ABC Science Updates: StarStuff asks 'Are dark matter and antimatter linked?'

ABC Science Updates, 4 December 2008
Science Updates is a weekly email alert from the Australian Broadcasting Corporation (ABC)

== ACE DAY JOBS: SENIOR FORESTRY CONSULTANT ==
Zoe Harkin is a key player in the international carbon trading market. Watch Ace Day Jobs to find out how she became a senior forestry consultant.
http://abcmail.net.au/t/340643/686964/6425/0/

== DR KARL: TIPPLE'S STATUS TOPPLES OVER PROOF ==
Alco-pops and other pre-mixed alcoholic drinks are cause for concern in the community. A century back it was absinthe that led the field in the social evil stakes. But Dr Karl reckons it's the same old problem.
http://abcmail.net.au/t/340643/686964/6426/0/

== SURFING SCIENTIST: SECRET PROBLEM ==
Sam needs to send Sally a secret inside a padlocked metal box. They can never meet or send each other keys. How can Sam share the secret with Sally?
http://abcmail.net.au/t/340643/686964/6427/0/

== TOP STORIES FROM NEWS IN SCIENCE == http://abcmail.net.au/t/340643/686964/1759/0/

GR8 SPLLRS R GOOD TXTRS, SAYS STUDY
People proficient in reading and writing are better at communicating via text messaging, an Australian psychologist says.
http://abcmail.net.au/t/340643/686964/6428/0/

GM BEER COULD BE GOOD FOR YOUR HEALTH
Here's a reason to raise a pint; scientists in the US are creating a beer that contains the same compound found in red wine, which has been linked to good health and longevity.
http://abcmail.net.au/t/340643/686964/6404/0/

OBESE CHILDREN 'CHEW THROUGH' ANTIOXIDANTS
Overweight or obese children use up antioxidants from fruit and vegetables much faster than other children, new research suggest.
http://abcmail.net.au/t/340643/686964/6410/0/

ANCIENT TIMES WERE HELL ON EARTH
A layer of rock deep inside the earth's mantle may have resulted in the planet being covered by a sea of lava several kilometres thick, more than 3.5 billion years ago, says an Australian researcher.
http://abcmail.net.au/t/340643/686964/6429/0/

== IN THE SKY THIS WEEK ==
The first quarter Moon is Friday 5 December. After last week's spectacular line-up, Venus and Jupiter pull away from each other, and form a line by the end of the week. Venus is easily recognised as the brightest object in the western evening sky, and Jupiter is the next brightest object, below and to the left of it. This week represents an opportunity to see a variable star brighten. Mira, in the constellation of Cetus the Whale, is now bright enough to see with the unaided eye, over the next two weeks it will brighten considerably from being dimmer than epsilon Crucis (the fifth and dimmest star in the southern cross) to being nearly as bright as Gamma Crucis (the third brightest star of the Southern Cross that forms the 'top' of the cross). In the morning sky, Saturn can be easily seen as the second brightest object above the north-eastern horizon almost midway between the bright stars Regulus and Spica. Saturn's yellow colour distinguishes it from these two stars.
http://abcmail.net.au/t/340643/686964/1764/0/

== STARSTUFF PODCAST: SATURN MOON LIKE EARLY 'PROTO-EARTH' ==
Titan's hydrocarbon lakes raise more questions than answers; are dark matter and antimatter linked?; and the largest cosmic ray observatory get to work.
http://abcmail.net.au/t/340643/686964/4567/0/

== ABC HEALTH & WELLBEING == http://abcmail.net.au/t/340643/686964/1765/0/

== YOUR STORY: Box jellyfish: a travel health warning ==
Andrew Jones's relaxing family holiday in Thailand went horribly wrong when his son was stung by a box jellyfish.
http://abcmail.net.au/t/340643/686964/6397/0/

== TRANSCRIPTS NOW ONLINE ==

BRYAN GAENSLER (In Conversation: 27/11/2008)
http://abcmail.net.au/t/340643/686964/6430/0/

UNIVERSITY ENROLMENTS IN IT HALVE IN AUSTRALIA (Science Show: 29/11/2008)
http://abcmail.net.au/t/340643/686964/6431/0/

TRADITIONAL INDIAN FARMING ENCOURAGES BIODIVERSITY (Science Show: 29/11/2008)
http://abcmail.net.au/t/340643/686964/6432/0/

CONSERVING PERU'S COASTAL FORESTS (Science Show: 29/11/2008)
http://abcmail.net.au/t/340643/686964/6433/0/

TRIBUTE TO MICHAEL CRICHTON – SCIENCE IN THE MEDIA (Science Show: 29/11/2008)
http://abcmail.net.au/t/340643/686964/6434/0/

DARWIN YEAR - 2009 (Science Show: 29/11/2008)
http://abcmail.net.au/t/340643/686964/6435/0/

THE FRAGILE INTERNET AND CELEBRATING MILTON AT CHRIST'S COLLEGE (Science Show: 29/11/2008)
http://abcmail.net.au/t/340643/686964/6436/0/

INNOVATION TODAY, NOT TOMORROW (Ockham's Razor: 30/11/2008)
http://abcmail.net.au/t/340643/686964/6437/0/

PERSONALISED MEDICINE - WHY DRUGS DON'T ALWAYS WORK (PART 2 OF 2) (Health Report: 01/12/2008)
http://abcmail.net.au/t/340643/686964/6418/0/

== COMING UP ON ABC RADIO == http://abcmail.net.au/t/340643/686964/1773/0/

THE SCIENCE SHOW - What is autism?
Saturday 6 December, 12.05pm & Monday 8 December, 7.05pm RN
Of all the mental states being reassessed in 2008 autism and Asperger's must come near the top. Wendy Barnaby visits the Royal Society in London to hear from international experts - and she also meets a brilliant young pianist with Asperger's who explains how he performs so well but needs help for everyday living.
http://abcmail.net.au/t/340643/686964/902/0/

ALL IN THE MIND - Extraordinary cases in psychology: Part 4 - Little Hans and the Oedipus complex
Saturday 6 December, 1.05pm & Monday 8 December, 1.05pm RN
The Oedipus complex - Dr Sigmund Freud's unusual theory that children desire their parent of opposite sex, and want harm to come to the other - has provoked much controversy. Head back to 1904, and it was a little Viennese boy's phobia of horses that became the unlikely evidence for Freud's thinking. A curious tale of castration anxiety, penis envy and the plight of poor Little Hans.
http://abcmail.net.au/t/340643/686964/903/0/

RADIO EYE - The cry of the Coorong
Saturday 6 December, 2.05pm & Wednesday 10 December, 1.05pm RN
The Coorong is one of Australia's most fragile wetlands - a narrow lagoon that runs parallel to the South Australian coast a couple of hours' drive south of Adelaide. The setting for Colin Thiele's famous story Storm Boy, it's been home to vast numbers of water birds. But now, the Coorong is choking to death. The cry of the Coorong is a meditation on the meaning of landscapes and how they call to us.
http://abcmail.net.au/t/340643/686964/905/0/

