta] signaling and highlight the potential of TGF-[beta]
as a therapeutic target in systemic sclerosis.
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=93&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Management of cardiovascular disease risk in chronic inflammatory disorders
Mariana J. Kaplan
p208 | doi:10.1038/nrrheum.2009.29
A wealth of evidence suggests that the prevalence of cardiovascular disease
is increased in patients suffering from chronic inflammatory disorders,
particularly rheumatoid arthritis and systemic lupus erythematosus, as
discussed in this Review. In the absence of specific guidelines, Dr Kaplan
highlights strategies for the prevention and treatment of cardiovascular
events in patients with chronic inflammatory disease.
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

Periodontitis in systemic rheumatic diseases
Paola de Pablo, Iain L. C. Chapple, Christopher D. Buckley and Thomas
Dietrich
p218 | doi:10.1038/nrrheum.2009.28
A potential association between periodontitis, a chronic inflammatory
disease characterized by loss of the periodontal ligament and alveolar
bone, and systemic rheumatic diseases-particularly rheumatoid
arthritis-has been suggested. Results from studies that support such a
link are outlined in this article, as are causal and non-causal factors
that could determine an association between the two conditions.
Abstract: http://links.ealert.nature.com/ctt?kn=72&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

----------------------
CASE STUDY
----------------------
Rapidly progressive fatal interstitial lung disease in a patient with
systemic sclerosis
Kristine Phillips, Cathryn Byrne-Dugan, Eric Batterson and James R. Seibold
p225 | doi:10.1038/nrrheum.2009.30
Interstitial lung disease is a common manifestation of systemic sclerosis,
and often leads to death in these patients. These authors describe the
case of a previously healthy woman with acute systemic sclerosis who
experienced an unusually fulminant course of interstitial lung disease,
which did not respond to treatment with intravenous cyclophosphamide.
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

----------------------
PERSPECTIVES
----------------------
OPINION
The cholinergic anti-inflammatory pathway: towards innovative treatment
of rheumatoid arthritis
Marjolein A. van Maanen, Margriet J. Vervoordeldonk and Paul P. Tak
p229 | doi:10.1038/nrrheum.2009.31
Evidence is mounting that the cholinergic pathway is involved in the
pathogenesis of rheumatoid arthritis and other immune-mediated inflammatory
disorders. This timely article provides an overview of the role of the vagus
nerve and [alpha]7 nicotinic acetylcholine receptor in this pathway, and
highlights novel strategies that could exploit these targets in the
treatment of rheumatic diseases.
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=32242286&r=MTc2NDQ4MTc5OAS2&b=2&j=NDcwNTIwOTgS1&mt=1&rt=0

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BRITISH JOURNAL OF CANCER

Volume 100 Number 7
Published online 31 March 2009 (1021 - 1212)

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----------------------
MINIREVIEW
----------------------
Childhood exposure to external ionising radiation and solid cancer risk
S Sadetzki and L Mandelzweig
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

----------------------
CLINICAL STUDIES
----------------------
Incidence and predictors of treatment-related mortality in paediatric acute leukaemia in El Salvador
S Gupta, M Bonilla, S L Fuentes, M Caniza, S C Howard, R Barr, M L Greenberg, R Ribeiro and L Sung
Abstract: http://links.ealert.nature.com/ctt?kn=119&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Cetuximab plus gemcitabine//oxaliplatin (GEMOXCET) in first-line metastatic pancreatic cancer: a multicentre phase II study
F Kullmann, S Hollerbach, M M Dollinger, J Harder, M Fuchs, H Messmann, J Trojan, E Gabele, A Hinke, C Hollerbach and E Endlicher
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Characteristics and outcomes of patients with advanced non-small-cell lung cancer who declined to participate in randomised clinical chemotherapy trials
C Tanai, H Nokihara, S Yamamoto, H Kunitoh, N Yamamoto, I Sekine, Y Ohe and T Tamura
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Evaluation of extension of breast screening to women aged 65-70 in England using screening performance measures
R L Bennett, R G Blanks and S M Moss
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=9&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Breast-conserving surgery with or without radiotherapy vs mastectomy for ductal carcinoma in situ: French Survey experience
B Cutuli, C Lemanski, A Fourquet, B de Lafontan, S Giard, A Meunier, R Pioud-Martigny, F Campana, H Marsiglia, S Lancrenon, E Mery, F Penault-Llorca, E Fondrinier and C Tunon de Lara
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

