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The EMBO Reports - Table of Contents alert December 2008 Volume 9, Number 12, pp 1157-1252

EMBO REPORTS TABLE OF CONTENTS

December 2008 Volume 9 Number 12, pp 1157-1252
(c) Copyright 2008 by the European Molecular Biology Organization
Now available at http://links.ealert.nature.com/ctt?kn=18&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

Visit EMBO reports online to browse the content of the current
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Contents: Volume 9, Number 12 (December 2008)

---------------------
EDITORIAL
---------------------


Burnout.
Frank Gannon
http://links.ealert.nature.com/ctt?kn=63&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

---------------------
SCIENCE AND SOCIETY
---------------------

VIEWPOINTS

The implications of the new brain sciences. The `Decade of the Brain' is over but its effects are now becoming visible as neuropolitics and neuroethics, and in the emergence of neuroeconomies.
Joelle M Abi-Rached
http://links.ealert.nature.com/ctt?kn=78&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


The evolution of biology. A shift towards the engineering of prediction-generating tools and away from traditional research practice.
Lawrence Kelley & Michael Scott
http://links.ealert.nature.com/ctt?kn=10&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

ANALYSES

The recruitment crunch.
Philip Hunter
http://links.ealert.nature.com/ctt?kn=54&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=9&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


What's in a name?
Howard Wolinsky
http://links.ealert.nature.com/ctt?kn=53&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=75&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


The power of words.
Samuel Caddick
http://links.ealert.nature.com/ctt?kn=32&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=21&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

---------------------
REVIEWS
---------------------

MEETING REPORTS

New insights into the chromosome cycle. Conference on the Replication & Segregation of Chromosomes.
Guillermo de la Cueva-Mendez & Karim Labib
http://links.ealert.nature.com/ctt?kn=51&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


Chlamydomonas: a sexually active, light-harvesting, carbon-reducing, hydrogen-belching `planimal'. Conference on the Cell & Molecular Biology of Chlamydomonas.
Kevin E Redding & Douglas G Cole
http://links.ealert.nature.com/ctt?kn=80&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


The `Odd Pols' are even when it comes to controlling cell function. Conference on RNA Polymerases I and III.
Ross D Hannan & Michael C Schultz
http://links.ealert.nature.com/ctt?kn=24&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

LITERATURE REPORT

A stress protein interface of innate immunity.
Didier Picard
http://links.ealert.nature.com/ctt?kn=65&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

REVIEWS

Urm1 at the crossroad of modifications. `Protein Modifications: Beyond the Usual Suspects' Review Series.
Patrick G A Pedrioli, Sebastian Leidel & Kay Hofmann
http://links.ealert.nature.com/ctt?kn=43&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=71&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


Kindlins: essential regulators of integrin signalling and cell[ndash]matrix adhesion.
Hannu Larjava, Edward F Plow & Chuanyue Wu
http://links.ealert.nature.com/ctt?kn=81&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=16&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

---------------------
SCIENTIFIC REPORTS
---------------------


Structural and functional analysis of SGT1[ndash]HSP90 core complex required for innate immunity in plants.
Yasuhiro Kadota, Beatrice Amigues, Lionel Ducassou, Hocine Madaoui, Francoise Ochsenbein, Raphael Guerois & Ken Shirasu
http://links.ealert.nature.com/ctt?kn=28&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=60&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1.
Elina Nikko, James A Sullivan & Hugh R B Pelham
http://links.ealert.nature.com/ctt?kn=2&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=52&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


ATM and Chk2 kinase target the p53 cofactor Strap.
Cassandra J Adams, Anne L Graham, Martin Jansson, Amanda S Coutts, Mariola Edelmann, Linda Smith, Benedikt Kessler & Nicholas B La Thangue
http://links.ealert.nature.com/ctt?kn=39&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=27&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase.
Markus T Bohnsack, Martin Kos & David Tollervey
http://links.ealert.nature.com/ctt?kn=8&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=26&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


Blm10 binds to pre-activated proteasome core particles with open gate conformation.
Andrea Lehmann, Katharina Jechow & Cordula Enenkel
http://links.ealert.nature.com/ctt?kn=49&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=12&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


[beta]-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways.
Vítezslav Bryja, Alexandra Schambony, Lukás Cajánek, Isabel Dominguez, Ernest Arenas & Gunnar Schulte
http://links.ealert.nature.com/ctt?kn=13&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=33&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