OCKHAM'S RAZOR - Anniversaries are what we make of them!
Sunday 7 December, 8.45am RN
Associate Professor Paul Lancaster, president of the Medical Alumni Association at the University of Sydney, tells us about the achievements of some of the past medical graduates from the university. We have much to celebrate in recalling with pride the notable achievements of these pioneering doctors who contributed so much, not only to medicine but to many other facets of public life.
http://abcmail.net.au/t/340643/686964/910/0/

INNOVATIONS
Sunday 7 December (0830hrs UT), Monday 8 December (1330 & 1705hrs UT), Wednesday 10 December (0430hrs UT), Radio Australia
Hope for a drug to treat victims of brain injury; Australian students have their car of the future, powered by compressed air, showcased in Detroit; and creating a business from butterflies.
http://abcmail.net.au/t/340643/686964/1775/0/

THE HEALTH REPORT - White coat hypertension
Monday 8 December, 8.30am & 8.05pm RN
Many people get so stressed when having their blood pressure taken in a doctor's office that it actually goes up due to anxiety and not because they have high blood pressure regularly. A recent study has examined this and found that people who have this so-called 'white coat hypertension' have substantially less risk of death than people whose blood pressure it elevated in all situations.
http://abcmail.net.au/t/340643/686964/920/0/

IN CONVERSATION - Recycled water - On or off in Queensland?
Thursday 11 December, 7.35pm RN
What, finally, does science offer in this continuing saga? As Queensland alternates like a berserk pendulum between accepting or rejecting recycling, Dr Stuart Khan from the Centre for Water and Waste Technology Research at the University of NSW tells Nicky Phillips what works and what doesn't.
http://abcmail.net.au/t/340643/686964/1468/0/

== HIGHLIGHTS ON ABC TV == http://abcmail.net.au/t/340643/686964/1773/0/

THE MEGAFALLS OF IGUACU
ABC1 7:30pm Sunday, 7 December 2008
Deep in the heart of South America, where Brazil, Argentina and Paraguay collide, lies one of the most spectacular geographical secrets of the natural world - Iguaçu, a place forged from the explosive clashing of the earth's tectonic plates. Over five kilometres long and 100 metres high, Iguaçu is the greatest waterfall on Earth. These awesome falls are also home to one of the richest habitats on earth: 2000 species of plants, 450 species of birds, 50 different mammals and more reptiles and insects than anyone has been able to count. This visually stunning HD documentary charts the dramas and intimacies of daily life for those animals adaptable enough to make Iguaçu their home, and follows the rangers who risk their lives to guard the animals from the poachers' guns.
http://abcmail.net.au/t/340643/686964/6438/0/

EXPOSED - PERSUADERS
ABC1 8:30pm Thursday, 11 December 2008
In the third of four episodes, psychologist, Dr John Marsden shows viewers how to master the art of persuasion, stand out from the crowd, control their behaviour and use peer pressure. Using actors, stooges and subliminal messages he details how to make people do want you want them to. From the overt to the downright discreet, Dr John Marsden shows the best way to queue-jump, introduces a hypnotist who can pull teeth without anaesthetic and talks to an ex-cult member about how persuasion can be used in extremely negative ways.
http://abcmail.net.au/t/340643/686964/6439/0/

ZOO DAYS
ABC2, 7:00pm weeknights
Zoo Days is an entertaining new wildlife series following the engaging characters, both animal and human, at two of Britain's largest zoos. With incredible behind-the-scenes access at Chester and Colchester Zoos, the series features a variety of storylines and strong personalities providing a mix of excitement, jeopardy and fun. We will experience close encounters with the scariest reptiles and the cutest baby monkeys, and find out what happens in the everyday lives of the zoo keepers.
http://abcmail.net.au/t/340643/686964/6440/0/

WAGGING SCHOOL
ABC2, 5:30pm Tuesday, 9 December 2008
Train your dog to be well-behaved - in just five minutes a day! Chrissie, the dog expert, shows you how on Wagging School. Manage your dog's natural instincts to chase cats, dogs, cars and bikes or to pick up and eat rubbish when you take it for a walk.
http://abcmail.net.au/t/340643/686964/6206/0/

SLEEP CLINIC
ABC2, 8:00pm Wednesday, 10 December 2008
The sleep clinicians at Papworth Hospital think adolescent Robert's tendency to sleep 17 hours a day is not just teenage indolence. They discover he has a sleep disorder that prevents his brain from switching on the wake-up button. It has cost the teenager his job and his long suffering mother is relieved to hear it is not Robert's fault when the doctors diagnose a physiological condition. Margaret, in her 60s, is a frail arthritic sufferer who can only walk with the aid of a stick. But at night, in her sleep, she gets about briskly, taking herself to the refrigerator and preparing herself a meal without waking, nor any memory of it the next day. But her night time activity leaves her exhausted and puts her at risk of injuring her already frail body.
http://abcmail.net.au/t/340643/686964/6424/0/

== Unsubscribe ==
If you need to unsubscribe your email address from this list please use the form at
http://abcmail.net.au/t/340643/686964/1776/0/

Nature 4 December 2008 Volume 456 Number 7222, pp545-674

NATURE

4 December 2008 Volume 456 Number 7222, pp 545-674

Visit Nature online to browse the journal.

Now available at http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0d4W0ES

Please note that you need to be a subscriber to enjoy full text access
to Nature online. To purchase a subscription, please visit:
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Alternatively, to recommend a subscription to your library, please visit
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----------------------
EDITORIALS
----------------------
The cost of silence? p545
Analyses of AIDS deaths attributable to misguided policies in South
Africa carry lessons for scientific leaders.
doi:10.1038/456545a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDC80El

Culture clash in China pp545-546
An online row highlights the need for Chinese universities to fix
their hiring policies.
doi:10.1038/456545b
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDA0Ev

Focus on Earth p546
Europe is rightly pioneering the systematic appliance of science in
space to societal needs.
doi:10.1038/456546a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDB0Ew

----------------------
RESEARCH HIGHLIGHTS
----------------------
Silent killer p548
doi:10.1038/456548a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDC0Ex

Astronomy: Blast from the past p548
doi:10.1038/456548b
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDD0Ey

Climate change: Mulled wine p548
doi:10.1038/456548c
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDE0Ez

Neurobiology: Mad mouse disease p548
doi:10.1038/456548d
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDF0E1

Statistics: One size fits all p548
doi:10.1038/456548e
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDG0E2

Evolution: Electric love pp548-549
doi:10.1038/456548f
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDH0E3

Pharmacology: Setting the pace p549
doi:10.1038/456549a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDI0E4

Quantum physics: Signature shift p549
doi:10.1038/456549b
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDJ0E5

Genomics: The baby-milk bacterium p549
doi:10.1038/456549c
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDK0E6

Geosciences: Deep-sea mix p549
doi:10.1038/456549d
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDL0E7

----------------------
JOURNAL CLUB
----------------------
Journal club p549
John Greally
doi:10.1038/456549e
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDM0E8

----------------------
NEWS
----------------------
Slow shipping hobbles Chinese science pp550-551
A lack of laboratory reagents is taking its toll on researchers.
David Cyranoski
doi:10.1038/456550a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDN0EA

European funding plan 'unviable' p551
Top universities shun Joint Technology Initiatives.
Natasha Gilbert
doi:10.1038/456551a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDO0EB