----------------------
TRANSLATIONAL THERAPEUTICS
----------------------
High cyclin B1 expression is associated with poor survival in breast cancer
K Aaltonen, R-M Amini, P Heikkila, K Aittomaki, A Tamminen, H Nevanlinna and C Blomqvist
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=121&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer
C Horlock, B Stott, P J Dyson, M Morishita, R C Coombes, P Savage and J Stebbing
Abstract: http://links.ealert.nature.com/ctt?kn=91&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Inhibition of androstenediol-dependent LNCaP tumour growth by 17[alpha]-ethynyl-5[alpha]-androstane-3[alpha], 17[beta]-diol (HE3235)
R Trauger, E Corey, D Bell, S White, A Garsd, D Stickney, C Reading and J Frincke
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential
S Khan, J R Aspe, M G Asumen, F Almaguel, O Odumosu, S Acevedo-Martinez, M De Leon, W H R Langridge and N R Wall
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

----------------------
MOLECULAR DIAGNOSTICS
----------------------
Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant
F Molinari, V Martin, P Saletti, S De Dosso, A Spitale, A Camponovo, A Bordoni, S Crippa, L Mazzucchelli and M Frattini
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival
N I Herath, J Doecke, M D Spanevello, B A Leggett and A W Boyd
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=107&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Screening for colorectal cancer: random comparison of guaiac and immunochemical faecal occult blood testing at different cut-off levels
L Hol, J A Wilschut, M van Ballegooijen, A J van Vuuren, H van der Valk, J C I Y Reijerink, A C M van der Togt, E J Kuipers, J D F Habbema and M E van Leerdam
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes
C Alfaro, N Suarez, A Gonzalez, S Solano, L Erro, J Dubrot, A Palazon, S Hervas-Stubbs, A Gurpide, J M Lopez-Picazo, E Grande-Pulido, I Melero and J L Perez-Gracia
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=116&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Impact of cellular folate status and epidermal growth factor receptor expression on BCRP//ABCG2-mediated resistance to gefitinib and erlotinib
C Lemos, I Kathmann, E Giovannetti, C Calhau, G Jansen and G J Peters
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas
A Torres-Rendon, S Roy, G T Craig and P M Speight
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Identification of novel helper epitopes of MAGE-A4 tumour antigen: useful tool for the propagation of Th1 cells
T Ohkuri, D Wakita, K Chamoto, Y Togashi, H Kitamura and T Nishimura
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma
W-F Cheng, C-Y Huang, M-C Chang, Y-H Hu, Y-C Chiang, Y-L Chen, C-Y Hsieh and C-A Chen
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=51&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo
I V Ulasov, A M Sonabend, S Nandi, A Khramtsov, Y Han and M S Lesniak
Abstract: http://links.ealert.nature.com/ctt?kn=47&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer
Y Kawano, S Diez, P Uysal-Onganer, R S Darrington, J Waxman and R M Kypta
Abstract: http://links.ealert.nature.com/ctt?kn=53&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