CORRIGENDA

PP4 is a [gamma]H2AX phosphatase required for recovery from the DNA damage checkpoint.
Shinichiro Nakada, Ginny I Chen, Anne-Claude Gingras & Daniel Durocher
http://links.ealert.nature.com/ctt?kn=38&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0


A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases.
Lucas M Velloso, Shyam S Bhaskaran, Raymond Schuch, Vincent A Fischetti & C Erec Stebbins
http://links.ealert.nature.com/ctt?kn=37&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

---------------------
REVIEWS
---------------------

ADDENDUM

The expanding field of poly(ADP-ribosyl)ation reactions. `Protein Modifications: Beyond the Usual Suspects' Review Series.
Antoinette Hakmé, Heng-Kuan Wong, Francoise Dantzer & Valérie Schreiber
http://links.ealert.nature.com/ctt?kn=64&m=30629004&r=MTM1Mzk2MDEwMAS2&b=2&j=NDM0NjUzNzUS1&mt=1&rt=0

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Gene Therapy Table of Contents alert Volume 15 Issue 24

GENE THERAPY

December 2008 Volume 15 Number 24, pp 1567 - 1622
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----------------------
ORIGINAL ARTICLES
----------------------
A strategy for genetic modification of the spike-encoding segment of
human reovirus T3D for reovirus targeting
D J M van den Wollenberg, S K van den Hengel, I J C Dautzenberg, S J
Cramer, O Kranenburg and R C Hoeben
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5f0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5g0ET

A strategy for systemic delivery of the oncolytic herpes virus
HSV1716: redirected tropism by antibody-binding sites incorporated on
the virion surface as a glycoprotein D fusion protein
J Conner, L Braidwood and S M Brown
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5h0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5i0EV

Persistent episomal transgene expression in liver following delivery
of a scaffold//matrix attachment region containing non-viral vector
O Argyros, S P Wong, M Niceta, S N Waddington, S J Howe, C Coutelle, A
D Miller and R P Harbottle
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5j0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5k0EX

Complex interactions with several arms of the complement system
dictate innate and humoral immunity to adenoviral vectors
D M Appledorn, A McBride, S Seregin, J M Scott, N Schuldt, A Kiang, S
Godbehere and A Amalfitano
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5l0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5m0EZ

----------------------
SHORT COMMUNICATION
----------------------
Bioluminescent virion shells: new tools for quantitation of AAV vector
dynamics in cells and live animals
A Asokan, J S Johnson, C Li and R J Samulski
Abstract:
http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5n0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epDI0Xztnp0Hin0CC5o0Eb

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Monday, December 1, 2008

Latest PhD Studentships - 2 December 2008


Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.

University of Edinburgh
Investigation of the nucleocytoplasmic transport mechanism by a conserved multifunctional viral protein in herpesvirus infected cells

Barts & The London School of Medicine & Dentistry
The PcG gene Bmi1 and the maintenance and function of muscle satellite cells.

University of Edinburgh
Using cosmogenic surface exposure dating to determine the evolution of active normal faults in Lazio-Abruzzo, central Italy

University of Sheffield
Mitochondria as a therapeutic target in motor neuron disorders

Cardiff University
Molecular genetic characterisation of probiotic bacteria and their effect on the diversity of the human gut microbiota

Cardiff University
Label-free multiphoton microscopy of intracellular lipids using Coherent Antistokes Raman Scattering (CARS)

Cardiff University
Investigating the mechanism of action of anti-Wnt signalling drugs

University of Manchester
Cardiovascular Sciences - cardiac physiology and vascular biology

University of Glasgow
The Role of av Integrins in Human B Lymphocyte Development

University of Glasgow
The use of spongy phase methods to crystallise membrane proteins with particular reference to purple bacterial core complexes.

University of Glasgow
Regulation of intracellular membrane traffic

University of Glasgow
Ion channel gates - analysis of redox control of a K+ channel model

University of Glasgow
MATHEMATICAL MODELLING OF CYTOKINE RECEPTOR SIGNALLING CROSS-REGULATION BY CYCLIC AMP

Cardiff University
Identifying tools for the directed differentiation of stem cells

Cardiff University
GSK-3: a genetic and molecular analysis of its role in cell chemotaxis

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Potentiating MSC by Serum Starvation

 

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Hello manoj kumar valluru,

New Feature - By popular demand, we've added a Send-to-a-Friend feature (BETA) so you can easily share our newsletters with your friends and colleagues.  Just click the big 'Send to a Friend' button at the end of each newsletter.