Space agency funding defies downturn p552
European ministers commit euro10 billion to space missions, Earth
monitoring and new facilities.
Declan Butler
doi:10.1038/456552a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDP0EC

Melanoma in mice casts doubt on scarcity of cancer stem cells pp553
Tumour treatments may need a rethink.
Monya Baker
doi:10.1038/456553a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDQ0ED

Can triniobium tin shrink accelerators? p555
Exotic superconductors promise savings.
Eric Hand
doi:10.1038/456555a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDR0EE

Europe to pay royalties for cancer gene p556
BRCA1 patent decision may be ignored in clinics.
Alison Abbott
doi:10.1038/456556a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDS0EF

Austrian ethics watchdog launched pp557
Scandals prompt formation of misconduct body.
Alison Abbott
doi:10.1038/456557a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDT0EG

UK charity launches assault on deadliest cancers p558
doi:10.1038/456558a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDU0EH

Greenhouse gases hit modern-day highs pp558-559
doi:10.1038/456558b
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDV0EI

Europe's synchrotron sharpens up its X-rays pp558
doi:10.1038/456558c
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDW0EJ

Europe rejects Wisconsin's key stem-cell patent pp559
doi:10.1038/456559a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDX0EK

Hawking plans long commute to Canada pp559
doi:10.1038/456559b
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDY0EL

Chemicals firm cancels plans for biodiesel plant p559
doi:10.1038/456559c
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDZ0EM

The Sputnik fable pp561
Oversimplifying the effect of the space race on US science funding
could lead scientists down the wrong path, says David Goldston.
doi:10.1038/456561a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDa0ET

----------------------
NEWS FEATURE
----------------------
Agronomy: Five crop researchers who could change the world pp563-568
The current crisis in worldwide food prices reinforces the need for
more productive agriculture.
Emma Marris meets five ambitious scientists determined to stop the
world from going hungry.
doi:10.1038/456563a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDb0EU

----------------------
CORRESPONDENCE
----------------------
Switch to ecological engineering would aid independence p570
Josef Settele, Jacobus Biesmeijer and Riccardo Bommarco
doi:10.1038/456570a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDc0EV

Offering unproven genetic tests to the public is irresponsible p570
J. R. M. Oliveira
doi:10.1038/456570b
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDd0EW

Speaking up for economic-sciences modelling p570
Jesper Stage
doi:10.1038/456570c
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDe0EX

----------------------
COMMENTARY
----------------------
Make secondary education universal pp572-573
The time is right to push global learning beyond primary-school level,
says Joel E. Cohen. The benefits could include a dramatically smaller
increase in world population by 2050.
doi:10.1038/456572a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDf0EY

----------------------
BOOKS AND ARTS
----------------------
Preparing for pandemics p574
More deadly than the First World War, the global outbreak of influenza
in 1918 terrified populations and tested governments. But would we
fare any better today, asks Michael Sargent?
Michael Sargent reviews Living with Enza: The Forgotten Story of
Britain and the Great Flu Pandemic of 1918 by Mark Honigsbaum
doi:10.1038/456574a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDg0EZ

Crimes in the name of research p575
Benno Muller-Hill reviews Das Robert Koch-Institut im
Nationalsozialismus by Annette Hinz-Wessels
doi:10.1038/456575a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDh0Ea

Conspiracy at the bench pp575-576
Henry Gee reviews Experimental Heart: A Novel by Jennifer L. Rohn
doi:10.1038/456575b
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDi0Eb

Q&A: Electronic music comes of age p576
The Columbia-Princeton Electronic Music Center in New York was the
first institution of its kind in the United States for experimenters
seeking new technology-based sounds. Fifty years after its founding,
director of research Doug Repetto explains how electronic music has
evolved and how the role of academic music centres is changing.
Daniel Cressey
doi:10.1038/456576a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDj0Ec

Hidden treasures: The Jagiellonian Museum, Krakow p577
Poland's oldest university museum celebrates the Sun-centred ideas of
Copernicus and the history of the nation itself,
explains Alison Abbott.
doi:10.1038/456577a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDk0Ed

----------------------
ESSAY
----------------------
Generosity: A winner's advice p579
Mathematical models can reveal how prosocial human behaviour -- and
even social intelligence and language -- have evolved,
argues Martin A. Nowak.
doi:10.1038/456579a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDl0Ee

----------------------
NEWS AND VIEWS
----------------------
Cancer stem cells: Here, there, everywhere? pp581-582
Can every tumour cell propagate human cancers or is this property
exclusive to an elite subset? Findings are divided. The latest set
shows that -- depending on circumstances -- both perspectives can
be correct.
Connie J. Eaves
doi:10.1038/456581a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDm0Ef

Materials science: Clear leap for superconductors pp582-583
Electric fields offer an innovative means of controlling
condensed-matter systems. The approach has been applied to nanoscale
oxide interfaces, for studying the physics of two-dimensional
superconductors.
Darrell G. Schlom and Charles H. Ahn
doi:10.1038/456582a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDn0Eg

Stem cells: Makeshift sperm production pp583-585
Early middle age is a difficult time, not least for male fruitflies
when sperm production falls. The unexpected reason for this decline
seems to be that, as tissues age, maintaining functional stem cells
becomes difficult.
Allan C. Spradling
doi:10.1038/456583a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDo0Eh

50 & 100 years ago p585
doi:10.1038/456585a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDp0Ei

Fertilization: Welcome to the fold pp586-587
The mammalian egg coat participates in fertilization and prevents
more than one sperm from entering the egg. Structural data pinpoint
a region common to egg-coat proteins that might mediate these
functions.
Paul M. Wassarman
doi:10.1038/456586a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDq0Ej

Astrophysics: Echo from an ancient supernova pp587-589
Light reflected off a dust cloud in the vicinity of the relic of
Tycho Brahe's supernova, whose light first swept past Earth more
than four centuries ago, literally sheds light on the nature of this
cosmic explosion.
Andrea Pastorello and Ferdinando Patat
doi:10.1038/456587a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDr0Ek

Behavioural ecology: The social side of wild yeast pp589-590
The workhorse of cell biology, yeast, is a surprisingly cooperative
organism. It uses an unusual means of identifying partners -- a
'green-beard gene', which encodes a tag that must match among
cooperating cells.
David C. Queller
doi:10.1038/456589a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDs0El

Neuroscience: Along memory lane pp590-591
Memories are encoded by efficient signalling between neurons. The
myosin V proteins help this process by shuttling receptors and
membranes to make synaptic junctions better detectors of incoming
signals.
Yukiko Goda
doi:10.1038/456590a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDt0Em

----------------------
BRIEF COMMUNICATIONS ARISING
----------------------
Pleiotropic scaling and QTL data pE3
Joachim Hermisson and Alistair P. McGregor
doi:10.1038/nature07452
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDu0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDv0Eo

Wagner et al. reply pE4
Gunter P. Wagner et al.
doi:10.1038/nature07453
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDw0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDx0Eq

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=====================================================================