----------------------
EPIDEMIOLOGY
----------------------
Occupational, domestic and environmental mesothelioma risks in the British population: a case-control study
C Rake, C Gilham, J Hatch, A Darnton, J Hodgson and J Peto
Abstract: http://links.ealert.nature.com/ctt?kn=17&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
N Munoz, G Hernandez-Suarez, F Mendez, M Molano, H Posso, V Moreno, R Murillo, M Ronderos, C Meijer and A Munoz
Abstract: http://links.ealert.nature.com/ctt?kn=5&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries
K S Louie, S de Sanjose, M Diaz, X Castellsague, R Herrero, C J Meijer, K Shah, S Franceschi, N Munoz and F X Bosch
Abstract: http://links.ealert.nature.com/ctt?kn=65&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=120&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Mean sojourn time, overdiagnosis, and reduction in advanced stage prostate cancer due to screening with PSA: implications of sojourn time on screening
N Pashayan, S W Duffy, P Pharoah, D Greenberg, J Donovan, R M Martin, F Hamdy and D E Neal
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Breast density and outcome of mammography screening: a cohort study
A H Olsen, K Bihrmann, M-B Jensen, I Vejborg and E Lynge
Abstract: http://links.ealert.nature.com/ctt?kn=118&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=103&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

----------------------
BOOK REVIEW
----------------------
Cancer and the Search for Selective Biochemical Inhibitors
D L Selwood
http://links.ealert.nature.com/ctt?kn=20&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

----------------------
CORRIGENDA
----------------------
Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice
K van Norren, D Kegler, J M Argiles, Y Luiking, M Gorselink, A Laviano, K Arts, J Faber, H Jansen, E M van der Beek and A van Helvoort
http://links.ealert.nature.com/ctt?kn=32&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

Unchanged incidence and increased survival in children with neuroblastoma in Denmark 1981-2000: a population-based study
H Schroeder, J Wacher, H Larsson, S Rosthoej, C Rechnitzer, B L Petersen and N L T Carlsen
http://links.ealert.nature.com/ctt?kn=70&m=32242263&r=MTc2MDAwMTgxNgS2&b=2&j=NDcwNTE4MzcS1&mt=1&rt=0

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EMBO Reports - Table of Contents alert Volume 10 Issue 4, pp 293-413

EMBO REPORTS TABLE OF CONTENTS

April 2009 Volume 10 Number 4, pp 293-413
(c) Copyright 2009 by the European Molecular Biology Organization
Now available at http://links.ealert.nature.com/ctt?kn=60&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

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*********************************************************************

Contents: Volume 10, Number 4 (April 2009)

---------------------
EDITORIALS
---------------------

Goodbye.
Frank Gannon
http://links.ealert.nature.com/ctt?kn=84&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

Change.
Hermann Bujard
http://links.ealert.nature.com/ctt?kn=78&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

Many pies, one finger.
Howy Jacobs
http://links.ealert.nature.com/ctt?kn=15&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

---------------------
SCIENCE AND SOCIETY
---------------------

CORRESPONDENCE

Comment on `When in Rome, reform'.
Maurizio Bifulco & Antonietta Santoro
http://links.ealert.nature.com/ctt?kn=45&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

OPINIONS

Darwin, race and gender.
Steven Rose
http://links.ealert.nature.com/ctt?kn=25&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

The greatest book you never read.
Gregory A Petsko
http://links.ealert.nature.com/ctt?kn=75&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

TALKING POINTS

Morality and human embryo research. Introduction to the Talking Point on morality and human embryo research.
Thomas Baldwin
http://links.ealert.nature.com/ctt?kn=77&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

Embryonic human persons. Talking Point on morality and human embryo research.
Robert P George & Patrick Lee
http://links.ealert.nature.com/ctt?kn=16&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

Destroying unwanted embryos in research. Talking Point on morality and human embryo research.
Thomas Douglas & Julian Savulescu
http://links.ealert.nature.com/ctt?kn=93&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

VIEWPOINTS

Societal dialogue needs more than public engagement. Science & Society Series on Convergence Research.
Maud Radstake, Eefje van den Heuvel-Vromans, Ninne Jeucken, Koen Dortmans & Annemiek Nelis
http://links.ealert.nature.com/ctt?kn=55&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

A forum for `doing society and genomics'. Science & Society Series on Convergence Research.
Emma K Frow
http://links.ealert.nature.com/ctt?kn=28&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

ANALYSIS

All in the mind? New molecular insights might bridge the gap between the effects of psychiatric therapy and drugs.
Philip Hunter
http://links.ealert.nature.com/ctt?kn=20&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