Last week an interesting paper was published describing how serum starvation of mesenchymal stem cells increases IGF-1 production by up to 200-fold.  This may be an easy method of potentiating therapeutic effects of MSC in existing experimental scenarios.  Perhaps more exciting was that the process of starvation was associated with epigenetic changes.

3 patents were issued of interest to our field.

The first one, #7,455,962, teaches how to isolate hemangioblasts by selection for a CD34-like molecule called podocalyxin-like protein 1 (PCLP-1).

The second patent, #7,455,983, covers methods of screening cultures of embryonic stem cells for media that can maintain the embryonic stem cells in an undifferentiated state, while allowing for their propagation.  This is one of the few "methods of screening" patents that we have come across.

The third patent, #7,456,333, discloses a transgenic mouse model of chronic myeloid leukemia (CML). This mouse has the leukemia-causing bcr-abl oncogene expressed selectively in cells positive for the stem cell antigen (SCA-1). The model resembles human CML pathology.  Too bad these sorts of patents cant be issued in Canada.

 

 


Method for preparing cell fraction containing hemangioblasts
 
 
Patent Number: 7,455,962

Therapeutic angiogenesis offers the possibility of treating a variety of diseases associated with ischemia.  For example, autologous bone marrow stem cells were used at Indiana University for the treatment of critical limb ischemia patients.  Although several studies have used various [Read More]

Ask a question OR leave your comments.

 


  Stressed Mesenchymals Make More IGF-1

Sunday November 30th, 2008 @ 20:53:23 EST

New Orleans, Louisiana -

We at StemCellPatents.com have been stating for a while now that one of the future areas of our field will be not simply determining if stem cell therapies work, but how to optimize them.  For example, bone marrow derived MSC are already in Phase III clinical trials, and numerous...[Read More]

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Stem Cells World Congress

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RMSC 2008 World Congress (2-4 December 2008)
The 3rd Annual Stem Cells World Congress (20-22 January 2009)
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  Method for preparing cell fraction containing hemangioblasts (7,455,962)
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  Direct differentiation method for making cardiomyocytes from human embryonic stem cells (7,452,718)
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  Transluminal application of adult stem cells for body organ tissue repair (7,452,532)
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  Treatment of muscular dystrophy with cord blood cells (7,452,529)
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  Method of expanding and differentiating cord blood cells by hyperthermic incubation (7,452,662)
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  Methods and compositions for tissue regeneration (7,449,333)
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  Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 antibodies (7,449,186)
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  Compositions and methods for enrichment of neural stem cells using ceramide analogs (7,445,931)
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Nature Cell Biology contents: December 2008 Volume 10 Number 12, pp 1373 - 1484

NATURE CELL BIOLOGY

December 2008 Volume 10 Number 12, pp 1373 - 1484

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=====================================================================

----------------------
EDITORIAL
----------------------
Italy fails to nurture knowledge p1373
Silvio Berlusconi's government seems set on its course to reform
Italy's troubled education system through heavy cuts in funding to
schools, universities and scientific research, prompting a belated
flurry of protests.
doi:10.1038/ncb1208-1373
http://links.ealert.nature.com/ctt?kn=8&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

----------------------
OBITUARY
----------------------
George Palade 1912-2008 p1374
David D. Sabatini
doi:10.1038/ncb1208-1374
http://links.ealert.nature.com/ctt?kn=27&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

----------------------
MEETING REPORT
----------------------
Exploring the pole: an EMBO conference on centrosomes and spindle
pole bodies pp1375 - 1378
Sue L. Jaspersen and Tim Stearns
doi:10.1038/ncb1208-1375
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

----------------------
COMMENTARY
----------------------
Do the protocadherins Fat and Dachsous link up to determine both
planar cell polarity and the dimensions of organs? pp1379 - 1382
Peter A. Lawrence, Gary Struhl and Jose Casal
doi:10.1038/ncb1208-1379
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
A TRP channel-steroid marriage pp1383 - 1384
A surprising functional association between TRPM3, a mysterious member
of the family of transient receptor potential (TRP) cation channels, and the
sulphated version of pregnenolone, 'mother' of all steroid hormones,
has been identified.
Bernd Nilius and Thomas Voets
doi:10.1038/ncb1208-1383
http://links.ealert.nature.com/ctt?kn=73&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