----------------------
ARTICLES
----------------------
Efficient tumour formation by single human melanoma cells pp593-598
Cancer stem cells in human tumours have been defined as cells that are
tumourigenic and self-renew when transplanted into immunocompromised
mice. It has been shown in a number of tumour types that such cancer
stem cells exist at relatively low frequencies. This paper now shows
that in human melanomas at least, there is a high proportion of
tumourigenic cells when the conditions for such transplanation
experiments are modified, casting doubt on the generality of the
cancer stem cell model.
Elsa Quintana et al.
doi:10.1038/nature07567
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDy0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDDz0Es

Centrosome misorientation reduces stem cell division during ageing p599
Asymmetric division of adult stem cells generates one self renewing
stem cell and one differentiating cell, thereby maintaining tissue
homeostasis. This paper shows that changes in stem cell orientation
within the niche during ageing contribute to the decline in
spermatogenesis in Drosophila male germ line.
Jun Cheng, Nezaket Türkel, Nahid Hemati, Margaret T. Fuller,
Alan J. Hunt & Yukiko M. Yamashita
doi:10.1038/nature07386
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDD10Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDD20Eg

Mitofusin 2 tethers endoplasmic reticulum to mitochondria pp605-610
It is shown that a mitochondrial protein, mitofusin 2, is enriched at
the mitochondrial-endoplasmic reticulum interface and mediates
tethering of both organelles. Ablation of mitofusin 2 results in
disruption of endoplasmic reticulum morphology and loss of calcium
transfer between the two organelles. Thus, mitofusin-2 mediates
tethering mitochondria to the endoplasmic reticulum.
Olga Martins de Brito and Luca Scorrano
doi:10.1038/nature07534
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDD30Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDD40Ei

Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal
dyneins pp611-616
This paper identifies a gene, kintoun (ktu), which is important for
dynein arm formation resulting in the formation of motile cilia. It
is conserved from ciliated unicellular organisms to higher mammals.
Mutations in the homologous gene of two human primary ciliary
dyskinesia families are also identified.
Heymut Omran et al.
doi:10.1038/nature07471
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDD50Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDD60Ek

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=====================================================================

----------------------
LETTERS
----------------------
Tycho Brahe's 1572 supernova as a standard type Ia as revealed by its
light-echo spectrum pp617-619
This study reports an optical spectrum of Tycho Brahe's supernova near
maximum brightness, obtained from a scattered-light echo more than
four centuries after the direct light of the explosion swept past
Earth. It is found that SN 1572 belongs to the majority class of
normal type Ia supernovae.
Oliver Krause et al.
doi:10.1038/nature07608
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDD70El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDD80Em

Atmospheric structure and dynamics as the cause of ultraviolet
markings in the clouds of Venus pp620-623
When seen in ultraviolet light, Venus has contrast features that arise
from the non-uniform distribution of unknown absorbers within the
sulphuric acid clouds. This paper reports multi-wavelength imaging
that reveals that the dark low latitudes are dominated by convective
mixing that brings the ultraviolet absorbers up from depth. The bright
and uniform mid-latitude clouds reside in the 'cold collar', which
suppresses vertical mixing. In low and middle latitudes, the visible
cloud top is located at a constant altitude of 72 +- 1 km in both the
ultraviolet dark and bright regions, indicating that the brightness
variations result from compositional differences caused by the colder
environment.
Dmitry V. Titov et al.
doi:10.1038/nature07466
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEA0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEB0Ex

Electric field control of the LaAlO3/SrTiO3 interface ground
state pp624-627
It has been a goal in applied physics to construct devices in which
superconductivity can be switched on and off with an electric field.
Recently, it was shown that the conducting interface between LaAlO3
and SrTiO3 (both in bulk form are insulators) can produce a
two-dimensional superconducting condensate. This paper now uses the
electric field effect, which tunes the charge carrier density, to
explore the phase diagram of the system.
A. D. Caviglia et al.
doi:10.1038/nature07576
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEC0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDED0Ez

Large tundra methane burst during onset of freezing pp628-630
A late-autumn shoulder is consistently observed in the seasonal cycles
of atmospheric methane at high latitude sites, but the sources
responsible remain uncertain. This study reports methane flux
measurements from a high Arctic setting during the onset of soil
freezing. The integral of the emissions during this freeze-in period
amount to approximately the same amount of methane emitted during the
entire summer season. It is found that the observed early winter
emission burst improves the agreement between the simulated seasonal
cycle and atmospheric data from latitudes north of 60degN. The results
suggest that permafrost associated freeze-in bursts of methane
emissions from tundra regions could be an important component of the
seasonal distribution of methane emissions from high latitudes.
Mikhail Mastepanov et al.
doi:10.1038/nature07464
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEE0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEF0E2

Partial rupture of a locked patch of the Sumatra megathrust during the
2007 earthquake sequence pp631-635
In March 2005 the Sunda megathrust earthquake, with a moment magnitude
of 8.6, occurred. Concern was then focused further south on the
Mentawai area, where large earthquakes had occurred in 1797
(magnitude 8.8) and 1833 (magnitude 9.0). On 12 September 2007, a
magnitude 8.4 earthquake occurred, followed by a magnitude 7.9
earthquake 12 hours later. This paper shows that these earthquakes
ruptured only a fraction of the area ruptured in 1833 and conclude
that the stress state on the portion of the Sunda megathrust that
ruptured in 1797 and 1833 was probably not adequate for the
development of a single major large rupture in 2007, meaning that the
potential for a large megathrust event in the Mentawai area thus
remains high.
A. Ozgun Konca et al.
doi:10.1038/nature07572
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEG0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEH0E4

The pectoral fin of Panderichthys and the origin of digits p636
Early hypotheses suggested that the digits of tetrapods (land
vertebrates) were homologues of fin radials, but this idea fell out of
favour on the basis of developmental studies and also on the fin of
Panderichthys, a fish closely related to land vertebrates, which
appeared to lack distal digit like fin radials. A new CT study of a
classic specimen of Panderichthys shows that the old interpretation
was in error. Panderichthys did indeed have digit like radials:
nothing stands in the way of the era of fish fingers.
Catherine A. Boisvert, Elga Mark-Kurik & Per E. Ahlberg
doi:10.1038/nature07339
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEI0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEJ0E6

Direct control of paralysed muscles by cortical neurons p639
Brain–machine interfaces are a promising approach for treating spinal
cord injury caused paralysis by rerouting control signals from the
brain directly to the muscles. This paper demonstrates that monkeys
can directly control stimulation of muscles using the activity of
neurons in motor cortex, restoring goal directed movement to a
transiently paralysed arm. In addition, monkeys learned to use these
artificial connections so that single neurons previously not
associated with the movement could be used to control functional
stimulation.
Chet T. Moritz, Steve I. Perlmutter & Eberhard E. Fetz
doi:10.1038/nature07418
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEK0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEL0E8

Sox18 induces development of the lymphatic vasculature in mice p643
A role for Sox18 transcription factor has been suggested by lymphatic
dysfunction in the human syndrome hypotrichosis lymphedema
telangiectasia (HLT), which is caused by mutations in Sox18. This
paper shows that Sox18 directly activates Prox1 transcription. Sox18
null embryos show a complete absence of Prox1 positive lymphatic
endothelial cells emanating from the cardinal vein.
Mathias François et al.
doi:10.1038/nature07391
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEM0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEN0EB