---------------------
REVIEWS
---------------------

MEETING REPORTS

How are neurons wired to form functional and plastic circuits? Meeting on Axon Guidance, Synaptogenesis & Neural Plasticity.
Esther Stoeckli & Yimin Zou
http://links.ealert.nature.com/ctt?kn=22&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

Change we can believe in[mdash]of the conformational type. Workshop on the Initiation of Antigen Receptor Signaling.
Pavel Tolar & Susan K Pierce
http://links.ealert.nature.com/ctt?kn=39&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

The quest for a better resolution of protein-translocation processes. Conference on the Control, Co-ordination and Regulation of Protein Targeting and Translocation.
Nica Borgese, Arnold J. M. Driessen, Doron Rapaport & Colin Robinson
http://links.ealert.nature.com/ctt?kn=74&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

In the land of the rising sun with the COP9 signalosome and related Zomes. Symposium on the COP9 signalosome, Proteasome and eIF3.
Elah Pick & Lionel Pintard
http://links.ealert.nature.com/ctt?kn=38&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

LITERATURE REPORT

Filamin B: a scaffold for interferon signalling.
Alan J Whitmarsh
http://links.ealert.nature.com/ctt?kn=59&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

CONCEPT

Revisiting the COP9 signalosome as a transcriptional regulator.
Daniel A Chamovitz
http://links.ealert.nature.com/ctt?kn=51&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=31&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

REVIEW

From cancer genomes to cancer models: bridging the gaps.
Anais Baudot, Francisco X. Real, José M. G. Izarzugaza & Alfonso Valencia
http://links.ealert.nature.com/ctt?kn=90&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=82&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

---------------------
SCIENTIFIC REPORTS
---------------------

Activation of RXR[ndash]PPAR heterodimers by organotin environmental endocrine disruptors.
Albane le Maire, Marina Grimaldi, Dominique Roecklin, Sonia Dagnino, Valérie Vivat-Hannah, Patrick Balaguer & William Bourguet
http://links.ealert.nature.com/ctt?kn=42&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=47&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.
Young Joo Jeon, Joon Seok Choi, Jung Yun Lee, Kyung Ryun Yu, Sangman Michael Kim, Seung Hyeun Ka, Kyu Hee Oh, Keun Il Kim, Dong-Er Zhang, Ok Sun Bang & Chin Ha Chung
http://links.ealert.nature.com/ctt?kn=57&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=81&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

Phosphorylation of NF-[kappa]B p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination.
Hui Geng, Tobias Wittwer, Oliver Dittrich-Breiholz, Michael Kracht & Michael Lienhard Schmitz
http://links.ealert.nature.com/ctt?kn=17&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=62&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

Midzone organization restricts interpolar microtubule plus-end dynamics during spindle elongation.
Vladimir Fridman, Adina Gerson-Gurwitz, Natalia Movshovich, Martin Kupiec & Larisa Gheber
http://links.ealert.nature.com/ctt?kn=1&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=7&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

Fork regression is an active helicase-driven pathway in bacteriophage T4.
David T Long & Kenneth N Kreuzer
http://links.ealert.nature.com/ctt?kn=61&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=86&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis.
Christoph A Gebeshuber, Kurt Zatloukal & Javier Martinez
http://links.ealert.nature.com/ctt?kn=29&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=88&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

A model for DNA replication showing how dormant origins safeguard against replication fork failure.
J Julian Blow & Xin Quan Ge
http://links.ealert.nature.com/ctt?kn=99&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=2&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

CORRIGENDUM

Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae.
Rafael Molina, Ana González, Meike Stelter, Inmaculada Pérez-Dorado, Richard Kahn, María Morales, Miriam Moscoso, Susana Campuzano, Nuria E Campillo, Shahriar Mobashery, José L García, Pedro García & Juan A Hermoso
http://links.ealert.nature.com/ctt?kn=83&m=32242203&r=MTc2MDI0MTQ4MQS2&b=2&j=NDcwNTE0NjAS1&mt=1&rt=0

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