Under arrest in mitosis: Cdc20 dies twice pp1385 - 1387
The spindle assembly checkpoint is crucial for maintaining genome
integrity in dividing cells by preventing premature chromosome segregation.
Degradation of the APC/C activator Cdc20 seems to be an essential and
conserved mechanism to maintain this checkpoint in the presence of
chromosomes that are not attached to the mitotic spindle.
Andrew M. Fry and Hiroyuki Yamano
doi:10.1038/ncb1208-1385
http://links.ealert.nature.com/ctt?kn=88&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

Staying alive: apoptosome feedback inhibition pp1387 - 1388
Studies in Drosophila melanogaster reveal a mechanism for regulating
caspases, the key executioners of the apoptotic cell-death program.
An initiator caspase and its activating partner promote degradation of
each other, thereby limiting the levels of the active protease complex.
This negative-feedback inhibition helps to explain how cells avoid
unwanted caspase activation and apoptosis.
Hermann Steller
doi:10.1038/ncb1208-1387
http://links.ealert.nature.com/ctt?kn=1&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

Out of the jaws of death: PRMT5 steers p53 pp1389 - 1390
The tumour suppressor p53 triggers either cell-cycle arrest or apoptosis.
Now, arginine methylation joins a panoply of other post-translational
modifications that regulate p53. PRMT5 mediates p53 methylation,
which disposes the cell to arrest rather than death.
Shelley L. Berger
doi:10.1038/ncb1208-1389
http://links.ealert.nature.com/ctt?kn=29&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights p1391
Nathalie Le Bot, Bernd Pulverer, Christina Karlsson Rosenthal and
Sowmya Swaminathan
doi:10.1038/ncb1208-1391
http://links.ealert.nature.com/ctt?kn=35&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

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=====================================================================

----------------------
ARTICLES
----------------------
Fluctuations of intracellular forces during cell protrusion pp1393 - 1400
Modelling intracellular force variations at cell protrusions suggests that
cell adhesion is regulated at the interface between vinculin and integrin
and reveals a putative feedback between increases in tension and
F-actin assembly.
Lin Ji, James Lim and Gaudenz Danuser
doi:10.1038/ncb1797
Abstract: http://links.ealert.nature.com/ctt?kn=69&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

Nature and anisotropy of cortical forces orienting Drosophila tissue
morphogenesis pp1401 - 1410
Quantitative analysis and mathematical modelling show that cortical
tension anisotropy at apical cell junctions drives cell neighbour exchanges
that are responsible for elongation of Drosophila embryos. This anisotropy
depends on myosin II activity.
Matteo Rauzi, Pascale Verant, Thomas Lecuit and Pierre-Francois Lenne
doi:10.1038/ncb1798
Abstract: http://links.ealert.nature.com/ctt?kn=71&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20
for destruction pp1411 - 1420
Ubiquitin-dependent degradation of Cdc20 by the APC/C ligase is a
conserved mechanism essential for maintaining the spindle assembly
checkpoint activated by unattached chromosomes.
Jakob Nilsson, Mona Yekezare, Jeremy Minshull and Jonathon Pines
doi:10.1038/ncb1799
Abstract: http://links.ealert.nature.com/ctt?kn=77&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

Transient receptor potential M3 channels are ionotropic steroid receptors
in pancreatic beta cells pp1421 - 1430
In an unanticipated cross-talk between the steroid and insulin endocrine
systems, the neuroactive steroid pregnenolone sulphate is found to
activate the TRPM3 channel, leading to enhanced insulin secretion
from pancreatic islets.
Thomas F.J. Wagner et al.
doi:10.1038/ncb1801
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

Arginine methylation regulates the p53 response pp1431 - 1439
The tumour suppressor p53 is subject to complex regulation and arginine
methylation is now shown to provide an additional level of control.
The protein arginine methyltransferase (PRMT) 5 is recruited by Strap to
methylate p53 in response to DNA damage, governing the p53 response.
Martin Jansson et al.
doi:10.1038/ncb1802
Abstract: http://links.ealert.nature.com/ctt?kn=95&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

----------------------
LETTERS
----------------------
Regulation of the Drosophila apoptosome through feedback inhibition
pp1440 - 1446
The apoptotic inhibitor IAP1 regulates a feedback loop between the
caspase Dronc1 and its apoptosome adaptor Apaf1 to maintain low
caspase activity in cells that are not destined to die.
Peter J. Shapiro et al.
doi:10.1038/ncb1803
Abstract: http://links.ealert.nature.com/ctt?kn=80&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