Incorporation of a non-human glycan mediates human susceptibility
to a bacterial toxin p648
Shiga toxigenic Escherichia coli causes severe gastrointestinal
disease, which is in part mediated by subtilase cytotoxin. The B
subunit of this toxin is now shown to have high affinity to glycans
containing N glycolylneuraminic acid, a saccharide that is not
synthesized by humans. Instead it is ingested by dietary intake of red
meat and dairy products and subsequently incorporated into intestinal
and kidney tissue.
Emma Byres et al.
doi:10.1038/nature07428
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEO0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEP0ED

Crystal structure of the ZP-N domain of ZP3 reveals the core fold of
animal egg coats pp653-657
Species-specific recognition between the egg extracellular matrix
(zona pellucida) and sperm is the first step of mammalian
fertilization. This paper reports the 2.3 A resolution structure of
the 'zona pellucida filament' of the egg, which act as sperm
receptors. The structure supports the presence of ZP-N repeats within
the amino-terminal region of ZP2 and other vertebrate zona
pellucida/vitelline proteins, and has implications for egg coat
architecture and the post-fertilization block to polyspermy and
speciation.
Magnus Monne et al.
doi:10.1038/nature07599
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEQ0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDER0EF

The ectodomain of Toll-like receptor 9 is cleaved to generate a
functional receptor p658
Endolysosomal proteolytric cleavage is shown to be required for TLR9
activation by CpG
Sarah E. Ewald et al.
doi:10.1038/nature07405
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDES0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDET0EH

Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to
tamoxifen p663
Tamoxifen is commonly used for breast cancer therapy. This paper shows
that the transcriptional repression of the ERBB2 oncogene by tamoxifen
in breast cancer cells is affected by an antagonistic interaction
between the transcriptional regulators PAX2 and AIB 1. This affects
the ability of tamoxifen to inhibit cancer cell proliferation. The
relative levels of PAX2 and AIP1 in breast cancer patients treated
with tamoxifen correlates with relapse free survival.
Antoni Hurtado et al.
doi:10.1038/nature07483
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEU0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEV0EJ

Role for perinuclear chromosome tethering in maintenance of genome
stability p667
Suppressing the homologous recombination of repetitive DNA sequences
is important for maintaining genome stability, and packaging of repeat
DNA into silent chromatin was generally thought to protect it from
recombination. Yeast ribosomal DNA (rDNA) repetitive sequences are
shown to associate with the nuclear periphery via inner nuclear
membrane proteins, and this tethering is required for rDNA stability.
Sir2 dependent silencing is not sufficient to inhibit rDNA
recombination.
Karim Mekhail, Jan Seebacher, Steven P. Gygi & Danesh Moazed
doi:10.1038/nature07460
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEW0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEX0EL

----------------------
NATUREJOBS
----------------------
Prospects p671
A disclaimer for graduate school.
Gene Russo
doi:10.1038/nj7222-671a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEY0EM

Career View
Exequiel Ezcurra, director, University of California Institute for
Mexico and the United States, Riverside, California p672
Political upheaval opens up an avenue for a scientific career.
Virginia Gewin
doi:10.1038/nj7222-672a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEZ0EN

Just cure it p672
Major donation fuels big plans for cancer-research institute in
Oregon.
Virginia Gewin
doi:10.1038/nj7222-672b
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEa0EU

All work and no play p672
Is my career taking over my life, one baboon at a time?
Aliza le Roux
doi:10.1038/nj7222-672c
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEb0EV

----------------------
FUTURES
----------------------
Kidroid p674
There's no time like the present.
Shane Clark
doi:10.1038/456674a
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEc0EW

----------------------
ADVANCE ONLINE PUBLICATION
----------------------
03 December 2008
Article
Spliceosomal cleavage generates the 3' end of telomerase RNA
Jessica A. Box, Jeremy T. Bunch, Wen Tang & Peter Baumann
doi:10.1038/nature07584
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEd0EX

Letters
Live-animal tracking of individual haematopoietic stem/progenitor
cells in their niche
Cristina Lo Celso et al.
doi:10.1038/nature07434
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEe0EY

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves
and ensure long-term survival
Patrick Narbonne & Richard Roy
doi:10.1038/nature07536
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEf0EZ

A simple model of bipartite cooperation for ecological and
organizational networks
Serguei Saavedra, Felix Reed-Tsochas & Brian Uzzi
doi:10.1038/nature07532
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEg0Ea

Detection of functional haematopoietic stem cell niche using real-time
imaging
Yucai Xie et al.
doi:10.1038/nature07639
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEh0Eb

30 November 2008
Letters
The dynein regulatory complex is required for ciliary motility and
otolith biogenesis in the inner ear
Jessica R. Colantonio et al.
doi:10.1038/nature07520
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEi0Ec

Protein kinase R reveals an evolutionary model for defeating viral
mimicry
Nels C. Elde, Stephanie J. Child, Adam P. Geballe & Harmit S. Malik
doi:10.1038/nature07529
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEj0Ed

Discovery of a sexual cycle in the opportunistic fungal pathogen
Aspergillus fumigatus
Céline M. O'Gorman, Hubert T. Fuller & Paul S. Dyer
doi:10.1038/nature07528
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEk0Ee

MicroRNA-21 contributes to myocardial disease by stimulating MAP
kinase signalling in fibroblasts
Thomas Thum et al.
doi:10.1038/nature07511
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEl0Ef

A core gut microbiome in obese and lean twins
Peter J. Turnbaugh et al.
doi:10.1038/nature07540
http://ealerts.nature.com/cgi-bin24/DM/y/epFh0Xztnp0HjB0CDEm0Eg

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Nature Structural & Molecular Biology Contents: December 2008 Volume #15 pp 1233 - 1351

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December 2008 Volume 15 Number 12, pp 1233 - 1351

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=====================================================================

----------------------
EDITORIAL
----------------------
World AIDS Day 2008 p1233
NSMB observes World AIDS Day by reflecting on the crucial role of
basic research in fighting this epidemic.
doi:10.1038/nsmb1208-1233
http://links.ealert.nature.com/ctt?kn=13&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
The importance of presentation pp1234 - 1235
Analysis of in vivo and in vitro interactions between chaperonins
and the whole spectrum of potential cytoplasmic substrates helps
answer the vexed question of substrate specificity in the TRiC
system.
Anthony R Clarke
doi:10.1038/nsmb1208-1234
http://links.ealert.nature.com/ctt?kn=7&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Is the spliceosome a ribonucleoprotein enzyme? pp1235 - 1237
New work suggests that Prp8, a highly conserved protein in the heart
of the spliceosome, both orients the substrate and participates in
catalysis.
John Abelson
doi:10.1038/nsmb1208-1235
http://links.ealert.nature.com/ctt?kn=43&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

The N-end rule at atomic resolution pp1238 - 1240
The N-end rule relates the in vivo half-life of a protein to the
identity of its N-terminal residue. The N-end rule pathway,
ubiquitin-dependent in eukaryotes, is also present in prokaryotes,
which lack the ubiquitin system. An illuminating new study presents
the crystal structure of a bacterial N-end rule recognition component
in complex with a peptide containing a cognate degradation signal.
Alexander Varshavsky
doi:10.1038/nsmb1208-1238
http://links.ealert.nature.com/ctt?kn=15&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