X-linked and cellular IAPs modulate the stability of C-RAF kinase and
cell motility pp1447 - 1455
The anti-apoptotic regulators XIAP and c-IAPs promote turnover of the
cRAF kinase to control cell migration. XIAP binding facilitates ubiquitylation
of cRAF through the ubiquitin ligase CHIP.
Taner Dogan et al.
doi:10.1038/ncb1804
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

An H+ P-ATPase on the tonoplast determines vacuolar pH and flower colour
pp1456 - 1462
P-ATPases in plants are typically thought to act at the plasma membrane.
In contrast, PH5, a P-type H+ ATPase functions within the vacuolar membrane
to control acidification during flower coloration.
Walter Verweij et al.
doi:10.1038/ncb1805
Abstract: http://links.ealert.nature.com/ctt?kn=36&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

Activation of TGF-beta/activin signalling resets the circadian clock
through rapid induction of Dec1 transcripts pp1463 - 1469
The circadian clock is synchronized with the environment. In mammals,
besides light input mediated by Per genes, little is known about resetting
mechanisms. TGF-beta and activin reset the clock by acting on the
circadian gene Dec1.
Naohiro Kon et al.
doi:10.1038/ncb1806
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

Glioblastoma microvesicles transport RNA and proteins that promote
tumour growth and provide diagnostic biomarkers pp1470 - 1476
Human glioblastoma cells release microvesicles containing a diverse
set of proteins, miRNAs and mRNAs, which can be taken up by normal
host cells that translate the mRNA. Glioma-derived microvesicles
carrying the specific tumour markers EGFRvIII and miRNA-21 promote
cell proliferation and may serve as a diagnostic tool.
Johan Skog et al.
doi:10.1038/ncb1800
Abstract: http://links.ealert.nature.com/ctt?kn=50&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

Glucose metabolism inhibits apoptosis in neurons and cancer cells by
redox inactivation of cytochrome c pp1477 - 1483
Neurons and cancer cells metabolize glucose extensively. Intracellular
gluthatione produced by this metabolic pathway reduces cytochrome c
release from mitochondria to increase cell survival.
Allyson E. Vaughn and Mohanish Deshmukh
doi:10.1038/ncb1807
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

----------------------
ERRATUM
----------------------
A model for transmission of the H3K27me3 epigenetic mark p1484
Klaus H. Hansen et al.
doi:10.1038/ncb1208-1484
http://links.ealert.nature.com/ctt?kn=9&m=30626948&r=MTM0NTA1MzMwNQS2&b=2&j=NDM0MzIwNDYS1&mt=1&rt=0

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Nature Clinical Practice Rheumatology - Table of Contents alert Volume 4 Issue 12

NATURE CLINICAL PRACTICE NEUROLOGY

December 2008 Volume 4 Number 12

Visit Nature Clinical Practice Neurology online to browse the journal.

Now available at http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0ox40ES

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----------------------
EDITORIAL
----------------------
Giving dementia a voice
Heather B Wood
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCre0EY

----------------------
RESEARCH HIGHLIGHTS
----------------------
Moderate exercise is safe and improves fitness in patients with Becker
muscular dystrophy
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrf0EZ

Sumatriptan reduces somatic and visceral pain in mice
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrg0Ea

Virtual reality identifies navigational defects in Alzheimer disease and
cognitive aging
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrh0Eb

Defects in transfer RNA processing cause pontocerebellar hypoplasia
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCri0Ec

COX inhibition reduces medulloblastoma proliferation
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrj0Ed

Lewy body pathology is seen in cutaneous nerves and can be detected in
skin biopsy samples
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrk0Ee

A miniature implantable neurostimulator can treat hemicrania continua
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrl0Ef

Headache in children is associated with obesity
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrm0Eg

Right-to-left shunt has no impact on recurrent stroke risk
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrn0Eh

In briefs
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCro0Ei

----------------------
PRACTICE POINTS
----------------------
Imaging blood-brain barrier disruption: an evolving tool for assessing
the risk of hemorrhage after thrombolysis
David Tanne
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrp0Ej

Early detection of nerve damage and repair in diabetic neuropathy
Rayaz A Malik
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrq0Ek

Identifying acute porphyria in patients with acute polyneuropathy or
encephalopathy
George H Elder and Sverre Sandberg
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrr0El

Neuropsychiatric comorbidities in childhood absence epilepsy
Gregory N Barnes and Juliann M Paolicchi
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrs0Em