When loose ends finally meet pp1241 - 1242
The tumor suppressor protein 53BP1 decorates DNA damage sites and
is instrumental for nonhomologous end joining. Evidence that 53BP1
facilitates synapsis of DNA ends by modulating chromatin dynamics
reveals a hitherto unanticipated strategy for joining distant ends.
Michael S Y Huen and Junjie Chen
doi:10.1038/nsmb1208-1241
http://links.ealert.nature.com/ctt?kn=36&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

PARP: a transferase by any other name pp1243 - 1244
A recent report shows that several 'poly-ADP-ribose-polymerases'
may function exclusively as a family of endogenous
mono-ADP-ribosyltransferases, providing a new, molecularly less
complex and broadened cellular role for this elusive
post-translational modification.
Susanne Till, Konstantina Diamantara and Andreas G. Ladurner
doi:10.1038/nsmb1208-1243
http://links.ealert.nature.com/ctt?kn=83&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights p1245
Ines Chen, Maria Hodges and Sabbi Lall
doi:10.1038/nsmb1208-1245
http://links.ealert.nature.com/ctt?kn=49&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Bach1 inhibits oxidative stress-induced cellular senescence by
impeding p53 function on chromatin pp1246 - 1254
Oxidative stress can lead to cellular senescence, in a p53-dependent
pathway. Bach1, a transcription factor that regulates the response
to oxidative stress, is now shown to inhibit senescence induced by
high oxygen concentrations or by Ras. Bach1 is recruited to a subset
of p53 target genes and contributed to impeding p53 action by
promoting histone deacetylation.
Yoshihiro Dohi et al.
doi:10.1038/nsmb.1516
Abstract: http://links.ealert.nature.com/ctt?kn=72&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Defining the TRiC/CCT interactome links chaperonin function to
stabilization of newly made proteins with complex topologies
pp1255 - 1262
The interactome of eukaryotic chaperonin TRiC/CCT is identified
through a genome-wide approach, revealing an enrichment in large,
multidomain proteins, or components of multimeric complexes, rich
in hydrophobic sequences and with high beta-sheet propensity.
Thus, TRiC substrates are slow-folding proteins with complex
topology, which are likely to be more prone to aggregation.
Alice Y Yam et al.
doi:10.1038/nsmb.1515
Abstract: http://links.ealert.nature.com/ctt?kn=19&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Single-RNA counting reveals alternative modes of gene expression in
yeast pp1263 - 1271
Understanding the kinetics of gene expression involves accurate
quantitation of gene expression. This is now undertaken by
quantifying nascent-RNA levels and relating this indication of
transcriptional activity to mRNA abundance in single yeast cells.
Combining these measurements with computational modeling indicates
that the tested yeast housekeeping genes are probably expressed
through single initiation events, whereas a SAGA-transcribed gene
shows behavior consistent with transcriptional bursting.
Daniel Zenklusen, Daniel R Larson and Robert H Singer
doi:10.1038/nsmb.1514
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Structure of a RSC-nucleosome complex and insights into chromatin
remodeling pp1272 - 1277
The ATP-dependent chromatin-remodeling complexes are involved in
repositioning, evicting and restructuring nucleosomes. The EM
reconstruction of the RSC remodeler in complex with a nucleosome
gives structural insights into remodeling.
Yuriy Chaban et al.
doi:10.1038/nsmb.1524
Abstract: http://links.ealert.nature.com/ctt?kn=17&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Structural basis for midbody targeting of spastin by the ESCRT-III
protein CHMP1B pp1278 - 1286
Emerging evidence suggests that ESCRT proteins, well characterized
in their role in multivesicular body trafficking, contribute to
various cellular processes including cytokinesis. Structural and
functional analyses indicate that the ESCRT-III protein CHMP1B
promotes the midbody localization of spastin, a microtubule-severing
protein required for membrane abscission.
Dong Yang et al.
doi:10.1038/nsmb.1512
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Structural insights into the Cyclin T1-Tat-TAR RNA transcription
activation complex from EIAV pp1287 - 1292
The replication of many retroviruses depends on interactions between
the viral TAR RNA element and Tat as well as Cyclin T1, a component
of the cellular transcriptional elongation complex. Structural
insights into this ternary complex now suggest that the equine
infectious anemia virus TAR is engaged by both proteins with Tat in
a helical conformation and that binding depends on flipping out
specific bases in the TAR loop region.
Kanchan Anand et al.
doi:10.1038/nsmb.1513
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Structure of the Shigella T3SS effector IpaH defines a new class
of E3 ubiquitin ligases pp1293 - 1301
The IpaH family of Shigella virulence factors are E3 ubiquitin
ligases that may target host proteins. Structural and functional
characterization of IpaH1.4 and IpaH9.8 reveal a unique C-terminal
catalytic domain that seems to have HECT-like E3 ligase activity.
Together with an accompanying publication from Zhu et al., these
data suggest that the IpaH proteins constitute a new category of
ubiquitin ligases.
Alexander U Singer et al.
doi:10.1038/nsmb.1511
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Structure of a Shigella effector reveals a new class of ubiquitin
ligases pp1302 - 1308
The IpaH proteins from Shigella show ubiquitin-ligase activity but
lack obvious sequence similarity to HECT- or RING-type ubiquitin
ligases. The crystal structure of IpaH3 reveals a two-domain protein
with HECT-like catalytic activity mapped to a C-terminal domain of
novel fold. These findings suggest that IpaH proteins represent a
new family of ubiquitin ligases, a conclusion supported by results
from a related study by Tyers et al.
Yongqun Zhu et al.
doi:10.1038/nsmb.1517
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Structural basis of nucleotide exchange and client binding by the
Hsp70 cochaperone Bag2 pp1309 - 1317
Bag2 acts as a nucleotide-exchange factor for Hsp70 and also binds
misfolded substrates. Now structural work reveals that Bag2 promotes
nucleotide exchange via a mechanism distinct from other Hsp70
nucleotide-exchange factors, and mapping of the binding sites for
client peptides suggests how Bag2 assists Hsp70 in processing
misfolded proteins.
Zhen Xu et al.
doi:10.1038/nsmb.1518
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

The MSL3 chromodomain directs a key targeting step for dosage
compensation of the Drosophila melanogaster X chromosome
pp1318 - 1325
The MSL complex is involved in upregulation of genes on the
Drosophila melanogaster male X chromosome during dosage
compensation. Using mutagenesis, the MSL3 chromodomain is now
shown to interact with methylated histone H3K36 and is implicated
in the spreading of the dosage-compensation complex from its
initial binding sites, defining a process of spreading by activation
complexes analogous to that defined for silencing complexes.
Tuba H Sural et al.
doi:10.1038/nsmb.1520
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Cooperative three-step motions in catalytic subunits of F1-ATPase
correlate with 80deg and 40deg substep rotations
pp1326 - 1333
F1 ATPase contains three catalytic beta subunits that hydrolyze ATP,
causing the central gamma subunit to rotate. Now, using fluorescent
tags, conformational changes in beta and rotation of gamma are
observed simultaneously within the same complex, allowing the
motions in beta to be correlated with catalytic events and ultimately
rotation.
Tomoko Masaike et al.
doi:10.1038/nsmb.1510
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Molecular basis of Pirh2-mediated p53 ubiquitylation pp1334 - 1342
Pirh2 is one of several ubiquitin ligases known to modify and
negatively regulate p53. Solution studies reveal the structures of
the three Pirh2 domains and indicate that the C-terminal domain of
Pirh2 interacts with the p53 tetramerization domain. Additional data
suggest that Pirh2 preferentially modifies the tetrameric,
transcriptionally active form of p53 for proteasome-mediated
degradation.
Yi Sheng et al.
doi:10.1038/nsmb.1521
Abstract: http://links.ealert.nature.com/ctt?kn=71&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

Structural insights into RNA recognition by the alternative-splicing
regulator muscleblind-like MBNL1 pp1343 - 1351
Muscleblind-like (MBNL) proteins have been implicated in
alternative-splicing regulation during development, and altered
levels of these proteins have been implicated in myotonic dystrophy.
The structure of the MBNL1 zinc finger domains in complex with RNA
indicates how the target sequence is recognized and suggests that an
antiparallel arrangement of the zinc fingers causes a trajectory
reversal in the pre-mRNA target. The potential role of such generated
looped segments in alternative splicing is discussed.
Marianna Teplova and Dinshaw J Patel
doi:10.1038/nsmb.1519
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=30631045&r=MTM0NDQ5NTYwNQS2&b=2&j=NDM0OTU4MDUS1&mt=1&rt=0

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Nature Clinical Practice Urology - Table of Contents alert Volume 5 Issue 12

NATURE CLINICAL PRACTICE UROLOGY

December 2008 Volume 5 Number 12

Visit Nature Clinical Practice Urology online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=16&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

=====================================================================

Metabolic Syndrome - now affecting over 25% of the world's population.

The 'Metabolic Syndrome 2008' web focus showcases a collection of
original research articles from our Academic and Clinical Practice
titles that provide further insight into this global disease.

8 distinguished titles, 16 insightful articles, one growing epidemic.

View 'Metabolic Syndrome 2008' online FREE of charge at
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=====================================================================

----------------------
EDITORIAL
----------------------
Where to draw the lifeline?
Nayanah Siva
http://links.ealert.nature.com/ctt?kn=49&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Raised levels of IGF-I increase the risk of developing prostate cancer
http://links.ealert.nature.com/ctt?kn=12&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Suprapubic drainage is a suitable alternative to catheterization after
prostatectomy
http://links.ealert.nature.com/ctt?kn=64&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Excess weight increases risk of death from prostate cancer
http://links.ealert.nature.com/ctt?kn=46&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Genetic polymorphism identified in men with lifelong premature ejaculation
http://links.ealert.nature.com/ctt?kn=56&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Tamsulosin improves clearance of renal calculi fragments after shockwave
lithotripsy
http://links.ealert.nature.com/ctt?kn=26&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Black men in the UK have an elevated risk of developing prostate cancer
http://links.ealert.nature.com/ctt?kn=67&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

CT urography accurately detects bladder cancer in patients with hematuria
http://links.ealert.nature.com/ctt?kn=31&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Tacrolimus ointment is a safe adjuvant treatment for lichen sclerosus in
boys
http://links.ealert.nature.com/ctt?kn=48&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Erectile function in end-stage renal disease is not improved by renal
transplantation
http://links.ealert.nature.com/ctt?kn=43&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

----------------------
PRACTICE POINTS
----------------------
Can imaging be used to assess treatment success after ablation of renal
tumors?
Stephen B Solomon
http://links.ealert.nature.com/ctt?kn=19&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Does adjuvant vitespen prevent recurrence in patients with locally advanced
kidney cancer?
Christian Doehn and Dieter Jocham
http://links.ealert.nature.com/ctt?kn=5&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Does antibiotic prophylaxis prevent renal scarring in children with
vesicoureteral reflux?
Jack S Elder
http://links.ealert.nature.com/ctt?kn=53&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Should patients with localized prostate cancer receive primary androgen
deprivation therapy?
Mikio Namiki, Atsushi Mizokami and Hideyuki Akaza
http://links.ealert.nature.com/ctt?kn=69&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

What is the current status of second-line chemotherapy for
castration-resistant prostate cancer?
Jonathan E Rosenberg and William K Oh
http://links.ealert.nature.com/ctt?kn=40&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

----------------------
VIEWPOINTS
----------------------
A unifying strategy for clinical trials in rare urological malignancy
Steve Nicholson
http://links.ealert.nature.com/ctt?kn=62&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Expediting the availability of drugs for US patients with cancer
Ann T Farrell, Richard Pazdur and Andrew C von Eschenbach
http://links.ealert.nature.com/ctt?kn=36&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
Sacral neuromodulation for urinary retention
Thomas M Kessler and Clare J Fowler
http://links.ealert.nature.com/ctt?kn=45&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Concurrent urinary tract infection and stone disease: pathogenesis,
diagnosis and management
Ben Thomas and David Tolley
http://links.ealert.nature.com/ctt?kn=15&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Molecular biomarkers for urothelial carcinoma of the bladder: challenges
in clinical use
Christian Bolenz and Yair Lotan
http://links.ealert.nature.com/ctt?kn=14&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

----------------------
CASE STUDIES
----------------------
A case of staghorn stones in a kidney with an ileal ureter treated by
percutaneous nephrolithotomy
Xiaofeng Gao, Tie Zhou, Jinyi Li and Yinghao Sun
http://links.ealert.nature.com/ctt?kn=6&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

Presentation and management of a patient with subcutaneous metastatic
transitional cell carcinoma of the bladder
Hannah H Alphs, Jennifer Miles-Thomas, Frank Attenello, Janis M Taube,
Gustavo Fonseca, Thomas J Guzzo, Mark P Schoenberg and Trinity J Bivalacqua
http://links.ealert.nature.com/ctt?kn=65&m=30630672&r=MTM2MjU5ODcxNAS2&b=2&j=NDM0OTEzNzcS1&mt=1&rt=0

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Genes and Immunity Table of Contents alert Volume 9 Issue 8

GENES AND IMMUNITY

December 2008 Volume 9 Number 8, pp 651 - 726
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Special Focus on Glycobiology of the Immune System
brought to you by Immunology & Cell Biology

Bringing you the latest on the glycobiology of
the immune system, this special feature and
accompanying web focus explore the current
understanding of how glycans play a role in a
ctivating the adaptive and innate immune responses.