How should pregnant women with spinal disease be managed?
Kathleen F Brookfield and Mark D Brown
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrt0En

----------------------
VIEWPOINT
----------------------
Should cannabinoids be used as analgesics for neuropathic pain?
Andrew SC Rice
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCru0Eo

----------------------
REVIEWS
----------------------
Nerve damage in leprosy and its management
Einar P Wilder-Smith and Wim H Van Brakel
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrv0Ep

Optical coherence tomography: a window into the mechanisms of multiple
sclerosis
Elliot M Frohman, James G Fujimoto, Teresa C Frohman, Peter A Calabresi,
Gary Cutter and Laura J Balcer
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrw0Eq

Botulinum neurotoxins in the treatment of refractory pain
Bahman Jabbari
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCrx0Er

----------------------
CASE STUDY
----------------------
A case of POEMS syndrome treated by autologous hematopoietic stem-cell
transplantation
Alain Creange, Ahmed Chater, Jean-Claude Brouet, Arnaud Jaccard, Alain
Rahmouni, Jean-Pascal Lefaucheur and Aline Santin
http://ealerts.nature.com/cgi-bin24/DM/y/eo8A0Xztnp0HjL0CCry0Es

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Cell Research Table of Contents alert Volume 18 Issue 12

CELL RESEARCH

December 2008 Volume 18 Number 12, pp 1157 - 1236

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----------------------
RESEARCH HIGHLIGHTS
----------------------
miRNAs: small changes, widespread effects
Sam EV Linsen, Bastiaan BJ Tops and Edwin Cuppen
http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzS0Ez

Paneth cells and inflammation dance together in Crohn's disease
Arthur Kaser and Richard S Blumberg
http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzT0E1

----------------------
REVIEW
----------------------
Transcriptional and signaling regulation in neural crest stem
cell-derived melanocyte development: do all roads lead to Mitf?
Ling Hou and William J Pavan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzU0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzV0E3

----------------------
ORIGINAL ARTICLES
----------------------
Yamanaka factors critically regulate the developmental signaling
network in mouse embryonic stem cells
Xiaosong Liu, Jinyan Huang, Taotao Chen, Ying Wang, Shunmei Xin, Jian
Li, Gang Pei and Jiuhong Kang
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzW0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzX0E5

MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated
protein kinase cascade to regulate innate immunity in plants
Minghui Gao, Jinman Liu, Dongling Bi, Zhibin Zhang, Fang Cheng,
Sanfeng Chen and Yuelin Zhang
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzY0E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzZ0E7

Isolation and initial characterization of GW5, a major QTL associated
with rice grain width and weight
Jianfeng Weng, Suhai Gu, Xiangyuan Wan, He Gao, Tao Guo, Ning Su,
Cailin Lei, Xin Zhang, Zhijun Cheng, Xiuping Guo, Jiulin Wang, Ling
Jiang, Huqu Zhai and Jianmin Wan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCza0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzb0EG

Apaf-1-deficient fog mouse cell apoptosis involves hypo-polarization
of the mitochondrial inner membrane, ATP depletion and citrate
accumulation
Iyoko Katoh, Shingo Sato, Nahoko Fukunishi, Hiroki Yoshida, Takasuke
Imai and Shun-ichi Kurata
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzc0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzd0EI

The role of granulocyte macrophage-colony-stimulating factor in acute
intestinal inflammation
Yinghua Xu, Nicholas H Hunt and Shisan Bao
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCze0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzf0EK

----------------------
LETTERS TO THE EDITOR
----------------------
Antibody-fused interferons as an effective approach to enhance target
specificity and antiviral efficacy of type I interferons
Lucy S Cheng, Seungmin Hwang, Tzu-Hsuan Huang, Ting-Chang Sheu, Ren
Sun, Sherie L Morrison, Genhong Cheng and Arash Shahangian
http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzg0EL

Effects of exposure to 1.8 GHz radiofrequency field on the expression
of Hsps and phosphorylation of MAPKs in human lens epithelial cells
Yibo Yu, Ke Yao, Wei Wu, Kaijun Wang, Guangdi Chen and Deqiang Lu
http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzh0EM

----------------------
ERRATUM
----------------------
Projection of an immunological self shadow to developing T cells via
macroautophagy
Christian Munz
http://ealerts.nature.com/cgi-bin24/DM/y/epB20Xztnp0Hhw0CCzi0EN


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