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Articles for this journal are published online ahead of print
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http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0BUpb0EL

----------------------
ORIGINAL ARTICLES
----------------------
Positive selection on mammalian MHC-DQ genes revisited from a
multispecies perspective
M Amills, O Ramirez, A Tomas, G Obexer-Ruff and O Vidal
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDBz0Eh
Article:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDB10EU

A functional polymorphism of the vasoactive intestinal peptide
receptor 1 gene correlates with the presence of HLA-B[thinsp][ast]2705
in Sardinia
F Paladini, E Cocco, A Cauli, I Cascino, A Vacca, F Belfiore, M T
Fiorillo, A Mathieu and R Sorrentino
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDB20EV
Article:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDB30EW

A novel transcript of mouse interleukin-20 receptor acts on glomerular
mesangial cells as an aggravating factor in lupus nephritis
C-C Wei and M-S Chang
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDB40EX
Article:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDB50EY

A transmembrane polymorphism in Fc[gamma]RIIb (FCGR2B) is associated
with the production of anti-cyclic citrullinated peptide
autoantibodies in Taiwanese RA
J-Y Chen, C-M Wang, C-C Ma, L-A Hsu, H-H Ho, Y-J J Wu, S-N Kuo and J
Wu
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDB60EZ
Article:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDB70Ea

Expression levels of FAS are regulated through an evolutionary
conserved element in intron 2, which modulates cystic fibrosis disease
severity
V Kumar, T Becker, S Jansen, A van Barneveld, K Boztug, S Wolfl, B
Tummler and F Stanke
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDB80Eb
Article:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDCA0El

High frequencies of alleles MICA[ast]020 and MICA[ast]027 in
Amerindians and evidence of positive selection on exon 3
L A Oliveira, F Ribas, M G Bicalho, L T Tsuneto and M L Petzl-Erler
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDCB0Em
Article:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDCC0En

Defining a transcriptional fingerprint of murine splenic B-cell
development
I Debnath, K M Roundy, D M Dunn, R B Weiss, J J Weis and J H Weis
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDCD0Eo
Article:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDCE0Ep

----------------------
SHORT COMMUNICATION
----------------------
Initial description of the human NLRP3 promoter
J P Anderson, J L Mueller, A Misaghi, S Anderson, M Sivagnanam, R D
Kolodner and H M Hoffman
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDCF0Eq
Article:
http://ealerts.nature.com/cgi-bin24/DM/y/epEr0Xztnp0Him0CDCG0Er

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The EMBO Journal Table of Contents alert Volume 27 Issue 23

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The EMBO Journal

Table of contents

Volume 27, Number 23 (03 December 2008)

In this issue...

Determination of bacterial rod shape by a novel cytoskeletal membrane
protein

Here, Hironori and coworkers identify RodZ as a novel cell
shape-determining protein in E. coli. Surprisingly in light of its
primary sequence and membrane protein topology, RodZ forms
cytoskeletal spirals similar to the bacterial actin homolog MreB, and
exhibits a similar loss-of-function phenotype with loss of bacterial
rod shape.
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4K0Es

Gq-coupled receptors as mechanosensors mediating myogenic
vasoconstriction

The mechanisms linking mechanical stress to ion channel activation are
not well understood. Gudermann and colleagues now report that GPCRs,
and not TRP ion channels, are the primary mechanosensors in vascular
smooth muscle, mediating activation of TRPC channels via intracellular
signalling.
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4L0Et

Articles

Determination of bacterial rod shape by a novel cytoskeletal membrane
protein.

Daisuke Shiomi, Masako Sakai and Hironori Niki

The EMBO Journal (2008) 27, 23, 3081-3091
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4K0Es
Published online: 13 November 2008

Gq-coupled receptors as mechanosensors mediating myogenic
vasoconstriction.

Michael Mederos y Schnitzler, Ursula Storch, Simone Meibers, Pascal
Nurwakagari, Andreas Breit, Kirill Essin, Maik Gollasch and Thomas
Gudermann

The EMBO Journal (2008) 27, 23, 3092-3103
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4L0Et
Published online: 6 November 2008

P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers
pressure overload-induced cardiac fibrosis.

Motohiro Nishida, Yoji Sato, Aya Uemura, Yusuke Narita, Hidetoshi
Tozaki-Saitoh, Michio Nakaya, Tomomi Ide, Kazuhiro Suzuki, Kazuhide
Inoue, Taku Nagao and Hitoshi Kurose

The EMBO Journal (2008) 27, 23, 3104-3115
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4M0Eu
Published online: 13 November 2008

Silencing and transcriptional properties of the imprinted Airn ncRNA
are independent of the endogenous promoter.

Stefan H Stricker, Laura Steenpass, Florian M Pauler, Federica
Santoro, Paulina A Latos, Ru Huang, Martha V Koerner, Mathew A
Sloane, Katarzyna E Warczok and Denise P Barlow

The EMBO Journal (2008) 27, 23, 3116-3128
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4N0Ev
Published online: 13 November 2008

A protein that replaces the entire cellular eIF4F complex.

Mohammad A Mir and Antonito T Panganiban

The EMBO Journal (2008) 27, 23, 3129-3139
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4O0Ew
Published online: 30 October 2008

Chk2-dependent phosphorylation of XRCC1 in the DNA damage response
promotes base excision repair.

Wen-Cheng Chou, Hui-Chun Wang, Fen-Hwa Wong, Shian-ling Ding, Pei-Ei
Wu, Sheau-Yann Shieh and Chen-Yang Shen

The EMBO Journal (2008) 27, 23, 3140-3150
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4P0Ex
Published online: 30 October 2008

Cytokinesis of neuroepithelial cells can divide their basal process
before anaphase.

Yoichi Kosodo, Kazunori Toida, Veronique Dubreuil, Paula Alexandre,
Judith Schenk, Emi Kiyokage, Alessio Attardo, Felipe Mora-Bermúdez,
Tatsuo Arii, Jon D W Clarke and Wieland B Huttner

The EMBO Journal (2008) 27, 23, 3151-3163
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4Q0Ey
Published online: 30 October 2008

Structural determinants of Kvbeta1.3-induced channel inactivation: a
hairpin modulated by PIP2.

Niels Decher, Teresa Gonzalez, Anne Kathrin Streit, Frank B Sachse,
Vijay Renigunta, Malle Soom, Stefan H Heinemann, Jürgen Daut and
Michael C Sanguinetti

The EMBO Journal (2008) 27, 23, 3164-3174
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4R0Ez
Published online: 6 November 2008

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex
structure.

David Komander, Ritu Garg, Paul T C Wan, Anne J Ridley and David
Barford

The EMBO Journal (2008) 27, 23, 3175-3185
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4S0E1
Published online: 23 October 2008

Auto-activation mechanism of the Mycobacterium tuberculosis PknB
receptor Ser/Thr kinase.

Carl Mieczkowski, Anthony T Iavarone and Tom Alber

The EMBO Journal (2008) 27, 23, 3186-3197
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4T0E2
Published online: 13 November 2008

Molecular basis for G-actin binding to RPEL motifs from the serum
response factor coactivator MAL.

Stephane Mouilleron, Sebastian Guettler, Carola A Langer, Richard
Treisman and Neil Q McDonald

The EMBO Journal (2008) 27, 23, 3198-3208
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4U0E3
Published online: 13 November 2008

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3
protein.

Dahai Luo, Ting Xu, Randall P Watson, Daniella Scherer-Becker, Aruna
Sampath, Wolfgang Jahnke, Sui Sum Yeong, Chern Hoe Wang, Siew Pheng
Lim, Alex Strongin, Subhash G Vasudevan and Julien Lescar

The EMBO Journal (2008) 27, 23, 3209-3219
http://ealerts.nature.com/cgi-bin24/DM/y/epDA0Xztnp0Hh50CC4V0E4
Published online: 13 November 2008

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